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National Institutes of Health

The National Institute of Neurological Disorders and Stroke (NINDS) is interested in supporting ambitious research projects to elucidate mechanisms of neurodegeneration in Alzheimer s disease-related dementias (ADRD) organized as a Center without Walls consortium. NINDS Centers without Walls are collaborative research networks that bring together diverse expertise from different institutions to tackle complex neurological problems that are not tractable by individual research projects.This program is considering using an activity code, such as the RM1, that enables interdisciplinary research consortia capable of identifying and characterizing novel ADRD mechanisms. Teams may include cross-disciplinary and cross-specialty expertise to address the complex co-pathologies, mixed etiologies, and disease heterogeneity in ADRD.This program is anticipated to support teams that can combine multiple approaches, such as state-of-the-art technologies, disease-relevant models, clinical science, and human specimens, to investigate unique disease mechanisms and identify new therapeutic targets, biomarkers, and other factors influencing ADRD susceptibility, resilience, and pathology. One awardee team would serve as a coordinating center for all awardees to facilitate recurring meetings, data harmonization and sharing, cross-site communication, and support the implementation of inter-laboratory rigor and reproducibility plans.This program is informed by key priorities from the ADRD Summit 2025, including embracing ADRD complexity and breaking down topic- and disease-based silos, and is intended to provide a mechanistic foundation for future translational and clinical ADRD research.Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. Investigators with complementary expertise in ADRD mechanisms, clinical phenotypes, and advanced technologies are encouraged to contact agency staff listed below for additional information.

National Institutes of Health

<p>The National Institute of Neurological Disorders and Stroke (NINDS) is interested in supporting ambitious research projects to elucidate mechanisms of neurodegeneration in Alzheimer’s disease-related dementias (ADRD) organized as a “Center without Walls” consortium. NINDS Centers without Walls are collaborative research networks that bring together diverse expertise from different institutions to tackle complex neurological problems that are not tractable by individual research projects.</p><p>This program is considering using an activity code, such as the RM1, that enables interdisciplinary research consortia capable of identifying and characterizing novel ADRD mechanisms. Teams may include cross-disciplinary and cross-specialty expertise to address the complex co-pathologies, mixed etiologies, and disease heterogeneity in ADRD.</p><p>This program is anticipated to support teams that can combine multiple approaches, such as state-of-the-art technologies, disease-relevant models, clinical science, and human specimens, to investigate unique disease mechanisms and identify new therapeutic targets, biomarkers, and other factors influencing ADRD susceptibility, resilience, and pathology. One awardee team would serve as a coordinating center for all awardees to facilitate recurring meetings, data harmonization and sharing, cross-site communication, and support the implementation of inter-laboratory rigor and reproducibility plans.</p><p>This program is informed by key priorities from the ADRD Summit 2025, including embracing ADRD complexity and breaking down topic- and disease-based silos, and is intended to provide a mechanistic foundation for future translational and clinical ADRD research.</p><p>Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. Investigators with complementary expertise in ADRD mechanisms, clinical phenotypes, and advanced technologies are encouraged to contact agency staff listed below for additional information.&nbsp;</p>

Central Carolina Community Foundation

Central Carolina Community Foundation ($200M in assets) supports nonprofits in SC through grants focused on education, community development, health, arts. Awards range from $2,000 to $75,000.

Central Indiana Community Foundation

Central Indiana Community Foundation ($1.0B in assets) supports nonprofits in IN through grants focused on education, community development, arts, health. Awards range from $2,500 to $200,000.

Central Minnesota Community Foundation

Central Minnesota Community Foundation ($150M in assets) supports nonprofits in MN through grants focused on education, community development, health, arts. Awards range from $1,000 to $50,000.

Central New York Community Foundation

Central New York Community Foundation ($300M in assets) supports nonprofits in NY through grants focused on education, community development, health, arts. Awards range from $2,000 to $100,000.

European Commission - ERASMUS2027

Centres of Vocational Excellence. Call: Centres of Vocational Excellence. Programme: ERASMUS2027. Keywords: Agri-food, Agriculture, Air and water pollution control, Architecture and building, Arts, Biology, Building, Circular economy, Computer sciences - Operating systems (software development only), Craft skills, E-virtual, Education, Electricity, Electronics, Engineering and engineering trades, Entrepreneurship, Environmental protection, Food and drink processing, Foreign languages and cultures, Health, Health and welfare, Horticulture and gardening, Hotel and catering, ICT based learning, ICT's interoperability in education, Inclusion, Informal and non formal learning, Innovation in learning, teaching and assessment practices supported by digital technologies, Inter generational learning, Key competences, Life sciences, Manufacturing and processing, Medicine, Metal work, Mining and extraction, Road motor vehicla operations, Seafood biotechnology, Social Care, Social Media, Sports and leisure, Textiles, Tourism, Travel and tourism, Vocational training, aerospace and defence, construction, digitalisation, green skills, work-based learning. Open call from the EU Funding & Tenders Portal.

NINDS - National Institute of Neurological Disorders and Stroke

PROJECT SUMMARY Autonomic dysfunction remains underdiagnosed and misunderstood but is a significant healthcare burden that affects millions of people in the United States. Autonomic disturbances are present in 40% of neurodegenerative diseases like Parkinson’s disease, Alzheimer’s disease, and other dementias and is often coupled with higher markers of cerebrovascular pathology. In this context, cerebrovascular health and autonomic function may be linked, but the connection is unknown. Additionally, little is understood about the contribution of autonomic dysfunction in tandem with drivers of cerebrovascular pathology on vascular contributions to cognitive impairment and dementia (VCID). The overarching objective of this proposal is to elucidate the link between drivers of cerebrovascular pathology and autonomic dysfunction and identify the impact on VCID biomarkers. Our preliminary data demonstrate that elevated cerebral pulsatility is associated with greater VCID biomarkers (e.g. white matter hyperintensities, WMH) in cognitively normal adults, and our published data demonstrate that adults with lower cardiovascular responses to physiological stressors are associated with greater WMH in healthy adults. Therefore, the central hypothesis is that disrupted cerebral hemodynamics will associate with impaired autonomic function, and together these contribute to greater VCID biomarkers. To test this hypothesis, I will use state-of-the-art magnetic resonance imaging (MRI) and the novel 4D flow MRI technique to measure cerebral hemodynamics (e.g., cerebral pulsatility and cerebral blood flow, CBF) in collaboration with experts in the field of MRI (e.g., Dr. Wieben, Co-sponsor). Additionally, I will use gold-standard techniques to directly measure autonomic function (e.g., sympathetic nerve activity, SNA; baroreflex sensitivity, BRS; and cardiovascular responses). Lastly, I will assess VCID neuroimaging biomarkers (e.g. WMH and cerebrovascular reactivity, CVR), and evaluate the associations between cerebral hemodynamics or autonomic function and these VCID biomarkers. Aim 1 will examine cerebral hemodynamics in middle-aged adults with and without symptoms of autonomic dysfunction. Aim 2 will determine the impact of cerebral hemodynamics and autonomic function on VCID biomarkers in middle-aged adults with and without symptoms of autonomic dysfunction. Collectively, these data will determine the link between cerebral hemodynamic and autonomic function and their contributions to brain health. The proposed work, in conjunction with the comprehensive training plan, will assist in the development of a scientific niche in the field and ensure success through the transition from a predoctoral trainee to a postdoctoral fellowship position. In addition, outcomes from this project will have broader implications for how to prevent or treat autonomic dysfunction that could also benefit brain health.

NIAID - National Institute of Allergy and Infectious Diseases

PROJECT SUMMARY Antiretroviral drug therapy (ART) is the gold standard for HIV therapy for suppressing HIV infection. However, these small molecule drugs cannot eliminate the viral reservoir and thus, ART is a life-long therapy. Broadly neutralizing antibodies (bNAbs) could supplement ART and be used to reduce the viral reservoir through their Fc effector functions. While passive infusion of multiple active bNAbs can suppress viremia after ART is lifted, this strategy still requires the need for multiple infusions to maintain therapeutic concentrations of the bNAbs. We have been using adeno-associated virus (AAV) vectors to deliver HIV bNAbs, SIV bNAbs, and antibody-like inhibitors. AAV vectors provide means for long-term expression of bNAbs at concentrations capable of maintaining viral suppression via a one-time intramuscular administration. One issue that has been plaguing the field, especially in nonhuman primate models, is the development of host anti-drug antibodies and immune responses against the expressed bNAbs. We have recently demonstrated that targeting the immune checkpoint pathway is a promising target to limit the host immune response after vector administration. This work has resulted in consistent expression of two HIV bNAbs in rhesus macaques at concentrations thought to be in therapeutic range to suppress an HIV or SIV infection. Additionally, our work in developing eCD4-Ig, an antibody-like HIV entry inhibitor, has produced promising prophylaxis results in rhesus macaques against SHIV and SIV challenges. Because eCD4-Ig neutralizes all HIV-1, HIV-2, and SIV isolates and no escape mutations have been identified to date, it is a powerful inhibitor to combine with bNAbs for HIV and SIV therapy. Unlike ART, both antibodies and eCD4-Ig can kill infected cells, thus, providing a promising strategy to reduce and eliminate the viral reservoir. Therefore, we hypothesize combining AAV-delivered eCD4-Ig with antibodies would generate a unique viral reservoir upon suppression in the absence of ART, both characteristically and quantitatively. In Aim 1, we will optimize our AAV delivery strategy for multiple SIV antibodies and eCD4-Ig. In Aim 2, we will characterize and quantify the viral reservoir upon suppression when mediated by SIV bNAbs and eCD4-Ig compared to ART. In Aim 3, we will determine whether AAV-delivered SIV bNAbs and eCD4-Ig can increase the rate of viral reservoir decay compared to ART. These results would provide a foundation for AAV-delivered inhibitors as an alternative to ART and move the field closer to realizing an HIV cure.

NIDA - National Institute on Drug Abuse

PROJECT SUMMARY Opioid receptors not only mediate pain relief but also act as the targets of potent exogenous opioids that are devastatingly addictive and cause overdose deaths. The principal target for both analgesia and addiction of exogenous opioids is the µ-opioid receptor (µOR). While traditionally thought to be regulated exclusively by opioids, recent work from our group has detailed an unexpected layer of complexity: endogenous neuromodulators such as endocannabinoids and oxytocin – classically associated with their own independently signaling receptors that regulate mood, pain, inflammation, and social behavior – can directly work to allosterically modulate µOR signaling. This unanticipated ligand-mediated crosstalk opens an entirely new dimension in opioid receptor pharmacology and suggests that targeting these pathways could yield novel interventions for opioid use disorder (OUD) and related conditions. The central goal of this project is to elucidate, at atomic resolution, the molecular mechanisms by which endogenous neuromodulators influence µOR structure and function. We will employ state-of-the-art cryo-electron microscopy (cryoEM) approaches to determine high- resolution structures of µOR in both its active and inactive states, bound to cannabinoids and neuropeptides like oxytocin. Critically, we will advance methodological innovations in time-resolved cryoEM to directly visualize the intermediate conformational states and the full activation/inactivation pathway of the receptor as it transitions between these endpoints. This will allow us, for the first time, to construct “molecular movies” that reveal the stepwise mechanisms by which natural modulators influence receptor activation, allostery, and signaling bias. Through these detailed structural insights, we aim to identify previously unrecognized allosteric sites and intermediate states that serve as "control points" for selective pharmacological intervention. These discoveries will inform the rational design of new therapeutic strategies that harness or mimic the brain’s own modulatory systems, offering a pathway to safer, more targeted treatments for OUD, pain, and overdose. In summary, this project will not only clarify the molecular basis of opioid receptor regulation in the brain, but will also set the stage for mechanism-driven drug discovery to address the current opioid crisis and advance our broader understanding of GPCR biology.

NIDA - National Institute on Drug Abuse

Project Summary Millions of individuals are affected with substance use disorders (SUD), posing a significant burden on these individuals, their families, and communities. There is a substantial comorbidity between SUD and HIV infection. HIV is also a risk factor for SUD because of the increased use of opioid pain medications that may lead to opioid addiction. The Single-Cell Opioid Responses in the Context of HIV (SCORCH) consortium was formed to gain insights into cellular and molecular responses in different brain regions to SUD and HIV by collecting single-cell transcriptomic and epigenomic data in affected brain regions from hundreds of human donors, as well as from animal models. It has been observed that SUD and HIV comorbidity may exacerbate cellular dysfunction beyond the effects of each condition alone, and the data generated by the SCORCH consortium provide opportunities for a comprehensive characterization of cellular states across conditions including control, HIV, OUD, and HIV+OUD. Preliminary data show substantial heterogeneity in molecular phenotypes across samples with the same exposure, e.g., HIV and SUD. Our premise is that the identifications of genetic variants mediating the effects of exposures to HIV and SUD will offer a unique angle to understand how different cell types in different brain regions respond to the exposures, and such understanding through genetic heterogeneity among individuals can lead to novel insights and clinical applications. We will apply state-of-the-art integrative methods to investigate how genetic variants affect molecular phenotypes in different cell types across brain regions with different exposure. We will accomplish this goal through three specific aims. The first aim will analyze total read counts from a transcript/isoform or peak using Bayesian methods that explicitly model shared genetic effects to borrow information across cell types and brain regions to increase statistical power. We will perform eQTL, caQTL, and isoQTL analyses. We will also leverage the multi-omic data to infer gene regulation networks and conduct grQTL analysis. The second aim will consider allele-specific analysis to complement analyses based on total counts. We will then combine allele-specific results with total read count results. To further improve statistical power, we will integrate SCORCH data with external data sets, computationally predicted effect sizes for genetic variants, and transfer known QTLs. We will develop gene expression and chromatin accessibility imputation models to facilitate genome-wide association studies. We will work with the SCORCH team to share our results with the broader scientific community. This project will be co-led by Dr. Hongyu Zhao, Dr. Mark Gerstein, and Dr. Ke Xu, who have complementary expertise covering statistical genetics/genomics, computational biology, single-cell analysis, SUD genetics, and HIV research.

NICHD - Eunice Kennedy Shriver National Institute of Child Health and Human Development

Abstract The Child Health Research Career Development Award (CDRCDA) Program was first established at Children’s National Hospital in 2000, and over the past 24 years, we have successfully trained 30 Scholars. The purpose of the program is to facilitate the development of successful basic, translational, and clinical research careers for junior faculty members in pediatrics across the T0-T4 spectrum. The rationale for the program is that while many opportunities exist to use molecular biology, biomedical engineering, and translational science to advance treatment of pediatric diseases, the comprehensive scientific knowledge and practical experience that are required to capitalize on these opportunities are often deficient among young pediatrician-investigators who have recently finished clinical training. The CHRCDA addresses this need by providing protected time for nascent scientists during their initial academic appointment. In our program, scholars: 1) take coursework in basic, translational, or clinical science areas relevant to their research; 2) learn state-of-the art laboratory and computational methodologies; 3) develop preliminary data under the supervision of established mentors that will lead to submission of independent NIH grant applications; and 4) learn to effectively advance accomplishments in basic, translational, and clinical research into improvements in child health. To accomplish these goals, the CHRCDA scholars spend at least 75% effort honing these skills under the mentorship of established mentors over a 3-4 year period. During this period, each of the above tasks will be addressed in a systematic fashion, including participation in a core curriculum in research methodology and biostatistics, training in responsible conduct of research, and performance of increasingly independent research under senior investigators. We fund 2-3 Scholars annually and match these scholars with senior mentors within four scientific affinity groups: neuroscience, molecular genetics, cancer and immunology, and biomedical engineering. The administrative structure includes a Principal Investigator/Program Director, a Training Director, an Executive Committee, and an external Advisory Committee. The outcomes of this program are measured by the products of the scholars’ subsequent academic careers: publications and independent external grant support. Recent innovations to our program include: expansion of funded research to include T2-T4 science with recruitment of a cadre of appropriate mentors, new pipeline programs to increase our pool of candidates including two R38 awards to fund research among pediatric residents and significant capital investments including the new Children’s National Research and Innovation campus. This administrative supplement is necessary to sustain the CDRCDA program during an unanticipated funding gap, ensuring uninterrupted support for scholars and continued program operations until a future funding opportunity is released.

Seattle Asian American Film Festival

The Seattle Asian American Film Festival will screen free films at Hing Hay Park, 423 Maynard Avenue South on two successive Saturdays, August 18th and 25th, 2018. The films are targeted to Asian Americans in the surrounding community with the film on August 18th being screened in it's original Chinese language. The screening on August 25th will focus on the Japanese American internment during WWII. The films will be preceded by live performances and arts and crafts.

City of Newark

The City of Newark provides grants to nonprofit organizations and community groups for programs and projects that improve quality of life for Newark residents, including youth services, senior programs, arts, and neighborhood development.

National Endowment for the Humanities

CLASSICAL EDUCATION AND THE AMERICAN EXPERIMENT ? THE DECLARATION OF INDEPENDENCE AT 250 [IN 2025-2026, THE GREAT HEARTS INSTITUTE WILL CELEBRATE THE 250TH ANNIVERSARY OF THE DECLARATION OF INDEPENDENCE BY EXPLORING ITS ENDURING CONNECTION TO CLASSICAL EDUCATION. THE GREAT HEARTS CELEBRATE AMERICA PROJECT, "CLASSICAL EDUCATION AND THE AMERICAN EXPERIMENT: THE DECLARATION OF INDEPENDENCE AT 250, SEEKS TO DEEPEN OUR UNDERSTANDING OF THE AMERICAN MIND THROUGH A YEAR-LONG SERIES OF EVENTS, INITIATIVES, AND PUBLICATIONS. THE 250TH ANNIVERSARY OF AMERICA'S FOUNDING PRESENTS A UNIQUE AND TIMELY OPPORTUNITY TO ENGAGE THE CLASSICAL EDUCATION COMMUNITY NATIONWIDE. THROUGH A YEAR-LONG INITIATIVE, THE GREAT HEARTS INSTITUTE WILL HIGHLIGHT THE ESSENTIAL ROLE OF CIVIC LEARNING?ROOTED IN THE GREAT TEXTS AND IDEAS OF THE AMERICAN TRADITION?AS A CORNERSTONE OF CLASSICAL LIBERAL ARTS EDUCATION IN THE UNITED STATES.]

Cleveland Foundation Arts

Project and operating grants for arts organizations and individual artists from Cleveland Foundation Arts. Supports visual, performing, literary, and media arts.

Cleveland Foundation

One of America's oldest community foundations, providing grants for arts, education, economic development, and neighborhood revitalization across Greater Cleveland.

NIAID - National Institute of Allergy and Infectious Diseases

PROJECT SUMMARY/ABSTRACT Cardiovascular disease (CVD) is the leading cause of death in the United States and worldwide. People with HIV (PWH) with virus suppression on antiretroviral therapy (ART) have a 2-fold increased risk of developing CVD compared to people without HIV (PWoH), even when controlling for age and traditional CVD risk factors. One factor that may contribute to the increased CVD in PWH is cytomegalovirus (CMV) coinfection. Nearly all PWH and about half of all adults without HIV in the United States have CMV, which is independently linked to CVD. In preliminary spatial transcriptomic analyses of vascular tissues of PWH and PWoH, all of whom have peripheral artery disease, we find that the proportion of myeloid cells in regions of interest (ROIs) across arteries is significantly higher in tissues from PWH. CMV can reactivate from latently-infected monocytes as they differentiate into macrophages, and virological and immunological evidence suggests that PWH have more frequent CMV reactivation events than do PWoH, so the cardiopathogenic effects of CMV may be more pronounced among PWH due to the increased numbers of macrophages harboring replicating CMV. We hypothesize that CMV reactivation in infiltrating macrophages provides antigenic signals for CMV-reactive T cells in vascular tissues. We will use the following Specific Aims to test this hypothesis. Aim 1: To define the spatial context of CMV expression in vascular tissues of PWH and PWoH. In Aim 1, we will test this hypothesis by (1) defining the spatial context of CMV expression in situ in vascular tissues of PWH and PWoH with and without CVD, (2) quantifying CMV expression in macrophages in vessels from PWH and PWoH with and without CVD, and (3) confirming spatial relationships of CD4 and CD8 T cells and CMV-expressing target cells in the vasculature. Aim 2. To determine if serum-derived MDMs from PWH with CMV are more effective at activating and presenting CMV antigens to T cells than are MDMs from PWoH with CMV. In Aim 2, we will use in vitro experiments to determine if serum-derived MDMs from PWH with CMV, which preserves the influence of systemic inflammatory mediators, are more effective at activating autologous T cells than MDMs from PWoH with CMV. Then, we will determine if that activation is due to CMV antigen presentation by the serum-derived MDMs, and whether statin treatment of the MDMs, which inhibits CMV replication in vitro, directly impairs their T cell activating capacity. Our studies may define mechanisms whereby chronic viral infection drives T cell- mediated vascular pathology and may identify novel targets beyond traditional risk factors to prevent/treat CVD in PWH and PWoH. Furthermore, understanding the role of CMV in CVD, and whether its activity is susceptible to statins, will help inform the interpretation of the A5332/REPRIEVE (pitavastatin) and A5383/ELICIT (letermovir) trials in PWH.

Coastal Community Foundation of South Carolina

Coastal Community Foundation of South Carolina ($300M in assets) supports nonprofits in SC through grants focused on education, environment, community development, arts. Awards range from $1,000 to $75,000.

Colorado Creative Industries

Colorado Creative Industries provides grants to support arts and cultural programming, artist fellowships, arts education, and community-based arts projects across CO.

Colorado Creative Industries

Colorado Creative Industries supports Creative Districts — defined areas where arts and culture are developed as economic and community development tools — providing grants to certified Creative Districts across Colorado.

Colorado Creative Industries

Colorado Creative Industries provides general operating support grants to Colorado arts organizations, enabling them to deliver arts programming, build capacity, and expand access to arts and culture statewide.

Columbia Basin Trust

Columbia Basin Trust supports residents of the Columbia Basin region of BC through grants for community development, arts, environment, youth, and economic initiatives.

Columbus Foundation Arts

Project and operating grants for arts organizations and individual artists from Columbus Foundation Arts. Supports visual, performing, literary, and media arts.