Non-Autonomous Regulation of Cardiac Aging
NIA - National Institute on Aging
About This Grant
Project Summary/Abstract Among all classes of phospholipids, ether phospholipids (mainly plasmalogens) have recently emerged as a novel regulator of mitochondrial membrane dynamics and animal aging. Plasmalogen deficiency has been linked to impaired mitochondrial dynamics, respiratory disorders, cardiomyopathy, and Alzheimer’s disease. The levels of plasmalogens in the circulation and animal brain decrease with age. However, the exact mechanisms underlying age-related reduction in plasmalogen biosynthesis and plasmalogen-regulated tissue homeostasis are largely unknown. Our recent studies identify the kidney as the site of plasmalogen biosynthesis and the source of circulating plasmalogens. Inhibition of kidney plasmalogen biosynthesis increases the production of inflammatory cytokines and cardiomyopathy. In contrast, plasmalogen supplements rescue cardiac defects in plasmalogen biosynthesis mutants. These findings suggest a previously unappreciated role of plasmalogen in kidney-heart communication. In this renewal application, we aim to take multi-disciplinary approaches to interrogate the novel role of kidney-derived plasmalogen ether phospholipids in inter-tissue communication and cardiac aging. Four specific aims are proposed: Aim 1. Determine the mechanisms underlying age-associated decreases in kidney plasmalogen biosynthesis. Aim 2. Determine how plasmalogens are transported from the kidney to the heart. Aim 3. Determine how kidney-derived plasmalogens regulate cardiac contractile performance.
Grant Summary
Non-Autonomous Regulation of Cardiac Aging is a NIA - National Institute on Aging grant providing up to $523K for university, nonprofit, healthcare org. Applications are due 2031-03-31 (open). Check eligibility and apply with FindGrants.
Focus Areas
Eligibility
How to Apply
Up to $523K
2031-03-31
- 1Confirm your organization is eligible for Non-Autonomous Regulation of Cardiac Aging from NIA - National Institute on Aging, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NIA - National Institute on Aging before the deadline.
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Non-Autonomous Regulation of Cardiac Aging: Frequently Asked Questions
Who is eligible for the Non-Autonomous Regulation of Cardiac Aging?
Non-Autonomous Regulation of Cardiac Aging is offered by NIA - National Institute on Aging and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the Non-Autonomous Regulation of Cardiac Aging provide?
Non-Autonomous Regulation of Cardiac Aging provides up to $523K per award from NIA - National Institute on Aging. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the Non-Autonomous Regulation of Cardiac Aging deadline?
Applications for Non-Autonomous Regulation of Cardiac Aging are due 2031-03-31 (open). Because deadlines can change, verify the date with the funder, NIA - National Institute on Aging, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the Non-Autonomous Regulation of Cardiac Aging?
To apply for Non-Autonomous Regulation of Cardiac Aging, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NIA - National Institute on Aging.