NMDA receptor regulation of rapid scaling and spinal excitability in fragile X syndrome.
NINDS - National Institute of Neurological Disorders and Stroke
About This Grant
NMDA receptor regulation of rapid scaling and spinal excitability in fragile X syndrome. Abstract Identifying the mechanisms that control the maturation of network excitability during development will be crucial to understanding how these networks are established with dysregulated activity in cases of neurodevelopmental disorders such as autism spectrum disorder (ASD). We are proposing to study a guiding principle for the maturation of network excitability during neonatal development. We have just recently published work in the chick embryo spinal cord showing that blockade of NMDA receptors triggers rapid compensatory changes in the strength of glutamatergic and GABAergic synapses, referred to as synaptic scaling. This rapid form of synaptic scaling was previously characterized in a very different model system - rodent hippocampal cultures and slices. The observation that rapid scaling has been identified in 2 very different systems illustrates the fundamental importance of this form of plasticity. In the current application we will study rapid scaling in the neonatal mouse spinal cord, as we have preliminary results suggesting this plasticity exists in mouse spinal neurons, and that some inputs are altered more than others (nonuniform). In Aim 1 we will identify which classes of neonatal mouse spinal neurons express AMPAergic (excitatory) and GABAergic (inhibitory) rapid scaling and assess the uniformity of this scaling. We hypothesize that the homeostatic scaling capacity will be correlated with NMDAR content and will impact the excitatory to inhibitory (E/I) balance within the network and therefore maturation of excitability. Interestingly several different autism spectrum disorder (ASD) models experience altered NMDAR function and altered E/I balance. It is therefore reasonable to suggest that NMDA-dependent rapid scaling may indeed be altered in these models of autism, thus changing their excitability. ASD models have significant delays in motor development, yet spinal cord studies in these model systems are surprisingly rare. In Aim 2 we will test the hypothesis that rapid scaling is dependent on NMDAR content and that this is altered in a mouse model of Fragile X Syndrome (FXS), the most common monogenetic cause of ASD. By understanding the mechanisms of homeostatic plasticity during circuit formation, we will better understand the maturation of network excitability in neurodevelopmental disorders like ASD.
Grant Summary
NMDA receptor regulation of rapid scaling and spinal excitability in fragile X syndrome. is a NINDS - National Institute of Neurological Disorders and Stroke grant providing up to $235K for university, nonprofit, healthcare org. Applications are due 2028-04-30 (open). Check eligibility and apply with FindGrants.
Focus Areas
Eligibility
How to Apply
Up to $235K
2028-04-30
- 1Confirm your organization is eligible for NMDA receptor regulation of rapid scaling and spinal excitability in fragile X syndrome. from NINDS - National Institute of Neurological Disorders and Stroke, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NINDS - National Institute of Neurological Disorders and Stroke before the deadline.
Don't want to draft it yourself?
We'll draft the complete application against NINDS - National Institute of Neurological Disorders and Stroke's requirements, run a quality review, and email you a submission-ready PDF plus an editable Word doc within 5 business days. Most orders deliver in 24-48 hours. Flat $399, any grant size.
AI Requirement Analysis
Detailed requirements not yet analyzed
Have the NOFO? Paste it below for AI-powered requirement analysis.
NMDA receptor regulation of rapid scaling and spinal excitability in fragile X syndrome.: Frequently Asked Questions
Who is eligible for the NMDA receptor regulation of rapid scaling and spinal excitability in fragile X syndrome.?
NMDA receptor regulation of rapid scaling and spinal excitability in fragile X syndrome. is offered by NINDS - National Institute of Neurological Disorders and Stroke and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the NMDA receptor regulation of rapid scaling and spinal excitability in fragile X syndrome. provide?
NMDA receptor regulation of rapid scaling and spinal excitability in fragile X syndrome. provides up to $235K per award from NINDS - National Institute of Neurological Disorders and Stroke. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the NMDA receptor regulation of rapid scaling and spinal excitability in fragile X syndrome. deadline?
Applications for NMDA receptor regulation of rapid scaling and spinal excitability in fragile X syndrome. are due 2028-04-30 (open). Because deadlines can change, verify the date with the funder, NINDS - National Institute of Neurological Disorders and Stroke, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the NMDA receptor regulation of rapid scaling and spinal excitability in fragile X syndrome.?
To apply for NMDA receptor regulation of rapid scaling and spinal excitability in fragile X syndrome., confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NINDS - National Institute of Neurological Disorders and Stroke.