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View full policyEnhancing Mechanistic Research on Precision Probiotic Therapies (R33 Clinical Trial Optional)
About This Grant
The purpose of this notice of funding opportunity (NOFO) is to support highly innovative mechanistic research to accelerate precision probiotic interventions. Specifically, this NOFO solicits R33 applications that will characterize person-specific features affecting probiotic responses to identify subgroups of probiotic responders and to enhance probiotic clinical outcomes. The ultimate goal of this NOFO is to identify, understand, and develop strategies to address barriers in precision probiotic therapies to account for the heterogenicity in humans that causes inconsistent probiotic responses. This NOFO will support studies to assess the ability of the unique patterns of host biology (e.g., native microbiome, immune system, gender, diet, age, genetic background, lifestyle, and health history) that are correlated with probiotic usage to detect the improvement of probiotic responsiveness. Well-suited applications must offer rigorously designed mechanistic studies using relevant/innovative animal models or in human subjects. This NOFO is intended to support projects where potential host biological patterns that are correlated with probiotic usage have been identified, as demonstrated with supportive preliminary data, but require further mechanistic studies to test for their causality or predictability. Applicants pursuing early-stage research to identify host biological patterns that may affect probiotic health outcomes should consider the companion (R61/R33) NOFO PAR-AT-24-XXX (TEMP-25412).
Grant Summary
Enhancing Mechanistic Research on Precision Probiotic Therapies (R33 Clinical Trial Optional) is a National Institutes of Health grant providing funding that varies by award for university, tribal government, nonprofit. Applications are due 2027-06-02 (open). Check eligibility and apply with FindGrants.
Focus Areas
Eligibility
- Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
How to Apply
Up to $0K
2027-06-02
- 1Confirm your organization is eligible for Enhancing Mechanistic Research on Precision Probiotic Therapies (R33 Clinical Trial Optional) from National Institutes of Health, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to National Institutes of Health before the deadline.
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Enhancing Mechanistic Research on Precision Probiotic Therapies (R33 Clinical Trial Optional): Frequently Asked Questions
Who is eligible for the Enhancing Mechanistic Research on Precision Probiotic Therapies (R33 Clinical Trial Optional)?
Enhancing Mechanistic Research on Precision Probiotic Therapies (R33 Clinical Trial Optional) is offered by National Institutes of Health and is generally open to university, tribal government, nonprofit, small business, municipality, school district. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the Enhancing Mechanistic Research on Precision Probiotic Therapies (R33 Clinical Trial Optional) provide?
Enhancing Mechanistic Research on Precision Probiotic Therapies (R33 Clinical Trial Optional) provides an amount that varies by award per award from National Institutes of Health. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the Enhancing Mechanistic Research on Precision Probiotic Therapies (R33 Clinical Trial Optional) deadline?
Applications for Enhancing Mechanistic Research on Precision Probiotic Therapies (R33 Clinical Trial Optional) are due 2027-06-02 (open). Because deadlines can change, verify the date with the funder, National Institutes of Health, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the Enhancing Mechanistic Research on Precision Probiotic Therapies (R33 Clinical Trial Optional)?
To apply for Enhancing Mechanistic Research on Precision Probiotic Therapies (R33 Clinical Trial Optional), confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from National Institutes of Health.