Grants

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Integrated Fire and Weed Management Planning through a National Parks and Protected Areas Cooperative Studies Program at Oregon State University Cascades Campus

National Park Service

United States Department of the Interior, National Park Service (NPS) Notice of Intent to Award. This is not a request for applications. This posting is to provide public notice of the NPS' intention to fund the following project activities without full and open competition: Cooperative Agreement P18AC01347 with Oregon State University, a partner under the Pacific Northwest Cooperative Ecosystem Studies Unit (Cooperative and Joint Venture Agreement P16AC00003), for the project titled, "Integrated Fire and Weed Management Planning through a National Parks and Protected Areas Cooperative Studies Program at Oregon State University Cascades Campus."

$55K – $201K

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Integrated Food Safety System Regulatory and Laboratory Training System National Coordination Center

Food and Drug Administration

Integrated Food Safety System Regulatory and Laboratory Training System National Coordination Center

Rolling

STEM

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Integrated G Protein Circuitry for Cancer Cell Signaling Autonomy

NCI - National Cancer Institute

SUMMARY/ABSTRACT The Problem: Cancer cells often reside in environments deprived of growth factors and nutrients. Yet they thrive by rewiring their signaling through autocrine and paracrine “secrete-and-sense” circuits, enabling self- sustaining growth. This phenomenon, known as growth signaling autonomy, is one of the earliest recognized hallmarks of cancer and central to cancer stemness, tumor progression, and treatment resistance. However, the core molecular mechanisms driving these circuits remain poorly defined, limiting therapeutic progress. Central premise: Our data identify GIV (Gα-interacting vesicle-associated protein) as a master regulator of cancer cell signaling autonomy. GIV is a multimodular scaffold protein that integrates signaling across monomeric and heterotrimeric G proteins—elements typically studied in isolation—into a coherent, feed-forward signaling circuit that sustains EGF/EGFR-dependent growth. Endogenously expressed in many breast cancers, particularly triple-negative breast cancers (TNBCs), GIV enables cells to sustain tumor progression under nutrient- and growth factor-limiting conditions. In contrast, ER+ BCs, which often lack endogenous GIV, acquire it via intercellular transfer from stromal neighbors, highlighting a novel mode of proteomic exchange. We hypothesize that GIV promotes cancer stem cell-like states, tumor growth, and drug resistance under nutrient- and growth factor-limited conditions. GIV-dependent cancer cell signaling autonomy may also extend to neighboring GIV-deficient cancer cells via paracrine signaling, enhancing cooperative growth among heterogeneous cancer cell populations. Our team—experts in breast cancer biology, GIV signaling, and in the use of both animal and non-animal models (patient-derived organoids and tissue microarrays) alongside synthetic biology tools (cells with engineered circuits) and quantitative live-cell imaging—is uniquely positioned to test this model through integrated experimental and computational approaches. Our aims are to discover how GIV’s modular domains orchestrate key states of cancer cells driving tumor progression in the setting of: (1) intrinsic autonomy in GIV-expressing TNBCs or (2) intercellular transfer- dependent acquired autonomy in ER+BCs; and 3) establish the cooperative dynamics by which GIV-expressing autonomous cells support non-autonomous GIV-deficient neighbors in heterogeneous tumors. We leverage human organoids and tissue microarrays to preserve translational potential and ensure clinical relevance. Impact: This work will redefine cancer signaling by identifying the first mechanistic framework of secrete- and-sense growth factor autonomy within the EGF/EGFR pathway. It will also chart how a single intracellular hub (GIV) coordinates autocrine and paracrine signaling across diverse cell populations to drive tumor progression. By mechanistically linking cancer growth signaling autonomy to stemness, plasticity, tumor heterogeneity and therapeutic resistance, our findings will uncover new intervention points and provide a transformative conceptual advance in targeting signaling rewiring in breast cancer and beyond.

Up to $638K

2031-04-30

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Integrated Human Neuroimmune Platforms to Define MECOM-Associated Microglial Mechanisms in HIV Persistence and Methamphetamine-Induced Neuroinflammation

NIDA - National Institute on Drug Abuse

Abstract People with HIV (PWH) who use methamphetamine (METH) experience disproportionately high rates of neurocognitive impairment and chronic neuroinflammation, even with suppressive antiretroviral therapy. Microglia are central to these CNS complications, yet the molecular mechanisms by which METH exacerbates HIV-induced microglial dysfunction remain poorly understood. A major limitation in the field has been the lack of integrative, systems-level studies capable of identifying key molecular regulators of neuroinflammation and viral persistence in the context of HIV and substance use comorbidity. Our preliminary studies implicate MECOM (MDS1 and EVI1 complex locus protein), a stress-responsive transcriptional regulator, as a potential mediator of METH-induced microglial reprogramming under HIV infection. We observed that METH alters HIV replication and cytokine production in iPSC-derived microglia, with persistent effects following their integration into brain organoids. Bulk transcriptomic analyses revealed MECOM upregulation under HIV/METH co-exposure, suggesting a role in neuroimmune dysregulation. This proposal combines integrated transcriptomic and proteomic (multi-omics) analyses with advanced human-derived models, including iPSC-derived microglia, neuroimmune organoids, and HIV-infected humanized NOG-hIL34 mice, to map and validate MECOM- associated networks. We will first define MECOM-regulated signaling pathways and protein interaction networks in HIV-infected microglia exposed to METH using integrative transcriptomic and proteomic analyses. Building on these findings, we will then determine the functional consequences of MECOM deletion in human-derived in vitro models and in HIV-infected humanized mice. By uncovering how METH alters MECOM-dependent signaling in HIV-infected microglia, this study will provide new mechanistic insight into HIV-associated neuroinflammation and identify candidate molecular targets to mitigate CNS complications in PWH with comorbid substance use.

Up to $668K

2028-03-31

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Integrated mass spectrometry strategies to decipher metabolite-protein cross regulation

NIGMS - National Institute of General Medical Sciences

Integrated mass spectrometry strategies to decipher protein-metabolite cross regulation Cellular metabolism relies on protein enzymes to convert substrates to products, working in interconnected networks to generate important biological precursors, remove toxic waste, balance redox and defend energy potential. However, the study of metabolic regulation in both healthy and disease states has proven challenging in part due to the intricate cross-regulation between metabolites and proteins. Current strategies to characterize metabolic regulation have generally focused on characterizing metabolites or protein enzymes, but not both. Consequently, how metabolites and proteins interact in the cellular context remains an open question in the field of metabolism and cellular biology. To bridge this gap, the Skinner lab is focused on characterizing the interactions between metabolites and proteins in the cellular context by using mass spectrometry to integrate existing multi-tiered methods in addition to developing new techniques to enhance the characterization and scope of both protein and metabolite measurements. Our primary research focus is on the regulation of proteins and metabolism by redox cofactors through signaling of sulfur-containing metabolites (Area 1) and the effect of vitamin B6 on metabolic and redox regulation as it is converted to protein cofactor pyridoxal-5-phosphate (PLP) (Area 2). These two areas each represent critical intersections of metabolome and proteome that play a key role across a variety of disease states. To better understand these two ranges of metabolite and protein cross-regulation, we will apply top-down proteomics and native mass spectrometry analyses of intact protein complexes coupled with full-scan and stable isotope labeling metabolomics to simultaneously probe metabolites and proteins. In Area 1, we will characterize how the abundance and redox state of specific thiol metabolites and cellular nicotinamide adenine dinucleotide phosphate (NADP+) redox state can modulate glycolysis and other core metabolic pathways Protein thiols have been demonstrated to be covalently modified at high stoichiometry with a variety of different groups, making this a likely axis for metabolic regulation. In Area 2, we will examine another key intersection between metabolite and protein regulation; the metabolism of vitamin B6 to its active form PLP prior to acting as a cofactor for 53 human enzymes. Specifically, we will characterize how some PLP-containing enzymes seem more resistant to extended B6 deficiency than others and how changes in subcellular nicotinamide adenine dinucleotide (NAD+) redox state can affect PLP levels and vice versa. This project integrates metabolomics with native mass spectrometry and proteomics and applies it to two pressing questions in the field of systems biology and regulation that lie at the intersection of metabolome and proteome.

Up to $434K

2030-12-31

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Integrated mechano-arthroscope for minimally invasive assessment of joint pathologies

NIBIB - National Institute of Biomedical Imaging and Bioengineering

Project Summary/Abstract The objective of this project is to develop and evaluate the feasibility of an integrated mechano-arthroscope for minimally invasive assessment of joint tissue pathology and micromechanics. Joint tissues, such as cartilage and meniscus, perform crucial mechanical function of bearing and dissipating loads imparted upon the joints. To support this functional role, joint tissues possess specialized solid and liquid extracellular matrix constituents that provide the necessary interplays of elastic stiffness and viscous dissipative behaviors. Degenerative joint disease (arthritis) disrupts these intricately designed mechanical machineries, directly degrading tissue function, causing pain and reduced mobility. Arthritis is a global health crisis that affects more than 500 million people worldwide, with prevalence and years lived with disability attributable to the disease projected to continue to rise. This crisis is exacerbated by the fact that an effective cure is yet to be found. A fundamental roadblock in the medical treatment of arthritis is the lack of effective ways to assess the deficiencies of joint tissues and their restoration of functional integrity following treatments in living patients. Despite mechanics being the direct determinant of function, current diagnostic paradigm for joint pathologies does not, in fact, include any direct measures of the mechanical quality of joint tissues. Diagnostic imaging provides structural metrics such as joint space narrowing and cartilage lesion size, while arthroscopy, the gold standard for grading cartilage defects and repair, provides visualization of gross appearance and manual palpation of intra-articular structures. This does not allow orthopedic surgeons to precisely evaluate the functional mechanical integrity of joint tissues to guide surgical treatments and monitor the status of tissue repair and healing following treatments. This gap not only hinders the direct medical care of patients with joint pathologies, but also severely restricts the development of effective therapies on a larger scale due to the absence of crucial mechanical outcome measures in living patients. This project directly addresses this critical gap. We propose to develop a new imaging tool termed ArthSHEAR, in the form of a needle-sized integrated mechano-arthroscope, that will permit minimally invasive assessment of both gross appearance and underlying micromechanical properties of intra-articular tissues in the doctor’s office. ArthSHEAR is based on the core technology of Speckle rHEologicAl microscopy (SHEAR) that enables passive, noncontact mapping of viscoelastic behavior in gross tissues without indenting or otherwise manipulating the sample. The first phase of project will develop and validate the ArthSHEAR instrument and data processing algorithms to permit arthroscopic mapping of the indices of mechanical firmness and viscous dissipation. The second phase will conduct an in vivo longitudinal imaging study in a swine model of osteoarthritis (OA) to evaluate the feasibility of ArthSHEAR for discerning and tracking the micromechanical changes due to degenerative disease. This study will provide the first in vivo longitudinal data that tracks micromechanical transformation over the full course of OA progression from healthy to complete joint damage.

Up to $206K

2029-05-31

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Integrated nanophotonic imaging and spectroscopy technology for scalable, purification-free, multi-parametric single exosome analysis

NIGMS - National Institute of General Medical Sciences

PROJECT SUMMARY Exosomes are nanoscale extracellular vesicles (30–150 nm in diameter) secreted by nearly all cell types into biological fluids such as blood, urine, saliva, and cerebrospinal fluid. Exosomes are known to play important roles in a variety of basic science and applied research fields such as cancer biology, neurological disorders, regenerative medicine, and dermatology. Exosomes are also heavily pursued for various diagnostic and therapeutic applications such as liquid biopsy and drug delivery. Current methods of analyzing exosomes have many limitations such as inadequate sensitivity and specificity, insufficient resolution for single exosome profiling, demanding sample volume, and heavily reliant on DNA amplification and sequencing techniques. In addition, most existing exosome pre-analytical sample preparation protocols require a multitude of steps involving purification, isolation, concentrating, and sophisticated labeling. These barriers have hampered the advances in exosome-centric basic and applied research and technology development. To address such an unmet need, the PI proposes to develop an Integrated Nanophotonic imaging and Spectroscopy Technology (INSPECT) for scalable, multi-parametric Single Exosome Analysis (SEA). The core is a nanophotonic chip to enable multi-modal imaging and spectroscopy based on three well-known nanoplasmonic enhancing mechanisms demonstrated in PI’s previous works: localized surface plasmon resonance (LSPR), plasmon- enhanced fluorescence (PEF), and surface-enhanced Raman scattering (SERS). These three techniques are highly complementary and can provide strong synergy in acquiring structural as well as compositional/molecular information from individual exosomes. Using LSPR-imaging, the PI has demonstrated individual exosomes can be detected, counted, and sized with 20 µL of undiluted and unpurified blood plasma. The same exosome population can then be interrogated by PEF using various fluorophore-labeled antibodies and molecular beacons to reveal exosomal surface and intravesicular molecular targets such as proteins and microRNAs. SERS will then provide a comprehensive, “non-targeting” molecular fingerprint.

Up to $432K

2030-02-28

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Integrated NSF Support Promoting Interdisciplinary Research and Education

U.S. National Science Foundation

The INSPIRE awards program was established to address some of the most complicated and pressing scientific problems that lie at the intersection of traditional disciplines. It is intended to encourage investigators to submit bold, exceptional proposals that some may consider to be at a disadvantage in a standard NSF review process; it is not intended for proposals that are more appropriate for existing award mechanisms. INSPIRE is open to interdisciplinary proposals on any NSF-supported topic, submitted by invitation only after a preliminary inquiry process initiated by submission of a required Letter of Intent. In fiscal year 2013, INSPIRE provides support through the following three pilot grant mechanisms: INSPIRE Track 1. This is essentially a continuation of the pilot CREATIV mechanism from FY 2012, which was detailed for 2012 in Dear Colleague Letter NSF 12-011. INSPIRE Track 2. These are "mid-scale" research awards at a larger scale than Track 1, allowing for requests of up to $3,000,000 over a duration of up to five years. Expectations for cross-cutting advances and for broader impacts are greater than in Track 1, and the review process includes external review.Director's INSPIRE Awards. These are prestigious individual awards to single-investigator proposals that present ideas for interdisciplinary advances with unusually strong, exciting transformative potential.All NSF directorates and programmatic offices participated in INSPIRE in FY 2012 and are continuing their participation in FY 2013.

$500K – $3M

sciencetechnology

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Integrated Pathogen Reduction Technologies for whole blood and blood components for transfusion (R01) Clinical Trial Not Allowed

Food and Drug Administration

CBER, FDA seeks to support the development of innovative pathogen reduction technologies for whole blood and blood components to prevent transfusion-transmitted infectious diseases.

Agriculturerural development

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Integrated Production and Product Development for Next-Generation Lithium-based Batteries for Mobility (BATT4EU and Made in Europe Partnerships)

European Commission - HORIZON

Integrated Production and Product Development for Next-Generation Lithium-based Batteries for Mobility (BATT4EU and Made in Europe Partnerships). Call: BATTERIES and MOBILITY. Programme: HORIZON. Open call from the EU Funding & Tenders Portal.

$50K

2026-10-08

infrastructure

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Integrated Research, Education, and Extension Competitive Grants Program – Organic Transitions

National Institute of Food and Agriculture

Integrated Research, Education, and Extension Competitive Grants Program – Organic Transitions

2026-07-13

Educationresearch

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Integrated Research, Education, and Extension Competitive Grants Program Organic Transitions

Agriculturerural development

National Institute of Food and Agriculture

The overall goal of the ORG program, under assistance listing 10.303 is to support the development and implementation of research, extension, and higher education programs that improve the competitiveness of U.S. organic livestock and crop producers, as well as those adopting organic practices.

$20K – $1M

2026-07-13

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Integrated Resource Management Internships

National Park Service

United States Department of the Interior, National Park Service (NPS) Notice of Intent to Award. This is not a request for applications. This posting is to provide public notice of NPS' intention to fund the following project activities without full and open competition: Task Agreement P17AC01536 under master Cooperative Agreement P13AC00786 with the Point Reyes National Seashore Association, for the project titled, "Integrated Resource Management Internships."

$94K

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Integrated Resource Management Internships and Science at the Seashore Education at Point Reyes National Seashore

National Park Service

United States Department of the Interior, National Park Service (NPS) Notice of Intent to Award. This is not a request for applications. This funding opportunity is to provide public notice of NPS's intention to fund the following project activities. Task Agreement P19AC00683 under master Cooperative Agreement P19AC00660 with Point Reyes National Seashore Association, for the project titled "Integrated Resource Management Internships and Science at the Seashore Education at Point Reyes National Seashore."

$135K

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Integrated Resource Management Internships and Science at the Seashore Education Program

National Park Service

United States Department of the Interior, National Park Service (NPS) Notice of Intent to Award. This is not a request for applications. This posting is to provide public notice of NPS' intention to fund the following project activities without full and open competition: Task Agreement P15AC01296 under master Cooperative Agreement P13AC00786 with the Point Reyes National Seashore Association, for the project titled, "Integrated Resource Management Internships and Science at the Seashore Education Program".

Education

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Integrated Resource Management Internships at Point Reyes National Seashore

National Park Service

United States Department of the Interior, National Park Service (NPS) Notice of Intent to Award. This is not a request for applications. This posting is to provide public notice of NPS' intention to fund the following project activities: Task Agreement P18AC01370 under master Cooperative Agreement P13AC00786 with Point Reyes National Seashore Association, for the project titled, "Integrated Resource Management Internships at Point Reyes National Seashore."

$120K

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Integrated Services for PWID using Person-centered Interactions, Reach, and Engagement (INSPIRE)

NIDA - National Institute on Drug Abuse

PROJECT SUMMARY First-ever data from Zambia on people who inject drugs (PWID) demonstrates major gaps in the HIV epidemic response. A recent biobehavioral survey show sharp health disparities along the entire PWID HIV care continuum, with gaps in HIV testing, linkage to ART, and viral suppression, and limited knowledge of PrEP. Failing to detect early HIV infections and address unsuppressed viral load poses a risk of ongoing community transmission as well as increased risk for HIV comorbidities and mortality, threatening the overall HIV epidemic control response in Zambia. The Zambia Ministry of Health has adopted a harm reduction approach to address the health disparities experienced by PWID. Starting in November 2024, the Zambia Ministry of Health will provide Medications for Opioid Use Disorder (MOUD) at two health facilities which also provide HIV services. There is currently minimal evidence in sub-Saharan Africa on MOUD integration with HIV care. The arrival of MOUD in Zamvia presents an exceptional opportunity to collaborate with Ministry of Health and key partners to develop a person-centered integrated collaborative care model for PWID and pilot testing implementation, feasibility, and preliminary effectiveness within the Zambian health system. We propose the Integrated Services for PWID using Person-centered Interactions, Reach, and Engagement (INSPIRE) study to co-adapt and evaluate an HIV status-neutral system-level integrated approach using a Collaborative Care Management Model (CoCM) for HIV prevention, HIV care, mental health, and MOUD. This implementation science study includes the following Aims: Aim 1: Assess the multilevel determinants of early implementation of MOUD services using rapid qualitative analysis. Aim 2: Co-adapt an HIV status-neutral CoCM with key stakeholders. Aim 3: Implement and evaluate the co-adapted CoCM, guided by Practical, Robust Implementation and Sustainability Model (PRISM), and including the Reach, Effectiveness, Adoption, Implementation, and Maintenance (RE-AIM) outcomes. The research team, led by Multiple Principal Investigators (MPI), has expertise in psychiatry, HIV clinical care, implementation science, behavioral and social sciences, HIV clinical care, epidemiology, and mixed methods, and has a deep knowledge of HIV response and service delivery models in Zambia for marginalized populations, and experience implementing opioid use treatment both in the US, and in Kenya. We will also leverage the University of Maryland Baltimore’s decade of experience implementing MOUD and HIV programs in Kenya. Addressing the unmet needs of PWID is urgently needed to achieve and maintain HIV epidemic control; our findings will inform the implementation of integrated care models for PWID. Lessons learned from INSPIRE will help develop best practices for system-level approaches to improve OUD treatment and HIV prevention and treatment programs in both sub-Saharan Africa and the US.

Up to $35K

2028-07-31

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Integrated Solid Waste Management South at Marine Corps Installations Pacific (MCI-PAC) Camp Smedley D. Butler, Okinawa, Japan

DEPT OF DEFENSE.DEPT OF THE NAVY.NAVFAC.NAVFAC PACIFIC CMD.NAVFAC FAR EAST.NAVFACSYSCOM FAR EAST

Integrated Solid Waste Management South at Marine Corps Installations Pacific (MCI-PAC) Camp Smedley D. Butler, Okinawa, Japan

2026-12-10

general

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Integrated Specific Pathogen Free Research Models and Human New Approach Methodologies to Advance HIV/AIDS Research (U42 Clinical Trial Not Allowed)

National Institutes of Health

This NOFO is issued during a period of accelerating development, validation, and adoption of human new approach methodologies (NAMs). Accordingly, it has two integrated priorities for NIH-funded HIV/AIDS research: (1) implementation of a NAMs-enabled stewardship framework, including optional HIV-relevant human in vitro testing support and pilot benchmarking activities, to reduce or replace specific pathogen free (SPF) in vivo model use where scientifically appropriate without compromising rigor, reproducibility, or translational relevance; and (2) support for high-quality SPF colony resources for studies in which well-characterized in vivo models remain scientifically necessary.Under the NAMs-enabled component, required elements include: (1) integration of a NAMs triage and consultation service within request intake and allocation workflows to identify NAM-feasible studies and document reductions or replacements in in vivo use; and (2) establishment of a formal referral pathway to NAM centers as well as human tissue and other human science based resources to facilitate collaborative HIV-relevant human NAM development, benchmarking, and refinement. Applicants may also propose optional NAMs-enabled HIV human in vitro testing support (research use only), including standardized operating procedures, quality control frameworks, and user guidance for viral load quantification, drug resistance assessment, and ex vivo susceptibility assays, as well as optional pilot benchmarking projects to define performance metrics, quality control benchmarks, and context-of-use statements for HIV-relevant human NAMs.Under the SPF resource component, the award will support core colony operations, including colony management and husbandry; transparent, merit-based request intake and allocation; comprehensive virologic surveillance and rapid mitigation to preserve SPF status; and high-resolution immunogenetic characterization (e.g., MHC typing) to enable rigorous, genotype-informed study design and efficient stewardship of limited in vivo resources.

$212K – $2.7M

2027-01-25

Health

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Integrated Specific Pathogen Free Research Models and Human New Approach Methodologies to Advance HIV/AIDS Research (U42 Clinical Trial Not Allowed)

National Institutes of Health

This NOFO is issued during a period of accelerating development, validation, and adoption of human new approach methodologies (NAMs). Accordingly, it has two integrated priorities for NIH-funded HIV/AIDS research: (1) implementation of a NAMs-enabled stewardship framework, including optional HIV-relevant human in vitro testing support and pilot benchmarking activities, to reduce or replace specific pathogen free (SPF) in vivo model use where scientifically appropriate without compromising rigor, reproducibility, or translational relevance; and (2) support for high-quality SPF colony resources for studies in which well-characterized in vivo models remain scientifically necessary.Under the NAMs-enabled component, required elements include: (1) integration of a NAMs triage and consultation service within request intake and allocation workflows to identify NAM-feasible studies and document reductions or replacements in in vivo use; and (2) establishment of a formal referral pathway to NAM centers as well as human tissue and other human science based resources to facilitate collaborative HIV-relevant human NAM development, benchmarking, and refinement. Applicants may also propose optional NAMs-enabled HIV human in vitro testing support (research use only), including standardized operating procedures, quality control frameworks, and user guidance for viral load quantification, drug resistance assessment, and ex vivo susceptibility assays, as well as optional pilot benchmarking projects to define performance metrics, quality control benchmarks, and context-of-use statements for HIV-relevant human NAMs.Under the SPF resource component, the award will support core colony operations, including colony management and husbandry; transparent, merit-based request intake and allocation; comprehensive virologic surveillance and rapid mitigation to preserve SPF status; and high-resolution immunogenetic characterization (e.g., MHC typing) to enable rigorous, genotype-informed study design and efficient stewardship of limited in vivo resources.

$212K – $2.7M

2027-01-25

Healthhealthcare

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Integrated Treatment of Adolescents with Substance Use Disorders and PTSD

NIDA - National Institute on Drug Abuse

PROJECT SUMMARY/ABSTRACT Substance use disorders (SUD) and post-traumatic stress disorder (PTSD) are debilitating mental health disorders that frequently co-occur and have onset during adolescence. Approximately 9% of adolescents aged 12-17 meet criteria for a current SUD, with more than 70% of those having experienced a traumatic event and 35% meeting criteria for PTSD. If left untreated, a cyclical relationship between substance use and PTSD serves to maintain or exacerbate the other, leading to a chronic course of illness. Adolescents with co-occurring SUD/PTSD are at increased risk of developing other serious mental health problems (e.g., depression, suicidal ideation), HIV-related risk behaviors, and academic and interpersonal problems. There is a critical need to intervene earlier in the developmental trajectory to prevent the long-term deleterious outcomes associated with SUD/PTSD in adulthood. However, there are no effective individual treatments for adolescents with SUD/PTSD. Clinicians agree that comorbid SUD/PTSD among adolescents is a significant problem, and that a feasible and effective intervention is clearly needed. Efficacious, evidence-based treatments for adults with SUD/PTSD have been developed over the past two decades and can be adapted to address the unique developmental needs of adolescents with SUD/PTSD and improve outcomes and functioning for this highly understudied population. Based on promising preliminary data, the proposed study will directly address this need by evaluating an integrated, trauma-focused intervention, Concurrent Treatment of PTSD and Substance Use Disorders using Prolonged Exposure (COPE), specifically adapted for adolescents (COPE-A). A Stage Ia study of COPE-A demonstrated safety, feasibility, and significant pre- to post-treatment reductions in SUD and PTSD symptoms, while a Stage Ib pilot RCT comparing COPE-A to Person Centered Therapy (PCT) showed safety, feasibility, and preliminary efficacy in significantly reducing substance use and PTSD severity. Stage I studies also resulted in a treatment manual, clinician training protocol, and fidelity monitoring procedures, all of which will be used in the proposed study. The primary objective of this Stage II RCT is to evaluate the efficacy of COPE-A, compared to PCT, in reducing (a) substance use frequency and amount, and (b) PTSD severity among a larger sample of adolescents (N = 120) with co-occurring SUD/PTSD. Secondary objectives are to examine the effects of COPE- A on associated areas of functioning including depression, HIV risk behaviors, interpersonal functioning, and quality of life. In line with our prior work, we will recruit nationally and deliver the intervention via telehealth. Ecological momentary assessment (EMA) will monitor daily substance use and PTSD symptoms to examine their temporal and reciprocal relationship and identify underlying mechanisms of change to inform future research.

Up to $675K

2031-01-31

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Integrated Upland Vegetation and Spring Vegetation Field Work for Mojave Desert Netweork

National Park Service

This agreement between Great Basin Institute and the Mojave Desert Network Inventory & Monitoring program provides an internship opportunity to collect Integrated Upland Vegetation Protocol (JU) data. These agencies will worth together to support and stimulate work, education, and training opportunities for young adults through natural resource monitoring in the Mojave Desert Network of National Parks. The primary purpose of this project is not the acquisition of property or services for the direct benefit or use by the Federal Government, but rather to accomplish a public purpose of support or stimulation authorized by the Legislative Authorities listed under Article II. In this project, Great Basin Institute and the Mojave Desert Network Inventory & Monitoring program will collaborate to provide an opportunity for young adults to conduct quality analysis/quality control for ecological data in the field and in the office as a vegetation technician. This position provides early career individual training and experiential learning in the fields of natural resources and conservation. The selected candidate will be provided with a full time technician position monitoring the flora, fauna, and hydrology of springs and upland plant communities in the Mojave Desert. The primary duty of the participant will be to assist NPS scientists in field work at springs in Parashant National Monument and other parks in the region. Field work will include plant size measurements, plant identification, and potential collection of vegetation. We anticipate that the selected candidate will be traveling and camping in the backcountry for at least 50% of the weekdays for the duration of the position. Occasionally weekend work may also occur. In addition to field work, the participant will assist with logistics, data entry, QA/QC, and reporting tasks in the office and assist NPS staff as needed with a variety of projects. The technician will gain experience in botanical and ecological field methods, and will have a chance to participate in all phases of the monitoring process, from planning to reporting. They will work closely with NPS scientists, and learn what it is like to work as a scientist for a federal agency.

$15K – $85K

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Integrated Viral Hepatitis Surveillance, Testing, Treatment, and Prevention Programs for Health Departments (IVH-STTP)