Grants

KIP AMERICA INC

Information Technology Broadcasting and Telecommunications

2026-09-14

infrastructuretechnology

Free to search & build · $99 one-time to unlock the application pack · No subscription

Least Chub Habitat Sensitivity Study

Environmentalsustainability

Fish and Wildlife Service

This is a Notice of Intent to award a Grant to State of Utah, Department of Natural Resources, for the purpose of conducting a habitat sensitivity study for the Least Chub. Analyze relationships of groundwater levels, precipitation, and evapotranspiration to the volume and surface area of aquatic habitat. Assess how spring discharge rates are related to variation in the volume of water and the depth of sediments in sampling units. Analyze relationships of solute concentrations in the sampling units to groundwater levels, spring discharge rates, precipitation, and evapotranspiration. Provide a statistical model for predicting variation in the surface area of aquatic habitat in the Leland Harris Spring Complex based on variation of groundwater levels, precipitation, and estimated rates of evapotranspiration. Provide a statistical model for predicting variation in the volume of aquatic habitat in the Leland Harris Spring Complex based on variation of groundwater levels, precipitation, and estimated rates of evapotranspiration. Provide Color-coded maps showing predicting amounts of surface water (extent and depths) under multiple scenarios for reductions in groundwater levels. Evaluate Least Chub habitat requirements on a seasonal basis (considering both breeding habitat and core habitat), and assessment of how amounts of suitable habitat are likely to change with changes in spring discharge rates (which influence solute concentrations, the amount of ice-free habitat in the winter, sediment transport, and is hypothesized to influence surface water levels) and precipitation (which influences amounts of surface water in pools). Provide a summary assessment of relationships between groundwater levels and the amount of suitable habitat for Least Chub at the Leland Harris Spring Complex. Past habitat data indicate that water depth is positively related to the presence and abundance of Least Chub during relatively dry times of the year (e.g., late summer), so the amount of water of adequate depth will be one of the dependent variables considered in this assessment. Other variables that will be considered include solute concentrations and interconnectivity of bodies of water.

$40K

rolling

Free to search & build · $99 one-time to unlock the application pack · No subscription

Lee Foundation Grants

Lee Foundation

One of Singapore's largest philanthropic foundations supporting education, welfare, arts, and healthcare.

$10K – $500K

Educationwelfarearts+1

Free to search & build · $99 one-time to unlock the application pack · No subscription

Lees Ferry and Lonely Dell Adaptive Reuse Planning

National Park Service

Lees Ferry and Lonely Dell Adaptive Reuse Planning

$55K

rolling

Education

Free to search & build · $99 one-time to unlock the application pack · No subscription

Legacy effects of randomization to caloric restriction and exercise on bone strength in older adults: a pooled analysis

NIA - National Institute on Aging

PROJECT SUMMARY Over 19 million older Americans have obesity, which is associated with disability and poor clinical outcomes. Clinical trials by our group and others show that diet-induced weight loss interventions, particularly when combined with exercise, improve body composition and physical and metabolic function over the short-term in older adults with obesity. However, clinical recommendations for obesity treatment in older age are controversial, as weight loss can exacerbate bone and muscle loss and the long-term risks have not been extensively studied. Musculoskeletal losses could increase the risk of osteoporotic fractures, which confer significant morbidity and mortality. Osteoporosis is assessed clinically using dual energy X-ray absorptiometry, but bone mineral density (BMD) measured by this method is often inaccurate in those with obesity and weight loss. Quantitative computed tomography (QCT) offers a more robust method that reduces measurement errors. Further, bone strength – a QCT and finite element modeling assessment of 3D bone morphology, volumetric BMD, and cortical thickness – is a stronger predictor of fracture risk than BMD alone. Nonetheless, the legacy effects of caloric restriction (CR) and exercise (EX) on biomechanical bone strength in older adults remain largely unquantified. Our proposed project leverages our unique access to five NIH-supported trials that randomized older adults (baseline age ≥60; BMI≥27 kg/m2) to CR+EX vs. EX alone at Wake Forest from 2005 to 2014, and the Health Outcomes after Participating in Exercise (HOPE) study (R01 AG056418; PI: Houston), which recently completed a follow- up of these participants ~10 years after they completed the intervention. Long-term follow-up QCT scans acquired for 272 HOPE participants will be analyzed to determine the long-term effects of prior randomization to CR+EX vs. EX alone on hip and lumbar spine bone strength [Aim 1]. We hypothesize that randomization to CR+EX will result in lower bone strength at long-term follow-up versus EX alone (controls). Aim 1 will also examine the effect of exercise modality on bone strength following CR, and we hypothesize that participants randomized to CR with aerobic training will have lower bone strength at long-term follow-up compared to participants randomized to CR with resistance training. Leveraging measures acquired at baseline, end of the intervention, and long-term follow-up, we will determine associations between change in lean mass and physical performance with long-term bone strength [Aim 2]. We will also assay stored blood specimens from three time points to explore associations between changes in biomarkers of bone formation (P1NP) and bone resorption (CTX-1) with long-term bone strength [Aim 3]. This work will be the first randomized, controlled design to test the legacy effects of caloric restriction and exercise interventions on bone strength in older adults. Results will inform obesity treatment guidelines for older adults and may identify new early musculoskeletal screening biomarkers and intervention targets to shift clinical paradigms for fracture prevention.

Up to $418K

2028-05-31

Free to search & build · $99 one-time to unlock the application pack · No subscription

Legal Assistance Enhancement Program Grants

upcoming

Administration for Community Living

Legal Assistance Enhancement Program Grants

general

Free to search & build · $99 one-time to unlock the application pack · No subscription

LEGAL SERVICES FOR THE OFFICE OF THE COOK COUNTY CLERK, ELECTION DIVISION

MICHAEL J KASPER

Management and Business Professionals and Administrative Services

2027-11-30

general

Free to search & build · $99 one-time to unlock the application pack · No subscription

LEGISLATIVE LIAISON CONSULTING RFP

Community DevelopmentHealth

Blaida and Associates LLC

Management and Business Professionals and Administrative Services

2027-02-27

Free to search & build · $99 one-time to unlock the application pack · No subscription

LEGO Foundation Learning Through Play Grants

LEGO Foundation

Funds organizations championing learning through play for children globally.

$100K – $5M

Educationchildrenplay+1

Free to search & build · $99 one-time to unlock the application pack · No subscription

Leichtag Foundation Jewish Innovation Grants

Leichtag Foundation

San Diego-based foundation supporting Jewish life, Israel education, and regional community development in North San Diego County.

$10K – $200K

Jewish lifeIsrael educationcommunity development+1

Free to search & build · $99 one-time to unlock the application pack · No subscription

Lemann Foundation Education Grants

Lemann Foundation

Major Brazilian foundation focused on improving public education quality and developing leaders.

$50K – $1M

Educationleadershippublic education reform

Free to search & build · $99 one-time to unlock the application pack · No subscription

Lemelson Foundation Invention & STEM Grants

Lemelson Foundation

Supports invention-based education, STEM learning, and inventor support programs. Focus on inspiring young inventors and commercializing socially beneficial inventions.

$50K – $500K

inventionSTEMEducation+1

Free to search & build · $99 one-time to unlock the application pack · No subscription

Length, methylation, and purity of expanded C9orf72 repeat across diseases, tissues, and cell populations

NINDS - National Institute of Neurological Disorders and Stroke

PROJECT SUMMARY/ABSTRACT We seek to elucidate the phenotypic heterogeneity seen in people with an expanded repeat in C9orf72, the most frequent genetic cause of two devastating neurodegenerative diseases: amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Remarkably, even within families, individuals can develop ALS, FTD, or both diseases. Although symptoms may appear when someone is about 20 years of age, others are 90 years of age. Similarly, survival after symptom onset ranges from several months to over 30 years. Presently, this substantial phenotypic heterogeneity remains largely unexplained. The need for a deeper understanding of this intriguing expansion is further substantiated by the recent failure of antisense oligonucleotide trials targeting C9orf72 transcripts. The C9orf72 repeat expansion is basically ill defined, even though it was discovered over a decade ago. In fact, a well-established pathogenic threshold is still lacking, resulting in uninterpretable size estimates of up to about one hundred repeats. This knowledge gap can probably be attributed to technical limitations of methods commonly used to characterize this expansion. Importantly, sequencing advances now enable an in- depth assessment of expanded repeats. As such, in our present application, we propose to employ a cutting- edge targeted long-read DNA sequencing technology to accurately obtain the repeat length, methylation profile, and sequence content of the C9orf72 expansion. We postulate that variability in these characteristics of the expansion might serve as disease modifiers, contributing to the reported phenotypic heterogeneity. To this end, we will include longitudinally collected ante-mortem blood specimens from C9orf72 expansion carriers who are symptomatic and belong to the ALS/FTD spectrum, pre-symptomatic, or phenoconverters (Aim 1). By capturing the length, methylation, and purity of their expansion at a single-molecule level, we can uncover vital differences between groups and changes over time, which might precede the occurrence of symptoms. Additionally, we will assess post-mortem brain specimens from C9orf72 expansion carriers who received a neuropathological diagnosis of ALS or frontotemporal lobar degeneration (FTLD; Aim 2). Because we will use cell sorting to specifically investigate major cell populations in multiple brain regions, we are equipped to find differences between diseases, regions, and cell types. Thus, our thorough assessment of the C9orf72 repeat expansion in a precious collection of ante-mortem and post-mortem specimens using a pioneering sequencing technology may aid in resolving this unusual expansion, paving the way for tailored treatment strategies.

Up to $627K

2031-04-30

Free to search & build · $99 one-time to unlock the application pack · No subscription

Leonard Cheshire — Disability & Development

disability inclusionEducationlivelihoods+1

Leonard Cheshire

Grants for programs promoting inclusion, education, and livelihoods for people with disabilities globally.

$20K – $150K

2026-09-30

Free to search & build · $99 one-time to unlock the application pack · No subscription

LERCH BATES (RENEWAL)

Community DevelopmentHealth

Lerch Bates Inc

Management and Business Professionals and Administrative Services

2026-09-30

Free to search & build · $99 one-time to unlock the application pack · No subscription

Let There Be Light: Projected Art on Pier 86

Friends of Art on Pier 86

Friends of Art on Pier 86 (FAP86) will project illuminated art onto the side of a building at Pier 86 in cooperation with the Port of Seattle. A pilot image or series of images will be projected for three months during the first half of 2018, and different art will be projected for a similar period at the end of 2018. They will do a call for artists, lead community workshops for input into art design, host opening events, and conduct community feedback surveys.

Up to $78K

infrastructure

Free to search & build · $99 one-time to unlock the application pack · No subscription

Let's Get Back To School!

Sisters of South Seattle

`Let?s Get Back to School` is an event to get K-12 students in the area excited about going back to school! The event will have food, games, school supply giveaways, as well as information on how to study, time management, and after school activities.

Up to $5K

EducationAgriculture

Free to search & build · $99 one-time to unlock the application pack · No subscription

Leukemia & Lymphoma Society — Research Grants

leukemia researchlymphomablood cancer

Leukemia & Lymphoma Society

Funds blood cancer research and treatment development.

$100K – $600K

Annual

Free to search & build · $99 one-time to unlock the application pack · No subscription

Levee Repairs at Saline County Levee District #2, Ray-Carroll Bottoms Consolidated Levee District of Carroll County, and Howard County Levee District #4

DEPT OF DEFENSE.DEPT OF THE ARMY.US ARMY CORPS OF ENGINEERS.ENGINEER DIVISION NORTHWESTERN.ENDIST KANSAS CITY.W071 ENDIST KANSAS CITY

Levee Repairs at Saline County Levee District #2, Ray-Carroll Bottoms Consolidated Levee District of Carroll County, and Howard County Levee District #4

general

Free to search & build · $99 one-time to unlock the application pack · No subscription

Leveraging a lung organoid model to study early cystic fibrosis lung disease

NCATS - National Center for Advancing Translational Sciences

PROJECT SUMMARY/ABSTRACT Cystic fibrosis (CF) is a multisystemic, autosomal recessive disorder with the majority of morbidity and mortality extending from lung disease. Given the benefits that older children and adults with CF have derived from cystic fibrosis transmembrane conductance regulator (CFTR) modulator therapies, it is anticipated that early childhood – or even in utero – treatment with CFTR modulator therapies may significantly delay or even prevent the development of CF lung disease. The role of CFTR protein in fetal lung development, and thus the potential impact of early CFTR modulator therapies, has yet to be fully elucidated. The proposed research project aims to better understand the pathogenesis of CF lung disease and the impacts of deficient CFTR protein on fetal lung development while overcoming a general roadblock in the study of many pediatric lung diseases, the scarcity of available human material. Previous immunohistochemistry studies in the fetal CF lung described a three-week delay in the developmentally regulated pattern of CFTR protein expression as well as an early, intrinsic, pro- inflammatory state. Leveraging a three-dimensional, in vitro and in vivo, lung organoid model that undergoes branching morphogenesis and alveologenesis – thus recapitulating early fetal lung development – we will characterize CFTR gene transcript expression and CFTR protein expression and function and articulate the transcriptome and proteome of normal and CF lung organoids. We hypothesize that CFTR protein deficiency in the fetal CF lung results in pro-inflammatory transcriptomic and proteomic profiles in respiratory epithelial cell populations and that this can be reasonably demonstrated using a lung organoid model. To test our hypotheses and validate the findings in the lung organoids, we will also articulate the cellular multi-omes in fetal normal and CF lungs, characterizing any disease-related cellular, transcriptomic, epigenomic, and proteomic changes. The proposed research project will provide critical insights into the pathogenesis of CF lung disease and establish a new, well characterized, in vitro and in vivo, model system of the CF lung that can be leveraged in future research endeavors (e.g. viral disease modeling, therapeutic testing). The proposed research project has the potential to identify the earliest pathogenic changes in the CF lung, determine the pulmonary impact of the application of in utero CFTR modulator therapies, and determine the need for alternative, novel treatment modalities to more readily change the early trajectory of CF lung disease.

Up to $168K

2028-04-30

Free to search & build · $99 one-time to unlock the application pack · No subscription

Leveraging a Novel Neural Circuit for Urinary and Fecal Incontinence

NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases

Project Summary/Abstract Interorgan communication between the brain and peripheral tissues maintains a range of adaptive responses that can degrade with aging. Using mouse models, we found a powerful neural circuit that simultaneously motivates spontaneous activity and overrides spinal reflexes that control bladder and colonic function. Our preliminary findings show a strong direct neural circuit between estrogen-responsive neurons in the hypothalamus and the major micturition center in the hindbrain that controls urination, the Pontine Micturition Center (PMC) or Barrington’s nucleus (BAR). When activated, this VMHvl-BAR monosynaptic circuit blocks all voiding, even when animals have been pre-loaded with saline; when inhibited, urine release increases. Similarly, when a glass bead is inserted into the colon, excretion of this pellet takes up to fifteen times longer (20 minutes versus 5 hours) if chemogenetics is used to activate this neurocircuit. In vivo cystometry results confirm the potency of this hypothalamic-hindbrain circuit in modulating urine and fecal release. Here, we will define how neurons in BAR override normal spinal reflexes in the pelvic region. We outline three independent aims to: 1) identify the molecular nature of the inhibitory neurons in BAR responsible for this change in urinary and colon function and map projections from BAR to the spinal cord controlling the bladder or colon, 2) determine the sufficiency of VMHvl-BAR circuity components in urine release, and finally, 3) determine the initiating signals in the hypothalamus that control this voiding and defecation neurocircuit. This last aim will bring us closer to translating our preclinical research to human health. Our research program adds to emerging work on brain-body physiology to advance strategies for improving health and blends the team’s expertise in neuroendocrinology and neurocircuits. We are using state-of-the-art methods to pursue hypothesis-driven questions to decode a robust neuroendocrine circuit that controls two essential processes—urination and defecation. Both functions degrade with aging, especially in older women. Eventually, we wish to translate these preclinical studies to mitigate the loss of pelvic control in the older adult US population.

Up to $513K

2030-02-28

Free to search & build · $99 one-time to unlock the application pack · No subscription

Leveraging Adaptive Evolution and High-Throughput Techniques to Dissect the Link Between Biochemical Function and Fitness

NIDCR - National Institute of Dental and Craniofacial Research

PROJECT SUMMARY/ABSTRACT Enzymes are the primary functional molecules in cells, providing enormous rate enhancements, specificity and regulation to the diverse chemical reactions that are necessary for life. Enzymes, like all biological macromolecules, are the products of evolution: all enzymes have evolved to operate within the complex environment of the organism/cell in specific environmental niches(s). Thus, an understanding of enzyme function and evolution is fundamental to biology. Enzymes also have tremendous potential in medicine (e.g., as targets for anti-cancer, antimicrobial and antiviral drugs and as therapeutics for metabolic disorders) and in industry (e.g. to make important commodity chemicals and as catalysts for bioremediation). Our central premise is that a quantitative, mechanistic understanding of enzyme function and its relationship to organism fitness is critically needed to precisely manipulate enzymes and to deeply understand biology. To generate this level of understanding, we need: (1) a quantitative, chemical, and physical knowledge of enzyme function, and (2) mechanistic data describing how and when these physical principles contribute to enzyme function within the complex environments where enzymes operate. An enhanced understanding of the relationships between protein sequence, protein function and cellular/organismal fitness will have profound impacts across biology and medicine, from improving our ability to predict how mutations will influence the virulence and drug susceptibility of human pathogens, to enhancing precision medicine by accurately predicting the consequences of allelic variants, to enabling the design of next-generation protein and cellular therapeutics. Achieving this understanding requires new tools and a new conceptual paradigm. Enzymes are highly interconnected, their functions are multifaceted, and their cellular environments are complex. Traditional biochemistry is enormously powerful, allowing for the intensive study of a few individual enzymes in vitro (10s) and providing detailed knowledge of their chemical mechanisms. But identifying the many residues that matter for enzyme function requires investigation of residues beyond the active site at a scale far beyond that of traditional biochemistry. Furthermore, this biochemical information then needs to be translated to organism fitness in vivo in a quantitative manner. Here we will overcome these challenges. We will first use evolutionary sequence information to direct enzyme variant design towards functionally important areas of sequence space. We will adapt high-throughput microfluidic technologies to quantitively measure the biochemical properties (e.g., kcat, Km, Ki, and ∆GFold) of this library of 104 enzyme variants in vitro (Aim 1). Then we will determine how each of these variants affects organismal fitness in vivo using pooled competition and barcode sequencing assays (Aim 2). Finally, we will use this sequence-function-fitness map to test long-standing models in biochemistry and evolution and reveal the biochemical determinants of fitness important for industry and medicine (Aim 3). Such a comprehensive and quantitative mapping of biochemical function to fitness has never been achieved.

Up to $803K

2027-08-31

Free to search & build · $99 one-time to unlock the application pack · No subscription

Leveraging adolescent plasticity mechanisms to enhance adult frontal dopaminergic circuit function

NIDA - National Institute on Drug Abuse

Abstract My goal is to head an independent research program studying dopaminergic system dysfunction in neurodevelopmental disorders. I have extensive in vivo two-photon microscopy, neural circuit dissection, microglial physiology, and behavioral assay experience. Under my proposed training plan, I will work closely with my co-mentors, Drs. Kuan Wang, Zhigang He, Yi Zuo, and Julie Fudge to broaden and strengthen my research expertise to prepare for full research independence. Dr. Wang is an expert in the developmental plasticity and function of dopaminergic projections to the frontal cortex and in vivo imaging. Dr. He is an expert in sequencing and bioinformatic analyses of transcriptomic changes in microglia in response to CNS milieu disruption. Dr. Zuo is an expert on behavioral assays and circuit plasticity. Dr. Fudge is an expert in the dopaminergic system and psychiatric conditions. Collectively, my mentorship team and experimental plans will provide me with the technical skills and conceptual expertise to become an independent researcher in the fields of dopaminergic development and neuroimmune interactions. The Del Monte Institute of Neuroscience will provide a rich and collaborative training environment with an extensive network of investigators working on neurodevelopmental disorders within the URMC UR-IDDRC. In the Wang Lab, I have explored the mechanisms which drive mesocortical plasticity. Previous published work in the Wang lab established that the mesocortical dopaminergic projections from the ventral tegmental area (VTA) to the frontal cortex undergo activity dependent axonal bouton formation in response to VTA stimulation in adolescents but not adults. However, dopamine receptor 2 (D2R) inhibition paired with stimulation reopens adult plasticity. Interestingly, chemogenetic stimulation of dopaminergic VTA projections during adolescence ameliorates circuit and behavioral deficits in mice with genetic mutations disrupting mesocortical circuit function. My postdoctoral work shows that activity-dependent changes in the adolescent mesocortical circuit increase microglial surveillance of the parenchyma and microglial contacts with axonal boutons and that DR manipulation disrupts these interactions. My immediate goals are to understand the signals which regulate mesocortical dopaminergic plasticity, and to evaluate the therapeutic potential of reopening plasticity after developmental insult. (Aim 1) I will evaluate if microglia are necessary for the reopening of mesocortical plasticity in adult animals. (Aim 2) I will determine if reopening plasticity in adult mice with circuit disruptions from juvenile Δ-9-tetrahydrocannabinol exposure is effective at rescuing both dopaminergic hypofrontality and behavioral deficits. (Aim 3) I will use single-cell sequencing to identify changes in dopaminergic receptor signaling pathways between adolescent and adult animals which close the window of mesocortical plasticity. These experiments will provide a mechanistic understanding of mesocortical plasticity regulation and they will evaluate the therapeutic potential of reopening plasticity in the adult mesocortical circuit.

Up to $157K

2031-04-30

Free to search & build · $99 one-time to unlock the application pack · No subscription

Leveraging ancient DNA to elucidate the genetic architecture of complex human traits

NHGRI - National Human Genome Research Institute

Ancient DNA has transformed our understanding of demographic events in the past, but its potential to reveal as much about biology as history has not been realizable until recently because estimating allele frequencies with enough precision to detect significant shifts over time requires larger sample sizes than were previously available. In preliminary work, we analyzed whole-genome data from 8,433 West Eurasians dating to the last 14,000 years, a six-times larger dataset than any previous study of this type. To control for population structure, we took a novel approach of using a Generalized Linear Mixed Model, searching for a consistent trend in allele frequency change over all regions and times while allowing starting frequency to vary across subgroups. We find 347 independent loci passing our threshold for genome-wide significance, and many complex phenotypes shaped by directional selection, described in a preprint posted in September 2024 (Ali Akbari et al. bioRxiv). These developments highlight the promise of ancient DNA for providing insight into complex trait architecture, as for the first time we can directly measure the selection coefficients of large numbers of variants with known effects on traits from Genome-Wide Association Studies, making it possible to fit models of the relationship between the frequency distribution of causal alleles for diverse traits and their effects. To take advantage of the opportunities opened up by these technical and data breakthroughs, we propose a four-part work plan: (1) Assemble an ancient DNA time-transect of 34,000 West Eurasians by the end of the grant period, quadrupling sample size and allowing measurement of selection coefficients down to around s = 0.25%. (2) Curate the data into a publicly available resource, released pre-publication to accelerate science. (3) Analyze the data to learn about how selection forces over time shape the distribution of alleles modulating phenotypes, thus characterizing the “selection architecture” of diverse traits. (4) Carry out the first ancient DNA studies of selection in three time-transects outside West Eurasia, analyzing about 1000 individuals each spread over 10000 years in Brazil, the Andes, and Mesoamerica. The anticipated result is an advance in our understanding of how selection impacts humans, based on analyses in multiple populations in parallel thus enabling more generalizable conclusions that are maximally relevant to the largest number of people. Since selection is expected to be a primary shaper of the distribution of frequencies of alleles contributing to traits, this should provide distinctive insights complementing other approaches for investigating complex trait architecture.

Up to $839K

2030-02-28