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NIAMS - National Institute of Arthritis and Musculoskeletal and Skin Diseases

Polyethylene (PE) wear and implant-related failure remain leading causes of revision in total shoulder arthroplasty (TSA), a procedure which now surpasses the growth rate of hip and knee arthroplasty. Both anatomic (aTSA) and reverse (rTSA) TSA outcomes are heavily influenced by complex interactions between rotator cuff function, scapular motion, implant design, and patient-specific loading—factors not adequately captured in current preclinical implant testing standards. Emerging evidence suggests that PE wear progression in TSA is highly dependent on shoulder kinematics, joint loading, implant positioning, and individual patient factors. Nonetheless, data on in vivo motion and load profiles remain sparse, and few tools exist to link these profiles to clinically relevant wear patterns or associated periprosthetic inflammatory tissue responses. Accordingly, the primary objective of this project is to develop validated, patient-specific models that predict PE wear in TSA and identify modifiable surgical, design, and rehabilitation targets to improve implant longevity and restore patient mobility. Additionally, we will establish histopathological hallmarks that indicate TSA failure caused by PE wear debris. Our central hypothesis is that specific shoulder kinematics and joint loading drive distinct PE wear patterns in TSA associated with mechanical failure or inflammatory-mediated osteolysis, depending on implant design and positioning. To achieve the overall objective of this work, shoulder motions and muscle excitations across 25 activities of daily living will be collected at pre-op and post-op (>6 months) in both aTSA and rTSA patients, with long-term follow-up of patient-reported outcomes via validated surveys (5 years). Unsupervised machine learning will categorize patients into movement-based phenotypes, which will then inform a multi-scale modeling framework to estimate in vivo shoulder joint loads and implant wear across the varying movement strategies. Predicted wear patterns will be validated using state-of-the-art preclinical wear simulators. Simultaneously, we will quantify how patient, surgical, and implant factors contribute to wear in retrieved TSA components (>400 samples), correlating imaging-based wear patterns with clinical outcomes, patient-reported function, inflammatory tissue responses, and radiographic indications of loosening. For that purpose, we will establish benchmarks of TSA wear rates and introduce a new histopathological approach augmented by infrared spectroscopic imaging. This work is innovative because we are linking patient-specific movement patterns following TSA with multi-scale computational models to predict PE wear, breaking the current approaches of using generic motions and loads in existing testing standards. This work will produce the first integrated, publicly available database of TSA kinematics, joint loading, and PE wear patterns and rates, along with validated computational tools to inform implant design, surgical planning, rehabilitation strategies, and personalized risk assessment. Ultimately, these advances will improve functional outcomes and long-term success for TSA patients and enable better preclinical testing methods and standards.

Fairfield County's Community Foundation

Fairfield County's Community Foundation ($400M in assets) supports nonprofits in CT through grants focused on education, economic opportunity, health, arts. Awards range from $2,500 to $100,000.

Freeway Park Association

The Freeway Park Association will organize a community lantern installation and Fall Festival event on Friday, October 26, 4-7pm, at Freeway Park, 700 Seneca St. Communities neighboring the park will be invited to help make lanterns and participate in the festival. The lanterns will hang throughout the fall and winter as a way to bring light, movement, color and community art into the park, making people feel safe and invested in Freeway Park.

Fargo-Moorhead Area Foundation

Fargo-Moorhead Area Foundation ($200M in assets) supports nonprofits in ND through grants focused on education, community development, health, arts. Awards range from $1,000 to $50,000.

National Endowment for the Humanities

FESTIVAL AND SYMPOSIUM FOR AMERICA'S 250TH [THE PROJECT BEGINS WITH A FESTIVAL OF WEEKLY SPEAKER EVENTS FOR STUDENTS, FACULTY, AND THE GENERAL PUBLIC TO CELEBRATE THE NATION?S FOUNDING, DEEPENING THEIR UNDERSTANDING OF THE REVOLUTION, FOCUS ON ITS VALUES, MEANINGS, AND LEGACIES, AND REFLECT ON ITS CALL TO CIVIC ENGAGEMENT. THE SPEAKERS ARE SERIOUS SCHOLARS WHO WILL ATTRACT AUDIENCES BY FRAMING THEIR PRESENTATIONS AROUND "HOOKS" SUCH AS ESPIONAGE, SATURDAY NIGHT LIVE, ART, AND THE MODERN RELEVANCE OF THE FOUNDERS. SEVERAL HUMANITIES DEPARTMENTS ARE INVOLVED. THE EVENTS OCCUR NEAR AN EXHIBITION OF ORIGINAL AMERICAN REVOLUTION DOCUMENTS FROM THE UNIVERSITY?S WEINER COLLECTION WITH COMPLEMENTS FROM THE AMERICAN BATTLEFIELD TRUST. AFTER THIS PERIOD OF INTENSE REFLECTION, OUR FACULTY AND STUDENT RESEARCHERS WILL PRODUCE ORIGINAL SCHOLARSHIP AND CREATIVE WORKS ON THE REVOLUTION?S THEMES. THEY WILL RECONVENE FOR A TWO-DAY PUBLIC SYMPOSIUM UNDER THE LEADERSHIP OF A KEYNOTE SPEAKER, WITH THE WEINER COLLECTION AGAIN AT THE CENTER.]

Sundiata African American Cultural Association

Festival Sundiata Black Arts Fest, an annual celebration of people of African descent is scheduled for Friday June 14 through Sunday, June 16, 2019 at Seattle Center, 305 Harrison Street. The event includes, music, dance, historical exhibits and arts and crafts.

festival:festival

The festival:festival organization will host a free two day arts festival to support artists and cultural workers. It will take place on August 2, 2019 from 5 pm - 10 pm at Northwest Film Forum located at 1515 12th Ave, on August 3, 2019 from 11 am - 4 pm at Amplifier located at 901 Hiawatha Pl S, and on E Denny Wy between 10th Ave and Broadway Ave from 5 pm - 10 pm on August 2 and 3, 2019.

Fidelity Foundation

Supports education, arts, health, and community development with emphasis on the Greater Boston area.

Sea-Mar Community Health Center

Fiestas Patrias is a two-day, free admission cultural festival which provides opportunities for the Puget Sound community to come together to celebrate Latin American arts, culture, and heritage through music, dance, food and more. Fiestas Patrias will take place in South Park located at 8319 8th Avenue South on September 14th and 15th from 11:00 a.m. - 6:00 p.m. beginning with a parade. There will also be a community fiesta and health fair located at the Seattle Center at 305 Harrison Street on September 14th and 15th from noon - 9:00 p.m. This project will be completed by November 29, 2019.

Florida Division of Arts & Culture

Florida Division of Arts & Culture provides grants to support arts and cultural programming, artist fellowships, arts education, and community-based arts projects across FL.

Florida Division of Arts and Culture

Supports Florida arts and cultural organizations through general program support, specific project grants, and cultural facility improvement funding.

National Institutes of Health

This Notice of Funding Opportunity (NOFO) supports projects relevant to the NIGMS mission that focus solely on the development of technologies with potential to enable acquisition of biomedical knowledge. Projects should be justified in terms of technical innovation and utility of such technical innovation for impacting future biomedical research. Outcomes or products of the proposed project should significantly advance the current state of the art and be sufficiently characterized for application in addressing a broad range of biomedical research questions.

National Institutes of Health

This Notice of Funding Opportunity (NOFO) supports projects relevant to the NIGMS mission that focus solely on the development of technologies with potential to enable acquisition of biomedical knowledge. Projects should be justified in terms of technical innovation and utility of such technical innovation for impacting future biomedical research. Outcomes or products of the proposed project should significantly advance the current state of the art and be sufficiently characterized for application in addressing a broad range of biomedical research questions.

Fondation Carasso

Supports sustainable food systems and citizen art in France and Spain. Focus on ecological transition and cultural inclusion.

Fondazione Cariplo

Milan-based banking foundation distributing 150M+ EUR annually for environment, art, research, and social services.

Fonds de recherche du Québec

FRQSC funds research and training in social sciences, humanities, arts, and letters in Quebec.

Ford Foundation

Grants for arts organizations and artists challenging narratives and advancing social justice through creative expression.

National Park Service

Produce four main-stage productions featuring Americana; daily offerings of the one act play One Destiny highlighting first person accounts leading up to Lincoln s assassination at Ford s Theatre; teacher and student workshops featuring America s past while revealing meaningful connections to today; teacher summer institutes; on-line learning programming including virtual field trips.

Foundation for Enhancing Communities

Foundation for Enhancing Communities ($100M in assets) supports nonprofits in PA through grants focused on education, community development, arts, health. Awards range from $1,000 to $50,000.

Freeway Park Association

The Freeway Park Association will be hosting a four season art installation that will be held at Freeway Park located at 700 Seneca Street. The Four installations are: Winter 2022 light-art installation starting in December 2022, Spring Freeway Park Bloom starting in June 2023, Summer Fountain Fest starting in July 2023 and culminate with Fall Fest starting September 2023. The event is free and open to the public.

NEI - National Eye Institute

The ocular lens serves as an excellent model for studying cell fate determination, as it consists of two distinct cell types derived from the surface ectoderm: lens epithelial and fiber cells. Lens development requires suppression of pro-neurogenic pathways, distinguishing it from other anterior placodes, such as the olfactory placode, which gives rise to neurons. Mutations in key transcription factors (TFs), including AP-2α, FOXE3, and PAX6, lead to overlapping developmental defects such as aphakia, incomplete lens separation, and fiber cell abnormalities, suggesting shared transcriptional targets and regulatory mechanisms. However, a major gap remains in understanding how FOXE3 functions as a transcriptional regulator and how its activity influences chromatin architecture to suppress pro-neurogenic gene expression during lens formation. Preliminary studies using CUT&RUN identified a de novo FOXE3-binding motif, with strong similarity to FOXD3, and revealed that FOXE3 is required to repress neurogenic gene expression in early lens cells. Additionally, RNA-seq analyses of Foxe3 mutant lenses demonstrated significant differential gene expression linked to pro-neurogenic pathways. This led to the hypothesis that FOXE3 functions as both a transcriptional activator and repressor, coordinating chromatin remodeling to establish and maintain lens cell identity. To test this, state-of-the-art chromatin and transcriptomic technologies, including single- nucleus multiomics (ATAC-seq + RNA-seq), CUT&RUN, and functional assays in chick embryos, to dissect FOXE3’s molecular mechanisms will be conducted. Aim 1 will identify FOXE3 transcriptional targets and determine how chromatin accessibility (DARs) and FOXE3-bound enhancers and promoters are altered in Foxe3 mutant lenses. This will be accomplished through the integration of single-nucleus multiomics and CUT&RUN data to map the FOXE3-dependent regulatory landscape. Aim 2 will determine the functional role of FOXE3 in cell fate decisions by (1) gain and loss of function assays in chick lens cells, (2) testing its ability to suppress neurogenesis in the developing chick retina, and (3) identifying FOXE3-interacting proteins via immunoprecipitation and mass spectrometry. The completion of these aims will provide mechanistic insights into FOXE3’s role in lens development, establish a FOXE3 DNA-binding motif, and identify targets of FOXE3 regulation. These studies aim to reveal how FOXE3 mutations contribute to congenital eye disorders such as aphakia, cataracts, microphthalmia, coloboma, and Peters anomaly. By elucidating the chromatin regulatory mechanisms underlying lens cell identity, this work has the potential to inform therapeutic strategies for human eye diseases linked to transcriptional dysregulation.

Path with Art

Path with Art's purpose for this project is to utilize the power of art to build community and to foster restoration for those who have experienced trauma. The project is two-fold: hold workshops to design, create and install five `Free Little Art Galleries`(FLAG's) and provide 100 free art kits at each site for community members. Each FLAG will be placed near Path With Art's social service partners (Yesler Terrace, DESC, Plymouth Housing, KC Drug Diversion Court, and Sound Health) in underserved neighborhoods creating low-barrier entry opportunities for art exploration, inner healing, and joyous connection. At the culmination of the project, an exhibition of all collected art works will be held at the Seattle Center. The anticipated project completion date is 11/30/2022

Fresno Regional Foundation

Fresno Regional Foundation ($150M in assets) supports nonprofits in CA through grants focused on education, health, arts, community development. Awards range from $2,000 to $75,000.

NIBIB - National Institute of Biomedical Imaging and Bioengineering

Applications of brain Positron Emission Tomography (PET) have been in place for over 40 years. The combination of quantitative PET systems with novel radiotracers has led to numerous imaging paradigms for understanding normal and pathological brain physiology and pharmacology. Brain-dedicated PET systems offer important advantages over currently available PET systems in terms of sensitivity and resolution. Funded by a BRAIN Initiative grant, we developed the NeuroEXPLORER (NX), an ultra-high performance brain PET system. To date, human results have produced exceptional image quality and the delineation of small brain nuclei. The system's performance derives from its long axial field of view, small crystal elements, depth of interaction measurement, and excellent time-of-flight resolution. This proposal takes the next steps to optimize system performance including accuracy and precision, expand on the capabilities for dynamic PET with tracer kinetic modeling, and demonstrate the real-world performance with a wide range of PET radiopharmaceuticals. The proposal includes the following Aims. Specific Aim 1: Optimize key aspects of the system performance and reconstruction methodology to maximize image quality and minimize noise. We will further optimize and improve rigid and non-rigid motion correction, investigate impact of detector crosstalk and corrections, and develop reconstruction methods with practical computation times. Specific Aim 2: Develop and extend the capabilities of the NX for dynamic analysis using tracer kinetic modeling. Our initial assessment of extracting image-derived input functions from the carotid arteries has been very successful, and we will further validate this approach against arterial blood samples with a large cohort study using multiple radiopharmaceuticals that are commonly used in research and have potential clinical impact. We will also develop and validate methods to estimate the radiopharmaceutical metabolite corrections using population modeling and kinetic analysis strategies. In addition, the ultra-high resolution and sensitivity of the NX allows the reassessment of optimal modeling methods, which will be explored for tracers with challenging spatiotemporal distributions. Specific Aim 3: Real-world performance of human brain scans. We will further develop our 3D printing methods to generate a full-brain phantom and use it to compare to other PET systems. We will facilitate access of this phantom to other sites with novel brain PET systems. To truly optimize NX human imaging, we will perform test/retest studies with multiple radiopharmaceuticals and compare NX images to those of a current state-of- the-art whole-body system (Siemens Vision). This work will demonstrate the significance of the NX's performance characteristics and enable harmonization with conventional PET/CT scanners. In addition, we will perform brain activation studies using functional PET in a paradigm targeting the olfactory system, which is highly relevant in the early manifestations of neurodegenerative disorders.