Grants

New Verticals LLC

Preservation

OD - NIH Office of the Director

Twenty-four NIH-funded investigators studying a wide range of biomedical research topics at the University of Maryland Baltimore (UMB) are requesting funds for a transmission electron microscope (TEM), the Talos L120C G2 (Thermo Fisher Scientific). UMB has a long history of TEM use conducted at the Electron Microscopy Core Imaging Facility (EMCIF), and the decommissioning of the current TEM has drastically impeded the ongoing research projects. This TEM will replace an 20-year-old Thermo Tecnai T12, a 120 kV tungsten filament instrument, whose reliability and stability were decreasing when we lost the capability to capture images. Through demonstrations of microscopes from several vendors as well as Director and user experiences, the Thermo Talos L120C G2 is the ideal replacement research microscope with its high-contrast, high-resolution optics for biological samples. Its lanthanum hexaboride crystal electron source and Ceta 16M CMOS and Smart digital camera will produce bright, well-contrasted images for all our users. Its user-friendly software interface with features such as motorized stage, alignment recall, automated apertures, and rapid specimen exchange make this a good fit for a core facility. The remote operation features are ideal for training users and providing fee-for-service to distant users. The Talos L120C will be placed in the current TEM room, which is a pre-existing, well-designed space with convenient access to the main Core lab and staff. It will be administered by the EMCIF which is part of the Center for Innovative Biomedical Resources (CIBR) which provides resources to UMB researchers. Our staff will provide training in sample preparation and in operation of the new TEM. EMCIF is jointly supported by the School of Dentistry and the School of Medicine. We support research across the entire UMB campus as well as the University of Maryland System. The new TEM will be placed into the existing recharge system available to users through an iLab software interface available through the web and as a smart phone app. The new TEM will support continued progress of NIH-funded research projects of UMB scientists that are relevant to our mission of improving the human condition and serve the public good of Maryland. The EMCIF has a strong record of collaboration with researchers providing electron microscopy results for presentations, publications and grant applications. Strong institutional support provides for Director and staff salaries, space, instrument service/maintenance, administrative services and other EMCIF operating costs. If funded, the Talos L120C will be the primary TEM for UMB faculty research, and it will expand our capacity for biomedical research at UMB and at regional institutions. The impact will extend beyond the cancer, blood, infectious disease, bone development and other research projects listed in this proposal. The EMCIF’s mission is to provide state-of-the-art instrumentation and training to researchers, trainees, graduate students and staff. We aim to train the next generation of scientists to appreciate and interpret electron micrographs.

City of Kansas City

Housing

Visual Arts Research and Resource Center Relating to the Caribbean

Renovate the 8,400 square foot firehouse on 125th street. The concept for the design consists of refinishing the façade and adapting the building, landmark by NYC Landmarks Preservation Commission, to a new vibrant program that includes a café, gallery space, flexible multi-purpose space, computer center, recording studio, and offices.

NCI - National Cancer Institute

PROJECT SUMMARY Osteosarcoma, the most common primary malignant bone tumor in children, begins in the cells that form bones and has the potential to rapidly metastasize if not diagnosed early. The implementation of natural killer cell immunotherapy to treat pediatric osteosarcoma lung metastases is an emerging treatment approach. However, clinicians are currently unable to verify the delivery of immunotherapy to desired target sites in the lungs, which is a critically unmet clinical need. An innovative approach for imaging immune cell delivery in vivo may provide new insight into the journey and destination of administered immunotherapy, which may lead to an increase in immunotherapy treatment-success rates for pediatric osteosarcoma patients with lung metastases. To address this clinical gap, I propose to use “hyperpolarized chemical exchange saturation transfer” (hyperCEST), a novel magnetic resonance lung imaging (MRI) strategy, to track the delivery of administered natural killer cell immunotherapy to the lungs in vivo. While traditional 1H MRI of the lungs suffers severe limitations due to low inherent tissue density, my innovative approach combines emerging, FDA approved and clinically relevant, hyperpolarized 129-Xenon gas and clinically translatable, FDA approved perfluorocarbon nanodroplets as hyperCEST contrast agents for natural killer cell labeling in the lungs. I hypothesize that labeling natural killer immunotherapy cells with perfluorocarbon nanodroplets optimized for 129-Xenon hyperCEST MRI detection will allow for non-invasive visualization of immunotherapy delivery in the lungs. To investigate this hypothesis, I will develop a 129-Xenon pre-scan calibration pulse sequence for a 7T preclinical MRI scanner in order to calibrate the MRI scanner prior to 129-Xenon imaging experiments. I will also develop a series of multi-compartment thermal 129-Xenon gas phantoms to simplify optimization of the conditions for 129-Xenon hyperCEST using perfluorocarbon-labeled natural killer cells (Aim 1). Next, I will optimize a hyperCEST saturation pulse in order to selectively saturate the frequency of dissolved-phase hyperpolarized 129-Xenon in perfluorocarbon-labeled natural killer cells and generate maximum hyperCEST contrast (CNR) in vitro (Aim 2). Finally, in vivo hyperCEST MRI using hyperpolarized 129-Xenon gas will be performed to produce a hyperCEST contrast map of the distribution of perfluorocarbon-labeled NK cells in the lungs of mice. We will validate our findings using Xerra cryo-fluorescence tomography, which will provide the distribution of fluorescent perfluorocarbon-labeled NK cells, which can be correlated with hyperCEST maps (Aim 3). The proposed training offered through this fellowship would further accentuate my existing research strengths, address gaps in needed skills such as MRI physics and pulse programming, provide mentored research experiences, grant me the opportunity to further extend my publication record, and allow me the ability to improve my scientific communication and research presentation skills. Additionally, the Magnetic Resonance Systems Laboratory is the ideal place to perform this research, as I have access to advanced MRI technologies and mentorship from my Sponsors, Drs. Bankson and Sokolov.

12th Ave SW Block Watch Group

Neighborhood Block Watch Event Meet Your Neighbors Seattle Night Out Against Crime By holding a Block watch event during Seattle Night Out Against Crime we plan to increase relationship building between neighbors, talk about community needs, update neighbors on steps taken to address speeding in the neighborhood, and update on proposed plans for a painted intersection street mural.

Upstate Revitalization Initiat Round 1

1366 Technologies Capital

NHLBI - National Heart Lung and Blood Institute

PROJECT SUMMARY We propose to organize and conduct the Thirteenth (13th) Annual Pediatric Transplant and Cellular Therapy Consortium (PTCTC) Meeting at the NMDP, which houses an indoor arena located in Minneapolis, MN, on April 28th, 2026. A unique aspect of the Annual PTCTC Educational Meeting is that it is jointly held with the international American Society of Pediatric Hematology Oncology Conference (April 29-May 2, 2026) and includes a Combined Plenary Session, bringing pediatric hematology oncology professionals together from around the world. Hematopoietic cell transplantation (HCT) is a potentially curative therapy for many childhood illnesses. Basic, translational, and clinical research advances have significantly increased non-relapse mortality after HCT. The remarkable success is partly owed to the presentation, dissemination, and sharing of new knowledge at annual meetings. This 1-day program will invigorate the field of pediatric HCT. The theme of the 13th Annual PTCTC Educational Meeting will be “Select & Sustain: From Donor Choice, to Short Term Safety and Long-Term Recovery”. The meeting will focus on donor selection for HCT (a special focus of the NMDP) as well as short-term transplant-related complications and improving care for our long-term survivors in the years after treatments. The first session will provide the latest on HLA typing to select the optimal donor and provide updates on clinical trials that expand donor access/availability. A session focusing on acute transplant complications will include presentations and discussions on endothelial injury, special considerations for patients requiring care in the pediatric intensive care unit, and complications in those being treated for non-malignant disease. A third session will provide further insight into the care of long-term survivors following HCT and cellular therapy. Their unique medical needs require knowledge about potential long-term side effects and how to best identify and screen for these complications. Presentations will focus on the appropriate use of guideline-directed care, challenges in transitions of care as patients age or move from the treating center, and unique considerations for the malignant vs non-malignant patient populations. Finally, we will have a session dedicated to healthcare provider resilience and mentorship. The primary objectives include: I) review the “state of the science” in donor selection, access, and HLA typing, II) providing evidence-based guidelines to screen, recognize, and treat acute toxicities after HCT through standardized strategies that can be implemented irrespective of the treating institution; III) review the up-to-date recommendations in long-term survivorship care, IV) enhance the understanding of wellness through resilience and mentorship, and V) provide mechanisms to recognized to promote networking and collaboration of research and clinical trials involving pediatric HCT patients. The results of the 13th Annual PTCTC Educational Meeting will enhance our understanding of the basic, translational, and clinical state of the scientific research on the above noted topic areas, which will provide an opportunity and platform to engage young and senior clinicians and scientists to develop collaborative research.

Star, Inc., Lighting the Way…

14 Vehicles

City of Kansas City

Economic Development

City of Kansas City

Community Health & Wellness

City of Kansas City

Economic Development

Le Leboratoire Cambridge

15 Points: A Random International Exhibition

Fish and Wildlife Service

The intent of this award is to conduct applied research and monitoring to evaluate the recolonization of Atlantic salmon in newly accessible habitats within two Lake Champlain tributaries, Winooski River and Boquet River. Specific limiting factors to successful natural recolonization such as thiamine deficiency syndrome and habitat suitability will be evaluated.

Fish and Wildlife Service

To develop a longterm objective of improving the effectiveness and efficiency of the Endangered Species Act.

PAN-OCEANIC ENGINEERING CO INC.

Engineering and Research and Technology Based Services

DEPT OF DEFENSE.DEFENSE LOGISTICS AGENCY.DLA AVIATION.DLA AV RICHMOND.DLA AVIATION

16--CONTROL STICK,AIRCR

Midway Green Development LLC

Preservation

Midway Green LLC

Preservation

OTR Holdings Inc. (3CDC affilate)

Loan

Outlaw Development LLC

New construction

City of Woodburn

173 Grant Street UST Removal and Cleanup

Vision Urbana, Inc.

Naturally Occurring Retirement Communities (NORCs)

Pan-Oceanic Engineering Co., Inc.

Highway engineering