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Grants $250,000 to $500,000

Large grants from $250,000 to $500,000 for major initiatives including research programs, community development projects, and public health interventions.

Open Grants

105

Amount Range

$250K-$500K

Top Grants $250,000 to $500,000

Showing 12 of 105 grants $250,000 to $500,000

12 grants on this page, worth up to $3.6M combined.

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Grant Details: Amounts and Deadlines

Grant NameFunderAmountDeadline
Community-Based Participatory Research to Advance Data and Practice Transformation (ADAPT) for Optimizing Oral Health for All (UG3/UH3 Clinical Trial Optional)National Institutes of HealthUp to $300KNov 16, 2028
Stellar Community FundStellar Development Foundation$10K - $300KRolling / Open
Advanced Development and Validation of Emerging Technologies for Basic and Clinical Cancer Research (R33 Clinical Trial Not Allowed)National Institutes of HealthUp to $300KNov 10, 2026
CCRP Initiative: Promoting a Basic Understanding of Chemical Threats to Skin (R01 Clinical Trial Not Allowed)National Institutes of HealthUp to $300KNov 5, 2028
Atlanta FY 2021 – FY 2023 EDA Planning and Local Technical AssistanceDepartment of CommerceUp to $300KRolling / Open
Draper Richards Kaplan Foundation ($300K)Draper Richards Kaplan Foundation$100K - $300KRolling / Open
Chemical Countermeasures Research Program (CCRP) Initiative: Basic Research on The Deleterious Effects of Acute Exposure to Ultra-Potent Synthetic (UPS) Opioids (R01 Clinical Trial Not Allowed)National Institutes of HealthUp to $300KNov 18, 2026
2027 CNIP Expansion – WIC, WIC Farmers’ Market Nutrition Program and Senior Farmers’ Market Nutrition ProgramCA Department of Food and Agriculture$10K - $300KDec 4, 2026
Early-Stage Development of Informatics Technologies for Cancer Research and Management (U01 Clinical Trial Optional)National Institutes of Health$50K - $300KOct 19, 2027
Chicago FY 2021 FY 2023 EDA Planning and Local Technical AssistanceDepartment of CommerceUp to $300KRolling / Open

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Frequently Asked Questions: Grants $250,000 to $500,000

Who awards grants in the $250K-$500K range?
Federal agencies (NIH, NSF, HUD, EPA, HRSA), large private foundations (Ford, Gates, Kresge, MacArthur), state agencies with federal pass-through funding, and some corporate foundations. Multi-year grants often have annual budgets in this range.
Do I need prior grant experience for grants this large?
Almost always. Funders awarding $250K+ expect a track record of successfully managing similar-sized grants. Organizations new to this level should start with smaller awards and build capacity, or partner with an experienced fiscal agent.

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