Cerebral Hemodynamics and Brain Health in Adults with and without Symptoms of Autonomic Dysfunction
NINDS - National Institute of Neurological Disorders and Stroke
About This Grant
PROJECT SUMMARY Autonomic dysfunction remains underdiagnosed and misunderstood but is a significant healthcare burden that affects millions of people in the United States. Autonomic disturbances are present in 40% of neurodegenerative diseases like Parkinson’s disease, Alzheimer’s disease, and other dementias and is often coupled with higher markers of cerebrovascular pathology. In this context, cerebrovascular health and autonomic function may be linked, but the connection is unknown. Additionally, little is understood about the contribution of autonomic dysfunction in tandem with drivers of cerebrovascular pathology on vascular contributions to cognitive impairment and dementia (VCID). The overarching objective of this proposal is to elucidate the link between drivers of cerebrovascular pathology and autonomic dysfunction and identify the impact on VCID biomarkers. Our preliminary data demonstrate that elevated cerebral pulsatility is associated with greater VCID biomarkers (e.g. white matter hyperintensities, WMH) in cognitively normal adults, and our published data demonstrate that adults with lower cardiovascular responses to physiological stressors are associated with greater WMH in healthy adults. Therefore, the central hypothesis is that disrupted cerebral hemodynamics will associate with impaired autonomic function, and together these contribute to greater VCID biomarkers. To test this hypothesis, I will use state-of-the-art magnetic resonance imaging (MRI) and the novel 4D flow MRI technique to measure cerebral hemodynamics (e.g., cerebral pulsatility and cerebral blood flow, CBF) in collaboration with experts in the field of MRI (e.g., Dr. Wieben, Co-sponsor). Additionally, I will use gold-standard techniques to directly measure autonomic function (e.g., sympathetic nerve activity, SNA; baroreflex sensitivity, BRS; and cardiovascular responses). Lastly, I will assess VCID neuroimaging biomarkers (e.g. WMH and cerebrovascular reactivity, CVR), and evaluate the associations between cerebral hemodynamics or autonomic function and these VCID biomarkers. Aim 1 will examine cerebral hemodynamics in middle-aged adults with and without symptoms of autonomic dysfunction. Aim 2 will determine the impact of cerebral hemodynamics and autonomic function on VCID biomarkers in middle-aged adults with and without symptoms of autonomic dysfunction. Collectively, these data will determine the link between cerebral hemodynamic and autonomic function and their contributions to brain health. The proposed work, in conjunction with the comprehensive training plan, will assist in the development of a scientific niche in the field and ensure success through the transition from a predoctoral trainee to a postdoctoral fellowship position. In addition, outcomes from this project will have broader implications for how to prevent or treat autonomic dysfunction that could also benefit brain health.
Grant Summary
Cerebral Hemodynamics and Brain Health in Adults with and without Symptoms of Autonomic Dysfunction is a NINDS - National Institute of Neurological Disorders and Stroke grant providing up to $39K for university, nonprofit, healthcare org. Applications are due 2028-12-20 (open). Check eligibility and apply with FindGrants.
Focus Areas
Eligibility
How to Apply
Up to $39K
2028-12-20
- 1Confirm your organization is eligible for Cerebral Hemodynamics and Brain Health in Adults with and without Symptoms of Autonomic Dysfunction from NINDS - National Institute of Neurological Disorders and Stroke, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NINDS - National Institute of Neurological Disorders and Stroke before the deadline.
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Cerebral Hemodynamics and Brain Health in Adults with and without Symptoms of Autonomic Dysfunction: Frequently Asked Questions
Who is eligible for the Cerebral Hemodynamics and Brain Health in Adults with and without Symptoms of Autonomic Dysfunction?
Cerebral Hemodynamics and Brain Health in Adults with and without Symptoms of Autonomic Dysfunction is offered by NINDS - National Institute of Neurological Disorders and Stroke and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the Cerebral Hemodynamics and Brain Health in Adults with and without Symptoms of Autonomic Dysfunction provide?
Cerebral Hemodynamics and Brain Health in Adults with and without Symptoms of Autonomic Dysfunction provides up to $39K per award from NINDS - National Institute of Neurological Disorders and Stroke. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the Cerebral Hemodynamics and Brain Health in Adults with and without Symptoms of Autonomic Dysfunction deadline?
Applications for Cerebral Hemodynamics and Brain Health in Adults with and without Symptoms of Autonomic Dysfunction are due 2028-12-20 (open). Because deadlines can change, verify the date with the funder, NINDS - National Institute of Neurological Disorders and Stroke, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the Cerebral Hemodynamics and Brain Health in Adults with and without Symptoms of Autonomic Dysfunction?
To apply for Cerebral Hemodynamics and Brain Health in Adults with and without Symptoms of Autonomic Dysfunction, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NINDS - National Institute of Neurological Disorders and Stroke.