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Nevada Arts Council

The Nevada Arts Council provides operating support and project grants to nonprofit arts organizations and educational institutions, strengthening arts infrastructure and expanding public access to arts and cultural programming across Nevada.

Nevada Community Foundation

Nevada Community Foundation ($100M in assets) supports nonprofits in NV through grants focused on education, community development, health, arts. Awards range from $1,000 to $50,000.

New Brunswick Arts Board

artsnb provides grants to professional artists in New Brunswick for creation, production, and career development across all disciplines.

New Hampshire Charitable Foundation — Regional Programs

New Hampshire Charitable Foundation — Regional Programs ($1.0B in assets) supports nonprofits in NH through grants focused on education, community development, health, arts, environment. Awards range from $2,000 to $100,000.

New Hampshire Charitable Foundation

New Hampshire Charitable Foundation ($900M in assets) supports nonprofits in NH through grants focused on education, health, community development, arts, environment. Awards range from $2,000 to $150,000.

New Hampshire State Council on the Arts

Operating grants provide general support to established New Hampshire arts organizations for sustaining core arts programming, building audiences, and strengthening organizational capacity across the state.

New Hampshire State Council on the Arts

Project grants support specific arts activities including festivals, exhibitions, performances, arts education programs, and community arts projects that expand public engagement with the arts in New Hampshire communities.

New Jersey State Council on the Arts

New Jersey State Council on the Arts provides grants to support arts and cultural programming, artist fellowships, arts education, and community-based arts projects across NJ.

New Jersey State Council on the Arts

The NJ State Council on the Arts funds arts organizations, artists, and cultural programs to support excellence in the arts, arts education, and ensure all New Jerseyans have access to diverse arts and cultural experiences.

New Mexico Arts Division

The Arts in Public Places program provides funding for the acquisition and installation of public artworks in state buildings and facilities, commissioning New Mexico artists to create site-specific works that reflect the state's diverse cultural heritage.

New Mexico Arts Division

Community Arts Grants support New Mexico nonprofit organizations in delivering arts programming, cultural preservation, and arts education that serves diverse communities, with emphasis on rural and tribal communities.

New Mexico Community Foundation

New Mexico Community Foundation ($100M in assets) supports nonprofits in NM through grants focused on education, community development, health, arts. Awards range from $1,000 to $25,000.

NIGMS - National Institute of General Medical Sciences

PROJECT DESCRIPTION Trace metal micronutrients, such as copper, iron, and zinc are vital to a host of biological processes, but their dyshomeostasis is associated with a number of disease states. The context in which a metal resides within a biological environment significantly influences its activity and function. Recent years have seen a rise in tools for monitoring metal ions and have illuminated the diversity in metal speciation in biology, but many of these tools are focused on probing metals in the intracellular space. The state-of-the-art methods for assessing metal status in extracellular fluids such as blood plasma focus either on absolute quantitation or evaluate a limited number of metal-containing species. While these methods have offered important insight into extreme cases of metal deficiency or overload, subtle imbalances are more challenging to diagnose and understand with the available methods. The objective of this research program is to expand and elucidate the metal speciation of the extracellular space, with an immediate focus on blood-based fluids due to their clinical importance in biomarker assessment. In previous work, we developed new bioluminescence-based probes and enrichment methods for mass spectrometry-based proteomics for identifying reactive copper pools and potential binding partners in serum. Additionally, we identified new interactions between transition metals and peptide hormones that influence their cellular behavior, quantitation in diagnostic assays, and interaction with other proteins in serum. In this proposal proposal, we seek to further develop the extracellular metal biochemical profile in the following ways. First, we seek to expand the toolbox for assessing extracellular metal interactions. Optical sensing approaches include the use of native albumin as a bioluminescence enzyme to pair with metal-responsive substrates and the development peptide-based detection platforms with metal-responsive cell surface interactions or internalization. Second, we will progress our metal-affinity enrichment strategies via on-resin digestion methods to gain new insight on metal chelate-interaction sites, with additional approaches that include incorporating pre-enrichment steps to identify metal-binding species in plasma subproteomes. Finally, we seek to expand the understanding of metal-mediated molecular interactions in blood plasma by developing and applying strategies to identify and investigate metal-mediated peptide/protein interactions these may influence hormone bioavailability and function. Objectives in this area include size-based fractionation methods develoepd and optimized with fluorescently-labeled peptide analogues, and catch-and-release peptide affinity strategies for identifying protein binding partners. The tools developed in this proposal will be applied to samples from collaborators, biorepositories, and mouse models to generate metal-centric biomarker profiles in metabolic disorders. The insights and technologies that emerge from this proposal will directly impact nutritional treatments, therapeutic peptide development, and biomarker discovery for metal status.

Allied Arts Foundation

Allied Arts Foundation, (AAF), will present 6 free and open-to-the-public outdoor performances by multicultural emerging and up-and-coming local artists during July and August 2022 at the Volunteer Park Amphitheater located at 1247 15th Ave E. This is a rare opportunity to present a series of free public performances by piggy-backing onto an existing production. We are partnering with Volunteer Park Trust, which is producing their Summer Series at the Amphitheater, and will sponsor New Voices at the Volunteer Park Amphitheater. Funds from this Small Sparks will help pay the artist fees for six opening acts ($500 x 6) who will present shorts sets, each performing as opening acts for bigger name bands. This series will help AAF promote opportunities for artists, give back to the people of Seattle, and fulfill our mission to the support the arts. 18,000 people are expected to attend. This project will be completed by September 30, 2022.

New York Community Trust

New York Community Trust ($3.0B in assets) supports nonprofits in NY through grants focused on education, health, arts, environment, community development. Awards range from $5,000 to $300,000.

New York State Council on the Arts

New York State Council on the Arts provides grants to support arts and cultural programming, artist fellowships, arts education, and community-based arts projects across NY.

New York State Council on the Arts

NYSCA General Support provides multi-year operating support for established New York arts organizations, enabling long-term planning and programmatic stability.

New York State Council on the Arts

NYSCA's Regrants Program supports arts organizations and individual artists in New York through a network of 47+ local arts agencies that distribute funding at the community level.

NIMH - National Institute of Mental Health

OVERALL - Summary: The Developmental AIDS Research Center New York-New Jersey – Center for Actionable NeuroHIV Biomarkers and Integrated Omics, (NYJ-CAN-BIO) proposes to develop the infrastructure and collaborative resources at Weill Cornell Medicine (WCM) and Rutgers Health (RH) to enable actionable neuroHIV biomarker driven discovery research. This Center is committed to provide expertise, cutting-edge technologies and training for identifying multidimensional biomarkers that are mechanistically meaningful, diagnostically useful, and translatable towards the development of transformative therapies for HIV-associated CNS dysfunction and strategies focused on the eradication of latent HIV within the CNS. While advances in understanding the pathophysiology of HIV effects on the CNS in the era ART have yielded much progress, current biomarkers are not specific to the CNS, and their utility for biotyping neuroHIV clinical manifestations remains unclear and a significant gap in our efforts to resolve the underlying mechanisms and efforts towards HIV eradication in the CNS. A major barrier to progress in the field is a lack of integrated centralized center to coordinate these efforts. NYJ-CAN-BIO is committed to filing this gap and advance a framework for neuroHIV biomarker discovery, fostering innovation, and promoting collaborative efforts to improve the delineation of CNS disease heterogeneity and clinical outcomes in people with HIV or at risk across the Bi-State (New York and New Jersey) area, a region with one of the highest burdens of HIV across the country. NYJ-CAN-BIO will pioneer biomarker-driven approaches that harness our researchers across two institutions and their basic, clinical and translational infrastructures, integrating cutting-edge technologies, such as 3D organoid and physiological systems, advanced multi-omic platforms and emerging innovations in computational analytics and AI that would ultimately provide a resource and biomarker expertise across the exciting nationwide of DARC and ARC networks beyond the bistate area. The Directors of the Center, Dr. Lishomwa Ndhlovu (WCM) and Dr. Tricia Burdo (RH) and Cores have demonstrated excellence and leadership in neuroHIV and will capitalize on the current expertise of affiliated investigators at WCM and RH through the establishment of an integrated Administrative (AC), Developmental and Mentorship (DMC), and Biosignature (BC) Core structure. To achieve these goals, NYJ-CAN-BIO proposes three aims. Aim 1 will catalyze actionable biomarker-driven neuroHIV research through formation of an AC that integrates translational clinical data with omics driven technologies, computational analytics and 3D brain organoid and physiological system-based modeling across collaborating institutions. Aim 2 will train and support all-encompassing cohorts of early-career, new and established investigators in the emerging fields of neuroHIV, biological indicators of disease, immunology, computational neuroscience, 3D brain organoid and physiological system-based modeling. Aim 3 will guide the discovery, validation, and dissemination of multimodal biomarker discovery omics platforms, computational analytics and human-biology-based new approach methodologies.

Newfoundland & Labrador Arts Council

Provides grants to artists and arts organizations in Newfoundland and Labrador for creation, production, and professional development.

NIGMS - National Institute of General Medical Sciences

ABSTRACT The goal of this project is to enable scientific discovery and advances in biomedical research through the development of cutting-edge software tools that provide integrated visualizations and analyses of molecular structures and related biological information. Our tools can be applied to diverse types of biomolecular data, including atomic-resolution coordinates, 3D cryo-EM and cryo-ET density maps, and protein and nucleic acid sequences, annotations, and networks. During the next five years we will continue our emphasis on the unmet software needs for basic and applied biomedical research using highly trained and talented staff, with excellent interdisciplinary knowledge and specialized, state-of-the-art expertise in software engineering, computer graphics, and data analysis. Our primary focus will be on the interactive visualization and analysis of structures of molecules, molecular assemblies, and sequence-structure relationships. These areas are critical for addressing important and highly relevant biomedical problems such as identifying the molecular bases of disease, identifying targets for drug development, designing drugs, and engineering proteins with new functions. The tools we develop and disseminate will enable scientists to understand, analyze, and illustrate to others the important principles of molecular structure, function, and interactions. Our tools such as ChimeraX are widely recognized as works of the highest quality, and are available for free on our website as executable applications and in source-code form through our GitHub repository. We fully support and maintain these tools, and provide detailed documentation and tutorials. Our technological developments are disseminated widely via scientific publications, lectures, software distribution, and web-accessible videos.

NEI - National Eye Institute

Project Summary The molecular mechanisms controlling the growth of axonal projections in the central nervous system (CNS) are still poorly understood. Similarly, the molecular basis of the failure of axon regeneration in the CNS are still elusive, and no regenerative therapies exist to date that could help patients with axonal injuries. Retinal ganglion cells (RGCs) are prototypical CNS projection neurons that do not spontaneously regenerate axons disrupted in optic neuropathies caused by trauma, ischemia, or glaucoma, resulting in irreversible loss of vision. Our goal is to investigate the molecular mechanisms through which the Nfe2l3 protein, whose neuroprotective functions we recently identified, regulates the regeneration process of the damaged optic nerve axons, and to test their potential for restoring simple visual functions after optic nerve injury. We will utilize established animal models and state-of-the-art technologies for investigating through which molecular mechanism the Nfe2l3 protein activates the retinal ganglion cells’ intrinsic capacity for regenerating long-distance axons through the optic nerve. We will also determine which retinal ganglion cells respond to the Nfe2l3 protein by regenerating injured axons. We expect that these studies will lead to the development of a novel approach for restoring simple visual functions after optic nerve injury, with the potential to treat different types of optic neuropathies.

NIAID - National Institute of Allergy and Infectious Diseases

The purpose of the NIAID Virology Quality Assurance (VQA) program is to provide a comprehensive quality assessment program for virologic assays for HIV and associated viral pathogens performed on samples collected from participants enrolled in NIAID-sponsored and collaborative multisite clinical studies. The goal of the VQA program is to ensure the validity and inter- and intra-laboratory comparability of virologic laboratory data by providing laboratories with proficiency testing (PT) panels and real-time assay run controls and analyzing PT panel and assay run data within each laboratory and across laboratories participating in the program. The VQA program implements standards of performance for new and existing state-of-the-art virologic assays, develops and employs biostatistical methods relating to the assays, and acquires, tests, stores and dispenses quality control materials (QCMs) and reagents. The VQA program is critical to the scientific integrity of on-going and future studies concerning HIV diagnosis, pathogenesis, drug resistance, and cure, including the assessment of vaccine and treatment efficacy, and post-exposure prophylaxis (PrEP).

National Institutes of Health

The overall goal of this program is to accelerate scientific discovery, improve research efficiency, and enhance the translation of research findings into improved health outcomes. Centers funded under this program will also foster multidisciplinary collaboration, support workforce development across career stages, and promote training in emerging areas such as data science, artificial intelligence, and implementation research. The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) requests applications for the NIAMS P30 Centers Program to support integrated research Centers within its mission areas of skin biology and diseases; bone, muscle, and orthopaedic research; and rheumatic diseases. The NIAMS P30 Centers Program supports Centers that provide coordinated research infrastructure, shared resources, and methodological expertise to advance basic, translational, and clinical research. These Centers are expected to integrate state-of-the-art research resources with capabilities that support clinical and translational research, including the development, testing, and dissemination of novel analytical methods, study designs, outcome measures, and data-driven approaches. The overall goal of this program is to accelerate scientific discovery, improve research efficiency, and enhance the translation of research findings into improved health outcomes. Centers funded under this program will also foster multidisciplinary collaboration, support workforce development across career stages, and promote training in emerging areas such as data science, artificial intelligence, and implementation research.