Grants

NYC Department of Cultural Affairs

Ansonia Music Outreach Organization, Inc.

Ansonia

Ansonia Sidewalk Repairs Part 2

Ansonia

Ansonia Sidewalks Repairs

U.S. National Science Foundation

Antarctic Research Not Requiring U.S. Antarctic Program (USAP) Field Support

U.S. National Science Foundation

Antarctic Research Requiring U.S. Antarctic Program (USAP) Support for Fieldwork

NYC Department of Cultural Affairs

Anthology Film Archives, Inc.

Storefront for Art and Architecture

Anthony Hamboussi - Hamboussi: Newtown Creek: A Photographic Study - Industrial Landscape

NYC Department of Cultural Affairs

Anthropologists, Inc.

Washington Heights Jaybie's Sports Academy

Youth

Union Settlement Association, Inc.

Local

NYC Department of Cultural Affairs

Anti-Social Music, Inc.

NIAID - National Institute of Allergy and Infectious Diseases

Streptococcus pyogenes (Strep A) is a major global pathogen responsible for significant morbidity and mortality. Efforts to develop a broadly protective immunization strategy against Strep A have been hindered by the extensive sequence variability of its primary virulence factor, the M protein, with over 220 known M types. The immune response to M proteins is typically type-specific, limiting broad protection. This project builds on recent structural and functional discoveries to design M protein-based immunogens that elicit cross-reactive antibodies against diverse Strep A strains. We hypothesize that conserved 3D structural patterns in M proteins can drive broad immune recognition and be leveraged to enhance immunogen design. A promising M protein-based immunogen that completed Phase I trials, StreptAnova, generates cross-reactive antibodies, yet the basis for this cross-reactivity is unknown. Our work suggests that the M type cross-reactivity may be due to conserved three-dimensional (3D) structural patterns within M proteins that mediate binding to human C4b-binding protein (C4BP), an essential virulence factor. Notably, half of the M proteins in StreptAnova contain a C4BP-binding pattern as do about half of the cross-reactive M types. In our own experiments, we have demonstrated that an M2 protein-derived immunogen, containing the C4BP-binding 3D pattern, elicits cross-reactive and opsonophagocytic antibodies against several M types that share this structural pattern. However, the breadth of this response was limited, revealing opportunities for improvement. Our recent findings identified a C4BP-binding pattern in M22 protein that is the most prevalent across Strep A strains. We hypothesize that an M22-based immunogen, particularly with structural modifications, will significantly expand M-type cross-reactivity. Additionally, our collaborator Pontus Nordenfelt (Lund University, Sweden) has identified human monoclonal antibodies that are cross-reactive against M proteins of multiple types, many of which do not bind C4BP. The basis for their M type cross-reactivity is not known and will be investigated here. Our specific aims are the following. (1) Develop an M protein-based immunogen with broad M type cross-reactivity. We will investigate whether an M22-based immunogen, incorporating natural or consensus sequences fused to immunogenic stabilizing sequences, can enhance protection across multiple Strep A strains. (2) Determine the structures of M-type cross-reactive antibodies bound to M proteins. We will use X-ray crystallography and site-directed mutagenesis to investigate antibody interactions with M proteins, testing whether cross-reactivity is driven by recognition of the C4BP-binding 3D pattern. We will also structurally characterize cross-reactive human antibodies isolated from convalescent patients to identify novel mechanisms of broad recognition. This project integrates structural biology, immunology, and rational immunogen design to address a long-standing challenge in Strep A research. Results will provide fundamental insights into M protein cross-reactivity and could serve as the foundation for a broadly protective strategy.

NIAID - National Institute of Allergy and Infectious Diseases

Chlamydia trachomatis is the most prevalent sexually transmitted infection (STI) in the US, with 1.64 million cases reported to the US Centers for Disease Control and prevention (CDC) in 2022. Women with untreated Chlamydia infection can develop pelvic inflammatory disease (PID) and suffer long-term reproductive harm including chronic pelvic pain, ectopic pregnancy, or infertility. There are no licensed vaccines for Chlamydia and a very limited vaccine pipeline. This application builds on our recent work demonstrating that Chlamydia- specific circulating memory and non-circulating TRM CD4 T cells can each provide protective immunity to the female reproductive tract. We will use new screening approach to, (i) identify target antigens recognized by both of these protective Chlamydia-specific memory CD4 T cells and validate these antigens, (ii) examine whether an mRNA vaccine approach can provide protection in the mouse model. Successful completion of these studies will provide a new foundation for vaccine development against a neglected disease that adversely affects the reproductive health of many young women in the US.

City of Richmond

anyanglu

Port of Astoria

AOC Integrated Planning

NYC Department of Cultural Affairs

Aperture Foundation, Inc.

NYC Department of Cultural Affairs

ApexArt Curatorial Program

Economic Development Initiatives 16-17

APG Neuros Corp. Working Capital

City of Oakland

General operating support for its seven core pan–Asian and Pacific Islander American (APIA) arts & cultural programs and operations that serve 25,000 people each year.  

WAPI Community Services

API Youth Voices. Young Asian and Pacific Islanders will learn media literacy skills and how to use audio and video technology to engage their peers in conversations about social justice and community development issues, such as gang culture and the immigrant and refugee experience.

Apollo Theater Foundation, Inc.

Apollo Music Café - Promotional and Marketing Support

NYC Department of Cultural Affairs

Apollo Theater Foundation, Inc.

Education Department

Under the Small, Rural School Achievement (SRSA) program, the U.S. Department of Education (Department) awards grants on a formula basis to eligible local educational agencies (LEAs) to address the unique needs of rural school districts. In this notice, we establish the deadline and describe the application process for the fiscal year (FY) 2026 SRSA grant. All LEAs eligible for FY 2026 SRSA funds must apply electronically via the process described in this notice by the deadline listed below.

Department of Housing and Urban Development

Application Instructions for the Indian Community Development Block Grant (ICDBG) Imminent Threat (IT) Program