Grants

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NIAID Clinical Trial Implementation Cooperative Agreement (U01 Clinical Trial Required)

National Institutes of Health

This notice of funding opportunity (NOFO) encourages applications for implementation of investigator-initiated, milestone driven clinical trials that need enhanced oversight, and as applicable, include mechanistic studies. Mechanistic work in clinical trials may be of great value because it promotes the understanding of human diseases and the development of future therapeutic modalities. Support is available for clinical trials up to 5 years, as well as for extended clinical trials of 6- or 7-years.Investigators are encouraged to visit this NIH website for additional information about the overall mission and research areas of NIAID.Only one clinical trial may be proposed in each NIAID Clinical Trial Implementation Cooperative Agreement (U01) application. In accordance with NIH standard peer-review processes, the applications will be peer-reviewed, and only meritorious applications will be considered.

2029-07-05

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NIAID Clinical Trial Implementation Cooperative Agreement (U01 Clinical Trial Required)

National Institutes of Health

2029-07-05

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NIAID Investigator Initiated Program Project Applications (P01 Clinical Trial Not Allowed)

National Institutes of Health

This notice of funding opportunity (NOFO) invites submission of investigator-initiated Program Project (P01) applications. The proposed Programs should address scientific areas relevant to the NIAID mission including: biology and pathogenesis of infectious microbes, including HIV; host-microbe interactions; mechanisms regulating immune system development and function across the lifespan, and in response to infectious pathogens; immune dysfunction resulting in allergy, asthma, autoimmunity, immunodeficiency, or transplant rejection; and translational research to develop vaccines, therapeutics, and diagnostics to prevent and treat infectious and immune-mediated diseases. Each application submitted to this NOFO must include at least two related, synergistic Research Projects that share a common central theme, focus, and/or overall objective; and an Administrative Core. An application may include Scientific Core(s), if needed for the proposed research.

2029-05-25

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NIAID Investigator Initiated Program Project Applications (P01 Clinical Trial Not Allowed)

National Institutes of Health

2029-05-25

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NIAID Resource-Related Research Projects (R24 Clinical Trial Not Allowed)

National Institutes of Health

This notice of funding opportunity (NOFO) invites applications for investigator-initiated Resource-Related Research Projects (R24). The proposed resource must provide a significant benefit to currently funded high priority projects in need of further coordination and support in the areas specified. This mechanism may also be used to support development of a new resource to the broader scientific community of the National Institute of Allergy and Infectious Diseases (NIAID). It is anticipated that the request for resource support through the R24 activity code will occur on an infrequent basis and only in circumstances where other mechanisms of support from the NIAID are not appropriate.The proposed resources should be relevant to the scientific areas of the NIAID mission including the biology, pathogenesis, and host response to microbes, including HIV; the mechanisms of normal immune function and immune dysfunction resulting in autoimmunity, immunodeficiency, allergy, asthma, and transplant rejection; and translational research to develop vaccines, therapeutics, and diagnostics to prevent and treat infectious, immune-mediated, and allergic diseases.

2029-05-25

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NIAID Science Education Awards (R25)

National Institutes of Health

Purpose. This funding opportunity announcement (FOA) solicits grant applications from applicant organizations that focus on the development of science education for K-12 students. It is expected that these education programs will provide outreach to a large audience of students, directly or through their teachers, using approaches whose success can be measured.

rolling

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NIAMS Clinical Trial Implementation Cooperative Agreement

upcoming

National Institutes of Health

The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications for the Clinical Trial Cooperative Agreement Program within the mission areas of the institute. This Notice of Funding Opportunity (NOFO) solicits cooperative agreement applications for implementation of investigator-initiated, single or multi-site, interventional clinical trials (all trial phases). Investigators who have completed all necessary preparation (e.g., the trial design, protocol synopsis, data analysis plan, etc.) through other means may apply for a NIAMS Cooperative Agreement Clinical Trial. The first phase is designed to allow the investigators to prepare the final aspects needed to start the trial, (e.g., establishing the single IRB (sIRB), contracts and reliance agreements with sites, hiring of staff, etc.). Transition to the second phase to begin the trial is dependent upon completion of the phase 1 milestones proposed by the investigator and approved by NIAMS. Phase 1 projects that meet their milestones will be administratively considered by NIAMS and prioritized for transition to the second phase. NIAMS expects trials to be hypothesis-driven and have the potential for high clinical impact within the research mission of NIAMS.

$250K

2027-07-02

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NIAMS Clinical Trial Implementation Cooperative Agreement

upcoming

National Institutes of Health

<p style="margin-left:0in;">The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications for the Clinical Trial Cooperative Agreement Program within the mission areas of the institute.  This Notice of Funding Opportunity (NOFO) solicits cooperative agreement applications for implementation of investigator-initiated, single or multi-site, interventional clinical trials (all trial phases). Investigators who have completed all necessary preparation (e.g., the trial design, protocol synopsis, data analysis plan, etc.) through other means may apply for a NIAMS Cooperative Agreement Clinical Trial. The first phase is designed to allow the investigators to prepare the final aspects needed to start the trial, (e.g., establishing the single IRB (sIRB), contracts and reliance agreements with sites, hiring of staff, etc.). Transition to the second phase to begin the trial is dependent upon completion of the phase 1 milestones proposed by the investigator and approved by NIAMS. Phase 1 projects that meet their milestones will be administratively considered by NIAMS and prioritized for transition to the second phase. NIAMS expects trials to be hypothesis-driven and have the potential for high clinical impact within the research mission of NIAMS.</p>

$250K

2027-07-02

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NIAMS Clinical Trial Implementation Cooperative Agreement (UG3/UH3 Clinical Trial Required)

National Institutes of Health

This NIAMS Clinical Trial Implementation Cooperative Agreement (UG3/UH3 Clinical Trial Required) PAR, a re-issue of PAR-24-208, was re-issued as a result of the Simplifying Review of Research Project Grant Applications [link: https://grants.nih.gov/policy-and-compliance/policy-topics/peer-review/simplifying-review]. The Simplified Review changes in Section V. Application Review Information of the funding opportunity are the only changes that have been made. All other aspects of this funding opportunity remain the same.

2027-03-04

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NIAMS Clinical Trial Implementation Cooperative Agreement (UG3/UH3 Clinical Trial Required)

National Institutes of Health

2027-03-04

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NIAMS P30 Centers Program (P30 - Clinical Trial Not Allowed)

upcoming

National Institutes of Health

The overall goal of this program is to accelerate scientific discovery, improve research efficiency, and enhance the translation of research findings into improved health outcomes. Centers funded under this program will also foster multidisciplinary collaboration, support workforce development across career stages, and promote training in emerging areas such as data science, artificial intelligence, and implementation research. The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) requests applications for the NIAMS P30 Centers Program to support integrated research Centers within its mission areas of skin biology and diseases; bone, muscle, and orthopaedic research; and rheumatic diseases. The NIAMS P30 Centers Program supports Centers that provide coordinated research infrastructure, shared resources, and methodological expertise to advance basic, translational, and clinical research. These Centers are expected to integrate state-of-the-art research resources with capabilities that support clinical and translational research, including the development, testing, and dissemination of novel analytical methods, study designs, outcome measures, and data-driven approaches. The overall goal of this program is to accelerate scientific discovery, improve research efficiency, and enhance the translation of research findings into improved health outcomes. Centers funded under this program will also foster multidisciplinary collaboration, support workforce development across career stages, and promote training in emerging areas such as data science, artificial intelligence, and implementation research.

2026-10-01

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NIB Environmental Bond Programme

renewable energyenergy efficiencyclean transport+1

Nordic Investment Bank

Finances projects that meet strict environmental criteria in renewable energy, energy efficiency, clean transport, water management, and waste treatment.

$1M – $10M

Rolling

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NIB Environmental Mandate Grants

environmentclean energypollution reduction+1

Nordic Investment Bank

Supports projects that improve the environment in the Nordic and Baltic region, including clean energy, pollution reduction, sustainable transport, and circular economy.

$500K – $5M

Rolling

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NIBCO BRONZE COPPER CAST FITTINGS AND ACCESSORIES

COLUMBIA PIPE & SUPPLY LLC

Distribution and Conditioning Systems and Equipment and Components

2026-07-14

Education

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NIBIB Research Revisions to Promote Clinical Resident Research Experiences (Revisions to Currently Active NIBIB R01 and R37 Grants)

National Institutes of Health

-Purpose. The intent of this Funding Opportunity Announcement (FOA) is to provide a 1-2 year period of research experience for physicians in a residency program through revisions to existing NIBIB grant awards. The program targets applicants who have demonstrated the potential for productive research in an area of interest to the candidate and of relevance to the mission of the NIBIB. -Mechanism of Support. This FOA will utilize the NIH revision award mechanism. -Funds Available and Anticipated Number of Awards. Because the nature and scope of the proposed research will vary from application to application, it is anticipated that the size and duration of each award will also vary. The total amount awarded and the number of awards will depend upon the mechanism numbers, quality, duration, and costs of the applications received.

Up to $100K

rolling

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NIBIB Research Supplements to Promote Clinical Resident Research Experiences (Supplements to Currently Active NIBIB P01, P41, P50, U01, U54 Grants)

National Institutes of Health

-The intent of this Program Announcement is to provide a 1-2 year period of research experience for physicians in a residency program through supplements (revisions) to existing NIBIB grant awards. -The program targets applicants who have demonstrated the potential for productive research in an area of interest to the candidate and of relevance to the mission of the NIBIB. -Because the nature and scope of the proposed research will vary from application to application, it is anticipated that the size and duration of each award will also vary. The total amount awarded and the number of awards will depend upon the mechanism numbers, quality, duration, and costs of the applications received.

Up to $100K

rolling

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NICHD Resource Program Grants in Bioinformatics (P41 Clinical Trial Not Allowed)

income_security_and_social_servicesHealth

National Institutes of Health

The purpose of this Notice of Funding Opportunity (NOFO) is to support the continued operation, maintenance, and dissemination of unique database bioinformatics resources that are of major importance to the research community using animal models of embryonic developmental processes. These grants will support ongoing development and enhancement of the resources, user training and services, provision of community generated data storage and curation, wide dissemination of the tools and/or resources, and expansion of interoperability with other NIH bioinformatics resources.

2027-09-25

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NICHD Resource Program Grants in Bioinformatics (P41 Clinical Trial Not Allowed)

National Institutes of Health

2027-09-25

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NICHD Small Research Grant Program (R03 Clinical Trial Required)

National Institutes of Health

The NICHD Small Research Grant Program (Clinical Trial Required) supports clinical trials that fall within the NICHD mission.

Up to $50K

2028-01-07

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NICHD Small Research Grant Program (R03 Clinical Trial Required)

income_security_and_social_servicesHealth

National Institutes of Health

The NICHD Small Research Grant Program (Clinical Trial Required) supports clinical trials that fall within the NICHD mission.

Up to $50K

2028-01-07

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Niche regulation of gastric epithelial cell differentiation

NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases

Project Summary Distinct stomach epithelial cell types, all arising from a common multipotential progenitor (stem cell), serve essential digestive or barrier functions. Defects in the fractions or properties of these cells are associated with various prevalent human disorders, including pre-neoplastic conditions. Pit (surface mucous), isthmus (epithelial self-renewal), neck (deep mucous), and chief (zymogenic) cells –each with distinctive morphology, functions and gene products– are precisely zonated along the long axis of gastric corpus glands. Informed by other self-renewing tissues –such as blood and intestine– and by growing appreciation of epithelial plasticity, each zonated cell type is regarded as a “committed” terminal product of a unidirectional cellular hierarchy that originates in proliferative isthmus cells and retains some capacity to “dedifferentiate”. However, we detect modest transcriptional or epigenetic distinction among the zonated cells and their phenotypes inter-convert readily in vitro and in vivo in response to specific cues: BMP signaling for pit cells and canonical Wnt signaling for neck/chief cells. Our preliminary data therefore suggest the radically different view that pit, neck, and chief cell properties are not hard-wired in the conventional sense of cell “determination”, but represent reversible, signal-responsive phenotypes within a continuum of native cell states directed by finely graded signals from specific sub-epithelial cells. Of mechanistic note, PDGFRA+ sub-epithelial mesenchymal cells positioned near pits are enriched for BMP expression, while Wnt/Rspo mRNAs localize in similar cells positioned near chief cells at the gland base; niche-derived NRG1 concentrates near the isthmus zone. We propose that isthmus cell replication and overt phenotypes of surface and deep corpus gland cells reflect the summation of these sub-epithelial signals. Challenging classical views of a gastric cell hierarchy, this project examines epithelial cell properties with respect to specific niche signals. Mechanistically, two Specific Aims address each side of this paracrine dialogue to decipher the epigenetic basis (Aim 1) and regulatory logic (Aim 2) of the mouse gastric corpus. In Aim 1, five discrete sub-Aims will collectively delineate determinants of zonated corpus epithelial cell properties. We will define how extracellular signals modulate groups of phenotype-restricted cis- regulatory enhancers to generate distinct phenotypes and test whether pit-biased (KLF4) and neck-biased (CREB3L4) transcription factors are required for these effects. Three sub-Aims in Aim 2 will define how key signaling components in the mesenchymal niche act individually and in combination to effect precise zonation. We will determine how individual BMPs, Wnt/Rspo signaling, and NRG1 together influence epithelial zonation and restrict cell replication to the isthmus. Significant gaps in knowledge currently limit actionable insights into gastric mucosal homeostasis, metaplasias, cancer, and other disorders. This project aims to narrow that gap via mechanistic investigation of a dynamic epithelium that continuously renews itself while generating specialized cellular phenotypes in response to an exquisitely graded mesenchymal niche.

Up to $741K

2031-01-31

health research

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Niche Trajectory Analysis of Spatial Omics Data

NHGRI - National Human Genome Research Institute

PROJECT SUMMARY The maintenance and function of a tissue/organ depends on cell-cell interactions among different cell types. The cell-cell interactome responds and regulates the tissue microenvironment (ME) which is altered in physiological processes such as development and aging, or during the onset and progression of various human diseases. Spatial transcriptomics offers an opportunity to systematically characterize the structural organization of the ME and its changes in various diseases. On the other hand, it requires the development of sophisticated computational methods to achieve these goals. In this project, we will develop a unifying modeling framework, called, ONTraC, and apply it to systematically characterize ME organization in multiple mammalian tissues. A unique feature of the ONTraC framework is that it uses the niche as the basic structural component instead of a cell, as commonly done. The specific aims are: 1. To develop a new framework for constructing niche trajectories from spatial transcriptomic and epigenomic data; 2. To extend the ONTraC framework for analyzing subcellular RNA localization patterns; and 3. To comprehensively characterize the ME organization in acute kidney injury mice through a systems biology approach. Taken together, our proposed research will generate powerful computational tools that will enable biologists and clinicians to investigate the structure and function of ME organization in health and diseases.

Up to $2.6M

2030-03-31

health research

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NICotinamidE riboside to improve functioning in PAD: The NICE Trial