Grants

artsinfrastructure

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Hijacking the neonatal Fc receptor: the novel biology of arterivirus entry, transmission, and persistence

NIAID - National Institute of Allergy and Infectious Diseases

PROJECT SUMMARY/ABSTRACT Understanding novel mechanisms by which animal viruses enter cells, evade immunity, and cause disease has scientific and public health importance. Arteriviruses are an understudied family of RNA viruses (related to coronaviruses) that infect a wide variety of mammals. The host and viral factors that determine arterivirus disease, persistence, and cross-species transmission remain unknown and unpredictable. This lack of understanding has implications for predicting/thwarting arterivirus emergence in humans, as some arteriviruses have been shown to infect human cells. Macrophages are exclusively infected by most arteriviruses, but the subpopulation(s) of macrophages that support arterivirus replication remain poorly defined. The process by which arteriviruses enter cells is highly novel and also poorly understood. Each virion displays an unusually large set of surface glycoproteins (7-11 depending on the virus) that are unlike any known viral fusion machinery. The macrophage-specific molecule CD163 is a required arterivirus receptor, yet CD163 by itself is insufficient to mediate arterivirus entry. We recently identified the neonatal Fc receptor (FcRn) as an important entry factor that arteriviruses use together with CD163 to gain entry into cells. Aim 1 of this project builds upon this discovery to define the molecular details of the arterivirus:FcRn interaction. In Aim 1a, we will map the site(s) on FcRn that are critical for arterivirus engagement by creating chimeric FcRn molecules that incorporate features of arterivirus-permissive and -resistant FcRn orthologs, with the goal of defining the domains, motifs, and residues involved in arterivirus/FcRn interactions. In Aim 1b, we will generate chimeric arteriviruses that contain combinations of glycoproteins from different arteriviruses, seeking to define the viral glycoproteins, domains, motifs, and residues involved in FcRn engagement. In Aim 1c, we will continue to develop our understanding of the host factors required for arterivirus entry by performing screens to identify additional host factors that are functionally redundant with FcRn for the viral entry process. In Aim 2, we will use the murine arterivirus (lactate dehydrogenase-elevating virus, LDV), which causes life-long viremia in adult mice, to understand several aspects of arterivirus infection in vivo. In Aim 2a, we will use a nanoluciferase-expressing LDV to perform body-wide imaging and identify the tissues that support LDV infection over time. In Aim 2b, we will hone in key tissues and identify the macrophage populations within these tissues that support LDV infection and determine how persistent arterivirus infection impacts recovery of target cell populations. Finally, in Aim 2c we will use FcRn-knockout mice to determine whether arteriviruses hijack FcRn’s physiologic role in placental biology, potentially explaining the high efficiency with which arteriviruses transmit vertically. This project will provide insights into novel mechanisms of viral entry, macrophage infection and dysfunction, viral persistence, and vertical transmission through the study of the neglected “pre-emergent” family of mammalian viruses, the arteriviruses.

Up to $615K

2031-03-31

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HiJAKing the System: Investigating the Impact Mechanisms of Low Variant Allele Frequency JAK2V617F Clone on the Pathobiology of Myeloproliferative Neoplasms

NCI - National Cancer Institute

PROJECT SUMMARY/ABSTRACT JAK2V617F (JAK2V/F) is one of the Clonal Hematopoiesis if Indeterminate Potential (CHIP)-associated mutations and a major driver of myeloproliferative neoplasms (MPN). JAK2V/F is present in diverse MPN phenotypes ranging from asymptomatic low-variant allele frequency (VAF) CHIP, erythroid-specific expansion in polycythemia vera (PV), platelet overproduction in essential thrombocythemia (ET), bone marrow (BM) scarring in primary myelofibrosis (PMF) or MPN transformation into acute myeloid leukemia (AML). Highly specific JAK inhibitors fail to provide curative outcomes of MPNs, therefore searching for alternative treatment strategies is critically needed. We recently created a traceable murine JAK2V/F MPN model in which the disease is induced in the unconditioned recipients (CD45.1) of BM transplantation (BMT) with a low-VAF JAK2V/F donor clone (CD45.2). Whole BMT was performed via a single injection of the JAK2V/F donor cells into the recipients, which resulted in development of a PV-like phenotype with an average chimerism of 2.7% in the recipient peripheral blood. Post-BMT, RNA-seq analysis of the sorted CD45.2+ BM cells showed an increase in transcripts specific to early erythroblast and myeloid cells, and downregulation of those specific to lymphoid (B, T, NK) cells. Unexpectedly, transcripts specific to myeloid cells and erythroblasts also increased in the sorted CD45.1+ BM cells not bearing JAK2V/F, suggesting the BMT recipients had a skewed hematopoiesis towards a myeloproliferative phenotype. Furthermore, RNA-seq analysis of the recipient BM stroma found a loss of osteo- mesenchymal transcripts, which was corroborated by a reduction of trabecular bone observed in µCT imaging. Based on these data, we hypothesize that JAK2V/F clone, even presented at low frequencies, profoundly impacts the host hematopoietic system as well as the BM stroma, thus contributing to the MPN and multiorgan dysfunction. To test this hypothesis we will use our developed BMT strategy and cell-type specific murine models- enabled single cell RNA sequencing coupled with secretome (cytokine/chemokine, proteome and metabolome) profiling to delineate the cellular and acellular factors that mediate pathogenic effects of the JAK2V/F clone on non-mutated hematopoietic cells (Aim 1). Using our established model of BMT w/o conditioning and DARLIN lineage tracing mouse line in serial BMT approach we will determine the MPN disease-inducing potential of JAK2V617F+ clone-exposed (primed) unmutated hematopoietic cells (Aim 2). Using mesenchymal progenitor (LepR+)-specific reporter mice as unconditioned BMT recipients, we will examine the impact of JAK2V/F clone on the differentiation and function of BM mesenchymal stromal cells (Aim 3). Our data indicate that JAK2V/F CHIP clone at low frequency induces profound and irreversible alterations in its microenvironment, which then prime pathogenic phenotype of the unmutated bystander cells. The outcome of this study will generate foundational information to explain why the JAK2V/F-targeted therapies are ineffective and inform new directions in MPN therapies.

Up to $689K

2031-04-30

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Hilarity for Charity — Alzheimer's Care Grants

Alzheimers carein-home carefamily support

Hilarity for Charity (HFC)

Grants for programs providing in-home care, adult day programs, and support groups for families affected by Alzheimer's.

$10K – $50K

2026-07-31

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Hillman City P-Patch Accessible Paths and Planning

Hillman City P-Patch

The Hillman City P-Patch garden community plans to reclaim the accessible gravel paths and develop an accessible gardening area at the site. The project also includes an update to their 2010 visioning plan and the initiation of a monthly serieis of events designed to engage the gardeners, neighbors and partner organizations.

Up to $15K

general

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Hillsborough County Arts — Project Grant

artsculturecommunity arts

Hillsborough County Arts

Project and operating grants for arts organizations and individual artists from Hillsborough County Arts. Supports visual, performing, literary, and media arts.

$2K – $50K

2026-12-31

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Hillsborough County Economic Development Grants

Hillsborough County Economic Development Department

Economic development incentives and grants supporting business growth, job creation, and workforce development in the Tampa/Hillsborough County area.

$10K – $200K

Business Developmentworkforce

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Hindu American Foundation Community Grants

Hindu American Foundation

Supports Hindu American community organizations, temple programs, and educational initiatives promoting Hindu heritage and interfaith dialogue.

$5K – $50K

Educationcommunity developmentinterfaith+1

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Hindu American Foundation Community Grants

Hindu American Foundation

Supports Hindu American advocacy, education, and community development. Promotes pluralism, religious liberty, and Hindu cultural heritage.

$5K – $50K

advocacyEducationcultural heritage+1

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Hinduja Foundation Grants

Hinduja Foundation

Supports education, healthcare, and community development in India and the UK.

$25K – $500K

Educationhealthcarecommunity development

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Hinesburg Comprehensive Energy Audit Program

Community DevelopmentEquity & Access

Public Service Department

Hinesburg Comprehensive Energy Audit Program

Up to $30K

2027-02-28

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HIPI CESU - Leadership, Coordination, and Adminsitrative Oversight for the Hawai'i Pacific Islands Cooperative Ecosystem Studies Unit

National Park Service

United State Department of the Interior, National Park Service (NPS) Notice of Intent to Award. This is not a request for applications. This funding opportunity is to provide public notice of NPS's intention to fund the following project activities without full and open competition. Task Agreement # P16AC01843 under Cooperative Agreement P14AC00637 with the University of Hawaii, Hilo, a partner under the Hawaii-Pacific Islands Cooperative Ecosystem Studies Unit, for project titled "HIPI Cesu - Leadership, Coordination, and Administrative Oversight for the Hawai'i Pacific Islands Cooperative Ecosystem Studies Unit"

Up to $31K

natural resources

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Hippo and Wnt pathway regulation of mammalian Muller glial cell reprogramming and proliferation

NEI - National Eye Institute

Retinal diseases such as glaucoma, macular degeneration, and diabetic retinopathy, as well as traumatic injury, result in loss of retinal neurons and thus sight, depriving many worldwide of one of our most valued senses. Thus, there is a critical need to devise strategies to restore lost retinal neurons, leading to vision recovery. Current efforts in retinal regenerative medicine are heavily invested in cell replacement approaches. However, it may also be possible to induce the mammalian retinae to undergo an intrinsic self-repair mechanism to regenerate neurons. The retinae of non-mammalian vertebrates, such as zebrafish, are known to exhibit the remarkable ability of retinal regeneration. Here, Müller glial cells (MGs) reprogram to proliferative, retinal progenitor-like cells that, in turn, differentiate into new photoreceptors, leading to restoration of vision. Unfortunately, for unknown reasons, mammalian MGs have lost this ability, or it is dormant. Our long-term goal is to identify the cellular and molecular mechanisms blocking mammalian MG-mediated retinal regeneration. By doing so, we may be able to devise strategies to bypass this system and thereby reawaken the regenerative potential of the mammalian retina. In this proposal, we will test the overarching hypothesis that transient modulation of the Hippo signaling pathway drives MGs into a progenitor-like state capable of generating new retinal neurons and MGs. To test this hypothesis, we will employ a multi-disciplinary approach using genetic loss- and gain-of-function experiments, fate mapping, and single-cell transcriptomics. Our specific aims will precisely determine the fate of proliferative MGs, which are non-responsive to Hippo pathway regulation, as being neurons and/or MGs. We will also determine how retinal damage triggers MG cell cycle entry prior to repression by Hippo. These data will provide an essential molecular entry point for further investigating novel methods to promote Müller glial cell-mediated retinal regeneration, and are likely to have a significant impact on the field of retinal regenerative medicine. We anticipate subsequent investigation into more translational, therapeutic methods to modulate Hippo pathway activity to promote retinal regeneration.

Up to $1.6M

2028-09-29

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Hire Heroes USA — Employment Program Grants

veteran employmentcareer servicesjob placement

Hire Heroes USA

Grants for veteran employment services including career coaching, resume assistance, and job placement.

$15K – $100K

2026-08-31

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Hispanic Serving Institutions: Equitable Transformation in STEM Education (ETSE)

U.S. National Science Foundation

Hispanic Serving Institutions (HSI) are an important component of the nation s higher education ecosystem and play a critical role in realizing the National Science Board Vision Report for a more diverse and capable science and engineering workforce. Aligned with this vision and the NSF Strategic Plan 2022 -2026 the goals of the NSF HSI Program are to: 1. Enhance the quality of undergraduate science, technology, engineering, and mathematics (STEM) education at HSIs. 2. Increase the recruitment, retention, and graduation rates of students pursuing associate s or baccalaureate degrees in STEM at HSIs. Meeting these goals requires institutions to understand and embrace their students strengths, challenges, identities and lived experiences. This can happen in many ways and across many areas of an institution. As such, the IUSE: HSI program provides multiple opportunities to support an institution s goal to become more student centered, including theEquitable Transformation in STEM Education (ETSE) competition. This competition includes the following tracks: Departmental/Division Transformation Track (DDTT) - New Institutional Transformation Track (ITT) Emerging Faculty Research Track (EFRT) - New HSI Program Resource Hubs (Hubs) This solicitation will also accept conference proposals and planning proposals, as defined by the PAPPG. The ETSE competition focuses on (1) institutional transformation projects that support HSIs in their effort to achieve equity in STEM education, and (2) the infrastructure the HSI-Net network of resource hubs which supports the overall program goals. Institutions are encouraged to consider how their HSI designation, and their organizational mission align to better support STEM success of all students. The ETSE competition welcomes proposals that look to implement and evaluate promising practices and/or conduct research related to broadening participation or improving recruitment, retention, graduation, and other successful outcomes in STEM undergraduate education. The ETSE solicitation supports projects designed to catalyze change and help HSIs meet students where they are, accounting for their assets and the challenges they may face. Identities and experiences are not determined solely by membership in a single monolithic population of students (e.g., Hispanic, first-generation, commuter, etc.). Consequently, institutions are expected to use institutional data to identify equity gaps, identify areas of need, and unpack the factors that shape students individual identities and shared experiences. The perspectives gained from this data should be central to the design of the proposed project. Please see below for specific information about each track. While proposals are focused on mechanisms for transforming undergraduate STEM education, projects should also consider student voices and include mechanisms to aggregate and analyze existing student feedback and collect quantitative and qualitative student data throughout the life of the proposed project.

sciencetechnology

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Hispanic-Serving Institutions Education Grants Program

National Institute of Food and Agriculture

To promote and strengthen the ability of Hispanic-Serving Institutions to carry out higher education programs that attract, retain, and graduate outstanding students capable of enhancing the nation s food, agricultural, and natural resource scientific and professional work force. Proposed projects should strengthen the ability of HSIs to enhance their Hispanic-serving capacity and attract, retain, and increase the number of Hispanics that graduate in food, agriculture, nutrition, and natural resources.

Up to $1.1M

Agriculturerural development

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HISTOLOGY INSTRUMENTS (IFB)

LEICA MICROSYSTEMS INC

Laboratory and Measuring and Observing and Testing Equipment

2026-11-09

workforce

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Histone methyltransferase, Setd2, in substance use disorders

NIDA - National Institute on Drug Abuse

Substance use disorders (SUDs) are characterized by long-lasting neuroadaptations, including changes in gene expression and the epigenome. The relevance of the epigenome in SUDs has been shown using overexpression or inhibition of epigenome modifying enzymes. However, such manipulations cannot distinguish between direct and indirect action of epigenetic modifications at a target gene. To address this, we apply locus-specific epigenetic editing with CRISPR/dCas9 to establish the direct causal relevance of a specific epigenetic modification to SUDs. We and others find that the epigenetic enzyme, SET domain containing 2 (Setd2), regulates cocaine-induced mouse behavior, gene expression, and alternative splicing. Setd2 specifically writes H3K36me3, a histone modification associated with active transcription and alternative splicing, which is altered in mouse brain regions by cocaine exposure. We and others have identified a role for Setd2/H3K36me3 in alternative splicing which mirrors cocaine-induced splicing events and is associated with cocaine-related behaviors in mice. We find that overexpression of Set2 in mouse brain reward regions increases H3K36me3 and drives mouse cocaine reward behavior. Together, these data provide strong evidence for Setd2/H3K36me3 in mediating the behavioral response to cocaine in mice through epigenetic and alternative splicing events. The overall goal of this proposal is to establish that Setd2 inhibition attenuates cocaine self-administration through cell-type specific regulation of alternative splicing and gene expression. First, we will determine both sufficiency and necessity of Setd2 to drive cocaine behavior, using pathway-specific Setd2 overexpression and small-molecule Setd2 inhibition (Setd2i), respectively. We hypothesize that NAc Setd2 inhibition will reduce cocaine self-administration. Second, we will define the pathway-specific effects of Setd2 on behavior, H3K36me3 and gene expression by cell-type specific epigenomic profiling and targeted epigenetic editing. Third, we will interrogate mechanisms by which Setd2 regulates alternative splicing by identifying interacting RNA-binding proteins (RBPs). Finally, this proposal will investigate non-enzymatic roles of a histone modifying enzyme in addiction. Recent studies and our preliminary data suggest non-enzymatic function of Setd2 through protein binding domains. We will distinguish Setd2 and H3K36me3 using combinatorial Setd2 overexpression, Setd2i, and epigenetic editing.

Up to $690K

2031-02-28

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Historians Roundtable Panel Discussion

National Park Service

This project will provide a historians roundtable panel discussion and follow-up reports for the purpose of transferring knowledge of historical expertise and current scholarship on multiple historical themes related to Pullman National Monument and National Historic Landmark. It involves working with local, state, and non-profit partners associated with Pullman. The Historians Roundtable Panel Discussion project is designed to collaborate with leading historians associated with historical themes at Pullman who can provide historical knowledge based on current scholarship and who will transfer that knowledge through a panel discussion and written reports. The information presented through this discussion will be made publicly available through a variety of sources, and will further the interpretive capabilities of local museums, educators, and the park unit.

$1 – $35K

Education

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Historic American Landscapes Survey Historical Report World War I Cemeteries

National Park Service

An award to a large format photographer for the purpose of completing documentation of the Seven World War I cemeteries managed by the American Battle Monuments Commission in France and Great Britain Recording Project, in accordance with final specifications based on the outline scope of work included below and as approved by the NPS.

$1 – $50K

other

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Historic and Contemporary Tribal Uses and Issues in the Lower Columbia Region

National Park Service

United State Department of the Interior, National Park Service (NPS) Notice of Intent to Award. This is not a request for applications. This funding opportunity is to provide public notice of NPS's intention to fund the following project activities without full and open competition. Cooperative Agreement P17AC01691 with Portland State University, a partner under the Pacific Northwest Cooperative Ecosystem Studies Unit, for project titled "Historic and Contemporary Tribal Uses and Issues in the Lower Columbia Region"

Up to $24K

Environmentalsustainability

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Historic Central District Seattle Documentary

Multimedia Resources and Training Institute (MMRTI)

Multimedia Resources Training Institute will create a 1 hour documentary, 30 photo portraits, and other multimedia projects produced by youth interns. They will focus on Seattle's Central Area, a Historic Arts and Cultural District. The project will empower youth to act as community advocates through photography and video.

Up to $20K

Educationarts

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Historic Inscription Documentation

National Park Service

Historic Inscription Documentation

$1 – $133K

information technologytechnology

Free to search & build · $99 one-time to unlock the application pack · No subscription

Historic Marconi/RCA Radio Sites Inventory and Museum Collections Planning

National Park Service

United State Department of the Interior, National Park Service (NPS) Notice of Intent to Award. This is not a request for applications. This is to provide public notice of the NPS's intention to fund the following project activities: Task Agreement P16AC01388 under the previously single source justified master Cooperative Agreement P14AC01640 with the Maritime Radio Historical Society for the project titled "Historic Marconi/RCA Radio Sites Inventory and Museum Collections Planning."

Up to $57K