Grants

U.S. National Science Foundation

Conferences, workshops,and related events (including seasonal schools andinternational travel by groups) support research and training activities of the mathematical sciences community. Proposals for conferences, workshops, or conference-like activities may request funding of any amount and for durations of up to three years. Proposals under this solicitation must select "Conference" as the proposal type, and they must besubmitted to the appropriate DMS programs in accordance with the lead-time requirements, submission windows, or deadlines specified on the program web page. See the DMS Programs page and click on the appropriate program for program-specific information.

$5K – $150K

sciencetechnology

Free to search & build · $99 one-time to unlock the application pack · No subscription

Confirmatory Efficacy Clinical Trials of Non-Pharmacological and Pharmacological Interventions for Mental Disorders (R01 Clinical Trial Required)

National Institutes of Health

Confirmatory Efficacy Clinical Trials of Non-Pharmacological Interventions for Mental Disorders (R01 Clinical Trial Required). As part of NIMH's clinical trials pipeline NOFOs, this announcement supports confirmatory efficacy testing of non pharmacological therapeutic and preventive interventions for mental disorders in adults and children that address unmet therapeutic needs, and are consistent with the NIMH emphasis on the experimental therapeutics approach. In this approach, clinical trials should be designed to increase knowledge of the relationship between underlying disease processes and the mechanisms of action through which any intervention produces therapeutic change.

2027-10-15

Healthhealthcare

Free to search & build · $99 one-time to unlock the application pack · No subscription

Confirmatory Efficacy Clinical Trials of Non-Pharmacological and Pharmacological Interventions for Mental Disorders (R01 Clinical Trial Required)

National Institutes of Health

2027-10-15

Health

Free to search & build · $99 one-time to unlock the application pack · No subscription

Conflict Management and Mitigation

West Bank, Gaza USAID-West Bank

USAID intends to make several awards under this APS to include up to five Fixed Obligation Grants (FOGs).The objective of this APS is to make significant strides in the overall goal of conflict mitigation, peace and reconciliation in Israel, the West Bank and Gaza; and contribute to USAID s developmental objectives. USAID will manage this APS in accordance with a Congressional appropriation to provide a central source of funding for reconciliation activities (see Public Law 111-117, Division F, Section 7065). To meet Congressional intent, this APS will support people-to-people reconciliation programs and activities which bring together individuals of different ethnic, religious or political backgrounds from areas of civil conflict and war in Israel and Gaza-West Bank. Programs that provide adversarial individuals or groups opportunities to meet and work together to address issues around potential, ongoing, or recent conflict will receive consideration for funding under this APS. Successful applications under this solicitation will describe a people-to-people approach based on a context and conflict analysis that leads to a concrete program change hypothesis.

$50K – $1.2M

other

Free to search & build · $99 one-time to unlock the application pack · No subscription

Confocal Microscope - Leica Stellaris

OD - NIH Office of the Director

Summary: The Lundquist Institute (TLI) is requesting funds to purchase a Leica STELLARIS confocal microscope to be housed in its established, centrally managed core facility. This new system is intended to replace an aging 12- year-old Leica SP8 microscope that no longer meets the evolving needs of our research community. A broad user group of 12 investigators (10 of whom are NIH-funded), who are all making significant and pioneering contributions to cross- disciplinary research at the interface between developmental biology, cell biology, molecular biology, cancer, endocrinology, neurobiology, immunology, and host-pathogen interactions, will immediately benefit from the transformative imaging capabilities of the instrument. The STELLARIS system offers major advancements in confocal imaging technology, including a tunable white light pulsed laser for fluorescence lifetime imaging microscopy (FLIM), integrated with the high-speed FALCON FLIM platform and capable of multiplexing up to 11 spectral channels. These features provide users with quantitative imaging modalities to monitor complex dynamic processes in live and fixed samples. The instrument also includes LIGHTNING super-resolution capabilities based on adaptive deconvolution, expanded spatial coverage, and Leica's proprietary HyD detectors with tunable spectral sensitivity (1-nm precision, 400–850 nm), enabling high- resolution, low-phototoxicity imaging across a wide range of fluorophores. Acquisition of this system will ensure continued access to state-of-the-art imaging technology, enabling investigators to generate high-quality, multidimensional datasets and address increasingly complex biological questions. This instrument will directly enhance the rigor, reproducibility, and competitiveness of NIH-supported research at TLI by facilitating transformative insights into molecular and cellular mechanisms of health and disease.

Up to $750K

2027-04-30

Free to search & build · $99 one-time to unlock the application pack · No subscription

Conformable Cranial Ultrasound Patch for Monitoring Neonates with Germinal Matrix Hemorrhage

NINDS - National Institute of Neurological Disorders and Stroke

Project Summary/Abstract Germinal matrix-intraventricular hemorrhage (GM-IVH) is a significant neurological complication associated with high mortality rates and substantial neurodevelopmental disabilities. While the majority of GM-IVH cases are clinically asymptomatic, it is the most common cause of hydrocephalus in premature infants. Progressive cerebral ventricular dilation is an important diagnostic component of hydrocephalus and is typically identified through trans-fontanelle, cranial Ultrasound (CUS) in neonates. It is safe, cost-effective and can be conducted at the bedside with minimal disruption to the infant. However, current CUS clinical application is limited by numerous constraints, including: i) results are contingent upon the skills and experience of the ultrasonographer and radiologist Iii) limited access to the appropriate equipment and trained personnel in certain institutions due to prohibitive costs iii) due to the medical complexity of this vulnerable patient population, there is often a need to minimize stress, which can delay acquisition of important imaging when a patient is too unstable to undergo standard, often time consuming diagnostic US assessment. Within the last six years, conformable ultrasound electronics have been intensively investigated for imaging of many internal organs, however, to our knowledge, there are currently no studies on the feasibility of trans- fontanelle continuous ventricular ultrasound. Our goal is to investigate the monitoring of ventricular volume in neonates with GM-IVH using a wearable, adhesive ultrasound patch, and test the feasibility of simultaneous measurement of ventricular and sub-arachnoid size as well as cerebral blood flow. We hope this research will standardize interpretation, increase availability and reduce costs. Our work will introduce a novel patch design along with advanced piezoelectric transducers design, and a new image reconstruction method along with machine learning analysis of standard measurements such as ventricular index (VI), and anterior horn width (AHW), but also introduce AI based volumetric analysis. This work will be based on (1) novel patch design and advanced microfabrication of electronics (electronic science and engineering), (2) signal decoding for beamforming and image reconstruction (biomedical engineering and signal processing) and (3) clinical study on neonates and machine learning analysis (biomedical engineering and artificial intelligence). This study will provide the first in vivo validation of a conformable cranial ultrasound patch for neonatal brain monitoring with a significant advancement in neonatal monitoring, combining state-of-the-art piezoelectric sensor technology with advanced deep learning algorithms. We aim to demonstrate generalizability, robustness, and the potential to standardize CUS in this at-risk patient populations. This could ultimately reduce the incidence of severe neurodevelopmental impairment by providing uniform neurodiagnostic accuracy in a condition that is a major cause of mortality and neurodevelopmental impairment in this fragile population.

Up to $197K

2028-04-30

Free to search & build · $99 one-time to unlock the application pack · No subscription

Conformance with the Egg Regulatory Program Standards

upcoming

Food and Drug Administration

Conformance with the Egg Regulatory Program Standards

Free to search & build · $99 one-time to unlock the application pack · No subscription

Conformation and functional dynamics of Class B PBPs in enterococcal antimicrobial resistance

NIAID - National Institute of Allergy and Infectious Diseases

PROJECT SUMMARY The continued and inevitable emergence of antibiotic resistance demands a vigorous and sustained effort to identify fundamentally new targets and strategies for innovative antimicrobial therapeutics. Antibiotic-resistant enterococci are major causes of hospital-acquired infections. Enterococci are successful hospital-acquired pathogens in part because of their intrinsic resistance to commonly used antibiotics that target the bacterial cell envelope, such as cephalosporins. However, many questions remain regarding the genetic and biochemical basis for cephalosporin resistance in enterococci. Our published and preliminary data reveal that each of the three class B penicillin-binding proteins (bPBPs) encoded in the enterococcal genome are required for cephalosporin resistance, and moreover that they are each required for a different reason (i.e. they perform non-redundant functions). Many questions remain regarding the mechanisms by which the bPBPs are regulated, although recent structural studies suggest that dynamic conformational changes play a key role. A non-enzymatic domain found in bPBPs, commonly referred to as the pedestal domain, has emerged as a site of protein-protein interactions with regulatory factors. Crystallographic studies have revealed that two prominent lobes of the bPBP pedestal domain can adopt distinct “closed” and “open” conformations, and in at least one case interaction with a regulatory partner requires adopting the open conformation. However, studies assessing the conformational dynamics of the pedestal domain in a full-length bPBP in the context of a membrane have not been reported. The major knowledge gaps to be addressed in the proposed research are (i) to determine the conformational dynamics and in vivo function of the pedestal domains for each of the three enterococcal bPBPs; and (ii) to understand how the bPBP pedestal domains contribute to enterococcal cephalosporin resistance, thereby defining new mechanisms of resistance critical to all clinically relevant enterococci. By doing so, we will provide new insights into the fundamental biological processes that drive key antibiotic resistance in enterococci and define new strategies for innovative therapeutics designed to impair enterococcal cephalosporin resistance.

Up to $649K

2031-01-31

Free to search & build · $99 one-time to unlock the application pack · No subscription

Conformational Dynamics in HIV-1 Gag during Viral Maturation

NIAID - National Institute of Allergy and Infectious Diseases

Project Summary Human immunodeficiency virus type 1 (HIV-1) remains a major global health challenge. While viral maturation has long been a promising target for inhibitor development, the emergence of resistance to protease inhibitors continues to limit their effectiveness. As such, the Group-Specific Antigen (Gag) polyprotein presents an alternative avenue for therapeutic intervention, marked by the recent development of novel antiretrovirals such as bevirimat and lenacapavir, which target the immature Gag and mature capsid (CA). Gag encodes the core structural proteins that form the viral particle and undergoes cleavage by the viral protease during maturation. Among the domains in Gag, CA-SP1 cleavage is the key determinant for CA maturation, a process marked by CA undergoing drastic conformational changes. In Aim 1, I will elucidate how the stability of SP1 helices evolves during proteolysis. SP1 helices are arranged mostly in relatively stable six-helix bundles in the immature lattice but are bound to the protease extended and unfolded. It remains unclear how SP1 loses its secondary structure as it binds to the protease. I hypothesize that the initial cleavage of a single SP1 helix destabilizes the six-helix bundle, promoting the unfolding of neighboring helices and allowing for easier access to the protease. Using MD simulations, I will elucidate and compare the unfolding timescale and mechanisms of SP1 helices within fully intact and partially cleaved hexamers. I predict that SP1 helices in the cleaved hexamers will unfold more readily, whereas the intact hexamer will remain predominantly stable. These simulations will provide mechanistic insights into how SP1 proteolysis propagates structural changes through the hexamer and contributes to how the crucial last step of Gag proteolytic processing occurs. The expertise from the Schiffer lab provides me with the necessary training needed to perform robust structural modeling and molecular dynamics simulations. In Aim 2, I will investigate how SP1 cleavage mediates CA conformational changes that facilitate maturation. The destabilization of the six-helix bundle has been identified as the key structural switch for CA maturation. Using smFRET, I will visualize the conformational changes of single CA molecules within oligomeric assemblies. I predict that destabilization of the six-helix bundle following CA-SP1 cleavage induces conformational changes to the CA domain that are relevant for virion maturation. These findings will provide mechanistic insights into the allosteric communication between the CA-SP1 cleavage site and CA domains, revealing how initial cleavage events prime the hexamer for further structural transitions. The Munro lab has a proven track record and expertise in visualizing dynamic events in virions using single molecule fluorescence- based techniques. This study will significantly advance our understanding of the molecular mechanisms underlying HIV-1 maturation, potentially shedding light on the maturation processes of other retroviruses.

Up to $38K

2030-05-31

Free to search & build · $99 one-time to unlock the application pack · No subscription

Conformational mechanisms underlying allosteric regulation of the human serotonin transporter

NIMH - National Institute of Mental Health

PROJECT SUMMARY The human serotonin transporter (hSERT) plays a critical role in regulating serotonin (5-HT) signaling across nearly all major systems in the body. Dysregulation of hSERT is linked to numerous psychiatric and gastrointestinal disorders, making hSERT a primary target for clinical therapeutics including selective serotonin reuptake inhibitors (SSRIs). While the core ion-coupled transport cycle of hSERT is well characterized, the allosteric mechanisms that fine-tune its activity to meet diverse physiological demands remain poorly understood. This proposal aims to define the structural mechanisms by which 5-HT and the microbial metabolite butyrate allosterically shape hSERT’s conformational landscape to modulate its function. Aim 1 will leverage innovative cryo-EM approaches capable of resolving the full range of conformational states that define hSERT’s transport cycle, enabling the distinct structural effects of ligand binding at the central (S1) and allosteric (S2) substrate- binding sites to be isolated and characterized. These conformational changes will be directly linked to transport activity using complementary 5-HT uptake and electrophysiological assays. Aim 2 will expand our understanding of hSERT allosteric regulation by identifying the binding site of butyrate, characterizing its effects on hSERT’s conformational equilibrium, and determining its impact on transport activity. The training plan outlined in this fellowship is designed to strengthen technical and conceptual expertise in membrane protein biochemistry, single-particle cryo-EM, and electrophysiology. Mentorship and training from Dr. Eric Gouaux, an internationally recognized leader in membrane protein structural biology, and Dr. Michael Kavanaugh, an expert in transporter electrophysiology, will ensure the successful completion of the proposed aims. Together, these studies will advance the fundamental understanding of hSERT regulation and contribute to a broader framework for understanding allosteric modulation in neurotransmitter transporters, informing the development of innovative therapeutic strategies for disorders involving transporter dysfunction.

Up to $76K

2029-02-28

Free to search & build · $99 one-time to unlock the application pack · No subscription

Congaree National Park Historic Resource Study

National Park Service

The project objective is to conduct a study to enhance and broaden existing National Register documentation as well as provide historical context for any future National Register work. The Historic Resource Study will synthesize all readily available cultural resource information from all disciplines in a narrative designed to serve managers, planners, interpreters, cultural resource specialists and interested public as a reference for the history of the region and the historic resources within a park.

$1 – $77K

sciencetechnology

Free to search & build · $99 one-time to unlock the application pack · No subscription

CONGAS: "Caribbean Omics 'N' Genomics for Alzheimer Study"

NIA - National Institute on Aging

Genetic studies in the context of Alzheimer Disease (AD) are significantly biased by information coming from the same homogeneous population: Non-Hispanics Whites (NHW). The ADSP Follow-Up Study (FUS) long term goals include to fully reveal the genetic architecture of AD in multiple ethnic groups and examine the AD genome in the context of US-representative population. As of 2016, approximately 13 million people of the total U.S. population, have Caribbean ancestry. The Caribbean Omics & Genomics Alzheimer Study (CONGAS) will contribute to ADSP-FUS mission with 5,000 samples from elderly individuals (>65 yo) across the Caribbean countries and Spain. We will generate blood biomarkers, array data, whole genome sequence, and proteomics for the CONGAS dataset. Participants will be classified according to ATN criteria that will be used as endpoint phenotype in genome, and proteome association analyses, while taking into account admixture and ancestry components. Ultimately, we will identify causal genes and druggable targets and create better prediction models, by using genetics and multi-omic data as tools.

Up to $101K

2031-02-28

Free to search & build · $99 one-time to unlock the application pack · No subscription

Congenital cytomegalovirus as a trigger in the pathogenesis of necrotizing enterocolitis

NIAID - National Institute of Allergy and Infectious Diseases

The overall goal of this proposal is to investigate a potential role for congenital cytomegalovirus (CMV) infection in triggering the development and worsening the severity of necrotizing enterocolitis (NEC), the leading cause of death from gastrointestinal disease in premature infants. NEC occurs in up to 10% of premature infants, and is characterized by the acute development of intestinal necrosis leading to death in over 40% of patients. CMV is a herpesvirus with a seroprevalence of 40-80%, and carries a 40% risk of virus transmission to the fetus during pregnancy. We have previously shown that NEC development requires activation of the lipopolysaccharide (LPS) receptor Toll-like receptor 4 (TLR4) on the intestinal epithelium. However, factor(s) that trigger exaggerated TLR4 signaling leading to NEC remain unknown. We now show that congenital CMV infection plays a critical role in triggering NEC and worsening NEC severity by increasing TLR4 signaling and inducing mitochondrial injury in the intestinal epithelium. In human infants, the presence of CMV infection in intestinal tissue from NEC resection specimens was associated with significantly higher TLR4 expression and greater NEC severity compared with CMV-negative infants. Explants from CMV-infected human intestine treated with LPS showed significantly higher TLR4-induced inflammation than uninfected tissue, and CMV-positive patients showed increased mitochondrial injury in the intestinal epithelium as measured by detection of mitochondrial DNA nicks and ROS release. In mice, the induction of congenital murine CMV infection that was achieved by injection of mouse CMV (mCMV) into the amniotic fluid at G17.5 resulted in greater NEC frequency and severity, higher Tlr4 expression and greater mitochondrial injury in the gut than uninfected mice. Congenital mCMV did not worsen NEC in Tlr4IEC mice, proving that TLR4 mediates CMV effects. Mechanistically, congenital mCMV infection induced epigenetic changes in the Tlr4 promoter, leading to increased Tlr4 expression, resulting in TLR4-dependent mitochondrial injury, ATP depletion and epithelial damage in the gut. Importantly, the administration of novel TLR4 antagonists or the oral administration of the ATP precursor adenosine reversed the CMV effects on triggering NEC and increasing NEC severity. Hypothesis: We hypothesize that congenital CMV infection exerts a critical role in triggering NEC and increasing NEC severity through increased TLR4-induced mitochondrial dysfunction and intestinal epithelial injury. We further hypothesize that novel TLR4 antagonists and intestinal-specific adenosine analogues represent new strategies to attenuate NEC in the presence of congenital CMV infection. We will test these hypotheses in the following two aims: Aim 1: To evaluate the role of congenital CMV infection in triggering and worsening NEC via increased TLR4 signaling; Aim 2: To evaluate the role of congenital CMV infection in triggering and worsening NEC via TLR4-induced mitochondrial injury. When completed, these studies promise to uncover novel mechanisms and treatment strategies for this devastating disease.

Up to $2.2M

2030-05-31

Free to search & build · $99 one-time to unlock the application pack · No subscription

Congenital Syphilis Treatment Trial (CONSISTENT): Phase IV, Open-label, Randomized Controlled Trial of Amoxicillin vs Benzathine Penicillin in Neonates with Possible Congenital Syphilis

NIAID - National Institute of Allergy and Infectious Diseases

Project Summary/Abstract Syphilis is caused by Treponema pallidum (T. pallidum) that can efficiently cross the placenta during all stages of pregnancy and cause fetal infection. In the absence of timely diagnosis and treatment in pregnancy, congenital syphilis (CS) can occur. CS rates have risen sharply in every region of the US over the past decade. Possible congenital syphilis is defined by in-utero exposure to syphilis in an asymptomatic infant with a negative syphilis evaluation (exam, CSF, CBC, and RPR ≤ 4-fold maternal RPR). Recommended treatment for possible CS is single dose benzathine penicillin G (BPG), an effective therapy that has intermittent shortages. The Congenital Syphilis Treatment Trial (CONSISTENT) was designed to test the efficacy of oral amoxicillin therapy (50 mg/kg po BID) compared to standard single dose intramuscular BPG therapy (50,000 u/kg) measured by serologic response within 6 months of treatment. CONSISTENT is a phase IV, open-label, randomized study that will enroll 374 infants (≥35 weeks) at twelve US clinical sites over a two-year enrollment period. Participants will be invited to participate in an optional pharmacokinetic substudy (n=30), and will have pre- and post-treatment oral/nasal swabs collected for T. pallidum PCR testing to carry out the following aims: Aim 1: Compare the treatment efficacy of liquid oral amoxicillin administered BID x 10 days compared to single dose IM BPG (standard of care) among 374 neonates with possible congenital syphilis; Aim 2: Confirm the oral amoxicillin dose of 50 mg/kg/dose BID for the treatment of congenital syphilis using the target plasma drug concentration of 0.42 mg/L as the MIC for T. pallidum; Aim 3: Assess the performance of quantitative PCR testing for T. pallidum on oropharyngeal and nasal swabs in refining the diagnosis of possible congenital syphilis in exposed neonates. Aim 1 will test the hypothesis that amoxicillin efficacy will be non-inferior (within a 10% margin) compared with standard IM BPG for the treatment of possible CS assessed by serologic RPR response within six months. Aim 2 will test the hypothesis that oral amoxicillin 50 mg/kg/dosed BID will be sufficient to maintain drug levels above the MIC threshold required to treat possible congenital syphilis. Aim 3 will test our hypothesis that newly developed quantitative PCR testing of easily collected oropharyngeal and nasal swabs will help refine and improve the diagnosis of syphilis in infants. Our expected outcome is to identify an alternative oral treatment option for infants with possible congenital syphilis. Our long-term goals are to improve options for the treatment and diagnosis of syphilis in infants to reduce long term adverse outcomes.

Up to $2.3M

2031-04-30

Free to search & build · $99 one-time to unlock the application pack · No subscription

CONGESTION MITIGATION AIR QUALITY - FED

Chicago Department of Transportation

STATE/LAKE LOOP ELEVATED

Up to $65.4M

2031-03-31

Free to search & build · $99 one-time to unlock the application pack · No subscription

Connect 10,000 - Video Storytelling

Rainier Chamber of Commerce

Over the next twelve months the Connect 10,000 Video Storytelling project will facilitate the creation of 50 professional videos showcasing the vitality of Southeast Seattle. Storytellers will be recruited from diverse businesses and organizations with a focus on women of color and youth. Several public events are planned.

Up to $53K

Free to search & build · $99 one-time to unlock the application pack · No subscription

CONNECT AND PROTECT

Chicago Police Department

CONNECT AND PROTECT - FY21

Up to $543K

2026-09-30

Free to search & build · $99 one-time to unlock the application pack · No subscription

CONNECT: A Diagnostic Disclosure Communication Intervention in Dementia Care

NIA - National Institute on Aging

Project Summary Dementia is a life-changing diagnosis for patients and caregivers. Response to a diagnosis often includes grief, shock, and despair. Yet receiving a formal diagnosis has significant benefits, including access to effective medical management, specialized services, and opportunities to engage in care planning. Despite the benefits, evidence demonstrates inadequate clinician communication at the time of diagnosis (‘diagnostic disclosure’), which contributes to unmet needs for patients and caregivers. Integration of person-centered communication practices into diagnostic disclosure can be a powerful intervention to improve the quality of communication and care. This application proposes to develop and optimize a structured diagnostic disclosure communication intervention that integrates skills from palliative care (e.g. delivering difficult news, responding to emotions, tailoring to patient and caregiver needs, partnering in care planning) to improve clinician communication with patients and caregivers at the time of a dementia diagnosis. The K23 will provide Dr. Joanna Paladino (palliative care physician-scientist) with training in: (1) dementia clinical care and research; (2) theory-driven intervention development and social determinants of health; and (3) clinical trials in dementia care. The training plan will augment Dr. Paladino’s prior experience in clinical education and pragmatic research of a structured serious illness communication intervention (Serious Illness Care Program), which will be adapted to develop the diagnostic disclosure communication intervention (CONNECT, or Collaborative Navigation and Nurturing Empathy through Communication Techniques). Dr. Paladino has an expert mentorship team with a track record of federally funded clinical trials and expertise in dementia, geriatrics, intervention development, and palliative care. Massachusetts General Hospital has a strong record of successful completion of K awards and K-to-R transitions. Dr. Paladino will: (1) Adapt and refine CONNECT using qualitative research with patients with mild dementia (n=15), caregivers (n=15), and interprofessional clinicians (neurology, geriatrics, neuropsychology, geriatric psychiatry) (n=24); the intervention will target clinician communication practices and will include a Conversation Guide, skills training, and post-training support; (2) Examine preliminary feasibility and acceptability in an open pilot in memory clinics to refine the intervention (n= 2 neurology and geriatrics clinicians, 4 patient/caregiver dyads); (3) Conduct a pilot feasibility randomized controlled trial in neurology and geriatrics (n=12 clinicians, n=48 patients) comparing the intervention to usual care to examine feasibility of trial procedures and preliminary impact on mechanisms (e.g. clinician motivation, confidence, opportunity), communication quality, and patient and caregiver experience and outcomes. The K23 will lay the foundation for an NIA stage II efficacy trial and facilitate Dr. Paladino’s transition to an independent career in patient-oriented dementia research. Her long-term goal is to develop innovative, evidence-based interventions that transform communication, experience, and care at the time of a dementia diagnosis to improve person-centered outcomes for individuals affected by dementia.

Up to $198K

2031-06-30

Free to search & build · $99 one-time to unlock the application pack · No subscription

CONNECT: Cohort-Oriented Network kNowledgebase for Enhanced CollaboraTion

NIEHS - National Institute of Environmental Health Sciences

PROJECT SUMMARY/ABSTRACT Cohort studies play a fundamental role in contemporary environmental health sciences, advancing our understanding of how chemical exposures, lifestyle factors, and genetics contribute to human health. The National Institutes of Health (NIH) has always recognized the importance of cohort studies, especially in enhancing collaboration by pulling cohort resources to include participants from various populations and backgrounds. Summarizing and managing the findings and knowledge from cohort studies are indispensable components of cohort development, yet these tasks have often been overlooked. It will inevitably result in a significant loss if the knowledge and findings from cohort studies are not easily available or accessible to the entire environmental health community and public. Therefore, in this project, we propose Cohort-Oriented Network kNowledgebase for Enhanced CollaboraTion (CONNECT), a directed knowledge graph summarizing the knowledge for children’s environmental health, to meet the emerging needs of contemporary environmental health science community. The CONNECT knowledgebase will harmonize existing cohort study knowledge in children’s health and align with future environmental health development directions for managing multi-cohort findings. Indeed, the proposed CONNECT knowledgebase is a unique resource that is distinguished from other existing knowledgebases in the environmental health community. Our aims are: Aim1. Develop an AI-assisted knowledge extraction pipeline with prompt engineering for harmonizing environmental health knowledge from published cohort studies; Aim 2: Develop the CONNECT knowledgebase for children’s environmental health; Aim3: Develop CONNECT knowledgebase webtool and showcase the utility of CONNECT knowledgebase for users. Specifically, we will first develop an AI-assisted pipeline for knowledge extraction, validation, and harmonization from publications. We will leverage ChatGPT to assist in extracting findings/associations from 17 NIEHS funded children’s cohort publications. We will harmonize our environmental health language based on the existing HHEAR Ontology. Secondly, we will further construct the CONNECT knowledgebase based on the extracted knowledge using the proposed pipeline. The CONNECT knowledgebase will consist of knowledge from each cohort, resulting in an overall knowledge graph with harmonized environmental health language. Moreover, we will develop a webtool to facilitate knowledge dissemination to the environmental health community. We also demonstrate the various utilities of the CONNECT knowledgebase, including exposure-outcome evidence mapping, mechanistic insights and hypothesis generation, statistical querying for meta-analysis, among many other applications. Finally, our proposed CONNECT knowledgebase will provide a unique opportunity to train undergraduate students to become the next generation biomedical scientists in both data science and environmental health.

Up to $605K

2029-04-15

Free to search & build · $99 one-time to unlock the application pack · No subscription

Connecticut Humanities Council Grants

Connecticut Humanities Council

Grants for humanities programming including lectures, exhibitions, oral history, documentary, and public humanities projects in Connecticut. Funded by NEH.

$500 – $15K

EducationArts & CultureCommunity Development

Free to search & build · $99 one-time to unlock the application pack · No subscription

CONNECTICUT'S REVOLUTION EXHIBITION [THE MUSEUM OF CONNECTICUT HISTORY SEEKS FUNDING TO CREATE A COMPREHENSIVE EXHIBIT C...

National Endowment for the Humanities

CONNECTICUT'S REVOLUTION EXHIBITION [THE MUSEUM OF CONNECTICUT HISTORY SEEKS FUNDING TO CREATE A COMPREHENSIVE EXHIBIT COMMEMORATING CONNECTICUT'S ROLE IN THE AMERICAN REVOLUTION. THE EXHIBIT, CONNECTICUT'S REVOLUTION, WILL OPEN ON JULY 4, 2026 FOR APPROXIMATELY ONE YEAR. THE EXHIBIT WILL ILLUSTRATE, WITH OBJECTS, DOCUMENTS, AND INTERPRETIVE CONTENT, BOTH HOW RESIDENTS OF CONNECTICUT IMPACTED AND WERE IMPACTED BY THE REVOLUTIONARY FORCES THAT SHAPED THE CREATION OF OUR NATION.]

Up to $25K

2026-10-31

Free to search & build · $99 one-time to unlock the application pack · No subscription

Connecting Seattle

Digital Promise

Expand Connecting Seattle - connecting low income housing to new computers and internet access

Up to $19K

EducationHousingtechnology

Free to search & build · $99 one-time to unlock the application pack · No subscription

Connecting Southern Paiute Indian Youth and Elders to Traditional Homelands Project

National Park Service

Personnel from KBPI and NPS will collaborate on this project and is intended to stimulate youth education and elder involvement in cultural and natural resources, and motivate traditional practices among Southern Paiute tribal youth and elders, an identified underserved population. The project develops Paiute Tribe capability in providing these educational experiences in a remote or educational environment and integrates federal employees into the program to expose youth to potential career opportunities. Additionally, this agreement will enable tribal elders to educate the public in an unofficial capacity, to develop a cultural respect for traditional Southern Paiute lands.

$1 – $33K

natural resources

Free to search & build · $99 one-time to unlock the application pack · No subscription

Connecting Students from Oxnard Union High School District to the National Park Service for Educational and Service Learning Opportunities

National Park Service

United States Department of the Interior, National Park Service (NPS) Notice of Intent to Award. This is not a request for applications. This posting is to provide public notice of NPS' intention to fund the following project activities without full and open competition: Cooperative Agreement P15AC01004 with the Oxnard Union High School District, for the project titled, "Connecting Students from Oxnard Union High School District to the National Park Service for Educational and Service Learning Opportunities".