Grants

City of Richmond

Brittany Crepes Inc

Dept. of the Army -- USAMRAA

BROAD AGENCY ANNOUNCEMENT (BAA) for Extramural Biomedical and Human Performance Research and Development Department of Defense

DEPT OF DEFENSE.DEPT OF THE AIR FORCE.AIR FORCE MATERIEL COMMAND.AIR FORCE RESEARCH LABORATORY.FA8650 USAF AFMC AFRL PZL AFRL/PZL

Broad Agency Announcement: Joint All Domain Persistent Adaptive Collaborative Technologies II (JADPACT II)

NIAID - National Institute of Allergy and Infectious Diseases

Abstract VIVA Viral Vaccines is developing a vaccine platform that leverages multiple innovations to meet key requirements for the rapid development and deployment of highly protective, broad-spectrum, distribution- enabled vaccines against seasonal and pandemic viral threats. Influenza is a serious public health concern, causing an estimated 1 billion infections and 650,000 deaths globally each year and accounting for 65% of the economic burden from all vaccine-preventable diseases. Current influenza vaccines suffer from several drawbacks, including the inability to protect against heterologous strains. Thus, vaccines must be reformulated and administered annually, and are only 10-60% effective. Additionally, there is growing concern for a potential antigenic shift resulting in the emergence of a new pandemic strain, and there is no way to predict these shifts or the resulting strains, as current vaccines offer no protection against pandemic influenza. VIVA Viral offers a solution through a novel vaccine and platform that targets the influenza neuraminidase (NA) protein, an enzymatic tetramer that cleaves sialic acid to release viral particles from host cells. The hemagglutinin protein (HA) is the target of current influenza vaccines and has a high potential for mutations that lead to immune escape. NA is highly conserved within serotypes however, and NA vaccines are known to provide broad heterologous immunity against diverse influenza strains. NA production is low in mammalian cells though, leading these vaccines to be produced in insect cell lines, which exhibit major glycosylation differences. VIVA has enabled efficient production of multivalent virus-like particles (VLPs) in mammalian cells that contain NA serotypes found in seasonal human influenza A strains. Ultimately, this allows for the production of VLPs in mammalian cells via presentation of viral glycoproteins in native conformation on particles that act as viral mimics, which enhances the resulting immune response. In this Phase I STTR, we will evaluate our multivalent NA-based vesicular stomatitis virus (VSV) vaccine platform in mice to evaluate the breadth of immune responses and then in ferrets against human challenge strains. The Specific Aims of this project are: 1. VIVA will produce multivalent VSVs in mammalian cells using NAs for N1, N2, influenza B, and avian influenza N1. The quality of the resulting VSVs will be evaluated using western blots, enzymatic activity assays, flow cytometry/virometry, and electron microscopy; 2. Mice will be vaccinated with the multivalent VSV vaccines and infected with homologous and heterologous influenza strains to evaluate neutralizing antibody response and protective effects; and 3. Ferrets will be vaccinated with the VSV vaccine and then challenged with homologous and heterologous human influenza strains. Study endpoints will include weight loss, survival, neutralizing antibody titers, lung viral loads, and signs of lung pathology.

United Indians of All Tribes Foundation

Build out broadband capabilities to extend to the Daybreak Star Indian Cultural Center. Update the outmoded technology infrastructure at the center to improve internet access and deliver a series of digital literacy workshops to serve the diverse, Native American community.

Public Service Department

Broadband Construction Grant: NEKCV CG4

Sherman County

Broadband Fiber Project

SouthEast Effective Development

Over the next twelve months Broadcasting SE Seattle Voices will educate & empower SE Seattle residents to produce community radio programs for KVRU 105.7 FM. The project includes: the development of a training program; the purchase of mobile recording and editing equipment for community use, and the equipment to broadcast live community programs. The equipment will be purchased and the training programs will be developed between September and December of 2018. The first series of classes is scheduled to begin in January of 2019, thereafter they will occur quarterly.

NSF

This grant fosters excellence and promotes student engagement and participation at the 7th Annual Learning for Dynamics and Control (L4DC) Conference, an event fostering interdisciplinary research at the intersection of machine learning, dynamical systems, control theory, and reinforcement learning. L4DC is committed to expanding the boundaries of model-based design through the integration of massive real-time data, both temporal and spatial, prompting a necessary reevaluation of established disciplinary foundations. L4DC 2025 will feature an array of presentations, including keynote addresses, oral presentations, and poster sessions, with a special emphasis on contributions that bridge multiple research domains. By facilitating these intersections, the conference not only advances the scientific area but also fosters a vibrant community where students and seasoned researchers collaboratively push the frontiers of knowledge in dynamics and control. The objective of this NSF-funded initiative is to substantially broaden student involvement in L4DC and enrich their academic and professional development, with a particular focus on students from underrepresented backgrounds. This grant will provide comprehensive support through several targeted initiatives. First, 25 to 40 travel grants will be offered to ensure broad student participation from across the country. These grants are aimed at students who might otherwise be unable to afford attendance, thus fostering a more inclusive academic environment. Additionally, the conference will host Industry Booths and facilitate networking events, providing critical career insights and networking opportunities that students can use to bridge the gap between their academic pursuits and future professional roles. By aligning with NSF's broader goals, this award supports the integration of education and research, preparing a new generation of researchers equipped to tackle emerging challenges at the crossroads of learning, dynamics, and control. This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

NIDCR - National Institute of Dental and Craniofacial Research

PROJECT SUMMARY/ ABSTRACT (Project 1 BETTER TMD) C-TMD IMPACT Research Project 1 refers to Broader Evaluation of TMD Treatment Efficacy & Response (BETTER-TMD) and will address the misdiagnosis and suboptimal treatment decision gaps in the TMDs. The overall goal of this project is to define and predict which existing treatments are likely to be most effective for specific patients from a whole-person perspective, considering their symptoms and psychosocial context. The proposed study leverages a custom-developed app, MyDocNote, to collect real-world, structured, patientreported treatment outcome data. These outcomes will be paired with de-identified, highly structured data on signs, symptoms, and diagnosis. Our preliminary studies have demonstrated the dinical utility of machine learning (ML) methodology to create a TMD orofacial pain {TMD-OFP) predictive diagnostic algorithm using data collected from 1,020 patients seen at the USC TMD-OFP clinic. We also showed the potential effectiveness of an algorithm to predict various TMD-OFP diagnoses based on clinical signs and symptoms. For this U54 phase, we propose to scale up the pilot work described above and add longitudinal treatment outcome data to our dataset as we seek to develop additional algorithms to predict optimal, individualized treatment decisions. This scale-up will be achieved by expanding our data collection to 19 sites across the US, including 4 university medical centers and 15 clinical private practice sites. All collected signs and symptoms data from these patients will be converted into a structured database format and then made available through the FaceBase Hub with appropriate human subject protections, so we and other interested researchers can conduct further analyses. We project to collect data from up to 1,000 patients per year, for a target total of 5,000 over the 5-year performance period. Our guiding hypothesis is that collecting and analyzing a large, longitudinal, highly structured, whole-person dataset associating clinical signs and symptoms with treatment outcomes will lead to algorithms that can accurately stratify patients and identify the best individualized treatments. To test this hypothesis, three specific aims are proposed. Aim 1 will establish a set of common data elements {CDEs) to characterize the phenotypic traits and treatment outcomes of TMD-OFP patients. Aim 2 will collect a large longitudinal, structured dataset of patient treatment outcomes using our mobile app, MyDocNote. Aim 3 will analyze patient data to improve diagnosis and treatment decision-making for TMDOFP. Successful completion of these Specific Aims will deliver: 1) a large-scale, longitudinal, structured, and whole-person database of TMD-OFP signs, symptoms, and treatment outcomes; 2) decision-making algorithms for diagnosis and treatment based on data analyses including ML methodology. Ultimately, these can form the basis of a real-time point-of-care system to support clinicians in diagnosing TMDs and planning treatment.

Town of Mt. Lake Park

Broadford Road Pump Station

Town of Mt. Lake Park

Broadford Road Pump Station

The Center for Book Arts, Inc.

Broadsides Reading Series - Writers Fees & Promotion

City of Seattle — Neighborhood Matching Fund

Renovate existing school playground and play areas which will benefit both the school and the surrounding neighborhoods, including the Bitter Lake Community Center.

Greenwood-Phinney Greenways

Greenwood-Phinney Greenways in collaboration with the Seattle Department of Transportation, (SDOT), will build a Home Zone pilot project in the Broadview Neighborhood between North 130th and North 125th Streets and between Greenwood Avenue North and Aurora Avenue North. The main purpose for the Home Zone is to provide a basic framework of traffic-calming treatments. This project will be completed by August 31, 2021.

BroadviewPrepares

The Broadview Hubs need a refresh and some new gear. Our plan is to build community around the subject of preparedness. Gathering neighbors together to practice supporting one another during the city-wide drill on June 1st. Their efforts will help us refresh and purchase the necessary gear for an efficient activation.

NYC Department of Cultural Affairs

Broadway Advocacy Coalition, Inc.

NYC Department of Cultural Affairs

Broadway Bound Kids

NYC Department of Cultural Affairs

Broadway Dance Lab

NYC Department of Cultural Affairs

Broadway for Arts Education, Inc.

Symphony Space

Broadway Plus!

DEEP

Brodie Park Restrooms

State of Maryland

Brome Plantation Slave Quarter

NYC Department of Cultural Affairs

Bronx Arts Ensemble