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Grants $250,000 to $500,000

Large grants from $250,000 to $500,000 for major initiatives including research programs, community development projects, and public health interventions.

Open Grants

5,900

Amount Range

$250K-$500K

Top Grants $250,000 to $500,000

Showing 12 of 5,900 grants $250,000 to $500,000

12 grants worth up to $3.0M match your search

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Grant Details: Amounts and Deadlines

Grant NameFunderAmountDeadline
Collaborative Research: BLoG: A Bi-Level Optimization Framework for Learning Over GraphsNSFUp to $250KAug 31, 2027
AMPS: Bayesian Physics-Informed Statistical Methods for Modern Power SystemsNSFUp to $250KAug 31, 2028
Secondary Prevention of Pouchitis With RifaximinNIDDK - National Institute of Diabetes and Digestive and Kidney DiseasesUp to $250KAug 31, 2027
Optimal Edge Decomposition of Graphs and Hamiltonicity of Tough ExpandersNSFUp to $250KJul 31, 2028
CAREER: Scalable Software Infrastructure for Analyzing Complex NetworksNSFUp to $250KDec 31, 2028
Universal Developmental ScreeningEncompass NorthwestUp to $250KRolling / Open
Understanding Post-Transcriptional Sex Differences in Neurological DiseaseNINDS - National Institute of Neurological Disorders and StrokeUp to $250KJan 31, 2028
Hearthstone Housing Foundation GrantsHearthstone Housing Foundation$25K - $250KRolling / Open
Unraveling Epigenetic and Transcription Control in Understudied Skin TypesNIAMS - National Institute of Arthritis and Musculoskeletal and Skin DiseasesUp to $250KAug 31, 2027
Role of nuclear paraspeckles in regulating HSV-1 infection in neuronsNIAID - National Institute of Allergy and Infectious DiseasesUp to $251KJan 31, 2028

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Frequently Asked Questions: Grants $250,000 to $500,000

Who awards grants in the $250K-$500K range?
Federal agencies (NIH, NSF, HUD, EPA, HRSA), large private foundations (Ford, Gates, Kresge, MacArthur), state agencies with federal pass-through funding, and some corporate foundations. Multi-year grants often have annual budgets in this range.
Do I need prior grant experience for grants this large?
Almost always. Funders awarding $250K+ expect a track record of successfully managing similar-sized grants. Organizations new to this level should start with smaller awards and build capacity, or partner with an experienced fiscal agent.

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