Grants

31,374 grants found

24 grants worth up to $9.0M match your search

Enter your email to see grant names, funders, and application links

Delineating developmental windows of vulnerability for cannabis exposure and assessing for causal relations between cannabis use, neurodevelopment, and behavior

NIDA - National Institute on Drug Abuse

With the ongoing trend of cannabis legalization in the United States and across the world, there is a critical need to better understand links between cannabis use, brain development, and cognitive-behavioral outcomes. Despite growing public belief that cannabis use is relatively benign, there remains a dearth of large longitudinal studies examining cannabis use and brain development in humans. We propose to leverage three large multimodal neuroimaging datasets, spanning preadolescence to late adulthood: ABCD (n=11,880; ages 9-20 followed longitudinally), IMAGEN (n=2,400; ages 14-23, followed longitudinally), and ENIGMA-Addiction (n=14,340; ages 12-80, from 118 studies). These large, rich datasets include measures of highly relevant behaviors (co-occurring alcohol and tobacco use, physical activity, psychopathology) while affording unparalleled statistical power. Leveraging these datasets, we will employ linear mixed-effects models to identify developmental windows in which areas and/or networks of the brain are most vulnerable to cannabis exposure. Similar analyses will be conducted for relevant behavioral trajectories (e.g., attention problems, internalizing symptomatology). Focusing on rigor and replicability, nonparametric permutation testing will be employed in imaging analyses, and we will explicitly test if findings in one dataset extend to others. We hypothesize that developmental windows with the greatest degree of prefrontal age-related change will be periods of greatest vulnerability to cannabis exposure. Using a range of methodologies (propensity score matching, cross-lagged panel design, discordant twin analyses, Bayesian causal networks), this proposal will move beyond associational analyses towards causal mechanisms. Such analyses are desperately needed to help bridge preclinical animal models with human neuroimaging findings. Based on our prior imaging work as well as existing rodent models, we hypothesize that early to middle adolescence, relative to other stages of development, will be associated with greater evidence for causal relationships involving cannabis use, neurodevelopment, and behavior. We will also examine the degree to which genetic liabilities for psychiatric conditions (e.g., ADHD, schizophrenia) qualify observed cannabis-related outcomes. Using polygenic risk scores, we will test genetic interactions with age and cannabis use. Similarly, we will examine how salient environmental and demographic factors linked to cannabis use trajectories (e.g., early adversity, sex at birth) interact with age and cannabis use. We hypothesize that cannabis’ hypothesized influence on neurodevelopment and behavior will be greatest for individuals with pre- existing genetic liabilities for associated psychiatric symptomatology (e.g., ADHD, schizophrenia) and/or established risk factors associated with the developmental trajectory to cannabis use disorder (e.g., early adversity and trauma). Importantly, the proposed work is fundamental to developing impactful policy initiatives as well as prevention and intervention efforts.

Up to $387K

2030-12-31

health research

Free to search & build · $99 one-time to unlock the application pack · No subscription

Grants

Delineating developmental windows of vulnerability for cannabis exposure and assessing for causal relations between cannabis use, neurodevelopment, and behavior

Delineating systemic roles of APOE genotypes on CNS health

Delineating the impact of beige adipocytes in the metabolism

Delineating the role of 5’ untranslated regions in prostate cancer clonality

Delineation of Alzheimer's Disease initiation and propagation using novel adult human brain organoids

Dell Scholars Program — College Completion

Dell Technologies Foundation Youth & STEM Grants

dell'Arte Opera Ensemble, Inc.

Deloitte Foundation Education Grants

Deloitte- Wadsworth Public Health Lab- Life Science Initiative

Delridge Business Survey and Outreach

Delridge Grocery Coop Research Studies

Delridge Neighborhoods Cultural Event Series

Delridge Neighborhoods Let's Talk Race Series

Delridge OnRamp Career and Computer Access Center

Delridge Triangle: Creating a Safe Community Space

Delta Regional Authority Grants

Delta Rural Integrated Health Network Program

Delving into peptide specificity of NK inhibitory receptors

Demand-led innovation in security

Dementia CAReS Grants for American Indian and Alaska Native Communities

Demo and Debris Removal 2 Bldgs. and General Landscaping Camp Creaser

Demo, remediation for affordable housing

Democratizing Discovery in Spatial Transcriptomics Through the Brain Image Library.

Browse by state

Browse by category

Browse by organization type

Browse by grant amount

Browse by audience

More categories

Grants

Delineating developmental windows of vulnerability for cannabis exposure and assessing for causal relations between cannabis use, neurodevelopment, and behavior

Delineating systemic roles of APOE genotypes on CNS health

Delineating the impact of beige adipocytes in the metabolism

Delineating the role of 5’ untranslated regions in prostate cancer clonality

Delineation of Alzheimer's Disease initiation and propagation using novel adult human brain organoids

Dell Scholars Program — College Completion

Dell Technologies Foundation Youth & STEM Grants

dell'Arte Opera Ensemble, Inc.

Deloitte Foundation Education Grants

Deloitte- Wadsworth Public Health Lab- Life Science Initiative

Delridge Business Survey and Outreach

Delridge Grocery Coop Research Studies

Delridge Neighborhoods Cultural Event Series

Delridge Neighborhoods Let's Talk Race Series

Delridge OnRamp Career and Computer Access Center

Delridge Triangle: Creating a Safe Community Space

Delta Regional Authority Grants

Delta Rural Integrated Health Network Program

Delving into peptide specificity of NK inhibitory receptors

Demand-led innovation in security

Dementia CAReS Grants for American Indian and Alaska Native Communities

Demo and Debris Removal 2 Bldgs. and General Landscaping Camp Creaser

Demo, remediation for affordable housing

Democratizing Discovery in Spatial Transcriptomics Through the Brain Image Library.