Grants

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NEI Collaborative Clinical Vision Research (UG1 - Clinical Trial Optional)

National Institutes of Health

The NEI uses UG1 cooperative agreement awards to support investigator-initiated clinical vision research projects, including multi-center clinical trials, human gene-transfer, stem cell therapy trials, epidemiological studies, and other studies that are complex, high resource, or that require increased oversight due to elevated safety considerations.These collaborative clinical vision research projects would address chronic diseases across the lifespan through research on the burden of eye and vision conditions, their causes, diagnoses, prevention, treatment, and rehabilitation. These projects are multifaceted and of high public health significance, requiring careful oversight and monitoring by National Institutes of Health (NIH) staff. The intent of this funding opportunity announcement is to provide a collaborative framework for the following components: Chair's Grant, Coordinating Center, and Resource Center(s).

2026-09-25

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NEI Collaborative Clinical Vision Research (UG1 - Clinical Trial Optional)

National Institutes of Health

The NEI uses UG1 cooperative agreement awards to support investigator-initiated clinical vision research projects, including multi-center clinical trials, human gene-transfer, stem cell therapy trials, epidemiological studies, and other studies that are complex, high resource, or that require increased oversight due to elevated safety considerations.These collaborative clinical vision research projects would address chronic diseases across the lifespan through research on the burden of eye and vision conditions, their causes, diagnoses, prevention, treatment, and rehabilitation.  These projects are multifaceted and of high public health significance, requiring careful oversight and monitoring by National Institutes of Health (NIH) staff.  The intent of this funding opportunity announcement is to provide a collaborative framework for the following components: Chair's Grant, Coordinating Center, and Resource Center(s).

2026-09-25

Health

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NEI Research Grant for Secondary Data Analysis (R21)

National Institutes of Health

The NEI Research Grant for Secondary Data Analysis (R21) program is designed to provide investigators with the support necessary to conduct secondary data analyses utilizing existing database resources. Applications may be related to, but must be distinct from, the specific aims of the original data collection. -The purpose of this mechanism is to provide limited support for meritorious research projects that involve secondary data analyses using existing database resources. -Because the nature and scope of the proposed research will vary from application to application, it is anticipated that the size and duration of each award will also vary. The total amount awarded and the number of awards will depend upon the mechanism numbers, quality, duration, and costs of the applications received. -This FOA will use the National Institutes of Health (NIH) Exploratory/Developmental Research Grant Award (R21) mechanism. -Award Amount and Project Period: The total project period for an application submitted in response to this funding opportunity may not exceed two years. Direct costs are limited to $275,000 over an R21 two-year period, with no more than $200,000 in direct costs allowed in any single year. -Eligible organizations: For-profit and non-profit organizations, public and private institutions (such as universities, colleges, hospitals, and laboratories), units of state and local governments, eligible agencies of the federal government, units of state and local tribal governments, domestic and foreign institutions. -Eligible Project Directors/Principal Investigators (PD/PIs): Any individual with the skills, knowledge, and resources necessary to carry out the proposed research. Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply for NIH support.

Up to $200K

rolling

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NEI Research Grant for Vision-Related Secondary Data Analysis (R21 Clinical Trial Not Allowed)

National Institutes of Health

The goal of this funding opportunity announcement (FOA) is to fund meritorious vision-related research projects that involve secondary data analyses using existing database resources. The development of statistical methodology necessary for improving methods to analyze vision health data using existing vision data may also be proposed.

2027-10-16

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NEI Research Grant for Vision-Related Secondary Data Analysis (R21 Clinical Trial Not Allowed)

National Institutes of Health

2027-10-16

Health

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NEI Translational Research Program for Therapeutics (R61/R33 Clinical Trial Not Allowed)

National Institutes of Health

NEI Translational Research Program for Therapeutics (R61/R33 Clinical Trial Not Allowed)

research

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NEIdeas Challenge

New Economy Initiative

Grants of $10,000 for existing businesses and $100,000 for growth-stage businesses located in Detroit, Hamtramck, and Highland Park. Supports neighborhood economic development.

$10K – $100K

Business DevelopmentCommunity Development

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Neighborhood Allies Community Grants

Neighborhood Allies Pittsburgh

Grants supporting neighborhood-based community development organizations in Pittsburgh, funding capacity building, small projects, and community-led revitalization efforts.

$5K – $50K

Community Development

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Neighborhood and individual environmental risk factors in early life and -omics biomarkers for kidney function trajectories across childhood and adulthood

NIEHS - National Institute of Environmental Health Sciences

PROJECT SUMMARY/ABSTRACT Chronic kidney disease (CKD) and hypertension (HTN) are substantial public health concerns in the US and are important risk factors for other adverse outcomes including acute kidney injury and premature mortality. CKD and HTN are typically diagnosed later in life, yet our understanding of the prenatal and early life environ- mental determinants of reduced kidney function and HTN across childhood and early adulthood remains incipi- ent. This research, however, faces several barriers including lack of assessment of both neighborhood- and individual-level environmental stressors at specific early life stages coupled with long-term follow-up from birth to early adulthood. This project will address these research gaps by leveraging high-quality data from Project Viva, an ongoing longitudinal prospective pre-birth cohort of mother-child pairs followed since pregnancy. The overall goals of the proposed project are to examine the extent to which early-life exposure to disadvantaged neighborhood contexts and nephrotoxicants (i.e., air pollutants and metals) leads to later life kidney dysfunc- tion and higher blood pressure (BP). The investigators will: (Aim 1) examine associations of early-life neighbor- hood environment with kidney function and BP across childhood and early adulthood; (Aim 2) assess associa- tions of individual-level early-life exposure to candidate nephrotoxicants with kidney function and BP from mid- childhood to early adulthood; and (Aim 3) characterize urinary proteomic signatures underlying altered kidney function and BP trajectory from childhood to early adulthood, and examine these signatures as potential mark- ers of toxicant exposure. This innovative proposal will be the first to examine both neighborhood- and individ- ual-level environmental determinants of kidney function and BP trajectories. We will identify actionable risk fac- tors and molecular signatures to identify high-risk individuals and pinpoint when primordial prevention efforts have the greatest potential to prevent future CKD and HTN.

Up to $3.8M

2030-04-22

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Neighborhood Chalk Art Project with Workshop

Call of Compassion NW

Call of Compassion NW will teach up to 20 youth-led teams of five people how to create temporary art pieces using chalk. The workshop will be on Saturday, August 26, 9am-12pm, at Blaine Memorial United Methodist Church in the parking lot (3001 24th Ave S). The day of art creation will happen on neighborhood business district sidewalks by September 15. A community celebration for the teams will be held in October.

Up to $5K

general

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Neighborhood conditions, neural circuits, and substance use behaviors across the early life course.

NIDA - National Institute on Drug Abuse

The etiology of substance use disorders (SUD, i.e., alcohol, cannabis, cocaine, opioids) are multifactorial, with risk factors including adverse social conditions, clinical comorbidities, neurodevelopmental influences, and genetic liabilities. However, little research has integrated data across these domains to study pathways of SUD risk. Given the changing landscape of cannabis legalization, the ongoing opioid crisis, and the decrease in life expectancy related to SUD, it is essential that we understand the etiologic pathways to SUD. While prior research shows a complex relationship, findings suggest that lower individual socioeconomic status, or SES (income, education, and employment), and contexts related to neighborhood SES (e.g., neighborhood disadvantage, residential segregation) are associated with greater risk of SUD, and that associations vary across sociodemographic characteristics and genetic vulnerabilities. Therefore, research utilizing sophisticated, longitudinal methods in representative samples is needed to examine the nature of the associations and interactions between individual and neighborhood social contexts and SUD. Atypical cognitive processing and development of neural communication have been widely documented both among those with SUD and those facing socioeconomic adversity. Our preliminary studies have used measures of EEG oscillatory activity (e.g., EEG functional connectivity, event-related oscillations during response inhibition) to demonstrate atypical neural networks in the resting state and during inhibitory control among individuals with SUD who have experienced early life adversity, with findings most prominent frontally in alpha frequency (8-12 Hz) and theta (3-7 Hz) frequency bands. Our data also established the first association with SUD polygenic scores and EEG connectivity, as well as differences by sex and throughout adolescence and young adulthood. However, it remains unclear how individual, family and neighborhood-level context influences neural communication and substance misuse across adolescent and young adult development, and how the associations may differ by genetic risk. This project will curate new neighborhood data to integrate alongside existing social, neurodevelopmental and genomic data from the Collaborative Study on the Genetics of Alcoholism (COGA)’s longitudinal, developmental study of adolescent and young adult offspring from families densely affected with SUD, to improve understanding of whether individual, family and neighborhood-level socioeconomic context influences neural communication across development and increases risk for SUD. Adding neighborhood-level data to COGA’s demographically and SUD enriched sample (DSM-5 alcohol use disorder: 40%, nicotine use disorder: 22%, cannabis use disorder: 32%, cocaine use disorder: 5%, opioid use disorder: 5%) with detailed assessments of individual-level social and economic adversity, EEG functional connectivity, and substance use behaviors/disorders, we will examine the influence of SES on trajectories of EEG activity and SUD from ages 12-34 in participants at high-risk for SUD, and the roles that sociodemographic characteristics and polygenic scores may play.

Up to $2.3M

2029-06-30

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Neighborhood Disadvantage and Obesity-Related Cancer Incidence in US Hispanics/Latinos: The Biobehavioral and Social Pathways

NCI - National Cancer Institute

Obesity can cause at least 13 different cancers, and more than 693,000 obesity-related cancers (ORC) are diagnosed in the United States each year. Neighborhoods inhabited by racial and ethnic groups that are not part of the majority population can be particularly vulnerable to higher ORC incidence, as their neighborhoods are typically disadvantaged due to neighborhood deprivation (characterized by a variety of impoverished economic, social, and living conditions) and redlining (restricting their resettlement and wealth accumulation through location-based unfair lending practices). Neighborhood disadvantage can exacerbate their exposure to several biobehavioral and social risk factors associated with obesity and ORC, including chronic stress, poor lifestyle, and social isolation. As the US second-largest population, Hispanics/Latinos have higher obesity prevalence than non-Hispanic Whites and are disproportionately affected by neighborhood disadvantage. However, the impact of neighborhood disadvantage on ORC incidence and its biobehavioral and social pathways have not been rigorously examined in US Hispanics/Latinos. Leveraging the Hispanic Community Health Study/Study of Latinos (HCHS/SOL), the largest and most comprehensive prospective multicenter cohort study of US Hispanics/Latinos, we will: 1) assess the association of neighborhood disadvantage with ORC incidence; 2) assess the association of biobehavioral and social risk factors with ORC incidence; 3) examine whether the underlying biobehavioral and social pathways mediate the association of neighborhood disadvantage with ORC incidence. Our findings can pinpoint vulnerable Hispanic/Latino neighborhoods at high risk of ORC incidence and inform actionable policy- and community-level interventions to tackle upstream drivers and reduce cancer health differences. Through the completion of proposed aims, the applicant (Dr. En Cheng) will actively participate in scientific and professional activities including 1) strengthening his skill set in cancer and social epidemiology, health differences, spatial analytics, and biostatistics; 2) refining leadership and management skills via working independently and collaboratively with colleagues of differing expertise, rank, and experience; and 3) generating findings for publications and presentations as well as preliminary data for R01-level independent research portfolios. As the demographic shift is happening in the HCHS/SOL, new cancer cases are rapidly accumulating that provides an exceptionally rare opportunity to examine cancer development and differences among US Hispanics/Latinos and unravel novel biobehavioral and social pathways. Leveraging findings and preliminary data generated from this K01 study plus extensive clinical, laboratory, genomic, microbiome, lifestyle, social, geographic, and cancer incidence data available in the HCHS/SOL, the applicant is well-positioned to obtain R01-level funding and launch independent research portfolios to further investigate cancer development and differences among US Hispanics/Latinos.

Up to $200K

2031-04-30

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Neighborhood Playground on Beacon Hill

Beacon Hill International School Playground Steering Committee

Beacon Hill International School, (BHIS), is a diverse community of learners and educators embedded in the culturally-rich neighborhood of North Beacon Hill. We seek funding for a community-led project to replace the outdated and unsafe playground structure that was recently removed from the school play area.

Up to $25K

Education

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NeighborWorks America Community Grants

NeighborWorks America

NeighborWorks supports a network of 250+ community development organizations. Provides grants for affordable housing, community revitalization, and financial capability.

$10K – $500K

Housingcommunity developmentfinancial literacy+1

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NEKRITZ AMDOR ANDERSSON GROUP LLC -

NEKRITZ AMDOR ANDERSSON GROUP LLC

Management and Business Professionals and Administrative Services

2026-11-30

general

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Nellie Mae Education Foundation — Student-Centered Learning

Nellie Mae Education Foundation

Funds student-centered learning approaches in New England schools.

$50K – $500K

student-centered learningeducation reformNew England

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Nemko North America, Inc.: Grant of Expansion of Recognition

Labor Department

In this notice, OSHA announces the final decision to expand the scope of recognition for Nemko North America, Inc. as a Nationally Recognized Testing Laboratory (NRTL).

See notice

workforce

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Neocortical-hippocampal coordination and plasticity in sleep-dependent memory storage

NINDS - National Institute of Neurological Disorders and Stroke

Project summary: Turning fleeting life experiences into long-lasting memories is a fundamental function of the brain and critical for survival. Across animal species, this process, which is linked to plastic changes at synapses between neurons, has been shown to require transition into a sleeping brain state. However, very little is known about 1) how and where this plasticity is brought about by state-specific brain activity, and 2) how sleep states facilitate de novo memory consolidation. The Aton laboratory has recently made inroads to addressing these gaps by studying contextual fear memory (CFM) in mice, a simple form of memory consolidation in which learning occurs in a single training trial (contextual fear conditioning; CFC), and consolidation occurs subsequently in a sleep-dependent manner. We have recently found that CFC selectively drives long-term transcriptional changes in the hippocampal dentate gyrus (DG), and that post-CFC sleep is essential for reactivation of “engram” neurons in DG – i.e. the population of neurons that encode CFC context during fear learning. Brief post-CFC sleep deprivation (SD), which disrupts CFM consolidation, prevents DG engram neuron reactivation in the first few hours following CFC. While sleep-associated coordination of activity between thalamocortical circuits and the hippocampus is thought to be critical for memory storage, the precise synaptic and circuit-level mechanisms affected by corticohippocampal communication during sleep remain unclear. Here, we propose to investigate the precise sleep-dependent processes that are associated with and necessary for successful CFM consolidation, with a focus on sleep regulation of corticohippocampal information transfer from entorhinal cortex (EC) to DG. These studies will use recently developed genetic tools for targeted recombination in activated populations (TRAP), which will allow selective visualization and manipulation of context encoding engram neurons in the EC and DG, as well as the connections between them. We will first quantify sleep-dependent reactivation of engram neurons in these two structures, in the hours immediately following CFC. We will then use state-targeted optogenetic manipulations to disrupt EC engram neurons’ input (or all EC input) to DG during bouts of post-CFC non-rapid eye movement (NREM) sleep, REM sleep, or wake. We will test how these state- specific disruptions of EC input affect reactivation of DG engram neurons, overall hippocampal network activity, and CFM consolidation. Finally, in collaboration with the Soiza-Reilly lab at the University of Buenos Aires, we will use nanoscale array tomography (AT) to quantify changes in synaptic density, size, and protein content resulting from CFC and post-CFC sleep vs. SD. These studies will separately characterize synapses formed between EC and DG engram neurons vs. corticohippocampal synapses where one or both partners are non- engram neurons. These studies will test the hypothesis that post-CFC sleep is required for the selective strengthening of excitatory synapses between EC and DG engram neurons. These studies will provide a highly detailed mechanistic understanding of sleep-dependent memory storage in corticohippocampal circuits.

Up to $420K

2028-01-31

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NEPA & Section 106 Project Planning and Compliance Death Valley National Park

National Park Service

he purpose of this agreement is to complete project planning and compliance associated with the National Environmental Policy Act (NEPA) and Section 106 of the National Historic Preservation Act (NHPA) at Death Valley National Park (DEVA). The Park s Resources Management Division; which includes Planning and Compliance, is responsible for coordinating NEPA and Section 106 compliance. The park manages a large volume of historic preservation, routine and deferred maintenance, new construction, and research activities all of which require compliance with NEPA and Section 106. There is a critical need to provide additional support for this work to protect both natural and cultural resources and park management needs. Expediting completion of resource conservation and stewardship projects increases access to popular sites in the park and therefore improves visitor experience.

$99K – $250K

rolling

natural resources

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Nestle Foundation US Programs

Nestle Foundation

Supports nutrition, water stewardship, and youth development in US communities.

$10K – $500K

nutritionwater stewardshipyouth development

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Network biomarkers for early detection of cognitive impairment using digital clock drawings

NIA - National Institute on Aging

Project summary/Abstract Our research aims to enhance the early detection of Alzheimer’s disease and related dementias (ADRD) by developing advanced AI tools using digital neuropsychological (NP) tests. While neuroimaging and blood-based biomarkers are precise, they are often expensive and inaccessible for routine screening. Digital NP tests are easy to administer and offer high-frequency time-stamped pen movement data that traditional methods miss, enabling a nuanced understanding of cognitive function. Despite these advancements, there remains a significant gap in modeling approaches that can leverage such data to predict cognitive impairment accurately. Our focus is on the digital clock drawing test (dCDT), a widely used screening tool in clinical settings that evaluates executive function, visuospatial abilities, and semantic memory. It has two parts: a command test (participants receive verbal/on-screen instructions) and a copy test (participants replicate a pre-drawn clock). Traditional approaches to analyzing the CDT and dCDT rely on extracting handcrafted features, which are subsequently analyzed using statistical or conventional machine learning models. However, these methods fail to fully utilize the rich temporal and spatial information captured by such granular data, often overlooking critical structural and sequential patterns associated with neurodegenerative disorders. The overall objective of our research is to (i) develop novel graph-based representations of dCDT drawings and (ii) build advanced machine learning models to detect cognitive impairment early and accurately. First, we will construct novel and comprehensive network representations of dCDT drawings, capturing the spatial positioning of clock components, their morphological attributes, and relative placement. Using these networks, we will develop a heterogeneous graph attention network with dual attention (GADA) to classify individuals as cognitively intact or impaired. We will then employ graph contrastive learning to enhance the generalizability of our models and identify key nodes and edges contributing to classification decisions. Second, we will develop a signed graph representation to quantify differences in how participants draw command and copy clocks in dCDTs. Using these signed networks, we will build a novel hypothesis testing framework to assess structural differences between test types across cognitive subtypes and develop a novel signed GADA to predict cognitive impairment. This approach leverages within-subject drawing differences for early detection. Our work will utilize data from the Framingham Heart Study, which includes extensive biological, genetic, and phenotypic data, along with digital NP data since 2011. By capturing nuanced aspects of dCDT drawings through advanced and comprehensive graph representations, we can identify subtle indicators of cognitive impairment. This will significantly enhance our ability for early detection of ADRD, providing critical insights for timely clinical interventions. Furthermore, early detection tools based on digital tests enhance accessibility in low-resource settings, particularly for elderly populations and in-home assessments.

Up to $324K

2027-12-31

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Network for Computational Nanotechnology (NCN)

U.S. National Science Foundation

NSF established the Network for Computational Nanotechnology (NCN) in 2002 at Purdue University as part of the National Nanotechnology Initiative (NNI). The NCN was established as a service facility to offer researchers the tools to explore nanoscale phenomena through theory, modeling, and simulation while also developing enhancements to science and engineering education. Through its cyber platform, nanoHUB.org, NCN has become a powerful resource for the worldwide nanoscience and nanoengineering community and currently serves over 170,000 researchers, educators, students, and other professionals worldwide. For more information on NCN, please see http://nanohub.org/about#funding NSF's NCN award expires in September 2012. Through this solicitation, NSF provides an opportunity for the broader community to compete to reconfigure the NCN. The configuration of the new Network for Computational Nanotechnology will be restructured as a stand alone Cyber Platform awardee, which will provide computation, simulation and educational services to the nanoscience and engineering communities, including the current nanoHUB tools and educational materials. This platform will be funded by one award to a single university. Linked to that platform will be three new Nodes that will develop new tools and content that will be delivered to Cyber Platform for worldwide dissemination. NSF will fund the Cyber Platform and these new Nodes through four separate awards, which will be joined through their respective cooperative agreements to constitute the new reconfigured NCN. The goals of the reconfigured NCN will continue to be those of the original NCN to: 1) engage an ever-larger and more diverse cyber community sharing novel, high-quality nanoscale computation and simulation research and educational resources; 2) accelerate the transformation of nanoscience to nanotechnology through the integration of simulation with experimentation; 3) develop open-source software to stimulate data sharing; and 4) inspire and educate the next generation workforce. The new content development Nodes will combine theory and experimentation to develop the computation and simulation tools, and educational materials for delivery on the Cyber Platform. The new content development Node areas will be: NanoBIO - Create integrated computational tools to simulate biological phenomena across length scales, for the design of devices and systems;NanoMFG - Computation and simulation software to address the challenges of scaling up nanoscale in manufacturing;Nano-Engineered Electronic Device Simulation Node (NEEDS) - Computation and simulation tools to facilitate the development of nanoelectronic-based circuits, devices, and systems. Proposals will be accepted only for the Nodes defined above and any proposal for another Node content area will be returned without review. There will be one award per Node and the configuration of each Node may involve more than one university. By linking these NCN Nodes to the NCN Cyber Platform, the result will be a comprehensive and integrated service delivery system, which links theory, simulation, and experimentation to continue to strengthen and support nanoscience and nanoengineering research and education.

rolling

sciencetechnology

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Network of the National Library of Medicine Coordinating Center (U24 Clinical Trial Optional)

National Institutes of Health

The National Library of Medicine (NLM) intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications for a Coordinating Center of the Network of the National Library of Medicine (NNLM).Established in 1965 and organized geographically across the United States and its territories, the NNLM promotes and supports the initiatives, products, and services of the NLM and the National Institutes of Health (NIH). Over the years, the network has expanded its impact through strategic partnerships with a broad array of member organizations, including health sciences, hospital, academic, and public libraries; health professionals; data organizations; and community-based groups.The NNLM s core mission is to enable the effective use of and contribution to health information and data made available by the NLM and NIH. The network achieves this by providing professional development for librarians and information specialists, and by supporting access to health information and outreach through libraries and community organizations. A central emphasis of the NNLM is increasing awareness of and engagement with NIH programs and resources.While the NNLM has traditionally focused on promoting NLM-specific products, it is now poised to expand its reach across the broader NIH community. The network will play a vital role in disseminating research findings, fostering community engagement and partnerships, and supporting participation in local clinical research. In doing so, the NNLM will enhance public understanding of NIH s contributions and increase the use of NIH-supported information and data resources.The NNLM consists of three major components: 1) the Network Coordinating Center (NCC), 2) Regional Medical Libraries (RMLs), and 3) the Network Training Center (NTC). This announcement specifically pertains to the NCC, with companion NOFOs forthcoming for RMLs and the NTC.The NCC will be responsible for the administration, evaluation, communication, and coordination of the Network, working closely with the NTC and the RMLs. The NCC will design and implement efficient, transparent systems for coordination and oversight. It will manage network-wide evaluation activities, including the development of tools and systems for data collection and analysis, and will lead the common metrics initiative and related reporting. In addition, the NCC will oversee internal communication tools that support coordination and knowledge management, as well as public-facing platforms such as the NNLM website.The NCC should have strong competencies in network management and evaluation, as well as evidence of creating strong partnerships with NIH and other organizations.Grant authority that allows NLM to forecast this opportunity is as follows: Medical Library Assistance Act of 1965 (MLAA, P.L. 89-291).

Up to $1.5M

2026-12-15