Grants

U.S. National Science Foundation

Life and Environments Through Time

Environmental

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Life Insurance Services

STATE, DEPARTMENT OF.STATE, DEPARTMENT OF.US EMBASSY BANGKOK

Life Insurance Services

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LIFE Operating Grants

European Commission - LIFE2027

LIFE Operating Grants. Call: LIFE Operating Grants. Programme: LIFE2027. Open call from the EU Funding & Tenders Portal.

$50K

2026-09-22

research

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Life-spanning study of Polycomb regulation by cohesin

NIA - National Institute on Aging

The epigenome controls cell type-specific gene expression, establishing the diversity of cell types in the human body. However, over time, the epigenome becomes dysregulated, which promotes aging. Despite the tight link between epigenetics and aging, the mechanisms that preserve the epigenome in young cells and why these mechanisms degrade over time remain poorly understood. Polycomb-mediated gene repression maintains cell identity by silencing the genes that specify other cell types. As facultative heterochromatin, Polycomb is highly dynamic during development, enabling differentiating stem cells to rapidly alter gene expression programs. However, Polycomb switches from being flexible during development to becoming a stable mechanism of repression throughout adulthood. Understanding Polycomb regulation is key to advancing our knowledge of aging, as disrupting Polycomb components alters lifespan across various organisms. How Polycomb repression is maintained in terminally differentiated cells remain unknown. However, studies in embryonic stem cells indicate that spatial organization of repressed sites is crucial, with Polycomb-repressed regions forming ultra-long-range loops to sustain silencing. While these loops were thought to be solely mediated by Polycomb complexes, preliminary work from the applicant shows that cohesin and CTCF (which facilitate long-range enhancer-promoter loops) also mediate repressive loops in embryonic stem cells. In the F99 phase of this proposal, performed at MIT, the applicant will use computational methods developed by the Mirny and Dekker labs to determine whether cohesin and CTCF-dependent looping is a broad regulatory mechanism of Polycomb repression. Aim 1.1 will identify Polycomb targets in embryonic stem cells that derepress when cohesin or CTCF is lost and Aim 1.2 will use mechanistic polymer modeling to link cohesin and CTCF’s roles in 3D looping activity to Polycomb repression. In Aim 1.3, machine learning and polymer modeling will predict how gene expression in different cell types, particularly mature hepatocytes, respond to site-directed CTCF perturbations. These insights will propel the applicant’s transition to aging research, where she will test whether enhancing cohesin activity can protect Polycomb repression in aging mouse livers (Aim 2). The K00 phase will also use cutting-edge and single-cell experimental techniques to measure genome re-organization as Polycomb becomes dysregulated during the normal aging process. In addition to training in machine learning and hepatic chromatin, the applicant will gain expertise in aging research during the F99 stage through lab visits, conference attendance, and a course on aging and its diseases. This study will advance our understanding of aging by comprehensively investigating a new mechanism of Polycomb regulation. Rejuvenating the epigenome is a promising strategy for reversing cellular aging, and this work will determine if targeting the 3D genome offers a new approach.

Up to $51K

2031-06-30

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LifePoint Health Community Health Grants

LifePoint Health

Supports community health programs in rural and small communities where LifePoint hospitals operate, focusing on health access and wellness.

$5K – $200K

rural healthhealth accesscommunity wellness+1

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Lifespan Respite Care Program: Grants to New States and States Re-Establishing Their Core Respite Infrastructures

Administration for Community Living

Lifespan Respite Care Program: Grants to New States and States Re-Establishing Their Core Respite Infrastructures

infrastructure

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Lifespan Respite Care Program: State Grants

income_security_and_social_services

Administration for Community Living

<p>ACL is seeking applications from eligible state agencies that will advance the provision of respite services through their statewide Lifespan Respite Care system as outlined in the Act. There are two application options for states contained in this single Notice of Funding Opportunity. State Applicants for Option A (Grants to New States and States Re-Establishing Their Core Respite Infrastructures): This opportunity is for states who have never had a grant, OR who had a grant before, but the program has stopped, and they wish to start it up again. State Applicants for Option B (State Program Enhancement Grants): This opportunity is intended for states that have had at least one grant in the past and/or wish to continue building and expanding upon their programmatic activities to enhance and expand the availability of lifespan respite services. Grantees will collaborate with state respite organizations and coalitions to enhance and expand the availability of lifespan respite services. The goal of the program is to enhance state systems and capacities to deliver respite care and related services to family caregivers of children and adults across all age groups, disabilities, and chronic conditions.</p>

$300K – $500K

2026-06-30

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Lifespan Respite Care Program: State Grants

Administration for Community Living

ACL is seeking applications from eligible state agencies that will advance the provision of respite services through their statewide Lifespan Respite Care system as outlined in the Act. There are two application options for states contained in this single Notice of Funding Opportunity. State Applicants for Option A (Grants to New States and States Re-Establishing Their Core Respite Infrastructures): This opportunity is for states who have never had a grant, OR who had a grant before, but the program has stopped, and they wish to start it up again. State Applicants for Option B (State Program Enhancement Grants): This opportunity is intended for states that have had at least one grant in the past and/or wish to continue building and expanding upon their programmatic activities to enhance and expand the availability of lifespan respite services. Grantees will collaborate with state respite organizations and coalitions to enhance and expand the availability of lifespan respite services. The goal of the program is to enhance state systems and capacities to deliver respite care and related services to family caregivers of children and adults across all age groups, disabilities, and chronic conditions.

$300K – $500K

2026-06-30

social services

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Lifespan Respite Care Program: State Grants

Administration for Community Living

Lifespan Respite Care Program: State Grants

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Lifespan Respite National Technical Assistance and Resource Center

Administration for Community Living

Lifespan Respite National Technical Assistance and Resource Center

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Lifestyle intervention to improve muscle function in older adults

NIA - National Institute on Aging

PROJECT SUMMARY/ABSTRACT In the United States, nearly one third of adults over 60 years of age have sarcopenic obesity which encompasses the combined effect of muscle impairment and obesity. Inducing loss of fat mass while slowing or preventing loss of skeletal muscle mass and quality are critical for preserving the musculoskeletal, cardiometabolic, and cognitive benefits of weight loss in older adults with obesity. As people age, muscle mass and quality decrease while fat mass progressively increases, and these body composition changes are associated with increased incidence of insulin resistance. Calorie restriction and exercise reduce body mass and improve physical performance but lean mass accounts for 22% to 33% of weight loss. Moreover, behavioral adaptations to calorie restriction make adherence a challenge. Energy deficits can be achieved without conscious practice. Since people tend to eat a consistent weight of food, eating a diet low in energy density reduces energy intake. Diets low in energy density reduce body weight and fat mass and moderate the loss of lean mass. Reduced energy intake combined with exercise increases fat loss and improves physical performance more than exercise alone. To date, no adequately powered randomized controlled feeding trial > 14 days has determined the effect of a diet low in energy density on metabolic outcomes. The proposed study will test the hypothesis that a diet low in energy density + exercise (1.0 kcal/g, LD+E) reduces fat mass (Aim 1), improves muscle function (Aim 2) and increases energy deficit (Aim 3). We will conduct a 12-week trial in 80 older adults (> 50 years) with obesity and insulin resistance. Participants will be randomized to LD+E or to the diet typically consumed by older adults + exercise (2.0 kcal/g, TD+E). Baseline energy requirements will be determined using an equation derived from doubly labeled water assessments. All meals for 12 weeks will be prepared in our metabolic kitchen. The macronutrient composition of the diet will be 40-45% carbohydrate; 20- 25% protein; and 35-40% fat. Participants will engage in a combination of supervised aerobic and resistance training for a total of 150 minutes per week, for 12 weeks. Aim 1 will test the hypothesis that LD+E reduces fat mass (dual x-ray absorptiometry) and moderates the loss of lean mass (creatine [methyl-d3] dilution) compared to TD+E. Aim 2 will test the hypothesis that LD+E improves muscle function (short physical performance battery, hand grip strength, six-minute walk test, and VO2 max test). Aim 3 will test the hypothesis that LD+E produces an energy deficit (changes in fat and fat-free mass). Using structural equation models, we will test the effect of circulating concentrations of glucagon-like peptide 1, gastric inhibitory peptide, cortisol, and leptin on energy balance and muscle function. Impairment of skeletal muscle function poses a serious health challenge especially in the context of the demographic trend towards an aging population. The hypothesized outcomes are of far-reaching consequence with the advent of incretin-based pharmacotherapy to treat obesity that causes rapid and significant loss of lean mass comparable to a decade or more of aging.

Up to $749K

2030-12-31

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Light adaptation in regionally and functionally distinct retinal circuits

NEI - National Eye Institute

PROJECT SUMMARY Visual tasks, like reading print or recognizing faces, often require detailed spatial information collected under changing lighting conditions. In the retina, as light intensity varies so do the gain and kinetics of neural responses—a process called adaptation that prevents saturation and supports a consistent perception of contrast. A significant gap in knowledge is how light adaptation functions in the fovea—the central most region of retina responsible for high-acuity vision. Retinal circuit adaptation relies on signal pooling, and therefore adaptation may vary between foveal and peripheral regions that differ in convergence. Additionally, cone photoreceptors in peripheral primate retina are known to be asymmetric in their sensitivity to light increments vs decrements. Therefore, circuit adaptation may differ in ON and OFF visual pathways. The objective of this project is to use distinct primate retinal circuits—foveal vs peripheral and ON vs OFF—to determine how circuits with differing signal to noise ratios modulate gain and kinetics across light conditions. Aim 1 will determine the impact of convergence on properties of retinal circuit adaptation (gain, kinetics, noise, and time course) in the primate foveal vs peripheral midget and parasol pathways, as well as the contribution of synaptic inhibition as a potential mechanism for circuit adaptation to luminance. Aim 2 will determine how asymmetries inherited from cone photoreceptors shape the functional properties of adaptation in the primate ON vs OFF peripheral midget pathway. Given the importance of the fovea for our everyday vision, this work will bridge a gap in our knowledge of how foveal circuits adapt to changes in contrast over varying background luminance, critical for the function of high-acuity vision. These results will positively impact the pursuit towards prosthetic retinal implants that can recapitulate properties of foveal circuits by providing a template for function in diverse retinal circuits. The training plan described in this proposal is designed to enable me to develop the skills necessary to reach my career goal of an independent investigator. By following this plan with the guidance of my sponsor and co-sponsor, I will continue to learn new electrophysiology techniques to build a strong foundation in retinal circuit research. I will develop my writing, communication, teaching, mentoring, networking, and scientific outreach skills. This research will take place at the University of Wisconsin-Madison where the strong intellectual environment and availability of primate tissue from the Wisconsin National Primate Research Center will be leveraged.

Up to $83K

2027-11-30

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Light for the World — Inclusive Development

inclusive developmenteye healthdisability

Light for the World

Grants for inclusive education, employment, and health programs for persons with disabilities in developing countries.

$15K – $100K

2026-10-15

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Light-Responsive Inorganic Compounds for Diagnosis and Therapy

NCI - National Cancer Institute

Surgery, alone or in combination with other therapies, is a cornerstone of cancer treatment. However, incomplete resection leads to increased risk of recurrence and reduced overall survival. Here optical image guided surgery (IGS) has a role to play by enhancing tumor visualization and improving surgical precision. It has notable advantages over visual inspection and histology aided by real-time CT, MRI, or optical scanners alone, but could be improved with new optical imaging agents. IGS could benefit from imaging agents that luminesce brightly in the wavelength region where tissue is most transparent. Further, IGS agents that also exert potent antitumor effects would enable simultaneous detection and treatment of disseminated cancer cells that cannot be removed due to their location around critical organ structures. This project will design osmium compounds that are highly luminescent at wavelengths where tissue is the most transparent. The optical agents will be inert and nontoxic, but phototoxic toward cancer cells through complementary modes of action, regardless of oxygenation status. The multidisciplinary strategy is based on the unique photophysical properties of certain immunostimulatory osmium compounds, with specialized ligands, that can be independently tuned for near-infrared luminescence output and phototherapy with minimal impact by oxygen. The molecular properties of these inorganic compounds can be further augmented by encapsulation in supramolecular structures such as nanolipid carriers. The project scope is to synthesize and characterize new compounds, determine their molecular properties, interrogate their photophysical and cellular mechanisms of action, and evaluate their utility as multifunctional optical imaging agents with therapeutic capacity. These activities will expose undergraduate students to multidisciplinary research and create new knowledge regarding optical imaging agents that addresses current challenges that have so far prevented IGS from being effectively used for hard-to-resect cancers. This project will also strengthen the research environment at UTA by enabling long-term sustainable biomedical research and inspiring a new generation of students to pursue innovative solutions to critical human health challenges.

Up to $566K

2029-05-31

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Lighting Alternatives Maximizing Performance & Suitability (LAMPS)

National Energy Technology Laboratory

Amendment 000001 to DE-FOA-0001558. To view the changes associated with this amendment, please refer to the EERE Exchange website. The U.S. DOE Building Technologies Office Emerging Technologies program is announcing the availability of up to 3 million dollars in funding to develop energy efficient replacement lamps in general illumination applications. DOE seeks projects to develop suitable replacement lamps that meet or exceed the 45 lm/W backstop requirement for one or more incandescent general service lamp categories and that maintain the base, shape, and lumen output of the incandescent lamps they are designed to replace. The objectives of this funding opportunity are to: Accelerate development of replacement lamps that maintain the needed performance attributes of the incandescent lamps they replace while eliminating or minimizing any performance compromises Overcome technical challenges that inhibit widespread market acceptance and impede the design, development and future sale of suitable and compliant lighting products for the identified general service lamp categories Offer consumer choice The full Funding Opportunity Announcement is posted on the EERE eXCHANGE website at https://eere-exchange.energy.gov. Applications must be submitted through the EERE eXCHANGE website to be considered for award. Information on where to submit questions regarding the content of the announcement and where to submit questions regarding submission of applications is found in the full FOA posted on the EERE Exchange website.

$750K – $1.5M

rolling

energyclean energy

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Lightning Protection System, Area 8500, Tyndall AFB, Fl

DEPT OF DEFENSE.DEPT OF THE AIR FORCE.AIR COMBAT COMMAND.FA4819 325 CONS PKP

Lightning Protection System, Area 8500, Tyndall AFB, Fl

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Lilly Endowment Education Grants

Lilly Endowment Inc.

Supports education programs in Indiana including K-12 improvement, higher education, and teacher quality. Also funds community development in Indianapolis.

$50K – $500K

EducationK-12higher education+1

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Lilly Endowment Religion Division Grants

Lilly Endowment Inc.

The largest private funder of religion in the U.S. ($500M+/yr religion division). Supports clergy renewal, congregational vitality, theological education, and religious research.

$50K – $2M

religionclergytheological education+1

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Lilly Endowment Religion Grants

Lilly Endowment Inc.

One of the largest private foundations in the U.S. Primary focus on religion, education, and community development in Indianapolis. Funds clergy renewal, congregational vitality, and theological education.

$50K – $500K

religionEducationcommunity development+1

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Lima/Allen County Foundation Community Grants

Lima/Allen County Foundation

Lima/Allen County Foundation ($75M in assets) supports nonprofits in OH through grants focused on education, community development, health, arts. Awards range from $1,000 to $25,000.

$1K – $25K

Educationcommunity developmentHealth+1

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Limited Competition for the Adolescent Brain Cognitive Development -Extended (ABCD-E) Study Renewal - Data Analysis, Informatics and Resource Center, and Coordinating Center (U24 Clinical Trial Not Allowed)

National Institutes of Health

This is a notice of funding opportunity (NOFO) for a Limited Competition that will invite applications from eligible organizations to apply. Please see Section III. Eligibility for additional information. In accordance with the National Institutes of Health (NIH) standard peer-review processes, the applications will be peer-reviewed, and only meritorious applications will be considered for funding. Only current award recipients will be eligible to apply. This NOFO seeks two separate U24 applications to renew the Adolescent Brian Cognitive Development (ABCD) Research Coordinating Center (CC) and the Data Analysis Informatics and Resource Center (DAIRC) to extend study visits into young adulthood. This renewal called Adolescent Brain Cognitive Development – Extended (ABCD-E) study is critical to be able to follow these youth through their emerging adulthood, when many of the outcomes of interest (e.g., substance use disorders, mental health disorders, chronic diseases, and other health conditions) will manifest. The structure of the ABCD-E study Consortium shall consist of three highly integrated components: (1) a set of linked Research Project Sites, (2) a single central Data Analysis, Informatics, and Resource Center, and (3) a single overall Coordinating Center. As such, this NOFO runs in parallel with a companion NOFO that solicits applications for research project sites (RFA-DA-27-002). It is expected that investigators, upon funding, will work jointly with NIH scientific staff to assist, guide, coordinate, or participate in project activities.

2026-07-09

Health

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Limited Competition for the Adolescent Brain Cognitive Development -Extended (ABCD-E) Study Renewal - Data Analysis, Informatics and Resource Center, and Coordinating Center (U24 Clinical Trial Not Allowed)

National Institutes of Health

Limited Competition for the Adolescent Brain Cognitive Development -Extended (ABCD-E) Study Renewal - Data Analysis, Informatics and Resource Center, and Coordinating Center (U24 Clinical Trial Not Allowed)

2026-07-09

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Limited Competition for the Adolescent Brain Cognitive Development -Extended (ABCD-E) Study Renewal - Data Analysis, Informatics and Resource Center, and Coordinating Center (U24 Clinical Trial Not Allowed)