Grants

NM Arts Council

General operating and project support for arts organizations and individual artists in NM. Funds visual arts, performing arts, literary arts, and arts education.

$2K – $50K

2026-12-31

artsculture

Free to search & build · $99 one-time to unlock the application pack · No subscription

NMDA receptor regulation of rapid scaling and spinal excitability in fragile X syndrome.

NINDS - National Institute of Neurological Disorders and Stroke

NMDA receptor regulation of rapid scaling and spinal excitability in fragile X syndrome. Abstract Identifying the mechanisms that control the maturation of network excitability during development will be crucial to understanding how these networks are established with dysregulated activity in cases of neurodevelopmental disorders such as autism spectrum disorder (ASD). We are proposing to study a guiding principle for the maturation of network excitability during neonatal development. We have just recently published work in the chick embryo spinal cord showing that blockade of NMDA receptors triggers rapid compensatory changes in the strength of glutamatergic and GABAergic synapses, referred to as synaptic scaling. This rapid form of synaptic scaling was previously characterized in a very different model system - rodent hippocampal cultures and slices. The observation that rapid scaling has been identified in 2 very different systems illustrates the fundamental importance of this form of plasticity. In the current application we will study rapid scaling in the neonatal mouse spinal cord, as we have preliminary results suggesting this plasticity exists in mouse spinal neurons, and that some inputs are altered more than others (nonuniform). In Aim 1 we will identify which classes of neonatal mouse spinal neurons express AMPAergic (excitatory) and GABAergic (inhibitory) rapid scaling and assess the uniformity of this scaling. We hypothesize that the homeostatic scaling capacity will be correlated with NMDAR content and will impact the excitatory to inhibitory (E/I) balance within the network and therefore maturation of excitability. Interestingly several different autism spectrum disorder (ASD) models experience altered NMDAR function and altered E/I balance. It is therefore reasonable to suggest that NMDA-dependent rapid scaling may indeed be altered in these models of autism, thus changing their excitability. ASD models have significant delays in motor development, yet spinal cord studies in these model systems are surprisingly rare. In Aim 2 we will test the hypothesis that rapid scaling is dependent on NMDAR content and that this is altered in a mouse model of Fragile X Syndrome (FXS), the most common monogenetic cause of ASD. By understanding the mechanisms of homeostatic plasticity during circuit formation, we will better understand the maturation of network excitability in neurodevelopmental disorders like ASD.

Up to $235K

2028-04-30

Free to search & build · $99 one-time to unlock the application pack · No subscription

NMR Console Avance NEO 800 MHZ

OD - NIH Office of the Director

Abstract In an era where static structural information about biomolecules is readily available from de novo structure prediction programs, understanding dynamics, allostery, conformational changes, and the effects of disease- causing mutations is critical for mechanistic studies. Solution NMR uniquely provides this vital information and plays a unique role in addressing disordered regions of the human proteome and elucidating their functional roles. Consequently, there has been increased interest in using NMR to paint a more complete molecular picture. For decades Harvard Medical School have been pioneering new NMR methods and applying them to challenging systems. However, the recent ending of the NIH program project grant that supported the MIT magnet lab and the quench of the 900 MHz magnet at MIT have left a significant void in high-field instruments in the Boston area. The current flagship high-field spectrometer, the 800 MHz at DFCI, has a 19-year-old console, the brains of the instrument, which is outdated and incompatible with new operating systems and software. In terms of functionality the spectrometer is essentially stuck in the year 2018. Upgrading to a new console will equip the Arthanari lab with the capabilities to deploy their new NMR methods and make their existing methods operate more efficiently. The new method such as in situ/Closed-loop optimization of NMR pulse sequences and Stochastic NMR which require the capabilities of a new console. The Arthanari lab has developed nitrogen detection methods with TROSY selection which holds potential to unlock new frontiers in NMR studies, especially for challenging proteins, such as disordered proteins and proteins that can only be expressed in eukaryotic systems, where traditional NMR fails. This 800 MHz also has a TXO probe which is tailored for maximum sensitivity for 15N-direct detection. This spectrometer at DFCI is used by several NIH-funded groups in the area, including Harvard, MIT, Boston University, and Boston College, as well as researchers from across the globe. The unique combination of expertise in NMR methodology, biochemistry that allows innovative labeling, and innovative data acquisition in the Arthanari lab, along with a track record of maintaining a world-class facility for the last 30 years in the Longwood Medical Area, makes the collaborative work here highly productive, turning challenges into opportunities for innovation. This facility benefits from the wisdom of experienced scientists and core directors, as well as the fearless pursuit of ideas by young researchers. The NMR methods developed here present an opportunity to democratize NMR by enabling automation in both setting up experiments and analyzing data, thereby opening the use of NMR to non-experts. This new console will usher in a new era for NMR at the Longwood Medical Area, rejuvenating scientific quests and development of new NMR methods. The well-oiled and time-tested NMR infrastructure here will ensure easy access, efficient workflow, adequate training, proper maintenance, and access to robust and cutting-edge methods, leaving no stone unturned.

Up to $894K

2027-05-31

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NMS (RENEWAL)

National Medical Services, Inc dba NMS Labs

Medical Equipment and Accessories and Supplies

2027-06-30

Health

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NNPN New Play Commission

National New Play Network

Commissions and production grants for new plays by emerging and established playwrights.

$5K – $40K

2026-11-30

new playstheater

Free to search & build · $99 one-time to unlock the application pack · No subscription

NNYEDF (Proceeds) Program

New York Power Authority (NYPA)

The Northern New York Power Proceeds program is made possible through net earnings resulting from the sale of unused economic development hydropower generated at NYPA's St. Lawrence-FDR Power Project. The Northern New York Power Proceeds Act, passed in December 2014, allows NYPA to deposit the net earnings from the market sale of unallocated St. Lawrence County Economic Development Power into a fund, which can then be used to support economic development projects in the County. Eligible projects are considered under five funding tracks, including Training & Workforce Development: Training and related programs that will provide the necessary skills to meet industry needs. Ideally, projects should focus on concentrations of underemployed and underrepresented populations in the Region and provide programs for those populations.

Educationworkforce

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No Child Left Inside Tier 1

Washington State Recreation and Conservation Office

Grant funds are available for outdoor environmental, ecological, agricultural, or other natural resource-based education and recreation programs serving youth.

Up to $25K

Free to search & build · $99 one-time to unlock the application pack · No subscription

No Child Left Inside Tier 1

Washington State Recreation and Conservation Office

Grant funds are available for outdoor environmental, ecological, agricultural, or other natural resource-based education and recreation programs serving youth.

Up to $25K

Free to search & build · $99 one-time to unlock the application pack · No subscription

No Child Left Inside Tier 2

Washington State Recreation and Conservation Office

Grant funds are available for outdoor environmental, ecological, agricultural, or other natural resource-based education and recreation programs serving youth.

Up to $75K

Free to search & build · $99 one-time to unlock the application pack · No subscription

No Child Left Inside Tier 2

Washington State Recreation and Conservation Office

Grant funds are available for outdoor environmental, ecological, agricultural, or other natural resource-based education and recreation programs serving youth.

Up to $75K

Free to search & build · $99 one-time to unlock the application pack · No subscription

NOAA Climate Program Office - Understanding Climate Impacts on Fish Stocks and Fisheries to Inform Sustainable Management

Department of Commerce

For FY 2014, the National Oceanic and Atmospheric Administration (NOAA), Climate Program Office (CPO), Coastal and Ocean Climate Applications (COCA) program, in partnership with the NOAA National Marine Fisheries Service (NMFS), will support a competition to improve understanding, projection, and management of the impacts of climate variability and change on fish stocks and fisheries in the U.S. Northeast Shelf Large Marine Ecosystem (NESLME). In addition, this competition is also soliciting proposals for one year and up to $50,000 to develop a workshop focused on bringing together scientists from various disciplines (e.g. physical, ecological, social, economic) to promote interdisciplinary partnerships and discuss and prioritize future research needs to advance understanding of the impacts of climate variability and change on fish or other species that support economically important fisheries in the U.S. Proposals should collaborate with relevant NOAA Laboratories, Fisheries Science Centers, and Cooperative Institutes to the extent this collaboration enhances the effectiveness of the research and its outcomes. Complete information regarding the FY14 research topic and priorities - along with the names and contact information of the relevant Competition Manager is outlined below and also provided in the COCA program information sheet (http://cpo.noaa.gov/GrantsandProjects.aspx).

Up to $600K

Environmentalsustainability

Free to search & build · $99 one-time to unlock the application pack · No subscription

NOAA Great Lakes Fish Habitat Restoration Partnership Grants

DOC NOAA - ERA Production

The principal objective of the NOAA Great Lakes Fish Habitat Restoration Partnership Grants competition is to provide federal financial and technical assistance to habitat restoration projects that meet NOAA's mission to restore coastal habitats and support the Great Lakes Restoration Initiative (GLRI) (https://www.epa.gov/sites/default/files/2019-10/documents/glri-action-plan-3-201910-30pp.pdf) goal to protect and restore habitats to sustain healthy populations of native fish species in the eight U.S. Great Lakes states. Proposals submitted under this solicitation will be evaluated based on alignment with our program priorities, including: 1) contribution to GLRI Focus Area 1 (Toxic Substances and Areas of Concern) goals to implement management actions within Areas of Concern (AOC), and 2) contribution to GLRI Focus Area 4 (Habitats and Species) goals to restore habitat for native Great Lakes fish species whose populations have been impacted by habitat degradation. Through this solicitation, we intend to address GLRI Focus Area 4 goals by prioritizing a subset of habitat restoration projects identified by the Lake Committees as Environmental Priorities to meet fish community objectives for Great Lakes fish species. Lake Committees are composed of senior officials from state, provincial, and U.S. intertribal fishery agencies, convened by the Great Lakes Fishery Commission. Together, they are responsible for managing the Lakes fisheries and developing plans and guidance to sustain healthy populations of Great Lakes commercial and recreational fish species. *Please note that the Project Abstract Summary Form is not required in the Application.

$250K – $30M

Environmentalsustainability

Free to search & build · $99 one-time to unlock the application pack · No subscription

NOAA Habitat Restoration Grants

National Oceanic and Atmospheric Administration

Grants for restoring coastal and marine habitats including wetlands, coral reefs, mangroves, and fish passage to benefit trust species and coastal communities.

$50K – $3M

environmenthabitat restorationmarine science

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NOAA Sea Grant Aquaculture Research Program 2012

Department of Commerce

Depending on the availability of funds, NOAA expects to have approximately $3,200,000 available for a national competition to fund marine aquaculture research projects for FY 2012. This is part of the overall plan to support the development of environmentally and economically sustainable ocean, coastal, or Great Lakes aquaculture. Aquaculture that occurs in the Great Lakes or its coastal zone is considered marine aquaculture for this competition. Priorities for this FY 2012 competition include: Research to inform specific regulatory decisions; Research that supports multi-use spatial planning; and Socio-economic research targeted to understand aquaculture in a larger context. Proposals must be able to express how the proposed work will have a high probability of significantly advancing U.S. marine aquaculture development in the short-term (1-2 years) or medium-term (3-5 years). This Federal Funding Opportunity includes information on application and criteria for aquaculture research projects requesting a total of $50,000 to $500,000 in federal funding for up to a two-year period. Matching funds are required. Given the anticipated amount of funding and the anticipated number and quality of proposals submitted, it is anticipated that at least seven projects will be awarded in FY 2012. Additional proposals from this competition may be selected for funding in the next fiscal year, subject to the availability of funds. Ideally, awards are anticipated to start no later than September 1, 2012.

$50K – $500K

Education

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NOAA Sea Grant College Program

National Oceanic and Atmospheric Administration

Grants through a national network of 34 Sea Grant programs for marine research, education, and extension activities in coastal communities.

$50K – $1M

marine scienceenvironmentEducation+1

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NOI - Fluid Power Off -Road

National Energy Technology Laboratory

The purpose of this Notice of Intent is to provide potential applicants advance notice that the Department of Energy, Office of Energy Efficiency and Renewable Energy intends to issue, on behalf of the Vehicle Technologies Office, a Funding Opportunity Announcement, number DE-FOA-0001814 titled "Energy Efficiency R&D for Fluid-Power Systems in Off-Road Vehicles". The objective of the FOA is to research technologies and innovations that can improve the energy efficiency of fluid power systems for commercial off-road where fluid power systems actuate most of the functions.

$500K – $4M

energyclean energy

Free to search & build · $99 one-time to unlock the application pack · No subscription

NOI to Sole Source to Imaging Service Solutions for maintenance support services

HEALTH AND HUMAN SERVICES, DEPARTMENT OF.NATIONAL INSTITUTES OF HEALTH.NATIONAL INSTITUTES OF HEALTH OLAO

NOI to Sole Source to Imaging Service Solutions for maintenance support services

general

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NOI to Sole Source to Precision for Medicine for repository services

HEALTH AND HUMAN SERVICES, DEPARTMENT OF.NATIONAL INSTITUTES OF HEALTH.NATIONAL INSTITUTES OF HEALTH OLAO

NOI to Sole Source to Precision for Medicine for repository services

general

Free to search & build · $99 one-time to unlock the application pack · No subscription

NOI to Sole Source to Qiagen for maintenance and service contract

HEALTH AND HUMAN SERVICES, DEPARTMENT OF.NATIONAL INSTITUTES OF HEALTH.NATIONAL INSTITUTES OF HEALTH OLAO

NOI to Sole Source to Qiagen for maintenance and service contract

general

Free to search & build · $99 one-time to unlock the application pack · No subscription

NOI- Global Project to Promote Safer and Healthier Workplaces

Bureau of International Labor Affairs

This Notice of Intent is not a request for funding applications. The United States Department of Labor (USDOL), Bureau of International Labor Affairs (ILAB) intends to award a cooperative agreement of up to $10,000,000 to the International Labor Organization (ILO) to implement a technical assistance project to support global efforts to create safer and healthier workplaces. The project will focus on increasing the capacity of countries and social partners to improve occupational safety and health, particularly for working youth. The project will also include efforts to build and strengthen partnerships across international and regional organizations to share best practices, raise awareness, and contribute to improved legislation and enforcement. Authority: DOL Manual Series (DLMS) 2-836 (G)(3): Services are available from only one responsible source and no substitute will suffice; or the recipient has unique qualifications to perform the type of activity.

employmentworkforce development

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NOI: Cities Leading through Energy Analysis and Planning (Cities-LEAP)

Golden Field Office

The Office of Energy Efficiency and Renewable Energy (EERE) intends to issue, on behalf of the Strategic Programs Office, a Funding Opportunity Announcement (FOA) entitled Cities Leading through Energy Analysis and Planning (Cities-LEAP) . As part of the Cities-LEAP project, EERE s Office of Strategic Programs, through its Policy and Analysis and Technology-to-Market Teams, intends to solicit applications to advance data-driven decision-making by local governments in support of their climate and energy goals. This anticipated funding opportunity is intended for local and tribal governments as prime applicants and strongly encourages partnerships between local and tribal governments and entities such as academic institutions, technology companies, utilities, regional planning bodies, and non-governmental organizations to develop and pilot data-driven decision frameworks that strengthen the analytical underpinning of energy-impacting actions by local governments across the United States. The purpose of this Notice is to provide potential applicants advance notice that the Office of Strategic Programs, on behalf of the DOE Office of Energy Efficiency and Renewable Energy (EERE), intends to issue a FOA titled, Cities Leading through Energy Analysis and Planning (Cities-LEAP) . NO APPLICATIONS WILL BE ACCEPTED THROUGH THIS NOTICE. Please do not submit questions or respond to this Notice of Intent. Prospective applicants to the FOA should begin developing partnerships, formulating ideas, and gathering data in anticipation of the issuance of this FOA. It is anticipated that this FOA will be posted to EERE Exchange in March 2016.

$1 – $2

energyclean energy

Free to search & build · $99 one-time to unlock the application pack · No subscription

Non-Addictive Analgesic Discovery from Marine Microbial Natural Products

NINDS - National Institute of Neurological Disorders and Stroke

Project Summary: Chronic pain, widely considered the United States’ #1 public health crisis, is the most common cause of long-term disability in the world, affecting more than 25 million people in the US and nearly one third of the world’s population overall. Current pharmaceutical treatment options are broadly ineffective and often contribute severe side effects, including anxiety, heart disease, liver disease, and/or addiction. To address the enormous unmet public health challenge of peripherally-mediated chronic pain, novel phenotypic screening tools and new, non-addictive chemical entities that serve as pain therapeutics are urgently needed. Here, we propose a new collaboration that aims to discover novel, non-opioid and non-addictive analgesics from marine microbial resources and advance them to enter the Pain Therapeutics Development Program (PTDP). Our proposal exploits a recently developed phenotypic assay, developed through the HEAL Initiative, that leverages human induced pluripotent stem cell (hiPSC) sensory neurons and glia cultured on multi-well microelectrode arrays (MEAs). This allows long-term and high- content characterization of sensory neuron electrophysiology under baseline (spontaneous) and evoked (thermal and electrical stimulus) conditions. This moderate throughput, pain-physiology-relevant system for hit identification represents a unique approach to compound screening that has yet to be applied to natural product-derived analgesic discovery outside of the preliminary data provided in this proposal. We will employ this unique assay to screen an existing library of purified and structurally characterized marine microbial natural products and extract fraction libraries generated from a diverse and chemically rich culture collection of marine bacteria. We further exploit a new approach called Small Molecule In Situ Resin Capture (SMIRC) to access chemical space that is not available using culture dependent techniques. The hiPSC assay will be used to identify high-priority hits and guide the isolation of active compounds, which will be structurally characterized and tested for toxicity and addiction phenotypes to inform prioritization. A carefully planned workflow, including collaboration with a small biotech company focused on analgesic lead optimization, will maximize the discovery potential of this program.

Up to $1.0M

2028-05-31

Free to search & build · $99 one-time to unlock the application pack · No subscription

Non-Autonomous Regulation of Cardiac Aging

NIA - National Institute on Aging

Project Summary/Abstract Among all classes of phospholipids, ether phospholipids (mainly plasmalogens) have recently emerged as a novel regulator of mitochondrial membrane dynamics and animal aging. Plasmalogen deficiency has been linked to impaired mitochondrial dynamics, respiratory disorders, cardiomyopathy, and Alzheimer’s disease. The levels of plasmalogens in the circulation and animal brain decrease with age. However, the exact mechanisms underlying age-related reduction in plasmalogen biosynthesis and plasmalogen-regulated tissue homeostasis are largely unknown. Our recent studies identify the kidney as the site of plasmalogen biosynthesis and the source of circulating plasmalogens. Inhibition of kidney plasmalogen biosynthesis increases the production of inflammatory cytokines and cardiomyopathy. In contrast, plasmalogen supplements rescue cardiac defects in plasmalogen biosynthesis mutants. These findings suggest a previously unappreciated role of plasmalogen in kidney-heart communication. In this renewal application, we aim to take multi-disciplinary approaches to interrogate the novel role of kidney-derived plasmalogen ether phospholipids in inter-tissue communication and cardiac aging. Four specific aims are proposed: Aim 1. Determine the mechanisms underlying age-associated decreases in kidney plasmalogen biosynthesis. Aim 2. Determine how plasmalogens are transported from the kidney to the heart. Aim 3. Determine how kidney-derived plasmalogens regulate cardiac contractile performance.

Up to $523K

2031-03-31