Grants

DEPT OF DEFENSE.DEPT OF THE AIR FORCE.AIR FORCE RESERVE COMMAND.FA6606 439 CONF PK

Maintain Pavement Markings

Free to search & build · $99 one-time to unlock the application pack · No subscription

Maintain Trails, Landscapes, and Picnic Areas with American Conservation Experience

National Park Service

United State Department of the Interior, National Park Service (NPS) Notice of Intent to Award. This is not a request for applications. This funding opportunity is to provide public notice of NPS's intention to fund the following project activities without full and open competition. Cooperative Agreement P18AC01400 with the American Conservation Experience, for project titled "Maintain Trails, Landscapes, and Picnic Areas with American Conservation Experience"

Up to $44K

natural resources

Free to search & build · $99 one-time to unlock the application pack · No subscription

Maintain, Develop and Promote Trail for the General Public

National Park Service

The purpose of this Cooperative Agreement is to engage recipients, partners, communities and visitors in a shared environmental stewardship of the Overmountain Victory National Historic Trail, while preserving, developing and keeping the trail accessible to the public.

$1 – $500K

Free to search & build · $99 one-time to unlock the application pack · No subscription

MAINTENANCE & REPAIR OF EST FIRE ALARM SYSTEM (SS)

CONVERGINT TECHNOLOGIES LLC

National Defense and Public Order and Security and Safety Services

2028-11-16

Free to search & build · $99 one-time to unlock the application pack · No subscription

MAINTENANCE AND REPAIR OF CATEPILLAR EMERGENCY GENERATORS

ALTORFER INDUSTRIES INC

Power Generation and Distribution Machinery and Accessories-Power sources-Motor or generator components

2027-02-28

Free to search & build · $99 one-time to unlock the application pack · No subscription

MAINTENANCE AND TECHNICAL SUPPORT FOR CLOSED CIRCUIT TV

AC DAUGHTRY SECURITY SYSTEMS

Defense and Law Enforcement and Security and Safety Equipment and Supplies-Security surveillance and detection

2026-10-17

justice

Free to search & build · $99 one-time to unlock the application pack · No subscription

MAINTENANCE OF ELECTRIC TIME STAMPS, ELECTRIC COURT SEALERS, DATE STAMPS, AND LOCAL DATA HAND STAMPS.

Trademark Products, Inc.

Industrial Production and Manufacturing Services

2028-03-31

Free to search & build · $99 one-time to unlock the application pack · No subscription

MAINTENANCE OF GREASE TRAP PUMPING AND WATER JETTING OF SEWER LINES

The Stone Group, Inc.

Distribution and Conditioning Systems and Equipment and Components

2026-06-30

Educationenvironment

Free to search & build · $99 one-time to unlock the application pack · No subscription

MAINTENANCE OF THE B.E.A.S.T.

PORTER LEE CORPORATION

Information Technology Broadcasting and Telecommunications

2030-03-31

technologyinfrastructure

Free to search & build · $99 one-time to unlock the application pack · No subscription

Maintenance of the South Rim Trail/Administrative Road

National Park Service

Maintenance of the South Rim Trail/Administrative Road

$1 – $40K

Free to search & build · $99 one-time to unlock the application pack · No subscription

Maintenance Project (repair fences, trails, remove vegetation) at Parashant National Monument

National Park Service

A.Project Goals This maintenance project will remove excess vegetation, repair fences, roads, and trails in and around cultural and natural sensitive areas at Parashant National Monument. B.Project Objectives This maintenance project will treat vegetation encroaching on historic structures and fences, repair fences designed to prevent the entry of livestock and feral animals into sensitive areas such as cultural sites and springs, and repair unpaved roads/trails to provide a better visitor experience to these sites. The areas that will be focused on are the Tassi Ranch cultural landscape, fence line, springs and forage reserves. This will require the use of a variety of tools and techniques to cater to the treatment of that particular area. The crews will learn about these techniques, tools to be used and their proper uses in the context of cultural and natural resource restoration and protection.

$12K – $112K

natural resources

Free to search & build · $99 one-time to unlock the application pack · No subscription

Maintenance Services for Elevators and Platform Lifts

STATE, DEPARTMENT OF.STATE, DEPARTMENT OF.US EMBASSY ROME

Maintenance Services for Elevators and Platform Lifts

Free to search & build · $99 one-time to unlock the application pack · No subscription

Maintenance to Historic Headland Trail

National Park Service

This Announcement is NOT a request for applications. This announcement is to provide public notice of the National Park Services intention to award financial assistance.

$59K

Free to search & build · $99 one-time to unlock the application pack · No subscription

Major pharmacy chain and retailer investments in primary care and implications for access to and quality of care in older adults

NIA - National Institute on Aging

PROJECT SUMMARY/ABSTRACT Access to high-quality primary care providers (PCPs), including physicians and advanced practice providers, is associated with better patient outcomes and is necessary to coordinate the complex needs of an aging population. Currently, primary care is experiencing significant corporate investment, which may have important implications for access to and quality of care in older adults. One key subset of investments has been from major pharmacy chains and retailers that own pharmacies. In the last five years, Walgreens invested over $6B to acquire majority stake in VillageMD, CVS acquired Oak Street Health for $10.6B, Walmart opened 51 Health Centers, and Amazon, which operates a mail-order pharmacy, acquired One Medical for $3.9B. In testing care models, these firms have acquired, opened, and closed many clinics, which are collectively referred to herein as retailer-owned primary care clinics. An important portion of these clinics focus on older adults, as firms see an opportunity to profit in value-based contracts in Medicare. Yet, the implications of retailer-owned primary care clinics for access to and quality of care in older adults is uncertain. The overall objectives for this proposal are to examine the implications of retailer-owned primary care clinics for access to and quality of care for older adults (age 65+). Through the proposed training plan, which includes formal coursework, workshops, and clinical shadowing, as well as a multi-disciplinary mentorship team of NIH-funded investigators, Dr. Kakani will gain clinical knowledge on primary care in older adults and on medication management of chronic disease, expertise in qualitative and mixed methods, and expertise in advanced statistical methods for causal inference. Dr. Kakani will use the knowledge gained through training activities to achieve the following specific aims: (1) Compare the area, PCP, and older adult patient characteristics of retailer-owned primary care clinics to other primary care practices to identify implications for access to and quality of care, (2) Evaluate the impact of retailer-owned primary care clinics on access to and quality of care for older adults, and (3) Characterize the perspectives of health care executives and PCPs of retailer-owned primary care clinics and specialist physicians treating patients using retailer-owned primary care clinics regarding factors impacting care delivery for older adults. This application is innovative because it will be the first study of retailer-owned primary care clinics and will leverage a mixed methods approach to provide nuanced insights into the implications of retailer-owned primary care clinics for older adults. The proposed research is significant because it will provide new, critical evidence on the impact of retailer-owned primary care clinics, which will inform innovators and policymakers seeking to reform and improve access to and quality of primary care in an aging population, and regulators of mergers and acquisitions in health care. This to access K01 Award will also provide Dr. Kakani with the training and mentoring needed become n R01-funded independent investigator leading a research program on primary care and medication and management in older adults. a

Up to $129K

2030-12-31

Free to search & build · $99 one-time to unlock the application pack · No subscription

Major Research Instrumentation Program

U.S. National Science Foundation

The Major Research Instrumentation Program (MRI) serves to increase access to shared scientific and engineering instruments for research and research training in our Nation's institutions of higher education, and not-for-profit museums, science centers and scientific/engineering research organizations. This program especially seeks to improve the quality and expand the scope of research and research training in science and engineering, by supporting proposals for shared instrumentation that fosters the integration of research and education in research-intensive learning environments. Each MRI proposal may request support for the acquisition (Track 1) or development (Track 2) of a single research instrument for shared inter- and/or intra-organizational use; development efforts that leverage the strengths of private sector partners to build instrument development capacity at MRI submission-eligible organizations are encouraged.To accomplish the program's goals, the MRI program assists with the acquisition or development of a shared research instrument that is, in general, too costly and/or not appropriate for support through other NSF programs. The instrument is expected to be operational for regular research use by the end of the award period. For the purposes of the MRI program, a proposal must be for either acquisition (Track 1) or development (Track 2) of a single instrument or for equipment that, when combined, serves as an integrated research instrument (in contrast to requests for multiple instruments that enable research in a common or focused research domain, which MRI does not support). The MRI program does not support the acquisition or development of a suite of instruments to outfit research laboratories/facilities or that will be used to conduct independent research activities simultaneously. Instrument acquisition or development proposals that request funds from NSF in the range $100,000-$4 million may be accepted from any MRI-eligible organization. Proposals that request funds from NSF less than $100,000 may also be accepted from any MRI-eligible organization for the disciplines of mathematics or social, behavioral and economic sciences and from non-Ph.D.-granting institutions of higher education for all NSF-supported disciplines. Cost-sharing of precisely 30% of the total project cost is required for Ph.D.-granting institutions of higher education and for non-degree-granting organizations. Non-Ph.D.-granting institutions of higher education are exempt from cost-sharing and cannot include it. National Science Board policy is that voluntary committed cost sharing is prohibited.Please see the solicitation text for definitions of organizational types used by the MRI program.

Up to $4M

sciencetechnology

Free to search & build · $99 one-time to unlock the application pack · No subscription

Major Research Instrumentation Program

U.S. National Science Foundation

Major Research Instrumentation Program

2026-11-16

research

Free to search & build · $99 one-time to unlock the application pack · No subscription

Major Taylor Gold Sprints Celebration

Bike Works

Bike Works will hold an event on Sunday, 11/5/23 to honor Marshall `Major` Taylor's birthday. Taylor is a hero to people interested in the intersections of cycling and social justice. The event will also include `Gold Sprint` ,an indoor cycling event. After the Sprints, we will watch a film about Taylor with food and beverages.

Up to $21K

justiceAgriculture

Free to search & build · $99 one-time to unlock the application pack · No subscription

Making America Healthy Again by Addressing Dementia Disparities

upcoming

Office of the Assistant Secretary for Health

Making America Healthy Again by Addressing Dementia Disparities

Health

Free to search & build · $99 one-time to unlock the application pack · No subscription

Making Europe a global magnet for talent - Attracting and retaining students, researchers and high-skilled workers from outside the EU

technologyEducationArts & Culture+1

European Commission - HORIZON

Making Europe a global magnet for talent - Attracting and retaining students, researchers and high-skilled workers from outside the EU. Call: Culture, Creativity and Inclusive Society 2026. Programme: HORIZON. Keywords: Education, general (including training, pedagogy, didactics). Open call from the EU Funding & Tenders Portal.

$50K

2026-09-23

Free to search & build · $99 one-time to unlock the application pack · No subscription

Making genome editing delivery vehicles in the body to amplify editing efficiencies

NIBIB - National Institute of Biomedical Imaging and Bioengineering

PROJECT SUMMARY/ABSTRACT Directly genome editing cells inside the body could treat numerous genetic diseases, including sickle cell disease. However, genome editing of most cell types outside of the liver, such as hematopoietic stem cells, is limited by inefficient delivery. Only a small subset of cells inside of a tissue are accessible to delivery vehicles and editing enzymes. To overcome this delivery problem, my central objective is to enable cells initially receiving delivery vehicles to transiently produce and distribute genome editing enzymes to neighboring cells in vesicles. This allows editing activity to spread beyond initial delivery. My proposal builds on my postdoctoral research studying the delivery mechanisms of Enveloped Delivery Vehicles (EDVs). EDVs are lentivirus-derived lipid vesicles engineered to package CRISPR-Cas9 ribonucleoproteins that can be targeted to specific cell types using surface-displayed fusogens and antibodies. I hypothesize that transient, local production of EDVs in vivo will amplify genome editing efficiency by increasing the concentration of genome editing enzymes and enabling their spread across cells. This hypothesis will be tested through three specific aims: (1) develop single nucleic acid molecules encoding EDVs, (2) establish methods to target EDV production and uptake to specific cell types, and (3) deliver EDV-encoding plasmids to amplify editing in vivo. In preliminary work for this proposal, I showed that hydrodynamic injection of EDV-encoding plasmids into mice amplified genome editing efficiencies compared to Cas9 only plasmid controls. Successful completion of this proposal will generate fundamental insights into propagating genome editing effects beyond cells initially reached by delivery vehicles starting with hematopoietic stem cells as a model therapeutic cell type. This approach could broadly transform biological therapy delivery by overcoming low delivery efficiencies through localized amplification and spread of therapeutic macromolecules. The training acquired through this proposal in primary cell culture, bioinformatics, and next-generation sequencing will bolster my readiness to lead an independent research program. I will be mentored by Dr. Jennifer Doudna, a global leader in genome editing technology, and leading experts and clinicians in primary cell engineering, hematopoietic stem cell biology and virology in the California scientific community. During the mentored phase of this project, I will hone my scientific and professional skills to become a scientific leader. I will engage in structured professional development activities and actively present my research at leading conferences to facilitate a successful transition to an independent academic research position. The vibrant and collaborative environment provided by UC Berkeley and the Innovative Genomics Institute offers an outstanding environment to complete my training and start my independent scientific career.

Up to $120K

2028-04-30

Free to search & build · $99 one-time to unlock the application pack · No subscription

Making the MOST of Relapse Prevention in Anorexia Nervosa: A Treatment Optimization Study Targeting Habits

NIMH - National Institute of Mental Health

Project Summary Anorexia nervosa (AN) is a serious disorder with a mortality rate among the highest of any psychiatric illness, and relapse rates range from 40-80% after acute treatment. Restriction of food intake is a central behavioral disturbance, and this persistent behavior is promoted by entrenched thoughts, feelings, and routines. Even with full weight restoration treatment, restrictive eating persists and has been linked to relapse. While many treatment approaches have been tried, there is little information about what elements of care contribute to maintaining remission. Relapse Prevention and Changing Habits (REACH+) targets the habitual control of maladaptive behavior to support patients with AN in the 6 months after acute treatment, a time of high vulnerability to relapse. Using the Multiphase Optimization STrategy (MOST) framework, we seek to identify an optimized, finalized, treatment package for relapse prevention in AN. The MOST framework is an ideal means for improving treatment efficacy by simultaneously and efficiently evaluating multiple possible intervention components to determine which contribute to positive treatment outcomes and thereby merit inclusion in a robust treatment package for relapse prevention. We have completed the Preparation Phase of the MOST framework and have shown feasibility and acceptability of REACH+, as well as preliminary support for treatment efficacy and target engagement. In this proposal, we conduct the next step: an Optimization Experiment to evaluate the components of REACH+ that will interrupt the habitual control of maladaptive behavior and, thereby, decrease relapse and improve outcomes. We will test competing versions of four components that together target habits: 1) Behavioral, 2) Cognitive, 3) Motivation, and 4) Food Monitoring. We will provide 6 months of REACH+ for 120 individuals with AN or atypical AN who have completed an acute weight-restoration treatment. REACH+ sessions are conducted via telehealth, to increase access and generalizability, and are augmented with psychoeducation and skill building through an online platform. Participants will be randomly assigned to different versions of each treatment component. Optimization criteria focus on the contribution of the component to weight maintenance (main effect), and will additionally consider effect sizes, treatment adherence, and end-of-treatment status. To ensure that the final treatment package will reach the patients we seek to help, we will obtain input from key end-users to plan for future effectiveness research.

Up to $922K

2031-02-28

Free to search & build · $99 one-time to unlock the application pack · No subscription

Malaria & Migration: Assessing Local Malaria Change near Migrant Communities in Panama

NIAID - National Institute of Allergy and Infectious Diseases

Despite recent regional control efforts that aimed to eliminate malaria by 2022, reduction in malaria transmission has stalled in Central America and in many cases is on the rise. In the Darien and Guna Yala regions of Panama, an extreme increase in international migration combined with potential changes in malaria vectors and vector ecology has coincided with increasing cases detected in the country. The majority of new malaria cases are occurring in indigenous communities, particularly near areas where transiting migrants are housed. These events – migration through Panama, temporary housing in indigenous communities, introduction of new malaria vectors, and increasing malaria rates – are likely interrelated and require further investigation to explain these new dynamics of malaria transmission. The overall goal of this project is to support interdisciplinary training and research experience in vector-borne disease epidemiology, migration, and environmental health, including the roles of hydrometeorological variables and land-use and land-cover (LULC) change in influencing disease ecology. The applicant’s long-term career goal is to become an independent academic researcher with expertise in vector-borne disease and One Health, with specific expertise in quantifying the effects of hydrometeorology and LULC changes on disease development. The proposed fellowship will support mentored training in (1) the assessment of human behavior with case-control survey design, data collection, and processing, (2) the application of entomological collections, morphological and genetic identification, and data processing, and (3) the development of Bayesian spatial-temporal models to assess local malaria risk. The described training will include coursework, one-on-one mentoring, fieldwork, extensive application of statistical methods, participation in workshops/conferences, and the publication of a minimum of 3 first-authored manuscripts. Two research aims are proposed for this application: (1) evaluating the effect of temporary migrant housing on malaria transmission in local communities using a longitudinal case-control study design; and (2) conduct mosquito collections to characterize the composition and distribution of vector species within communities with and without transiting migrants. Both aims will employ Bayesian models and assess the role of hydrometeorological and LULC change variables. These aims will test the main hypothesis that migration and vector ecology are contributing to increased malaria transmission in Panama, and that environmental change is impacting this dynamic. The proposed research leverages two externally funded studies supporting malaria elimination in Panama, including a longitudinal study evaluating risk factors associated with elevated malaria risk in the Darien. The proposed study will be a subset of the parent project. Ultimately, the proposed projects will provide critical insight into this new malaria landscape in Panama and will help inform malaria control efforts. Further, they will provide the applicant with intersectional training and unique expertise for a career in One Health and vector-borne disease epidemiology.

Up to $50K

2028-12-31

Free to search & build · $99 one-time to unlock the application pack · No subscription

Malaria importation and the role of agriculture in local transmission in Eswatini (MIRA)

NIAID - National Institute of Allergy and Infectious Diseases

Project Summary/Abstract As malaria transmission declines, an increasingly large proportion of the parasite reservoir is imported, with transmission persisting in specific sub-populations with high exposure to malaria and barriers to accessing and utilizing malaria prevention. Epidemiological data alone are unable to establish transmission links between infections or distinguish those that arise from importation events, posing a key barrier to measuring progress toward elimination targets. The long-term goal of this proposal is to leverage the confluence of cutting-edge molecular methods, genomic data, and novel analytic approaches to improve malaria case classification, identify drivers of residual transmission, and understand the introduction and spread of antimalarial drug resistance mutations. The overall objective is to quantify the contribution of infections imported by agricultural populations—including those carrying antimalarial drug resistance markers—to transmission in Eswatini. The central hypothesis is that imported infections in agricultural populations disproportionately contribute to ongoing malaria transmission and the spread of antimalarial drug resistance mutations. The hypothesis will be tested by pursuing two specific aims: (1) To improve case classification using high-resolution genomic data. (2) To characterize transmission dynamics and patterns of drug resistance markers in relation to imported cases within agricultural populations. To achieve these aims, existing and new high-resolution parasite genomic data will be analyzed with epidemiological data from samples collected through complementary studies conducted in Eswatini between 2012-2017 and 2023. For the latter, contemporaneous genomic data from Mozambique in 2023 will be used as a source population to assess genomic connectivity and improve genomic case classification models. Genomic transmission networks will be constructed for each dataset in addition to probabilistic models of importation based on travel history. Temporal, spatial, and demographic characteristics of highly related clusters will be quantified, and epidemiological metrics will be inferred from reconstructed networks. Findings are expected to shed light on the contribution of malaria importation and agricultural work in ongoing transmission and detection of parasites harboring antimalarial drug resistance markers in Eswatini and serve as proof of concept for innovative genomic transmission network methods for case classification and estimates of transmission between subpopulations. These contributions will be significant in providing critical evidence of the role of cross-border movement and agricultural populations in maintaining transmission and spread of antimalarial drug resistance markers in Eswatini. In addition to generating key metrics to inform decision-making in Eswatini, findings will support the broader use of genomic data and transmission network models for case classification and drug resistance surveillance. Results will be used to develop future R01 clinical trials focused on targeted active surveillance and intervention strategies at agricultural worksites and inform strategies for global surveillance of resistant parasites that pose an immediate threat to U.S. travelers.

Up to $246K

2028-04-30

Free to search & build · $99 one-time to unlock the application pack · No subscription

Malaria Reservoir Study (MRS) II: reducing parasite diversity to break intervention resilience in Plasmodium falciparum populations at high endemicity

FIC - John E. Fogarty International Center for Advanced Study in the Health Sciences

Malaria presents a significant health challenge in sub-Saharan Africa (SSA). It is a threat to US citizens in relation to health security, safe travel, missionary work and military operations. The relevance of malaria control and elimination in SSA to US economic opportunity and role in geopolitics cannot be underestimated. In SSA, a large fraction of the population across all ages harbors the malaria parasite Plasmodium falciparum without clinical manifestation, providing a vast infection reservoir for mosquito transmission. This asymptomatic reservoir is sustained by enormous antigenic diversity of the parasite. Our proposal addresses the hypothesis that progress toward falciparum malaria elimination should focus on reducing the number of antigenically diverse strains. Here we test this hypothesis in Ghana, a stable country in West Africa with a National Strategic Plan for malaria elimination including regions of economic and strategic importance to the US. Malaria Reservoir Study-II (MRS-II) takes advantage of enhanced intervention efforts in northern Ghana as major perturbations reducing the transmission reservoir, to address the sharp transition postulated by previous theory in both parasite diversity and infection prevalence with changes in transmission intensity. We test the importance of strain diversity to resilience of the transmission system, with a framework that combines longitudinal surveys of unprecedented depth with novel metrics for molecular surveillance of variant antigen diversity and computational models encompassing generalized and variant antigen immunity. Our three major inter-related aims are: (1) Field work for surveillance of enhanced interventions in two sites of northern Ghana differing in recent malaria control; (2) Characterization of the resilience of high-transmission systems to the major perturbation of targeted mass drug administration to children aged 3 months to 12 years in terms of changes in strain diversity; (3) Computational modeling to evaluate and predict dynamical responses to enhanced intervention in the context of the fundamental positive feedback between strain diversity and transmission intensity. The project will provide real world experience for US trainees in disease surveillance and control as well as training in quantitative tools for biomedicine. Quantitative characterization based on molecular surveillance, together with mathematical models that consider strain diversity and structure, will inform public health policy on the impact of control efforts in high-transmission regions. Current efforts are designed to reduce disease burden in children with no surveillance of the impact on the reservoir of asymptomatic infections in the community. MRS-II fills this significant gap in regions of northern Ghana with relevance to high-transmission areas of the Sahel in West Africa. More generally, our study aims to shift the paradigm in malaria epidemiology to make the parasite rather than the infected host the unit of measurement for evaluation of control and a target for elimination.

Up to $126K

2031-05-31