Grants

Hecker and Company, Inc.

Engineering and Research and Technology Based Services

2027-06-01

technology

Free to search & build · $99 one-time to unlock the application pack · No subscription

Heifer International Community Development Grants

Heifer International

Supports sustainable agriculture, livestock programs, and community development to end hunger and poverty. Works with smallholder farmers in 21 countries.

$25K – $500K

Agriculturefood securitycommunity development+1

Free to search & build · $99 one-time to unlock the application pack · No subscription

Heifer International Sustainable Agriculture Grants

Heifer International

Supports smallholder farmers in 21 countries through livestock, training, and community development programs to end hunger and poverty sustainably.

$25K – $500K

Agriculturelivestockfood security+1

Free to search & build · $99 one-time to unlock the application pack · No subscription

Heightened cholesterol efflux by lymph node macrophages facilitates their transfer of large lymph-borne antigen to resident dendritic cells

NIAID - National Institute of Allergy and Infectious Diseases

PROJECT SUMMARY High-density lipoproteins (HDL) perform the essential function of removing excess insoluble cholesterol from cells. The process is so important that abnormal HDL levels were recently linked to all-cause mortality including for non-cardiovascular diseases such as cancer and to the severity of infectious disease. However, due to the focus on HDL in cardiovascular disease, what cell types and biological processes require homeostatic cholesterol efflux remains unknown. Humans lacking two cholesterol transporters that facilitate cholesterol efflux to HDL, present with yellowed and lipid-laden lymphoid tissues without developing premature cardiovascular disease. Preliminary data shows that specific deletion of these transporters in the macrophages causes mice to develop profound lipid accumulation in the medullary sinus of the lymph node even on a diet without excess cholesterol. Furthermore, fluorescently tagged HDL developed in the Randolph laboratory is enriched in the medullary sinus and binds to macrophages. Medullary sinus macrophages (MSMs) filter molecules draining from tissues in the lymph, including apoptotic cell products. The capture of particulate and apoptotic debris would introduce excess cholesterol to MSMs but also provide MSMs with a complete survey of antigens in the lymph. Current dogma states that antigen is acquired and presented by migratory dendritic cells (DCs) or can be directly captured by resident DCs if it is small enough to enter the T cell zone of the lymph node (LN). Studies of viral infection found that DCs resident to the lymph node were essential to produce a CD8 T cell response, but it is unclear how these resident DCs could acquire antigens that are too large to enter the T cell zone. This fellowship proposes that MSMs capture particulate antigens and transfer them to resident DCs but rely on HDL-mediated cholesterol efflux to clear accumulating cholesterol. Previous work showed that macrophages in the spleen directly transfer antigen to DCs and that LN macrophages are required for developing a tumor-protective CD8 T cell response against injected dead cell-associated antigen independent of migratory DCs. The proposed work will test whether MSMs transfer large model antigens to resident DCs in the lymph node using novel genetic approaches to target MSMs and imaging approaches to capture the interactions between MSMs and DCs. It will also define interactions between LN macrophages and HDL for the first time using a novel fluorescently tagged HDL and asses the contribution of dead cell cholesterol to MSMs. MSMs in tumor-draining LNs have an elevated signature of lipid handling, thus the proposed study will test if mice with cholesterol efflux-impaired macrophages are unable to form a cytotoxic T cell response against an immunogenic tumor. The proposed fellowship will take place under the mentorship of Gwendalyn Randolph an expert in macrophages, DCs, lymphatics, and HDL with support from a committee of experts in the exceptional environment of the Washinton University Immunology program. The proposed fellowship will train the awardee to be a skilled immunologist with an interdisciplinary twist that will aid in understanding complex biology at the root cause of disease in their future scientific career.

Up to $37K

2029-03-31

Free to search & build · $99 one-time to unlock the application pack · No subscription

Heising-Simons Foundation — Climate & Clean Energy

Heising-Simons Foundation

Supports policy research and advocacy for clean energy and climate solutions.

$100K – $2M

clean energyclimate policyenergy efficiency

Free to search & build · $99 one-time to unlock the application pack · No subscription

Heising-Simons Foundation — Early Learning

early learningquality improvementchild care

Heising-Simons Foundation

Funds quality early learning programs and systems improvement.

$50K – $1M

By invitation

Free to search & build · $99 one-time to unlock the application pack · No subscription

Heising-Simons Foundation Climate & Clean Energy

Heising-Simons Foundation

Funds clean energy transition, climate policy, and environmental justice with focus on decarbonizing the energy and transportation sectors.

$100K – $1.5M

climateclean energyenvironmental justice+1

Free to search & build · $99 one-time to unlock the application pack · No subscription

Heising-Simons Foundation Science Grants

Heising-Simons Foundation

Supports fundamental physics, astronomy, and mathematics research, and initiatives to increase diversity in STEM fields.

$100K – $2M

sciencephysicsastronomy+1

Free to search & build · $99 one-time to unlock the application pack · No subscription

Helen J. Serini Foundation: Small Grant Programs

Helen J. Serini Foundation

The Helen J. Serini Foundation supports innovative interventions that remove or address root causes of systemic barriers to health, safety, shelter, and opportunity in the communities where we work and live. The small grants program supports specific projects: personal/professional development and support; offsetting harm done by past fiscal sponsors; or for support of specific work around diversity, equity, and inclusion practices. Applications are open on a rolling basis. Click here for more information .

HealthHousingsocial justice

Free to search & build · $99 one-time to unlock the application pack · No subscription

Helen Keller International — Vision & Disability Programs

vision healthnutritiondisability prevention

Helen Keller International

Grants supporting programs for vision, nutrition, and neglected tropical diseases in underserved communities.

$50K – $300K

2026-09-15

Free to search & build · $99 one-time to unlock the application pack · No subscription

Helicopter Acquisition → Purchase No Financing

Bell Textron Inc.

Reconnaissance helicopters

2028-07-31

general

Free to search & build · $99 one-time to unlock the application pack · No subscription

HELICOPTER, APACHE GUARDIAN AH-64E; FAIRING, AIRCRAFT

DEPT OF DEFENSE.DEFENSE LOGISTICS AGENCY.DLA AVIATION.DLA AV RICHMOND.DLA AVIATION

HELICOPTER, APACHE GUARDIAN AH-64E; FAIRING, AIRCRAFT

2027-04-27

general

Free to search & build · $99 one-time to unlock the application pack · No subscription

Helmets to Hardhats — Building Trades

veteran apprenticeshipconstruction tradescareer transition

Helmets to Hardhats

Grants for apprenticeship and training programs connecting transitioning military to careers in building and construction trades.

$10K – $75K

2026-07-01

Free to search & build · $99 one-time to unlock the application pack · No subscription

Helmsley Charitable Trust Health Program

Helmsley Charitable Trust

Supports type 1 diabetes research, Crohn's disease treatment, and rural healthcare access. Major funder of healthcare infrastructure in underserved areas.

$100K – $3M

Healthrural healthcarediabetes+1

Free to search & build · $99 one-time to unlock the application pack · No subscription

HelpAge International — Global Grants

global agingolder persons rightsinternational development

HelpAge International

Grants for programs supporting older people's rights, health, and economic security in developing countries.

$25K – $200K

2026-10-01

Free to search & build · $99 one-time to unlock the application pack · No subscription

Helping Hands for Honu'ea

National Park Service

United State Department of the Interior, National Park Service (NPS) Notice of Intent to Award. This is not a request for applications. This funding opportunity is to provide public notice of NPS's intention to fund the following project activities without full and open competition. Cooperative Agreement P17AC01306 with the University of Hawaii, a partner under the Hawaii-Pacific Islands Cooperative Ecosystem Studies Unit, for project titled "Helping Hands for Honu'ea"

Up to $34K

rolling

natural resources

Free to search & build · $99 one-time to unlock the application pack · No subscription

Helping Veterans with obstructive sleep apnea determine "what matters most" in choosing a treatment option: a randomized trial

NIH

Significance to VA: Obstructive sleep apnea (OSA) poses a treatment challenge to older Veterans. A common cause of daytime sleepiness and poor sleep quality and a risk factor for cardiovascular disease, cognitive impairment, and mortality, OSA is typically treated with medical devices (e.g., positive airway pressure, oral appliances). Unfortunately, therapy nonacceptance is common. Devices can be uncomfortable and device maintenance problematic, especially in the context of comorbidity (e.g., limited mobility). Typical OSA care begins with telling patients what is wrong with them rather than asking what matters most to them (i.e., their priorities). The objective of this trial is to evaluate the benefits of the Decide2Rest+ program—a 4 session program (patient decision aid plus sessions directed at treatment adherence) for improving patient reported outcomes (PROs) and aligning OSA care for older adults with their health priorities and values. Our central hypothesis is that it will improve the “inputs” (e.g., knowledge, patient priorities) needed to move towards patient priority-directed care, increase activities associated with this care (e.g., decisions that reflect each patient’s priorities), and optimize adherence and PROs. The rationale is that understanding how disease- specific treatments affect overall health and clarifying priorities are critical to improving the selection of treatments with features that matter most to the Veteran and are most likely to improve sleep quality for the Veteran and to engaging in behaviors necessary to adhere to a chosen therapy. The proposed program aims to improve sleep PROs among older Veterans with OSA by helping them align priorities with their care, which is a VA national priority. The work is also responsive to the 2024 VA/DoD Clinical Practice Guidelines for OSA and Insomnia, which recommend shared decision making when initiating OSA therapy. Innovation and Impact: This alternative, person-centered approach is a key aspect of the VA's “age-friendly” transformation and could set a different tone for OSA treatment and adherence among older Veterans. Our goal is to align OSA-related treatment decisions with patients’ health priorities to improve PROs and support’ use of OSA therapy in older Veterans newly diagnosed with OSA. Specific Aims: The aims of the study are (1) to determine whether the Decide2Rest+ program will improve patient-reported sleep disturbance and daytime sleepiness, (2) to determine whether Decide2Rest+ improves OSA device therapy acceptance/adherence, and 3) assess the impact of Decide2Rest+ on the congruency between decisions and health priorities/values. Methodology: We propose a 5-year multi-site randomized controlled trial of Veterans aged 50+ years with untreated OSA (n=128) comparing the Decide2Rest+ to an active-control program that includes behavioral adherence components from a clinical program that is currently used in our sleep center. We used a user- centered approach to develop and refine the decision aid. It provides a mechanism for helping patients clarify what treatment feature matter most to them, reflect upon decisional needs, and identify their health priorities. Path to Translation/Implementation: This phase II trial (T2) will assess the efficacy of the DecideRest+ program for improving PROs and acceptance/adherence to OSA therapy. We use the Ready, Willing, and Able Model as framework for guiding implementation. We will obtain input from Veterans and clinicians and collect implementation measures. In prior related projects that inform our line of research, we have used strategies that will facilitate implementation including sending OSA educational links through secure messages to patients, providing an OSA decision aid in waiting rooms of sleep clinics, and training providers to deliver our behavioral interventions using the training model for the VA’s cognitive behavioral therapy for insomnia rollout. The proposed project in combination with our prior research inform a future type 2 hybrid design trial that will test the effectiveness of the program and potential for implementation (T3).

2030-03-31

Free to search & build · $99 one-time to unlock the application pack · No subscription

Hematopoiesis

NHLBI - National Heart Lung and Blood Institute

Abstract Support is requested for a Keystone Symposia conference entitled “Hematopoiesis,” organized by Drs. Vijay G. Sankaran, Anna E. Beaudin and Esther Obeng, with scientific programming input from Keystone Symposia. The meeting will take place February 23–26, 2026 at the Keystone Resort in Keystone, Colorado, USA. Hematopoiesis is a fundamental biological process that underlies the production of all blood and immune cells, and consequently drives immune function, oxygen transport, and tissue homeostasis. Alterations in hematopoiesis can lead to a wide spectrum of disorders and conditions ranging from anemia to immunodeficiencies, inflammatory disorders and blood cancers. Given the vital role of hematopoiesis in health and disease, this conference will explore the molecular and cellular mechanisms that govern blood cell development and maintenance, highlight the latest technological advances in the field and underscore the broader

Up to $12K

2027-01-31

Free to search & build · $99 one-time to unlock the application pack · No subscription

Heme regulates neurocognition by modulating Tau pathology in sickle cell disease

NINDS - National Institute of Neurological Disorders and Stroke

Project Summary Majority of Individuals with sickle cell disease (SCD) experience neurocognitive complications including cerebrovascular lesions with poor performance in learning and memory functions. Cognitive impairment is a risk factor of dementia. The vascular contributions to cognitive impairment and dementia (VCID) in SCD have not been reported. Hemolysis within the cerebrovascular space representing severe anemia, is a strong predictor of neurocognitive impairment in SCD. Excess circulating free heme, a byproduct of intravascular hemolysis, is implicated for multiorgan complications in SCD. However, the mechanistic approaches interpreting the heme- driven pathogenesis of VCID linking cerebral microvasculature with cognitive impairment in SCD are lacking. In pilot studies, we discovered that heme instigates phosphorylation of microtubular associated protein Tau (pTau) in the cerebrovascular endothelium of transgenic SCD mice. Free heme activates endothelial toll-like receptor 4 (TLR4) and insulin growth factor binding protein 3 (IGFBP3) associated with Tau phosphorylation. Sickle bone marrow chimera mice deficient in TLR4 had reduced pTau associated with impeded IGFBP3 expression in the cerebrovascular endothelium. Moreover, heme induced the intercellular protein transporter, low-density lipoprotein receptor -1 (LRP1) in the microvessel adjacent astrocytes, where pTau was accumulated following heme challenge. Based on these preliminary data, we formulated the overarching hypothesis that heme triggers phosphorylation of endothelial Tau that is accumulated in the astrocytes via LRP1 and promotes neuroaxonal damage and cognitive impairment in SCD. In Aim 1, we will perform magnetic resonance angiography (MRA), diffusion tensor and weighted imaging (DTI/DWI), immunohistopatholgy, cognitive testing (Y-maze and novel object recognition), and bone marrow trasplantation (BMT) to assess the role of Tau in the development of heme-induced cognitive impairment in sickle mice. In Aim 2, we will determine whether TLR4-IGFBP3 signaling stimulates Tau phosphorylation. Aim 3 will determine the role of LRP1 in pTau accumulation and calcium signaling in the astrocytes. Overall, this study aims to determine the role of heme in the pathogenesis of neurovascular damage and cognitive impairment, delineating an innovative VCID pathway in SCD.

Up to $515K

2031-03-31

Free to search & build · $99 one-time to unlock the application pack · No subscription

Hemogenic mesoderm heterogeneity, regulation, and function

NHLBI - National Heart Lung and Blood Institute

PROJECT SUMMARY / ABSTRACT The mammalian hematopoietic system develops in the early embryo through a series of spatio-temporally separated programs, each of which harbors different functional potential, culminating in the specification of the hematopoietic stem cell (HSC). The overall goal of our research is to understand the origins and development of each program in the embryonic hematopoietic system. Where does each developmental program originate from? How does it develop? Why is each different? And, is there clinical utility to embryonic cell types that are no longer found in adult donors? Dr. Sturgeon's prior work has focused on these questions, through the lens of human pluripotent stem cell (hPSC) directed differentiation, leading to the pivotal discovery of hematopoietic commitment occurring very early, within nacent mesoderm, referred to as hemogenic mesoderm (HM). The proposed research program builds upon Dr. Sturgeon's productive research track record to delineate the molecular and transcriptional mechanisms by which HM gives rise to the embryonic hematopoietic programs. Dr. Sturgeon has shown that HMs are found in multiple immunophenotypically distinct subsets, each of which are specified in ACTIVIN/NODAL- and/or WNT-dependent processes. Further, Dr. Sturgeon has found that each HM first gives rise to a hemogenic endothelial cell (HEC) population, in VEGF- and RA-dependent processes. HM express genes associated with early gastrulation, yet each HM is highly restricted, ultimately each giving rise to a specific hematopoietic program, such as yolk sac-like erythromyeloid progenitors (EMPs), or intra- embryonic-like definitive multipotent progenitors (MPPs). Finally, Dr. Sturgeon has found that hematopoietic lineages common across multiple HM populations harbor distinct functional properties from one another. Building off these groundbreaking findings, the research program is divided into 3 projects. The first project will delineate the signal, transcriptional, and epigenetic mechanisms underlying how each hematopoietic program is specified and functionally restricted. These studies will improve our ability to obtain progenitors from each program, including the HSC. The second project will define the mechanisms regulating how HECs give rise to different lineages. Finally, the third project will continue our studies on the translational potential of hematopoietic lineages from each developmental program. Collectively, these studies will provide us with a more comprehensive understanding of hematopoietic development. This is of fundamental importance to basic biology, and the insights generated from these studies will have clinical implications, such as the in vitro generation of HSCs or other embryonic hematopoietic lineages for a wide array of regenerative medicine applications.

Up to $1.2M

2033-01-31

Free to search & build · $99 one-time to unlock the application pack · No subscription

Henry Ford Health Community Health Investment

Henry Ford Health

Invests in community health programs in Southeast Michigan, addressing health equity, social determinants, and chronic disease in underserved communities.

$5K – $300K

health equitysocial determinantschronic disease+1

Free to search & build · $99 one-time to unlock the application pack · No subscription

Henry Luce Foundation Religion in Public Life Grants

Henry Luce Foundation

Supports understanding of religion's role in public life through academic research, journalism, and public programming. Major funder of religious studies.

$50K – $500K

religion in public liferesearchjournalism+1

Free to search & build · $99 one-time to unlock the application pack · No subscription

Henry M. Jackson Foundation — Elder Health Research

elder health researchclinical trialshealth services

Henry M. Jackson Foundation

Grants for research advancing healthcare for aging populations including clinical trials and health services research.

$50K – $300K

2026-11-01

Free to search & build · $99 one-time to unlock the application pack · No subscription

Hepatic Lymphatics and the Immune Response in Acute Liver Failure

NIAID - National Institute of Allergy and Infectious Diseases

PROJECT SUMMARY Though the liver produces most of the lymph in the body, the role of hepatic lymphatics in liver disease is relatively less studied. While it is recognized that alterations in hepatic lymphatics cause ascites formation in chronic liver disease like cirrhosis, its contribution to acute liver failure (ALF), like that caused by drugs such as acetaminophen (APAP) are not well characterized. An APAP overdose is the most common cause of ALF in the United States, partly due to the short therapeutic window of the only FDA approved antidote, N-acetylcysteine (NAC). Excess APAP induces centrilobular necrosis, and a failure of inherent liver regeneration in a significant percentage of patients, especially after a severe overdose, causes ALF. Thus, insight into mechanisms of liver recovery which are compromised in patients with ALF, would allow their targeting to complement NAC treatment. One such beneficial phenomenon is the innate immune response induced by hepatocyte necrosis. Though interaction between the infiltrating immune cells and surviving hepatocytes facilitates their regeneration, repopulation of areas of necrosis also requires an orderly exit of the infiltrating immune cells to allow coordinated reestablishment of liver infrastructure and lymphatics to regain functional homeostasis. The lymphatic system is a central mode of immune cell emigration from tissues, and specific pro-resolving lipid mediators (SPMs) facilitate resolution of inflammation. However, their role in immune cell exit after acute APAP-induced ALF is unknown. Our preliminary data shows transient changes in hepatic lymphatics after APAP overdose with elevations in SPMs, which are known to facilitate lymphangiogenesis and immune cell clearance. Blocking lymphangiogenesis after an APAP overdose also extended hepatic residency of immune cells. Treatment with Wharton's Jelly mesenchymal stem cells (WJMSC) which are cleared for human use, also enhanced liver recovery in the mouse model with elevation in circulating VEGF-D, which activates lymphangiogenesis. This data led to the hypothesis that hepatic lymphatics play a critical role in immune cell clearance during liver recovery from an APAP overdose, a process facilitated by SPMs which could be targeted by WJMSC treatment to enhance liver recovery. This hypothesis will be tested by 1) evaluating mechanisms of immune cell clearance through hepatic lymphatics after acute APAP overdose, and 2) examining the role of SPMs and immune cell clearance as mechanisms facilitating recovery after delayed treatment with WJMSC. Collectively, we will define the molecular mechanisms responsible for efficient immune cell exit through hepatic lymphatics after reconstruction of areas of hepatic necrosis and study the consequence when this exit is compromised such as ALF. We will also evaluate a therapeutic intervention to enhance recovery, which can be rapidly translated to the clinic.

Up to $426K

2028-01-31