Grants

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Honing Precision Medicine for Type 2 Diabetes in the Veteran Population

NIH

PROJECT SUMMARY/ABSTRACT Significance and Impact to Veterans Healthcare: Type 2 Diabetes (T2D) represents a significant health challenge among US veterans, with 25% affected and a growing prevalence over the past decade. Managing the progression of T2D and its complications such as kidney disease, neuropathy, retinopathy, and heart attack, is essential to mitigating the health consequences for veterans – particularly those in underserved populations and marginalized communities who are at the greatest risk – while also reducing the overall costs to the VA health system. Precision medicine, which leverages multi-modal data to identify and tailor risk prediction and treatment to individual veterans, holds promise in addressing this issue, and is the cornerstone of our proposed approach. Our proposal centers around addressing two major VHA/ORD priorities for the VA in the 2022-2028 strategic plan, including (i) Health Equity to underserved communities to address disparities, and (ii) Innovation from emerging methods in Genomics, Artificial Intelligence / Machine Learning, and Personalized Medicine. Background and Innovation. Our team leads the T2D Global Genomics Initiative (T2D-GGI), aimed at improving the understanding of the genetic basis of T2D and its complications. This international effort, which includes contributions from the Million Veteran Program (MVP), has identified >600 risk loci for T2D from over 2.5 million subjects, with substantial diversity among participants. Building on this, our proposal seeks to integrate genetic data with lifestyle, dietary, and newly available methylation data to predict T2D risk and its complications among veterans. Towards these objectives, in Aim One, we will develop a multi-factorial predictor for T2D and disease progression, using genetic risk factors, lifestyle, and dietary data on T2D and its complications from ~289,000 veterans from diverse populations, further enhanced using machine learning models and methylation data from VA participants. In Aim Two, using newly generated methylation profiling in MVP, we will map genetic variants associated with methylation differences among >45,000 subjects, linking these variations to T2D and metabolic traits. In Aim Three, we will apply statistical causal inference methods to define T2D subtypes and their impact on disease progression in veterans. Quantifying the causal effects of these subtypes on disease complications will guide the application of preventive precision medicine. Particularly innovative components of the proposal include: (i) the application and use of newly generated lifestyle, dietary, and genomics data in veterans to risk prediction problem and inference of gene regulatory networks, (ii) the scale of genomics study that is representative of the diverse demographics of the US, helping to address health disparities, (iii) the focus on disease progression and development of complications, important for veterans health now and into the future, and (iv) novel application of statistical methods and machine learning approaches to prediction and causal inference problems addressed in the proposal. Path to Translation/Implementation: By understanding the interplay between genetic, lifestyle, and environmental factors, we aim to develop tailored risk prediction models which could facilitate early identification and timely intervention of high-risk veterans. Identifying genetic variation associated with methylation differences could also reveal novel therapeutic targets. Furthermore, characterizing T2D subtypes and their impact on disease progression will guide targeted interventions, bringing precision medicine closer to reality for veterans. By achieving these aims, we hope to significantly advance the field of precision medicine for T2D, providing tailored and effective interventions for veterans at high risk of T2D and its complications.

2030-03-31

health research

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Honor & Care - Event for Black ChildCare Providers

Black Child Development Institute

To honor Black Childcare providers and offer them resources that support their own care and their status as essential care givers, educators and business owners. This event is free and will include self-care advocates, nutrition support, dialogue with mental health professionals, business and finance consultants, and local funders. The event will be held from 10am until 3pm on October 22, 2022 at Rainier Beach Community Center.

Up to $5K

HealthAgriculture

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Honouliuli and World War II Valor in the Pacific National Monuments Cultural Resource Management Internships

National Park Service

This announcement is not a request for applications. This announcement is to provide public notice of the National Park Service's intention to award financial assistance for the following project activities: Cooperative Agreement P19AC00740 with University of Hawaii for Honouliuli and World War II Valor in the Pacific National Monuments Cultural Resource Management Internships

$32K – $92K

rolling

other

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Hop-On Facility

European Commission - HORIZON

Hop-On Facility. Call: Hop-on Facility. Programme: HORIZON. Open call from the EU Funding & Tenders Portal.

2026-09-24

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HOPE Crew for Youth Historic Preservation Projects at Channel Islands National Park

National Park Service

United States Department of the Interior, National Park Service (NPS) Notice of Intent to Award. This is not a request for applications. This posting is to provide public notice of NPS' intention to fund the following project activities without full and open competition: Task Agreement P17AC00535 under master Cooperative Agreement P13AC00165 with the California Conservation Corps, for the project titled, "HOPE Crew for Youth Historic Preservation Projects at Channel Islands National Park."

Up to $86K

rolling

Education

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Hope For The Warriors — Transition Grants

veteran transitioncareer developmentclinical health

Hope For The Warriors

Grants for transition services including career development, clinical health, and community building for post-9/11 veterans.

$10K – $75K

2026-07-01

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HOPE Heart study: A Clinical Trial of HIV to HIV Transplantation

NIAID - National Institute of Allergy and Infectious Diseases

PROJECT SUMMARY/ABSTRACT We led the landmark trials in kidney (U01AI134591; NEJM 2024) and liver (U01AI138897) to establish the safety and efficacy of HOPE transplants, resulting in the 2024 HHS decision to expand HIV D+/R+ kidney and liver transplantation beyond research protocols to clinical practice. Yet the HOPE Act promise of heart transplants remains unrealized. People with HIV have twice the risk of clinical heart failure as the general population (6.5% prevalence), and HIV-associated cardiomyopathy is a major long-term complication of HIV infection. Transplanting hearts from donors with HIV (HIV D+) could lead to substantial public health benefit by decreasing the organ shortage, wait times, and waitlist mortality for people with and without HIV on the heart waitlist. Heart transplantation from donors without HIV to recipients with HIV (HIV D-/R+) confers a substantial survival advantage (77% vs 33% at 5 years), with post-transplant survival comparable to recipients without HIV. We performed the world’s first HIV D+/R+ heart transplants, and our 6 recipients are alive with follow-up as long as 3 years. In the proposed multicenter trial, we will evaluate the safety and efficacy of HIV D+/R+ heart transplantation. Furthermore, we will conduct important mechanistic studies to characterize dysregulated adaptive immune responses common to HIV and transplantation, linking them with allograft inflammation/fibrosis and clinical endpoints in the trial. Participants with HIV will be offered HIV D+ and HIV D- (including false positive) hearts as they become available in a quasi-random process mimicking a randomized trial. We will compare outcomes in 40 HIV D+/R+ and 40 HIV D-/R+ heart transplant recipients, enrolled over 5 years at 25 transplant centers. We aim: (1) to compare heart transplant outcomes (rejection, graft failure, and mortality) between HIV D+/R+ and HIV D-/R+, (2) to investigate whether dysregulated adaptive immune responses are associated with increased progression of inflammation and rejection after transplantation, in HIV D+/R+ recipients versus HIV D-/R+ recipients, and (3) to investigate whether HIV D+/R+, versus HIV D-/R+ recipients, demonstrate more intragraft inflammation and fibrosis, particularly whether inflammation and subclinical fibrosis in HIV D+ donor hearts is associated with clinical endpoints of the trial, and whether rejection in HIV D+/R+ has a distinct phenotype from rejection in HIV D-/R+. The proposed trial will determine whether the use of hearts from HIV D+ donors is safe and effective. If HIV D+/R+ transplantation can be implemented, the additional donors will help save the lives of both patients with and without HIV. The mechanistic studies have been designed to complement clinical endpoints, ensuring the knowledge gained will be novel and informative regardless of outcomes.

Up to $1.7M

2033-03-31

health research

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HOPWA

Department of Public Health

HOPWA 2023 - 2025

Up to $12.5M

2026-09-05

general

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HOPWA

Department of Public Health

HOPWA 2024-2026

Up to $12.8M

2027-09-09

general

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HOPWA HOUSING AND HEALTH STUDY

Department of Public Health

HOPWA - HOUSING & HEALTH STUDY

Up to $1.6M

2027-12-16

HealthHousing

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Horace M. Albright Collection, NPS History Internships

National Park Service

Create internship opportunities to work with NPS History Collection archivist to survey, process, and catalog c. 40 LF of former NPS Director Horace M. Albright s Papers. Intern will receive training and gain hands-on experience in professional archives work, including archival methods and preventive conservation. Training also provided in use of the Interior Collection Management System (ICMS). Excellent opportunity for current archives student or recent graduate.

$1 – $39K

rolling

Education

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Horatio Alger Association — Scholarship Grants

scholarshipsadversityhigher education

Horatio Alger Association

Funds scholarships for students who have overcome adversity.

$10K – $100K

Annual

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Horiuchi P-Patch Bulletin Board and Path

GROW

This Eagle scout candidate project will bring a beautiful, decorative bulletin board to the Horiuchi P-Patch, to help increase communication between the gardeners at Horiuchi P-Patch and between the Horiuchi P-Patch gardeners and the community. This project will also improve the gravel walkway in the P-Patch. It is a partnership between a youth volunteer and a very diverse, mainly elderly group of gardeners in the Yesler neighborhood of Seattle.

Up to $5K

general

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HORIZON-EIC-2026-BAS-02-SCLATEUP

European Commission - HORIZON

HORIZON-EIC-2026-BAS-02-SCLATEUP. Call: EIC Scaling Club 2.0. Programme: HORIZON. Keywords: Angel investment, Business model innovation, Crowdfunding, Gender in innovation development, Innovation Fund, Innovation strategies, Innovation systems, Market-creating innovation, Private equity, Seed capital, Training and support, Venture operator. Open call from the EU Funding & Tenders Portal.

technologyEducationBusiness Development

2026-06-25

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HORIZON-JU-EDCTP3-2026-Dr Pascoal Mocumbi Prize

European Commission - HORIZON

HORIZON-JU-EDCTP3-2026-Dr Pascoal Mocumbi Prize. Call: HORIZON-JU-EDCTP3-2026-Dr Pascoal Mocumbi Prize. Programme: HORIZON. Open call from the EU Funding & Tenders Portal.

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HORIZON-JU-EDCTP3-2026-Outstanding Female Scientist Prize

European Commission - HORIZON

HORIZON-JU-EDCTP3-2026-Outstanding Female Scientist Prize. Call: HORIZON-JU-EDCTP3-2026-Outstanding Female Scientist Prize. Programme: HORIZON. Open call from the EU Funding & Tenders Portal.

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HORIZON-JU-EDCTP3-2026-Outstanding Research Team Prize

European Commission - HORIZON

HORIZON-JU-EDCTP3-2026-Outstanding Research Team Prize. Call: HORIZON-JU-EDCTP3-2026-Outstanding Research Team Prize. Programme: HORIZON. Open call from the EU Funding & Tenders Portal.

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HORIZON-JU-EDCTP3-2026-Scientific Leadership Man EU Prize

European Commission - HORIZON

HORIZON-JU-EDCTP3-2026-Scientific Leadership Man EU Prize. Call: HORIZON-JU-EDCTP3-2026-Scientific Leadership Man EU Prize. Programme: HORIZON. Open call from the EU Funding & Tenders Portal.

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HORIZON-JU-EDCTP3-2026-Scientific Leadership Woman EU Prize

European Commission - HORIZON

HORIZON-JU-EDCTP3-2026-Scientific Leadership Woman EU Prize. Call: HORIZON-JU-EDCTP3-2026-Scientific Leadership Woman EU Prize. Programme: HORIZON. Open call from the EU Funding & Tenders Portal.

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HORIZON-JU-EDCTP3-2026-Scientific Leadership Woman SSA Prize

European Commission - HORIZON

HORIZON-JU-EDCTP3-2026-Scientific Leadership Woman SSA Prize. Call: HORIZON-JU-EDCTP3-2026-Scientific Leadership Woman SSA Prize. Programme: HORIZON. Open call from the EU Funding & Tenders Portal.

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Horizontal business innovation and clean technology review statistical tables

Treasury Board of Canada Secretariat | Secrétariat du Conseil du Trésor du Canada

These statistical tables are one of the results from a project undertaken by Statistics Canada on behalf of the Treasury Board Secretariat (TBS) in support of the Horizontal Innovation and Clean Technology Review. They were produced from program data provided by 22 federal government departments and Crown corporations and their subsequent integration into Statistics Canada’s Linkable File Environment (LFE), which comprises a large number of administrative and survey data linked at the enterprise level. More than 430,000 individual records were collected, from 98 program streams over the 2007-2016 period. Program streams were also grouped in seven aggregate categories: grants, repayable contributions, non-repayable contributions, conditional repayable contributions, financing, government performed services and other. Program recipients at the enterprise level (whether for-profit or public entities) were matched to Statistics Canada’s Business Register (BR), which contains all active ent

government

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Hormel Foundation Community Grants

Hormel Foundation

Supports hunger relief, education, and community programs in Austin, MN and Hormel communities.

$10K – $250K

hunger reliefEducationcommunity development

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Hormonal and behavioral dysregulation following exposure to antiretrovirals and chronic cocaine