Grants

CDFI

Alternatives-Cooperative CDFI 19

CDFI

Alternatives/ Cooperative CDFI 17

CDFI

Alternatives/ Cooperative CDFI 18

U.S. Mission to Kazakhstan

Alumni Engagement Innovation Fund (AEIF) 2026: Strengthen U.S.–Kazakhstan Partnerships Through Alumni-Led Innovation

Cambridge Community Television

Alumni Media Artist Newtork and Production Group

East Hartford

Alumni Park Improvements - Basket ball courts

City of Richmond

Alvaro Dominguez - Consultant

City of Richmond

Alvaro Martinez

NYC Department of Cultural Affairs

Alvin Ailey Dance Foundation, Inc.

NIA - National Institute on Aging

Alzheimer disease (AD) is the fifth most frequent cause of death in the U.S. and currently affects nearly 55 million individuals of all ancestries worldwide; this number is predicted to double over the next 20 years. Clinical trials for effective therapeutics have almost all failed, and the few currently approved treatments provide only modest slowing of progression for a subset of individuals, with potentially severe side effects. Thus, focusing on additional and alternative therapeutic targets is critical to address this increasing health crisis. Genetically driven targets significantly improve the probability of successful clinical trials, but despite the identification of numerous AD-associated loci through GWAS, few have advanced to potential therapeutic intervention. In part, this is because GWAS itself is a blunt instrument that cannot differentiate among the many genes often underlying an associated locus. This leaves a critical gap where numerous GWAS-identified loci have not been sufficiently examined to support or refute their candidacy as a therapeutic target. ADAPTT aims to fill this knowledge gap by leveraging all available data from the growing datasets of the Alzheimer Disease Sequencing Project (ADSP) and the Alzheimer Disease Genetics Consortium (ADGC). Analyses of these genetic data will be significantly enhanced through integration of the currently separate SNV, indel, and structural variant (SV) data. We will also leverage extant in silico data and use existing and generate new in vitro molecular genetic functional data. Our goal is to identify the most likely functional genes/variations lying under each GWAS- identified locus, providing the foundation for critically needed, and genetically-driven, therapeutic development. We will achieve this goal through three parallel specific aims: Specific Aim 1 will integrate and analyze data for all SNVs, indels, and SVs within 54 AD GWAS-identified loci. We will leverage the increasingly multi-ancestry and diverse ADSP and ADGC datasets to reduce the list of probable functional genes/variations. Specific Aim 2 will assess the impact of these 54 loci on the clinically critical endophenotypes of age-at-onset and disease progression. We will first model disease progression and age-at-onset using harmonized data from the ADSP’s Phenotype Harmonization Consortium and then test the influence of the GWAS-identified loci on these endophenotypes. Specific Aim 3 will integrate extant and new molecular genetics functional data to validate causal genetic variations driving the locus associations. The results of this study will generate a set of genetically-driven potential targets that will accelerate the development of new and better therapeutics for AD.

National Institutes of Health

Alzheimer's Drug-Development Program (U01 Clinical Trial Optional)

NYC Department of Cultural Affairs

Amanda & James, Incorporated

The Dance Complex, Inc.

aMaSSiT Lab and Performance

Buhl Investors

New Construction

Buhl Investors

New construction

Buhl Investors

New construction

Norfolk

Ambulance Building Security Cameras

City of Pocomoke

Ambulance Garage

AMC MECHANICAL INC

Travel and Food and Lodging and Entertainment Services

AMC MECHANICAL INC

Building and Facility Construction and Maintenance Services

Board of Allegany County Commissioners

Amendment - Locust Grove Sewer Improvements

City of Richmond

America Salon Beauty

National Endowment for the Humanities

AMERICA AT 250: SERVICE AND CIVICS AT THE INTREPID MUSEUM [AS THE NATION APPROACHES ITS 250TH ANNIVERSARY, THE INTREPID MUSEUM?S MISSION TAKES ON RENEWED RELEVANCE. THROUGH ITS EXHIBITIONS AND PROGRAMS, THE MUSEUM INVITES THE PUBLIC TO ENGAGE WITH THE CORE VALUES THAT HAVE SHAPED THE AMERICAN EXPERIENCE AND TO CONSIDER HOW THOSE IDEALS CONTINUE TO INFLUENCE OUR SHARED FUTURE. WITH SUPPORT FROM NEH?S CELEBRATE AMERICA! GRANT, THE MUSEUM WILL PRESENT A SERIES OF PUBLIC PROGRAMS, EDUCATIONAL INITIATIVES, AND COMMEMORATIVE CEREMONIES DESIGNED TO FOSTER REFLECTION ON THE ENDURING SIGNIFICANCE OF SERVICE, CIVIC ENGAGEMENT, INNOVATION, AND RESILIENCE. THESE OFFERINGS WILL CONNECT PAST AND PRESENT, GIVING PARTICIPANTS OF ALL AGES MEANINGFUL OPPORTUNITIES TO ENGAGE WITH THE VALUES THAT DEFINE AMERICAN DEMOCRACY. PROGRAMS WILL INCLUDE STUDENT SESSIONS FEATURING VETERAN SPEAKERS, AS WELL AS EDUCATOR- AND CURATOR-LED ACTIVITIES FOR FAMILIES CENTERED AROUND THE MUSEUM?S POIGNANT VETERANS DAY, PEARL HARBOR, AND MAY, PEARL HARBOR AND MEMORIAL DAY CEREMONIES.]

NYC Department of Cultural Affairs

America SCORES New York