Neighborhood and individual environmental risk factors in early life and -omics biomarkers for kidney function trajectories across childhood and adulthood
NIEHS - National Institute of Environmental Health Sciences
About This Grant
PROJECT SUMMARY/ABSTRACT Chronic kidney disease (CKD) and hypertension (HTN) are substantial public health concerns in the US and are important risk factors for other adverse outcomes including acute kidney injury and premature mortality. CKD and HTN are typically diagnosed later in life, yet our understanding of the prenatal and early life environ- mental determinants of reduced kidney function and HTN across childhood and early adulthood remains incipi- ent. This research, however, faces several barriers including lack of assessment of both neighborhood- and individual-level environmental stressors at specific early life stages coupled with long-term follow-up from birth to early adulthood. This project will address these research gaps by leveraging high-quality data from Project Viva, an ongoing longitudinal prospective pre-birth cohort of mother-child pairs followed since pregnancy. The overall goals of the proposed project are to examine the extent to which early-life exposure to disadvantaged neighborhood contexts and nephrotoxicants (i.e., air pollutants and metals) leads to later life kidney dysfunc- tion and higher blood pressure (BP). The investigators will: (Aim 1) examine associations of early-life neighbor- hood environment with kidney function and BP across childhood and early adulthood; (Aim 2) assess associa- tions of individual-level early-life exposure to candidate nephrotoxicants with kidney function and BP from mid- childhood to early adulthood; and (Aim 3) characterize urinary proteomic signatures underlying altered kidney function and BP trajectory from childhood to early adulthood, and examine these signatures as potential mark- ers of toxicant exposure. This innovative proposal will be the first to examine both neighborhood- and individ- ual-level environmental determinants of kidney function and BP trajectories. We will identify actionable risk fac- tors and molecular signatures to identify high-risk individuals and pinpoint when primordial prevention efforts have the greatest potential to prevent future CKD and HTN.
Grant Summary
Neighborhood and individual environmental risk factors in early life and -omics biomarkers for kidney function trajectories across childhood and adulthood is a NIEHS - National Institute of Environmental Health Sciences grant providing up to $3.8M for university, nonprofit, healthcare org. Applications are due 2030-04-22 (open). Check eligibility and apply with FindGrants.
Focus Areas
Eligibility
How to Apply
Up to $3.8M
2030-04-22
- 1Confirm your organization is eligible for Neighborhood and individual environmental risk factors in early life and -omics biomarkers for kidney function trajectories across childhood and adulthood from NIEHS - National Institute of Environmental Health Sciences, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NIEHS - National Institute of Environmental Health Sciences before the deadline.
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Neighborhood and individual environmental risk factors in early life and -omics biomarkers for kidney function trajectories across childhood and adulthood: Frequently Asked Questions
Who is eligible for the Neighborhood and individual environmental risk factors in early life and -omics biomarkers for kidney function trajectories across childhood and adulthood?
Neighborhood and individual environmental risk factors in early life and -omics biomarkers for kidney function trajectories across childhood and adulthood is offered by NIEHS - National Institute of Environmental Health Sciences and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the Neighborhood and individual environmental risk factors in early life and -omics biomarkers for kidney function trajectories across childhood and adulthood provide?
Neighborhood and individual environmental risk factors in early life and -omics biomarkers for kidney function trajectories across childhood and adulthood provides up to $3.8M per award from NIEHS - National Institute of Environmental Health Sciences. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the Neighborhood and individual environmental risk factors in early life and -omics biomarkers for kidney function trajectories across childhood and adulthood deadline?
Applications for Neighborhood and individual environmental risk factors in early life and -omics biomarkers for kidney function trajectories across childhood and adulthood are due 2030-04-22 (open). Because deadlines can change, verify the date with the funder, NIEHS - National Institute of Environmental Health Sciences, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the Neighborhood and individual environmental risk factors in early life and -omics biomarkers for kidney function trajectories across childhood and adulthood?
To apply for Neighborhood and individual environmental risk factors in early life and -omics biomarkers for kidney function trajectories across childhood and adulthood, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NIEHS - National Institute of Environmental Health Sciences.