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The Headstrong Project

Grants for barrier-free mental health treatment for post-9/11 veterans with PTSD and related conditions.

National Institutes of Health

Forty to sixty percent of individuals with opioid use disorder (OUD) have co-occurring chronic pain (CP), which impacts their ability to fully engage in treatment. Effective management of both conditions is hindered by siloed medical disciplines and health systems. HEAL Integrative Management of Chronic Pain and OUD for Whole Recovery (IMPOWR) was funded in FY21 to support 11 unique clinical trials to test novel interventions for the management of co-occurring chronic pain and OUD at the patient-level. The current NOFO will develop strategies to address barriers to the sustainable and effective delivery of integrated OUD/pain care at the health systems level. IMPOWR identified patient interventions that were effective and ready to implement. The current NOFO will address how health systems could be improved to facilitate the use of effective integrative interventions, including the involvement and roles of peer specialists, clinicians, health system leaders and other key decision makers. Also, this NOFO will characterize where such care can be optimally and efficiently delivered. Studies will identify collaborative care models, implementation strategies, and other innovative health system approaches to meaningfully integrate CP and OUD service provision in health settings. These studies will address complex factors that influence the ability to scale and sustain effective collaborative and integrated care for pain and OUD. The National Institute on Drug Abuse (NIDA) in partnership with National Institute on Alcohol and Alcoholism (NIAAA), National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institute of Mental Health (NIMH), and National Center for Complementary and Integrative Health (NCCIH), and National Institute of Neurological Disorders and Stroke (NINDS) intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications for research on the effective management of OUD and CP. Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the RM1 activity code. Investigators with expertise and insights into this area of chronic pain management and OUD/opioid misuse are encouraged to begin to consider applying for this new NOFO. In addition, collaborative investigations combining expertise in community-based participatory research approaches, implementation science, and other strategies to amplify scalability and sustainability will be encouraged and, these investigators should also begin considering applying for this NOFO.

National Institutes of Health

<p>Forty to sixty percent of individuals with opioid use disorder (OUD) have co-occurring chronic pain (CP), which impacts their ability to fully engage in treatment. Effective management of both conditions is hindered by siloed medical disciplines and health systems. HEAL Integrative Management of Chronic Pain and OUD for Whole Recovery (IMPOWR) was funded in FY21 to support 11 unique clinical trials to test novel interventions for the management of co-occurring chronic pain and OUD at the patient-level. The current NOFO will develop strategies to address barriers to the sustainable and effective delivery of integrated OUD/pain care at the health systems level. IMPOWR identified patient interventions that were effective and ready to implement. The current NOFO will address how health systems could be improved to facilitate the use of effective integrative interventions, including the involvement and roles of peer specialists, clinicians, health system leaders and other key decision makers.&nbsp;Also, this NOFO will characterize where such care can be optimally and efficiently delivered. Studies will identify collaborative care models, implementation strategies, and other innovative health system approaches to meaningfully integrate CP and OUD service provision in health settings. These studies will address complex factors that influence the ability to scale and sustain effective collaborative and integrated care for pain and OUD.&nbsp;</p><p><br></p><p>The National Institute on Drug Abuse (NIDA) in partnership with National Institute on Alcohol and Alcoholism (NIAAA), National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institute of Mental Health (NIMH), and National Center for Complementary and Integrative Health (NCCIH), and National Institute of Neurological Disorders and Stroke (NINDS) intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications for research on the effective management of OUD and CP. Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the RM1 activity code. Investigators with expertise and insights into this area of chronic pain management and OUD/opioid misuse are encouraged to begin to consider applying for this new NOFO. In addition, collaborative investigations combining expertise in community-based participatory research approaches, implementation science, and other strategies to amplify scalability and sustainability will be encouraged and, these investigators should also begin considering applying for this NOFO.</p>

National Institutes of Health

<p>40-75% percent of individuals with opioid use disorder (OUD) have co-occurring chronic pain (CP), which impacts their ability to fully engage in treatment. Effective management of both conditions is hindered by siloed medical disciplines and health systems. HEAL Integrative Management of Chronic Pain and OUD for Whole Recovery (IMPOWR) was funded in FY21 to test novel interventions for the management of co-occurring CP and OUD at the patient level. This initiative will test different implementation strategies and other approaches to address scalability and sustainability of evidence based practices for CP and OUD from a health system perspective. Studies will engage key decision leaders in health systems including but not limited to: peer specialists, clinicians, health system leaders, and payers. Studies will execute a single hybrid II/III implementation-effectiveness trial to focus on collaborative care models and implementation strategies to meaningfully integrate CP and OUD service provision in diverse health settings. These studies will address complex factors that influence the ability to scale and sustain effective and integrated care for CP and OUD. The BEACON Center will provide: (1) network coordination support, (2) capacity building at the intersection of CP, OUD, and implementation science, (3) annual surveys/qualitative activities to understand different barriers and attitudes impacting access and sustained use to integrated CP and OUD service delivery, (4) develop important resources for key stakeholder audiences that can inform/improve sustainability and scalability of evidence-based practices.</p><p>The National Institute on Drug Abuse (NIDA) in partnership with National Institute on Alcohol and Alcoholism (NIAAA), National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institute of Mental Health (NIMH), and National Center for Complementary and Integrative Health (NCCIH), and National Institute of Neurological Disorders and Stroke (NINDS) intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications for research on the effective management of OUD and CP. Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the U2C activity code. Investigators with expertise and insights into this area of CP management and OUD/opioid misuse are encouraged to begin to consider applying for this new NOFO. In addition, collaborative investigations combining expertise in community-based participatory research approaches, implementation science, and other strategies to amplify scalability and sustainability will be encouraged and, these investigators should also begin considering applying for this NOFO. Grant authorities that allow NIDA to forecast this opportunity are as follows: 42 U.S.C. § 241 and § 284.</p>

National Institutes of Health

40-75% percent of individuals with opioid use disorder (OUD) have co-occurring chronic pain (CP), which impacts their ability to fully engage in treatment. Effective management of both conditions is hindered by siloed medical disciplines and health systems. HEAL Integrative Management of Chronic Pain and OUD for Whole Recovery (IMPOWR) was funded in FY21 to test novel interventions for the management of co-occurring CP and OUD at the patient level. This initiative will test different implementation strategies and other approaches to address scalability and sustainability of evidence based practices for CP and OUD from a health system perspective. Studies will engage key decision leaders in health systems including but not limited to: peer specialists, clinicians, health system leaders, and payers. Studies will execute a single hybrid II/III implementation-effectiveness trial to focus on collaborative care models and implementation strategies to meaningfully integrate CP and OUD service provision in diverse health settings. These studies will address complex factors that influence the ability to scale and sustain effective and integrated care for CP and OUD. The BEACON Center will provide: (1) network coordination support, (2) capacity building at the intersection of CP, OUD, and implementation science, (3) annual surveys/qualitative activities to understand different barriers and attitudes impacting access and sustained use to integrated CP and OUD service delivery, (4) develop important resources for key stakeholder audiences that can inform/improve sustainability and scalability of evidence-based practices.The National Institute on Drug Abuse (NIDA) in partnership with National Institute on Alcohol and Alcoholism (NIAAA), National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institute of Mental Health (NIMH), and National Center for Complementary and Integrative Health (NCCIH), and National Institute of Neurological Disorders and Stroke (NINDS) intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications for research on the effective management of OUD and CP. Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the U2C activity code. Investigators with expertise and insights into this area of CP management and OUD/opioid misuse are encouraged to begin to consider applying for this new NOFO. In addition, collaborative investigations combining expertise in community-based participatory research approaches, implementation science, and other strategies to amplify scalability and sustainability will be encouraged and, these investigators should also begin considering applying for this NOFO. Grant authorities that allow NIDA to forecast this opportunity are as follows: 42 U.S.C. 241 and 284.

Health Canada

Grants for community-based mental health promotion, substance use prevention, and harm reduction programs across Canada.

NIDA - National Institute on Drug Abuse

PROJECT SUMMARY Alcohol, tobacco, and other drug use (ATOD), sexual health risks, and postpartum depression (PPD) are common and significant interrelated factors that are associated with poor health consequences for pregnant women and their infants, especially among rural, under-resourced communities. Thus, there is an urgent need to simultaneously address these health risks together during this vulnerable time. While pregnancy has been recognized as a window of opportunity in which to intervene, there are no empirically supported interventions tailored to specifically address these growing public health concerns together in rural women during pregnancy and postpartum. The objective of this R01 study is to fill this critical gap by building upon our promising R21/R01 findings by (1) partnering with a community advisory board to adapt and optimize the existing Health Check-up for Expectant Moms (HCEM) web-delivered Screening, Brief Intervention and Referral to Treatment or Prevention (SBIRT/P) program to include the interconnected risks of tobacco use and postpartum depression (PPD) among rural pregnant women (herein referred to as HCEM+), and (2) testing the efficacy of the HCEM+ in reducing ADOT, STI, and PPD risk more than a time and information matched control condition in rural pregnant women seeking prenatal care. This research addresses cross-cutting priorities in line with NIDA’s Strategic Plan to advance science on drug use: (1) prioritizing research to combat stigma and improve engagement in treatment, (2) developing and enhancing culturally responsive and tailored interventions, and (3) delivering care for substance use and co-occurring health conditions such as STIs and mental illness. We propose a two-group, randomized controlled trial in which a sample of 250 high-risk rural pregnant women attending prenatal care will be assigned to either (a) a web-delivered, two-session SBIRT/P plus two booster sessions consistent with motivational interviewing and informed by the Information-Motivation-Behavior (IMB) model, the HCEM+, or (b) a web-delivered control condition. Web-delivered follow-up assessments will occur at 8 and 24 weeks antenatally, and at 6 weeks postpartum, extending outcomes to the postpartum period. Specific Aim 1 is to test the hypothesis that HCEM+, compared to an attention, time and information matched control condition, will reduce unprotected sexual occasions and ADOT use among at-risk pregnant women during pregnancy at 2 and 6-months follow-up, and will increase treatment engagement. Specific Aim 2 is to test the hypothesis that HCEM+, compared to control, will reduce STIs and ADOT use at 6 weeks postpartum and will result in better birth outcomes and reduced rates of PPD. An economic evaluation of the costs of the HCEM+ will occur to guide future implementation and dissemination. Results of this program of research are expected to inform the development of a practical, cost-effective, high-reaching web-delivered SBIRT/P program tailored to reach high-risk rural and under-resourced women with extended impact to the postpartum period.

National Institutes of Health

-Purpose. The purpose of this Funding Opportunity Announcement (FOA) is to invite grant applications for biological, behavioral, social, addictive, and mental health research related to the health of lesbian, gay, bisexual, transgender, intersex, and other diverse populations. Proposed research should be appropriate for the missions of one or more of the participating Institutes. -Mechanism of Support. This FOA will utilize the NIH Research Project Grant (R01) award mechanism. Research applications that better fit under other award mechanisms, including the NIH Small Research Grant (R03) (see http://grants.nih.gov/grants/guide/pa-files/PA-06-180.html ), the NIH Academic Research Enhancement Award (R15) (see http://grants.nih.gov/grants/guide/pa-files/PA-06-042.html ), and the NIH Exploratory/Developmental Research Grant (R21) (see http://grants.nih.gov/grants/guide/pa-files/PA-06-181.html) are encouraged to be submitted under those other mechanisms. -Funds Available and Anticipated Number of Awards. Awards issued under this FOA are contingent upon the availability of funds and the submission of a sufficient number of meritorious applications.

State Treasurer's Office

Eligibility -Must be a health facility as defined in the Authority's Act (Section 15432(d) of the California Government Code) -Must be a non-profit 501(c)(3) corporation and qualify as a small or rural health facility or public health facility (e.g., district hospital) as defined in the Authority's Act (Section 15432(e) of the California Government Code)  -Small facilities must have annual gross revenues of $30 million or less (no revenue limit for rural facilities or district hospitals) -Must be licensed by the State of California, typically through the Department of Health Care Services, Public Health, or Social Services -Must have been in existence for at least three years, providing the same types of services -Must demonstrate evidence of discal soundness and the ability to meet the terms of the proposed loan -Facility must be certified, organized, maintained and operated for the diagnosis, care, prevention, and treatment of human illness, or physical, mental, or developmental disability, including convalescence and rehabilitation and including during care during and after pregnancy Use of Funds Funds may be used for: -Purchase, construction, renovation, or remodeling of real property -Purchase equipment and furnishings -Perform feasibility studies, site tests, and surveys associated with real property -Pay permit fees, architectural fees, and pre-construction costs -Refinancing existing debt Loan Terms -Minimum loan amount of $25,000 -Maximum loan amount of $1.5 million ($1 million for refinancing existing debt) -Interest rate of 3% (4% for refinancing existing debt) -Maximum loan maturity depends on use of funds.  Between 5 years for equipment and furnishings and 20 years for the purchase, construction and renovation of real property (15 years for refinancing existing debt) -Gross revenue pledge, as well as a lien on the equipment or property, is required -Maximum loan-to-value ratio of 95% -Borrowers must contribute a minimum of 5% (in the form of cash or documented project expenditures) toward project costs -Proforma debt service coverage of at least 1.0x Fees -$50 non-refundable application fee -Initial fee of 1.25% of the loan amount payable at closing -No ongoing program fees Required Documentation -Three most recent fiscal years of audited financial statements -Proof of adequate property and business insurance  

FIC - John E. Fogarty International Center for Advanced Study in the Health Sciences

Healthy Choices is a four-session behavior change communication intervention that was developmentally tailored for emerging adults to address self-management of health behaviors and HIV with evidence of positive effect on stigma and depression, built on Motivational Enhancement Therapy, integrating Motivational Interviewing with brief cognitive-behavioral strategies. Healthy Choices can be delivered in community settings by trained community health workers. When delivered with fidelity and in adequate dose, Healthy Choices results in reductions in alcohol use, HIV stigma, viral loads, and depression over follow-up compared to standard care. In the Dominican Republic, stigmas harm young people with HIV (YPWH). The Dominican Republic is a low- to middle- income country in the Latin America and Caribbean region, is 1 of 5 countries that accounts for over 95% of Caribbean HIV infections and has a culture that perpetuates stigmatizing attitudes and behaviors toward YPWH. To our knowledge, there are no Spanish-language interventions that concurrently address mental health, viral suppression, and stigma, tailored for young adults who are in a developmental period marked by exploration and a need for autonomy in health decision making. Considering the need for stigma reduction among YPWH to improve rates of viral suppression, reduce poor mental health, and encourage healthy coping by reducing problem alcohol use, we propose to adapt Healthy Choices for Spanish with local contexts plus co-create implementation strategies with community advising for future scale up. We will pilot test the adapted intervention and proposed intervention strategies, using a community-led implementation approach for feasibility, acceptability, and to assess for a signal of potential effectiveness on continuum of care outcomes including antiretroviral adherence and viral load. Considering the importance of context and the community-orientation of this study, we will apply the Exploration, Preparation, Implementation, Sustainment (EPIS) implementation science model, focusing on the Exploration and Preparation phases. We will engage community-based organizations (CBO) and a clinic in the Dominican Republic that work extensively with YPWH. Our investigator team has a long history of successful collaboration with impact on public health policy in the Latin American and Caribbean region. We propose three aims: (1) Elucidate barriers and implementation strategies for the Healthy Choices intervention; (2) Adapt and culturally translate the intervention for local contexts, and (3) Pilot test Healthy Choices with implementation strategies for feasibility and acceptability. If successful, we will have preliminary data for a full-scale hybrid type 1 effectiveness implementation randomized controlled trial of the intervention for underserved Spanish-speaking YPWH in the Dominican Republic with potential relevance to Spanish-speaking groups in the United States.

Health and Human Services Department

Thanks to President Trump's leadership, since 2017, the country has made significant progress in addressing mental health and substance use. However, President Trump and HHS Secretary Kennedy realize that the Department and country have more work to do. To facilitate this effort, HHS invites public comment in response to this RFI on the research, development, programs, and policies that have been most successful in improving availability of and access to effective prevention, treatment, and recovery interventions for addiction, mental illness, and co-occurring substance use and mental disorders. The purpose of this RFI is to identify research, programs, and policies that have been successful and recommend novel policy ideas and gaps in research that could be addressed and implemented to further the Great American Recovery using existing funding.

National Institutes of Health

-Purpose. This purpose of this Funding Opportunity Announcement (FOA) solicits Small Business Innovation Research (SBIR) grant applications from small business concerns (SBCs) that propose to develop and commercialize technologies for high throughput data acquisition and analysis that could aid the research fields of basic behavioral science, neuroscience or neuroAIDS relevant to the missions of the National Institute of Mental Health (NIMH) and National Institute of Neurological Disorders and Stroke (NINDS). -Mechanism of Support. This FOA will utilize the SBIR (R43/R44) grant mechanisms for Phase I, Phase II, and Fast-Track applications and runs in parallel with a FOA of identical scientific scope, PA-08-002, that solicits applications under the Small Business Technology Transfer (STTR) (R41/R42) grant mechanisms. -Funds Available and Anticipated Number of Awards. For this FOA, budgets up to $300,000 total costs per year and time periods up to 2 years for Phase I may be requested. Budgets up to $500,000 total costs per year and up to 3 years may be requested for Phase II. Awards issued under this FOA are contingent upon the availability of funds and the submission of a sufficient number of meritorious applications.

National Institutes of Health

-Purpose. This purpose of this Funding Opportunity Announcement (FOA) solicits Small Business Technology Transfer Program (STTR) grant applications from small business concerns (SBCs) that propose to develop and commercialize technologies for high throughput data acquisition and analysis that could aid the research fields of basic behavioral science, neuroscience or neuroAIDS, relevant to the missions of the National Institute of Mental Health (NIMH) and the National Institute of Neurological Disorders and Stroke (NINDS). -Mechanism of Support. This FOA will utilize the STTR (R41/R42) grant mechanisms for Phase I, Phase II, and Fast-Track applications and runs in parallel with a FOA of identical scientific scope, PA-08-001, that solicits applications under the Small Business Innovation Research (SBIR) (R43/R44) grant mechanisms. -Funds Available and Anticipated Number of Awards. For this FOA, budgets up to $300,000 total costs per year and time periods up to 2 years for Phase I may be requested. Budgets up to $500,000 total costs per year and up to 3 years may be requested for Phase II. Awards issued under this FOA are contingent upon the availability of funds and the submission of a sufficient number of meritorious applications.

NIMH - National Institute of Mental Health

PROJECT SUMMARY / ABSTRACT Monitoring neuronal activity modulation is pivotal for elucidating brain functionality and addressing neurological disorders. Despite the advancements brought by green fluorescent calcium indicators like GCaMP and neuromodulator sensors, a considerable gap persists in the development of red fluorescent sensors that match the properties of their green counterparts. This gap, characterized by limitations in dynamic range, photostability, and kinetics, restricts a more comprehensive exploration of neuronal interactions, especially in multiplexed, dual-imaging imaging scenarios. Additionally, the iterative engineering approach for new sensor development is notoriously slow and labor-intensive. Our central goal is to leverage our sensor screening platform, Opto-MASS, as well as our recent successes in using machine learning to expedite the optimization of fluorescent sensors. This project aims to engineer red fluorescent calcium and neuromodulator sensors that match the kinetics and dynamic range of green sensors and further enhance their properties. Our objectives include the rigorous benchmarking of these sensors against the best-in-class for properties such as dynamic range, kinetics, and photostability, followed by comprehensive in vivo validation across multiple laboratories and application scenarios using fiber photometry and two and 3-photon imaging. Our project is innovative because it utilizes a high-throughput screening assay capable of evaluating over 10,000 sensor variants from library collections in under an hour, a significant advancement over current methods. Coupled with pioneering machine learning models that identify key residues affecting sensor performance, we will significantly accelerate fluorescent sensor development, particularly for red calcium and GPCR-based sensors. Importantly, we aim to achieve these goals while reducing time and resource commitments. Our project directly addresses critical needs outlined in this FOA, including a broader range of reliable sensors in neuroscience research that facilitate nuanced, multidimensional studies of brain activity. By developing sensors with improved dynamic ranges, kinetics, and photostability, we aim to overcome existing barriers to multiplexed imaging of neuronal dynamics in vivo. Ultimately, the successful completion of this project would not only fill a vital gap in neuroscientific research tools but also align with the NIH BRAIN Initiative's objectives to advance neurotechnology and set new standards for molecular tool development and in vivo validation in neuroscience.

National Institutes of Health

-Purpose. This funding opportunity announcement (FOA) issued by the National Institute of Mental Health and National Institute on Drug Abuse invites grant applications from applicant organizations to advance scientific research and intervention regarding HIV treatment adherence. -Mechanism of Support. This FOA will utilize the NIH Small Research Grant (R03) mechanism and runs in parallel with FOAs of similar scientific scope, PA-07-338, which solicits applications under the Research Project Grant (R01) mechanism; PA-07-340, which solicits applications under the Exploratory/Developmental (R21) mechanism; and PAR-07-341, which solicits applications under the Exploratory Grants for Mental Health Interventions and Services (R34) mechanism. Please note that the participating organizations vary across this set of FOAs. -The R03 grant mechanism supports different types of projects including pilot and feasibility studies; secondary analysis of existing data; small, self-contained research projects; development of research methodology; and development of new research technology.

National Institutes of Health

-Purpose. This funding opportunity announcement (FOA) issued by the National Institute of Mental Health, National Institute on Drug Abuse, and National Institute of Nursing Research invites grant applications from applicant organizations to advance scientific research and intervention regarding HIV treatment adherence. -Mechanism of Support. This FOA will utilize the NIH Exploratory/Developmental (R21) grant mechanism and runs in parallel with FOAs of similar scientific scope, PA-07-338, which solicits applications under the Research Project Grant (R01) mechanism; PA-07-339, which solicits applications under the under the Small Research Grant (R03) mechanism; and PAR-07-341, which solicits applications under the Exploratory Grants for Mental Health Interventions and Services (R34) mechanism. Please note that the participating organizations vary across this set of FOAs. -The R21 grant mechanism is intended to encourage exploratory and developmental research projects by providing support for the early and conceptual stages of these projects. These studies may involve considerable risk but may lead to a breakthrough in a particular area, or to the development of novel techniques, agents, methodologies, models, or applications that could have a major impact on a field of biomedical, behavioral, or clinical research.

National Institutes of Health

-Purpose. This funding opportunity announcement (FOA) issued by the National Institute of Mental Health invites applications for Exploratory Grants for Mental Health Interventions and Services (R34) from applicant organizations to advance scientific research and intervention regarding HIV treatment adherence. -Mechanism of Support. This FOA will utilize the NIMH Exploratory Grants for Mental Health Interventions and Services (R34) grant mechanism and runs in parallel with FOAs of similar scientific scope, PA-07-338, which solicits applications under the Research Project Grant (R01) mechanism; PA-07-339, which solicits applications under the under the Small Research Grant (R03) mechanism; and PA-07-340, which solicits applications under the Exploratory/Developmental (R21) mechanism. Please note that the participating organizations vary across this set of FOAs. -Funds Available and Anticipated Number of Awards. Awards issued under this FOA are contingent upon the availability of funds and the submission of a sufficient number of meritorious applications.

National Institutes of Health

-Purpose. This Funding Opportunity Announcement (FOA) issued by the National Institute of Mental Health (NIMH), the National Institute on Drug Abuse (NIDA), and the National Institute on Alcohol Abuse and Alcoholism (NIAAA), National Institutes of Health (NIH), invites research grant applications focused on persons with severe mental illness (SMI), either before or after HIV infection, and the expansion of HIV-related research to include homeless persons. The FOA solicits studies on the development, implementation, evaluation, and dissemination of effective HIV-prevention interventions, and studies related to the epidemiology of HIV infection in the target populations. Multidisciplinary research teams and collaborative alliances are encouraged. -Mechanism of Support. This FOA will utilize the NIH Research Project Grant (R01) grant mechanism, Applications of related or identical scientific scope are also solicited under the NIH Small Research Grant (R03), the NIH Exploratory/Developmental Grant (R21), and the NIMH Clinical Exploratory Research Grant (R34) grant mechanisms, responding to FOAs PA-06-180, PA-06-181, and PAR-06-248, respectively. -Funds Available and Anticipated Number of Awards. Because the nature and scope of the proposed research will vary from application to application, it is anticipated that the size and duration of each award will also vary. The total amount awarded and the number of awards will depend upon the mechanism numbers, quality, duration, and costs of the applications received.

Hogg Foundation for Mental Health

Funds mental health programs and policy in Texas communities.

Black Child Development Institute

To honor Black Childcare providers and offer them resources that support their own care and their status as essential care givers, educators and business owners. This event is free and will include self-care advocates, nutrition support, dialogue with mental health professionals, business and finance consultants, and local funders. The event will be held from 10am until 3pm on October 22, 2022 at Rainier Beach Community Center.

NIMH - National Institute of Mental Health

PROJECT SUMMARY To retain new memories over long periods of time, the brain must be able to change in response to learning and then stabilize those changes to store long-term memories. However, the cellular mechanisms that enable long-term memory recall remain incompletely understood. Intriguingly, recent evidence suggests that myelin, the lipid-rich substance produced by glial cells known as oligodendrocytes, is critical for long- term memory recall. Myelin, previously thought to be static and stable after development, is critical for nervous system function; its primary role is to increase the conduction velocity of electrical signaling by neurons. In the adult brain, learning can induce the formation of new myelinating oligodendrocytes, known as oligodendrogenesis. The new myelin sheaths created by oligodendrogenesis are critical for the recall of long-term memories. However, how myelin is precisely modulated to regulate the neural activity underlying long- term memory storage remains an open question. To address this, I use an active avoidance paradigm in which mice learn to associate a light cue with a mild footshock and escape by shuttling to avoid footshock. The trial-based structure, the ability to compare correct and incorrect trials, and the greater diversity of behavioral readouts enable precise correlation between neural features and behavior. Furthermore, the specificity of these readouts can help uncover the precise circuits that are impacted by new myelin formation. Using the active avoidance, I will 1) identify which neurons become myelinated in the medial prefrontal cortex after avoidance learning using two-photon microscopy and 2) determine how oligodendrogenesis influences synchronization in the cortical-hippocampal-amygdala network during avoidance memory recall. Together, I will uncover how learning shapes myelination and how this myelin plasticity influences neural dynamics during long-term memory. These studies will shed light on underexplored, non-neuronal plasticity mechanisms that shape neural dynamics and have broad implications for our understanding of how the brain changes after learning. I will be conducting these experiments in Dr. Mazen Kheirbek’s laboratory, where all the techniques necessary for my project have been set up. The Kheirbek laboratory is located at the University of California, San Francisco, a world-renowned biomedical research facility. With the support of Dr. Kheirbek, co-sponsor Dr. Vikaas Sohal, and additional support from Dr. Jonah Chan, I am perfectly positioned to complete the described project. My postdoctoral work will enable me to achieve my ultimate career goal of running an independent academic laboratory studying how neuron-glia interactions influence neural circuit dynamics and behavior.

NIMH - National Institute of Mental Health

ABSTRACT The dynamics of HIV infection in the brain is poorly understood. Infected cells that transport HIV across the blood brain barrier and into the brain causes inflammation and subsequent damage to resident brain cells. This manifests as a group of symptoms collectively referred to as HIV associated neurocognitive deficits (HAND). Today, in the post ART era, HAND consists of mild to moderate symptoms. This research is significant because it uses an in vivo model to assess the unique interactions among brain cells and peripheral immune cells in vivo in an HIV infected ASRT treated model. Results from these studies will give a better understanding of the events that define neuroHIV in the ART era.

NIDA - National Institute on Drug Abuse

SUMMARY/ABSTRACT Adolescent nicotine vaping remains prevalent alongside increases in cannabis vaping, nicotine-cannabis co-vaping, and daily/near-daily nicotine and cannabis vaping rates since 2019. Nicotine and cannabis vaping are associated with nicotine and cannabis dependence, carcinogen exposure, and pulmonary, cognitive, and mental health symptoms, with co-vaping posing additive health risk. Despite the critical role of parents in preventing adolescents’ tobacco and cannabis smoking, adolescents’ vaping poses difficulties for parents in their ability to engage in vaping prevention parenting behaviors (VPPBs), as vape devices may be disguised as other products and modified to vape cannabis and higher levels of nicotine. Less than half of parents report knowledge of vape device characteristics, vaping health consequences, adolescent vaping norms, and youth-targeted vaping marketing. Social media messages about vaping and VPPBs are ideal prevention tools, as 90% of US parents use social media regularly including for health information and parenting advice. This proposal is informed by social cognitive theory and the health belief model and builds on our team’s expertise in longitudinal studies of parenting and adolescent substance use and experimental studies testing youth vaping messaging. The overall goal of this work is to understand how to empower parents to prevent adolescent nicotine and cannabis vaping. We will conduct a 6-wave longitudinal survey study among 1,000 US parent-adolescent (ages 12-17) dyads recruited via social media and a 5-week online experimental study among a subset of 300 parents with low parent vaping knowledge (PVK) to test messages designed to improve PVK and VPPBs. Parents will be randomly assigned to view Facebook posts in a 4 (within-persons) X 3 (between-persons) mixed design. Each parent will view: 1) 4 sets of messages aimed at promoting PVK (device characteristics, harms, norms, youth-targeted marketing) in a randomized order; and 2) one of 3 sets of messages aimed at promoting VPPBs (rules, monitoring, communication). Experimental outcomes include PVK (i.e., device characteristics, health consequences, vaping norms, youth-targeted marketing), use of VPPBs (i.e., rules, monitoring, communication), and adolescents’ vaping outcomes (i.e., any current nicotine/cannabis vaping, frequency of nicotine/cannabis vaping, co-vaping vs. nicotine-/cannabis-only vaping, susceptibility to future nicotine/cannabis vaping). We will address 2 specific aims: Aim 1 (longitudinal surveys) - Examine 1a) direct associations of PVK and VPPBs with adolescents’ nicotine and cannabis vaping trajectories; and 1b) indirect associations of PVK with adolescents’ nicotine and cannabis vaping trajectories via VPPBs as mediators; and Aim 2 (experimental study) - Examine: 2a) within-persons effects of PVK messaging themes on PVK outcomes and between-persons effects of VPPB messaging themes on VPPB outcomes; and 2b) within-persons effects of PVK messaging themes on adolescents’ vaping outcomes via increases in PVK and between-persons effects of VPPB messaging themes on adolescents’ vaping outcomes via increases in VPPB use. This proposal is responsive to NIDA’s NOT-DA-22-004: Epidemiology of Drug Abuse and will inform large-scale social media messaging campaigns empowering parents to prevent adolescent nicotine and cannabis vaping initiation and progression.

NIMH - National Institute of Mental Health

PROJECT SUMMARY/ABSTRACT. The overall objective of the proposed K23 is to support Dr. Rachel Siciliano in acquiring the skills necessary to become an independent investigator focused on elucidating mechanisms underlying treatment and individual differences corresponding to treatment response in trauma- exposed youth. Trauma-related mental health problems are a major public health problem. Over four million adolescents meet criteria for posttraumatic stress disorder (PTSD) in the U.S., and while evidence-based treatments (EBTs) are effective, up to a quarter of youth do not respond. EBT mechanisms and predictors of EBT components remain largely unknown. EBTs for PTSD include repeated imaginal exposure to trauma- related content, hypothesized to impact distress and PTSD symptoms via shifts in biological reactivity. Further, baseline threat reactivity and emotion regulation characteristics may influence EBT response. The proposed K23 directly addresses critical gaps in understanding how and for whom repeated imaginal exposure is effective in adolescents with trauma-exposure and PTSD symptoms. The goals of the proposed project are to: (1) examine the biobehavioral effects of repeated imaginal exposure and assess psychophysiological change as a potential mechanism of anxiety change; (2) assess baseline threat reactivity and emotion regulation as predictors of exposure task response; and (3) determine if baseline characteristics and exposure task responses relate to PTSD symptoms longitudinally. Dr. Siciliano is a promising candidate with a strong foundation in biobehavioral assessment and trauma-focused treatment but requires additional training. The proposed training plan closely aligns with the research goals and includes: (1) clinical and randomized controlled trials for adolescent PTSD; (2) EEG and EMG acquisition and analysis with data integration techniques; (3) experimental therapeutics, treatment mechanisms, causal inference, and longitudinal statistics; (4) precision medicine approaches and subgroup analyses; and (5) professional development. The rich academic environment at the Medical University of South Carolina and collective expertise of the mentorship team (Drs. Danielson, McTeague, Cisler, Whitfield-Gabrieli, Hayat) are uniquely suited to provide this training. The mentorship team, coursework, seminars, workshops, and conference attendance afforded by the K23 are essential for launching the candidate's independent career as a high impact translational scientist focused on EBT mechanisms and precision medicine advances for trauma-exposed youth. Findings have wide-ranging implications, as imaginal exposure is a central component in multiple interventions, and identifying distinct combinations of baseline characteristics matching onto exposure may improve treatment response predictions, thus advancing more precise interventions. Results from the proposed research will inform the development of future R01 grants targeting specific mechanisms of EBT components and testing if response to those components varies as a function of baseline characteristics or profiles.