Grants

DEPT OF DEFENSE.DEPT OF THE NAVY.SPAWAR.SPAWAR LANT.NIWC ATLANTIC

OCONUS Integrated Electronic Security Systems (IESS) Sustainment Support

Rolling

general

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Ocular mustard keratopathy elicits induced autophagy, which is detrimental to the cornea

OD - NIH Office of the Director

PROJECT SUMMARY/ABSTRACT The long-term goal of this project is to understand the pathological mechanisms of sulfur mustard gas keratopathy (MGK) in the cornea. Sulfur mustard (SM) is an alkylating agent that has been used as a chemical warfare agent. SM exposure to the eye results in acute corneal injury. A subset of patients, particularly those with high exposure levels, develop chronic or delayed symptoms, which is known as MGK. Thus far, there are no specific treatments available to stop or reverse the detrimental effects of MGK. One of reasons for the lack of a specific treatment is that the mechanisms of MGK are not fully understood. Autophagy is a process by which cells break down and recycle their own cellular components, including damaged proteins and organelles. Even though autophagy has been recognized as a fundamental cellular process against stress, autophagy can play beneficial or detrimental roles depending on the context. In the cornea, it has been demonstrated that in response to most of stresses, autophagy plays beneficial roles to protect tissue homeostasis. Our laboratory and many other investigators have been focusing on such protective roles of autophagy in the cornea. However, the detrimental role of autophagy in the cornea has not been studied. Interestingly, when we investigated the role of autophagy in corneal injury due to chemical exposure, we found that nitrogen mustard (NM), an analog of sulfur mustard, induced a unique autophagy, which plays a harmful role in the cornea. It has been shown that the liberation of Beclin1, a key regulator in induction of autophagy, from Beclin1-Bcl2 complex can induce autophagy. Our preliminary data suggest that after NM exposure, sequestration of Beclin1 in Beclin1-Bcl2 complex attenuates NM-induced corneal inflammation. Therefore, we hypothesize that corneal mustard exposure induces autophagy via liberating Beclin1 from Beclin1-Bcl2 complex and such induced autophagy promotes corneal inflammation and contributes to MGK. In Aim 1, we will explore: (i) whether NM exposure will affect Beclin1-Bcl2 binding in vitro and in vivo; and (ii) whether manipulation of Beclin1-Bcl2 binding will affect NM-induced autophagy in cornea. In Aim 2, we will capitalize on our ability to conduct gain- and loss-of-function studies of induced autophagy in mice. We will inhibit induced autophagy via either reducing Beclin1 expression or preventing the disassociation of Beclin1-Bcl2 complex in vivo. We will also enhance induced autophagy via preventing the binding of Beclin1 to Bcl2 in vivo. We will utilize these genetically modified mouse models to determine whether the detrimental effects of NM exposure in cornea will be: (i) attenuated by inhibition of induced autophagy, while (ii) increased by enhancement of induced autophagy. Finally, in Aim3, we will test whether transient, pharmacological inhibition of autophagy attenuate NM-induced corneal injury. Knowledge from this project will reveal the pathological importance of induced autophagy in corneal MGK and will form the foundation for the development of novel therapies for this disease by targeting this Beclin1-Bcl2 complex-regulated autophagy pathway.

Up to $1.4M

2029-04-30

health research

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ODEP — Disability Employment Initiative

disability employmentworkforce systemspolicy

Office of Disability Employment Policy

Federal grants for programs that improve employment outcomes for people with disabilities through systems change.

$50K – $500K

2026-10-01

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ODEP — Youth Transition Grants

youth transitiondisability employmenteducation-to-work

Office of Disability Employment Policy

Grants for programs that support youth with disabilities transitioning from school to employment.

$25K – $200K

2026-08-01

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OEC MEDICAL SYSTEMS (RENEWAL)

OEC MEDICAL SYSTEMS INC

Medical Equipment and Accessories and Supplies

2027-04-30

EducationHealth

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Off Highway vehcile Restoration and Archeological Surveys for Joshua Tree NP

National Park Service

The recipient shall recruit and hire at least two early career Archeological Technicians and one Off-Highway Vehicle Restoration Coordinator to support project work. The NPS, in a collaborative effort, will help in the hiring process to assist in determining the best candidates. The hired associates will perform the following duties: Archeological Technicians will survey off-highway vehicle restoration areas for archeological and historic resources to ensure that these resources are not impacted by project actions. The Off-Highway Vehicle Restoration Coordinator will locate and prioritize areas for restoration projects and develop project plans to restore the disturbance in these areas. The Off-Highway Vehicle Restoration Coordinator, in a collaborative effort with NPS, will implement restoration actions at these prioritized areas. Actions include revegetation using local native plant materials, vertical and horizontal mulch, the installation of protective fencing and other barriers, and the de-compaction of tracks. The Off-Highway Vehicle Restoration Coordinator will also assist in recruiting and coordinating volunteers to assist in completing project actions. The Off-Highway Vehicle Restoration Coordinator will also conduct treatment effectiveness monitoring of the above mentioned treatments once implemented. The NPS will provide vehicles, tools, equipment, computers, and office space for the hired associates to use in completing project work. The NPS will also provide technical expertise and training for the hired associates as well as evaluation of completed projects and performance.

$10K – $200K

natural resources

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Office of Elementary and Secondary Education (OESE): Comprehensive Centers Program: National Comprehensive Center on Improving Literacy for Students with Disabilities; ALN 84.283D

Department of Education

Program Description: The purpose of the Comprehensive Centers (CC) program is to provide capacity-building services to state educational agencies (SEAs), regional educational agencies (REAs), local educational agencies (LEAs), and schools that improve educational opportunities and student outcomes, close achievement gaps, and improve the quality of instruction for all students, particularly for groups of students with the greatest need. The Department intends to fund one Content Center, a National Comprehensive Center on Improving Literacy for Students with Disabilities (NCIL) focused on children in early childhood education programs through high school at risk of not attaining full literacy skills due to a disability, including dyslexia impacting reading or writing, or developmental delay impacting reading, writing, language processing, comprehension, or executive functioning. Assistance Listing Number: 84.283D Applicants are required to follow the 2025 Common Instructions for Applicants to Department of Education Discretionary Grant Programs, published in the Federal Register on August 29, 2025 (90 FR 42234) and available at ED 2025 Common Instructions. Note: For new potential grantees unfamiliar with grantmaking at ED, please consult our Getting Started with Discretionary Grant Applications webpage.

Up to $1.5M

2026-06-30

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Office of Elementary and Secondary Education (OESE): Program and Grantee Support Services: Comprehensive Centers Program, Assistance Listing Number 84.283B

Department of Education

2026-06-30

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Office of Elementary and Secondary Education (OESE): Well-Rounded Education Programs: Jacob K. Javits Gifted and Talented Students Education (Javits) Program, Assistance Listing Number 84.206A

Department of Education

Program Description: The Jacob K. Javits Gifted and Talented Students Education Program (Javits) supports evidence-based research, demonstration projects, innovative strategies, and similar activities designed to build and enhance the ability of elementary schools and secondary schools nationwide to identify gifted and talented students and meet their special educational needs. A major emphasis of the program is on implementing evidence-based activities that accelerate learning and improve student outcomes. Assistance Listing Number: 84.206A. Applicants are required to follow the 2025 Common Instructions for Applicants to Department of Education Discretionary Grant Programs, published in the Federal Register on August 29, 2025 (90 FR 42234) and available at ED 2025 Common Instructions. Note: For new potential grantees unfamiliar with grantmaking at ED, please consult our Getting Started with Discretionary Grant Applications webpage.

2026-06-23

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Office of Just Energy Transition (OJET) Growing the Clean Energy Workforce (GCEW)

Educationenvironmentworkforce

Labor

The purpose of the OJET GCEW Request for Proposals (RFP) is to provide funding to eligible organizations to expand or create statewide clean energy training or pre-apprenticeship programs and provide wraparound services to participants in these programs. Eligible organizations may utilize the services of a training provider to deliver the programs.

Up to $5M

Rolling

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Office of Just Energy Transition (OJET) Renewable Energy Training Initiative (RETI)

EducationenvironmentHealth+4

Labor

Funding will be provided to Local Workforce Development Boards (LWDBs) for the up-skilling or re-skilling of workers transitioning from fossil fuel to clean energy positions; the up-skilling or re-skilling of residential workers in weatherization, building performance, and retrofitting, including fees required for industry-recognized credentials; and wraparound services during training, including but not limited to, childcare, transportation, housing, food, mental health services, and substance use treatment or services.

Up to $4M

Rolling

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Office of Naval Research (ONR) Global Research Opportunity: Global-X Challenge 2024

Office of Naval Research

The purpose of this Global-X Challenge is to discover, and ultimately provide a catalyst through a research grant, for subsequent development and delivery of revolutionary capability to the U.S. Navy and Marine Corps, the commercial marketplace, and the public. The expected outcomes of this Global-X Challenge are promising, potentially game-changing, concepts whose technology maturity may be accelerated under separate follow-on technology development efforts.

Up to $1M

sciencetechnology

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Office of Postsecondary Education (OPE): Centers Aligned with Areas for National Need (CAANN) Program Assistance Listing Number: 84.015C

Department of Education

Program Description: In coordination with the Bureau of Educational and Cultural Affairs at the U.S. Department of State (State), the U.S. Department of Education (ED) is soliciting applications in support of the administration of the Centers Aligned with Areas for National Need program. This program provides grants to institutions of higher education (IHEs) or consortia of IHEs to address one or more of the following areas of national need by teaching languages of strategic importance to the United States national security and economic prosperity, such as Spanish, Portuguese, Italian, Hungarian, Polish, Russian, Czech, Arabic, Swahili, Hausa, Hindi, Urdu, Mandarin, Korean, Japanese, Farsi, Bahasa, Thai, and other languages; providing instruction in fields needed to provide understanding of areas, regions, or countries in which the language is used; supporting research and training in international studies and the international and foreign language aspects of professional and other fields of study; and advancing the national security interests of the United States by providing instruction on critical regions such as Latin America, Europe, Eurasia, Middle East, Africa, and Asia. Assistance Listing Number: 84.015C. Applicants are required to follow the 2025 Common Instructions for Applicants to Department of Education Discretionary Grant Programs, published in the Federal Register on August 29, 2025 (90 FR 42234) and available at ED 2025 Common Instructions.

2026-07-07

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Office of Postsecondary Education (OPE):Mutual Educational and Cultural Exchange (MECE) Program, Assistance Listing Number 84.021C

Department of Education

Program Description: In coordination with the Bureau of Educational and Cultural Affairs at the U.S. Department of State (State), the U.S. Department of Education (ED) is soliciting applications in support of the administration of the Mutual Educational and Cultural Exchange (MECE) program. The purpose of the program is to promote, improve, and develop the study of modern foreign language training and area studies in U.S. schools, colleges, and universities by supporting visits and study in foreign countries by teachers and prospective teachers. The program provides opportunities for teachers and prospective teachers to improve their skill in languages, their knowledge of the culture of the people of other countries, and finances visits by teachers from those other countries to the United States for the purpose of participating in foreign language training and area studies in U.S. schools, colleges, and universities. Assistance Listing Number: 84.021C Applicants are required to follow the 2025 Common Instructions and Information for Applicants to Department of Education Discretionary Grant Programs, published in the Federal Register on August 29, 2025 (90 FR 42234) and available at ED 2025 Common Instructions.

2026-07-15

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Office of Special Education and Rehabilitative Services (OSERS): Office of Special Education Programs (OSEP): Accessible Education Video Projects; Assistance Listing Number (ALN) 84.327C

Department of Education

Program Description: The purpose of the Educational Technology, Media, and Materials for Individuals with Disabilities Program is to improve results for children with disabilities by (1) promoting the development, demonstration, and use of technology; (2) supporting educational activities designed to be of educational value in the classroom for students with disabilities; (3) providing support for captioning and video description that is appropriate for use in the classroom; and (4) providing accessible educational materials to students with disabilities in a timely manner. This competition establishes Accessible Education Video Projects that are designed to meet requirements under the Individuals with Disabilities Education Act (IDEA). Specifically, section 674(c) of IDEA requires, in part, that the Secretary of Education support audio description, open captioning, and closed captioning that is appropriate for use in early learning and kindergarten through grade 12 (K-12) settings of (a) television programs; (b) videos; or (c) other materials, including programs and materials associated with new and emerging technologies. ALN: 84.327C. Applicants are required to follow the 2025 Common Instructions and Information for Applicants to Department of Education Discretionary Grant Programs, published in the Federal Register on August 29, 2025 (90 FR 42234) and available at ED 2025 Common Instructions. Note: For new potential grantees unfamiliar with grantmaking at ED, please consult our Getting Started with Discretionary Grant Applications webpage.

Up to $1.1M

2026-06-26

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Office of Special Education and Rehabilitative Services (OSERS): Office of Special Education Programs (OSEP): National Center for Accessible Education Videos; Assistance Listing Number: 84.327N

Department of Education

Program Description: The purpose of the Educational Technology, Media, and Materials for Individuals with Disabilities Program is designed to improve results for children with disabilities by (1) promoting the development, demonstration, and use of technology; (2) supporting educational activities designed to be of educational value in the classroom for students with disabilities; (3) providing support for captioning and video description that is appropriate for use in the classroom; and (4) providing accessible educational materials to students with disabilities in a timely manner. In alignment with the requirements in the Individuals with Disabilities Education Act (IDEA), this competition establishes a National Center on Accessible Education Videos. Specifically, section 674(c) requires, in part, that the Secretary of Education support video and audio description, open captioning, and closed captioning, which is appropriate for use in early learning and kindergarten through grade 12 (K-12) settings of (a) television programs, (b) videos, and (c) other materials, including programs and materials associated with new and emerging technologies. Additionally, this section requires support of distributing such materials through such mechanisms as a loan service. ALN: 84.327N. Applicants are required to follow the 2025 Common Instructions and Information for Applicants to Department of Education Discretionary Grant Programs, published in the Federal Register on August 29, 2025 (90 FR 42234) and available at ED 2025 Common Instructions. Note: For new potential grantees unfamiliar with grantmaking at ED, please consult our Getting Started with Discretionary Grant Applications webpage.

2026-06-26

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Office of Special Programs

U.S. National Science Foundation

DMR's Office of Special Programs (OSP) coordinates and supports crosscutting activities in DMR and in conjunction with NSF-wide programs, including enhanced international collaborations in materials research and education. OSP activities are often co-funded with other NSF units, such as the Office of International Science and Engineering and the MPS Office for Multidisciplinary Activities. Examples of OSP activities include: International Materials Institutes (IMI) The IMIs advance fundamental materials research by coordinating international research and education projects. Their long-term goal is the creation of a worldwide network in materials research and the development of a generation of scientists and engineers with international leadership capabilities. Opportunities for International Cooperation in Materials Research DMR supports international collaborative research and education projects in partnership with funding organizations in Europe and the Americas. Collaborative activities in partnership with funding agencies in Asia and in Africa are being developed. Research Experiences for Undergraduates (REU) Sites and Research Experiences for Teachers

sciencetechnology

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Office of Special Programs in Materials Research

U.S. National Science Foundation

DMR's Office of Special Programs im Materials Research (OSP) coordinates and supports crosscutting activities in DMR and in conjunction with NSF-wide programs, including activities that focus on education, broaden participation of underrepresented groups, or engage participants from several disciplines across the division. Many OSP activities are co-funded with other NSF units. OSP activities include Research Experiences for Undergraduates (REU) Sites and Research Experiences for Teachers (RET). The Materials World Network program has been ended, please see the Dear Colleague Letter- International Collaboration in the Division of Materials Research

sciencetechnology

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Office of the Assistant Secretary for Policy; Proposed Extension of Information Collection; Formative Data Collections for Research and Evaluation