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Salt Lake City Department of Economic Development

Low-interest loans and grants supporting small business development, commercial revitalization, and economic growth in Salt Lake City neighborhoods.

City of San Antonio Economic Development Department

Financial assistance for small businesses in San Antonio including microloans, facade grants, and technical assistance programs focused on underserved entrepreneurs.

City of San Diego Economic Development Department

Grants of $5,000 to $25,000 for small businesses in San Diego, supporting storefront improvements, marketing, equipment purchases, and business expansion.

San Francisco Office of Economic and Workforce Development

Grants and financial assistance for small businesses, neighborhood commercial districts, and workforce development programs throughout San Francisco.

U.S. Small Business Administration

Mission-focused lending through CDFIs and nonprofits providing SBA 7(a) loans up to $350K to small businesses in underserved communities.

U.S. Small Business Administration

Provides small loans up to $50,000 through nonprofit intermediary lenders for startup and expansion of small businesses and childcare centers.

U.S. Small Business Administration

Phase I feasibility awards for small businesses to conduct R&D on innovative technologies with commercial potential. 11 federal agencies participate.

U.S. Small Business Administration

Phase II continuation awards for successful Phase I recipients to further develop their innovations into prototype products or services.

National Institutes of Health

The Commercialization Readiness Pilot (CRP) program helps small business concerns (SBCs) move NIH-funded SBIR or STTR projects from late-stage development to commercialization. The CRP supports later-stage research and development (R&D) and/or technical assistance that Phase II and Phase IIB Strategic Breakthrough awards do not typically support. This includes:Independent replication or confirmation of key studiesIND- or IDE-enabling studiesClinical studiesManufacturing scale-up and related quality activitiesRegulatory and other specialized technical supportSBCs may subcontract (outsource) a significant amount of the work in a CRP to meet the project goals.

National Institutes of Health

The Commercialization Readiness Pilot (CRP) program helps small business concerns (SBCs) move NIH-funded SBIR or STTR projects from late-stage development to commercialization. The CRP supports later-stage research and development (R&D) and/or technical assistance that Phase II and Phase IIB Strategic Breakthrough awards do not typically support. This includes:Independent replication or confirmation of key studiesIND- or IDE-enabling studiesClinical studiesManufacturing scale-up and related quality activitiesRegulatory and other specialized technical supportSBCs may subcontract (outsource) a significant amount of the work in a CRP to meet the project goals.

U.S. Mission to Bolivia

Project Background, Goals, and Objectives Bolivia has one of the largest informal economies in Latin America, with a significant portion of entrepreneurial activity occurring outside formal business structures. Many entrepreneurs operate small-scale businesses in sectors like retail, food services, construction, and personal services without formal registration, limiting their access to credit, legal protections, and growth opportunities. These informal businesses also face barriers to adopting modern business practices and technologies, including U.S.-based financial management tools and digital solutions that could enhance their competitiveness. By bringing businesses into the formal economy, ScaleUp Bolivia will expand the customer base for U.S. products and services, create more reliable supply chain partners for American companies, and open new markets for American technology providers and suppliers. The program will strengthen the rule of law and economic governance, reduce unfair competition in the marketplace, increase municipal tax revenues that support local development, and generate economic growth that benefits both Bolivian communities and U.S. commercial interests. Additionally, formalized businesses become better positioned to engage in international trade and adopt U.S. business standards, creating a foundation for sustained bilateral economic partnership.Project Audience(s): Primary beneficiaries should include: Informal entrepreneurs currently operating outside the formal economy who are ready to legitimize their businesses. Micro and small business owners in sectors such as retail, food services, construction, and personal services lack knowledge of formalization processes. Entrepreneurs who face additional barriers to entering the formal market due to limited access to information, capital, and networks.Project Goal: The project goal is to transition 100 informal Bolivian businesses into the formal economy within 12 months by providing world-class entrepreneurship education, formalization guidance, and U.S. business partnerships, thereby expanding markets for American products and services while strengthening Bolivia's economic governance and creating sustainable commercial ties between Bolivian entrepreneurs and U.S. companies. OObjective 1: Business Formalization and Education Enroll 100 informal Bolivian entrepreneurs in world-class business education through the Najafi 100 Million Learners Global Initiative and formalize at least 40 businesses within 12 months through guided support on registration, tax compliance, permits, and financial management using U.S.-based tools.Objective 2: U.S. Commercial Partnerships Establish commercial relationships between at least 20 newly formalized Bolivian businesses and U.S. suppliers or technology providers within 12 months, generating purchases of American products and services and expanding markets for U.S. companies.Objective 3: Institutional Collaboration and Economic Impact Partner with Bolivia's tax authority, municipal governments, chambers of commerce, and U.S. fintech companies to streamline formalization, increase municipal tax revenue, create 150+ formal jobs, and establish a peer network of 50+ entrepreneurs for sustained growth and U.S. business engagement.Expected Outcome:The program should achieve the following outcomes within 12 months: formalize at least 15 businesses per city; connect at least 20 newly formalized businesses with U.S. suppliers or service providers; increase tax revenue for Bolivian municipalities; and create a peer support network of formalized entrepreneurs.2. Substantial InvolvementThis award is expected to be a cooperative agreement because the U.S. Embassy in La Paz anticipates substantial involvement in program implementation.U.S. Embassy Roles and ResponsibilitiesThe U.S. Embassy may: Review and approve the final participant recruitment and selection approach. Review and approve key program themes, speakers, and technical framing. Provide input on U.S. foreign policy messaging and public diplomacy objectives. Review branding, visibility, and outreach materials. Coordinate Embassy participation in selected program events. Monitor implementation and performance throughout the award period.Recipient Roles and ResponsibilitiesThe recipient will: Design and implement all program activities in accordance with the approved proposal and budget. Manage logistics, participant outreach, and event coordination. Identify and coordinate qualified trainers, speakers, and partners. Ensure program content is technically sound and aligned with the objectives of this NOFO. Track participant engagement and program performance. Submit all required financial and programmatic reports.

Schoharie

Small Business

National Institutes of Health

Purpose. This Funding Opportunity Announcement (FOA) encourages the formation of partnerships between academic institutions and school systems in order to develop and implement controlled, school-based intervention strategies designed to reduce the prevalence of obesity in childhood. This FOA also encourages evaluative comparisons of different intervention strategies, as well as the use of methods to detect synergistic interactions between different types of interventions. Mechanism of Support. This FOA will utilize the NIH Research Project Grant (R01) award mechanism and runs in parallel with FOAs of identical scientific scope, PA-06-416 and PA-06-417, that solicit applications under the Small Research Grant (R03) and the Exploratory/Developmental Grant (R21) award mechanisms, respectively. Funds Available and Anticipated Number of Awards. Because the nature and scope of the proposed research will vary from application to application, it is anticipated that the size and duration of each award will also vary. The total amount awarded and the number of awards will depend upon the mechanism numbers, quality, duration, and costs of the applications received. Eligible Institutions/Organizations. Public/State Controlled Institution of Higher Education; Private Institution of Higher Education; Nonprofit with 501(c)(3) IRS Status (Other than Institution of Higher Education); Nonprofit without 501(c)(3) IRS Status (Other than Institution of Higher Education); Small Business; For-Profit Organization (Other than Small Business); State Government; U.S. Territory or Possession; Indian/Native American Tribal Government (Federally Recognized); Indian/Native American Tribal Government (Other than Federally Recognized); Indian/Native American Tribally Designated Organization; Non-domestic (non-U.S.) Entity (Foreign Organization); Hispanic-serving Institution; Historically Black Colleges and Universities (HBCUs); Tribally Controlled Colleges and Universities (TCCUs); Alaska Native and Native Hawaiian Serving Institutions; Regional Organization; Other(s): Eligible agencies of the Federal government; Faith-based or community based organizations.

U.S. Small Business Administration

Supports the SCORE network of volunteer mentors providing free business mentoring, workshops, and educational resources to small business owners.

San Francisco Office of Small Business

Financial assistance, grants, and fee waivers for small businesses in San Francisco, including storefront improvement grants and legacy business preservation funding.

National Institutes of Health

Purpose. The NIH Blueprint for Neuroscience Research is a framework to enhance cooperative activities among the NIH Office of the Director and 15 NIH Institutes and Centers that support research on the nervous system. This FOA is released in affiliation with the Neuroscience Blueprint, with Institutes and Centers participating independently, and with participation by Institutes that are not part of the Neuroscience Blueprint. Institutes that are not part of the Blueprint are also participating. Sharing data and tools across a research community adds tremendous value to the efforts of that community. Search engines like Google show the power of sharing text based data. While strides have been made, the infrastructure necessary to share and query data sets that have more than just textual biomedical data is still under development. Examples of such heterogeneous data sets include those that contain images, clinical data, or genomic/gene expression data. Two large NIH supported infrastructure projects to allow data and tool sharing are the caBIG program and the Biomedical Informatics Research Network (BIRN). Many of the communities involved in neuroscience research embrace the data/tool sharing idea. Some communities, such as neuroimaging researchers, have seized it, and in so doing, have accrued scientific benefits that would have been otherwise out of reach. As a specific example, three neuroimaging research communities are serving as the biological test beds for the BIRN infrastructure (http://www.nbirn.net). The BIRN infrastructure has now matured to the point where it can serve as a platform for data sharing and informatics tool sharing that extends beyond the neuroimaging researchers involved in the test beds, to include other areas of neuroscience beyond imaging, and to include biomedical research beyond neuroscience. The caBIG program has goals that are related to those of the BIRN program, but has chosen a different development path. caBIG aims to develop applications and underlying architecture that connects data and tools in an open, federated environment. Interoperability in caBIG is based on standardizing interfaces and data, rather than on specific software systems used in BIRN. General information concerning caBIG can be found at https://cabig.nci.nih.gov/ . This FOA invites applications to make either data or tools more broadly available to the research community by making use of the BIRN and/or the caBIG infrastructure. Mechanism of Support. This FOA will utilize the NIH Research Project Grant (R01) award mechanism. Funds Available and Anticipated Number of Awards. Awards issued under this FOA are contingent upon the availability of funds and the submission of a sufficient number of meritorious applications. Because the nature and scope of the proposed research will vary from application to application, it is anticipated that the size and duration of each award will also vary. The total amount awarded and the number of awards will depend upon the mechanism numbers, quality, duration, and costs of the applications received. However, it is anticipated that many of the awards will be for limited amounts ($100,000 to $200,000 direct costs per year) and for short periods of time (2-3 years). It is not likely that these R01s will be renewed. Eligible Institutions/Organizations. Public/State Controlled Institution of Higher Education; Private Institution of Higher Education; Nonprofit with 501(c)(3) IRS Status (Other than Institution of Higher Education); Nonprofit without 501(c)(3) IRS Status (Other than Institution of Higher Education); Small Business; For-Profit Organization (Other than Small Business); Non-domestic (non-U.S.) Entity (Foreign Organization). Eligible Project Directors/Principal Investigators (PDs/PIs). Individuals with the skills, knowledge, and resources necessary to carry out the proposed research are invited to work with their institution/organization to develop an application for support. Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply for NIH support. Number of Applications. Applicants may submit more than one application, provided each application is scientifically distinct. Renewals and Resubmissions. Applicants may submit a resubmission application, but such application must include an Introduction addressing the previous peer review critique (Summary Statement). Number of PDs/PIs. More than one PD/PI, or multiple PDs/PIs, may be designated on the application. Application Materials. See Section IV.1 for application materials. General Information. For general information on SF424 (R and R) Application and Electronic Submission, see these Web sites: SF424 (R and R) Application and Electronic Submission Information: http://grants.nih.gov/grants/funding/424/index.htm General information on Electronic Submission of Grant Applications: http://era.nih.gov/ElectronicReceipt/ Hearing Impaired. Telecommunications for the hearing impaired is available at: TTY 301-451-0088. Technical Assistance Workshop. A technical assistance workshop is planned on October 18 to answer questions about this FOA. Participants can attend the meeting in person at the Natcher Auditorium on the NIH Campus or can participate via a videocast. Registration for the workshop and additional information can be found at http://www.nbirn.net . Special Submission/Receipt Date(s): January 18, 2008, September 18, 2008, January 21, 2009, and September 21, 2009 Special Review convened by CSR.

National Institutes of Health

This is a Notice of Funding Opportunity (NOFO) for a Single Source that will invite an application from the eligible organization to apply. Please see Section III. Eligibility for additional information. In accordance with NIH standard peer-review processes, the application will be peer-reviewed, and if it is not a meritorious application, it will not be funded. This single source NOFO is intended to support a Data Coordinating Center (DCC) to conduct the activities of the Cardiothoracic Surgical Trials Network (CTSN). The DCC will consist of two collaborating components including a Data Management and Analytics Center (DMAC) and a Clinical Coordination Center (CCC). NHLBI strongly encourages multi-PD/PI applications with two PDs/PIs; one PD/PI for the DMAC and one PD/PI for the CCC. The primary responsibility of the DCC is to oversee the conduct of multiple randomized clinical trials in the CTSN.The DCC will support regulatory and administrative activities, data collection and management, and statistical analysis and reporting of trial results in a timely manner. The DCC will promote collaboration and communication among CTSN investigators and the broader research community and will coordinate outreach activities including engaging foundations, research entities, and small businesses in trials of mutual interest and public health importance. The DCC is responsible for integrating the efforts of clinical sites, core laboratories, and other collaborators, and conducting long-term follow-up centrally via telephone follow-up at the DCC. The NHLBI anticipates that the DCC will manage a Clinical and Implementation Research Skills Program centrally. The clinical and implementation research scholars program will support the expanded integration of clinical skills with dissemination and implementation science scholarship to enhance implementation research capacity. The scholars program would be designed to foster additional research questions within CTSN as well as generate a cohort of researchers who would transport their scholarship as they transition to leadership positions in academic and clinical programs.

State University of New York (SUNY)

Provides assistance to the small business community through expert management and technical assistance to start-up and existing businesses across the state by linking the resources of Federal, state and local governments with the resources of the educational community and the private sector.

Administration for Community Living

Small Business Innovation Research (SBIR) program, Phase I

National Institute of Standards and Technology

NIST invites applications for a program involving technical and business engagement activities directed at small firms participating in NIST s SBIR Program. The recipient will provide NIST SBIR Phase I and/or Phase II awardees with technical and business expertise and resources to identify optimum pathways to promote successful transition of the Phase I and/or Phase II results to commercialization.

U.S. National Science Foundation

Small Business Innovation Research / Small Business Technology Transfer Phase I, Phase II, Fast-Track Programs (SBIR/STTR): A Pilot Emphasis on Scientific Instrumentation.

U.S. National Science Foundation

NSF invests in scientific discoveries, technological breakthroughs, and transformative innovations that strengthen economic growth, enhance security, and improve the lives of Americans and people around the world. Our ability to support that mission requires a robust scientific and engineering (S&E) enterprise in the United States that allows scientists to innovate at the frontier. In addition to funding scientists, America needs next-generation scientific instrumentation that allows scientists to pursue new innovations. In many fields, it is critical that this new scientific instrumentation is developed in the United States. In support of this mission, NSF is initiating a pilot emphasis area for itsSBIR/STTR programs to invest in startups and small businesses that are specifically developing enabling technologies that include next-generation instrumentation, novel experimental platforms, and other scientific equipment to advance the frontiers of scientific discovery and strengthen the American scientific and engineering enterprise. This encompasses novel instrumentation necessary for the coming era of AI-driven discoveries. This pilot will prioritize investing in the necessary infrastructure to support entirely new fields of scientific discovery, making new technological breakthroughs and transformative applications possible. Through this approach, NSF will continue to lead in propelling the scientific enterprise to new frontiers. This pilot emphasis area for the NSF SBIR/STTR programs funds across enabling technology areas and market sectors in alignment with the above goals; the programs do not solicit specific technologies for the purpose of procuring goods and services for the agency from startups and small businesses. NSF will continue to invest in other deep-tech ventures through the historic NSF SBIR/STTR programs available here. Funding opportunities are available through the NSF SBIR/STTR programs: Phase I, Phase II, Fast-Track, and Supplements. Each company can receive up to $2.0 million for R&D. Separately, NSF welcomes Strategic Breakthrough proposals, upon recommendation from the Program Officer, for Phase II awardees. NSF takes no equity and awardees keep full ownership of their company and intellectual property. Expanding Participation in STEM and Gold Standard Science: NSF prioritizes cutting-edge discovery science and engineering research, advancing technology and innovation, and creating opportunities for all Americans. NSF also expects the highest standards of scientific rigor, integrity and adherence to tenets ofGold Standard Sciencein proposals, as appropriate for the field of science and research modality.

Administration for Community Living

Small Business Innovation Research Program (SBIR) Phase II

U.S. National Science Foundation

The Small Business Innovation Research (SBIR) Program stimulates technological innovation in the private sector by strengthening the role of small business concerns in meeting Federal research and development needs, increasing the commercial application of federally supported research results, and fostering and encouraging participation by socially and economically disadvantaged and women-owned small businesses.