Search Grants — Free, No Account Required

NIAID - National Institute of Allergy and Infectious Diseases

PROJECT SUMMARY With the most people ever in history currently living with HIV, stopping the HIV epidemic remains imperative. Combination antiretroviral therapy (ART) limits viral replication, but is not curative. Thus, there is an urgent need to design a functional cure via elimination of the viral reservoir. We recently found that the combination of antiretroviral therapy, broadly neutralizing antibodies, and CCR5 blockade were able to completely clear establishment of infection in newborn macaques when delivered by day three post-infection. However, it remains unclear how far post-infection this treatment window extends in newborns and if this treatment is also effective in adults. In specific aim 1, we will systematically identify the window of opportunity for this novel triple therapy treatment to clear the latent reservoir by delaying treatment multiple days. In specific aim 2, we will determine if this remarkable clearance of reservoir establishment via triple therapy is also effective in adults infected via sexual transmission. Because all three components of this triple therapy are currently being tested individually in humans, successful completion of the aims here will set the stage for clinical trials to for HIV cure.

U.S. National Science Foundation

TheCombustion and Fire Systemsprogram is part of the Transport Phenomena cluster, which also includes 1) theFluid Dynamicsprogram; 2) theParticulate and Multiphase Processesprogram; and 3) theThermal Transport Processesprogram. The goal of theCombustion and Fire Systemsprogram is tocreate new knowledge to support advances in clean energy, climate change mitigation, a cleaner environment and public safety. The program endeavors to createfundamental scientific knowledge that is needed for safe, clean and useful combustion applications and for mitigating the effects of fire.The program aims to identify and understand the controlling basic principles and to use that knowledge to create predictive capabilities for designing and optimizing practical combustion devices and understanding fire. Important outcomesfor this program include: broad-based tools experimental, theoretical, andcomputational that can be applied to a variety of problems in combustion technologies and fire; science and technology for clean and efficient generation of power; discoveries that enable clean environments (for example, by reduction in combustion-generated pollutants); and enhanced public safety and climate change mitigation through research on wildland and building fire growth, inhibition, and suppression. Research areas of interest for this program include: Basic combustion science: Combustion of gas, liquid, and solid fuels over abroad range of temperatures, pressures, and compositions; combustion at supercritical conditions; advanced propulsion concepts; flame synthesis ofmaterials; integration of fuel design and combustion; control of reaction pathways; development of chemical kinetics models, analytical and numerical predictive methods, and advanced diagnostic tools. Combustionscience related to clean energy: Increasing efficiency and reducing pollution; production and use of renewable and/or carbon-free fuels; biomass pyrolysis, gasification, and oxidation; technologies such as oxy-fuel combustion and chemical looping combustion for carbon capture. Fireprevention: Improved understanding of building and wildland fires to prevent their spread, inhibit their growth, and suppress them; prediction and mitigation of fires in the wildland-urban interface. Turbulence-chemistry interactions:Fundamental understanding of turbulent flow interactions with finite-rate chemical kinetic pathways at high Reynolds and Karlovitz number conditions, including but not limited to: (1) fundamental experiments to generate physico-chemical data to reduce theuncertainty of combustion chemistry and turbulent combustion models; (2)spatially/temporally well-resolved, multi-scale/multi-physics computations;novel approaches of developing embedded multi-scale direct numericalsimulation (DNS) of complex geometries and data-assimilations forincorporating measured data from the state-of-art in situ diagnostic approaches; (3) other innovative approaches on development and validation of predictive computational methods. NOTE: This is an NSF-AFOSR (Air Force Office of Scientific Research) joint funding area. Proposals will be jointly reviewed by NSF and AFOSR using the NSF merit reviewprocess.Actual funding format and agency split for an award(depending on availabilityof funds) will be determined after the proposal selection process. The AFOSR program that participates in this initiative is the program on Energy, Combustion, and Nonequilibrium Thermodynamics. Innovative proposals outside of these specific interest areas may be considered.However, prior to submission, it is recommended that the Principal Investigator contact the program director to avoid the possibility of the proposal being returned without review. INFORMATION COMMON TO MOST CBET PROGRAMS Proposals should address the novelty and/orpotentially transformative natureof the proposed work compared to previous work in the field.Also, it is important to address why the proposed work is important in terms of engineering science, as well as to also project the potential impact on society and/or industry of success in the research.The novelty or potentially transformative nature of the research should be included, as a minimum, in the Project Summary of each proposal. The duration of unsolicited proposal awards in CBET is generally up to three years. Single-investigator award budgets typically include support for one graduate student (or equivalent) and up to one month of PI time per year(awards for multiple investigator projects are typically larger). Proposal budgets that are much larger than typical should be discussed with the program director prior to submission. Proposers can view budget amounts and other information from recent awards made by this program via the What Has Been Funded (Recent Awards Made Through This Program, with Abstracts) link towards the bottom of this page. Faculty Early Career Development(CAREER)program proposals are strongly encouraged.Award duration is five years.The submission deadline for Engineering CAREER proposals is in July every year. Learn more in theCAREER program description. Proposals for Conferences, Workshops, and Supplements: PIs are strongly encouraged to discuss their requests with the program director before submission of the proposal. Grants forRapid Response Research(RAPID)andEArly-concept Grants for Exploratory Research(EAGER)are also considered when appropriate.Please note that proposals of these types must be discussed with the program director before submission.Grant Opportunities for Academic Liaison with Industry (GOALI)proposals that integrate fundamental research with translational results and are consistent with the application areas of interest to each program are also encouraged. Please note that RAPID, EAGER, and GOALI proposals can be submitted anytime during the year. Details about RAPID, EAGER, and GOALI are available in the Proposal & Award Policies & Procedures Guide (PAPPG), Part 1, Chapter II, Section E: Types of Proposals. Compliance: Proposals that are not compliant with theProposal & Award Policies & Procedures Guide (PAPPG)will be returned without review.

U.S. National Science Foundation

TheCombustion and Fire Systemsprogram is part of the Transport Phenomena cluster, which also includes 1) theFluid Dynamicsprogram; 2) theParticulate and Multiphase Processesprogram; and 3) theThermal Transport Processesprogram. The goal of theCombustion and Fire Systemsprogram is to<span>create new knowledge to support advances in clean energy, climate change mitigation, a cleaner environment and public safety.</span> The program endeavors to createfundamental scientific knowledge that is needed for safe, clean and useful combustion applications and for mitigating the effects of fire.The program aims to identify and understand the controlling basic principles and to use that knowledge to create predictive capabilities for designing and optimizing practical combustion devices and understanding fire. Important outcomesfor this program include: <ul type="disc"> <li>broad-based tools &mdash; experimental, theoretical, andcomputational &mdash; that can be applied to a variety of problems in combustion technologies and fire;</li> <li>science and technology for clean and efficient generation of power;</li> <li>discoveries that enable clean environments (for example, by reduction in combustion-generated pollutants); and</li> <li>enhanced public safety and climate change mitigation through research on wildland and building fire growth, inhibition, and suppression.</li> </ul> Research areas of interest for this program include: <ul type="disc"> <li>Basic combustion science: Combustion of gas, liquid, and solid fuels over abroad range of temperatures, pressures, and compositions; combustion at supercritical conditions; advanced propulsion concepts; flame synthesis ofmaterials; integration of fuel design and combustion; control of reaction pathways; development of chemical kinetics models, analytical and numerical predictive methods, and advanced diagnostic tools.</li> <li>Combustionscience related to clean energy: Increasing efficiency and reducing pollution; production and use of renewable and/or carbon-free fuels; biomass pyrolysis, gasification, and oxidation; technologies such as oxy-fuel combustion and chemical looping combustion for carbon capture.</li> <li>Fireprevention: Improved understanding of building and wildland fires to prevent their spread, inhibit their growth, and suppress them; prediction and mitigation of fires in the wildland-urban interface.</li> <li>Turbulence-chemistry interactions:Fundamental understanding of turbulent flow interactions with finite-rate chemical kinetic pathways at high Reynolds and Karlovitz number conditions, including but not limited to: (1) fundamental experiments to generate physico-chemical data to reduce theuncertainty of combustion chemistry and turbulent combustion models; (2)spatially/temporally well-resolved, multi-scale/multi-physics computations;novel approaches of developing embedded multi-scale direct numericalsimulation (DNS) of complex geometries and data-assimilations forincorporating measured data from the state-of-art in situ diagnostic approaches; (3) other innovative approaches on development and validation of predictive computational methods. NOTE: This is an NSF-AFOSR (Air Force Office of Scientific Research) joint funding area. Proposals will be jointly reviewed by NSF and AFOSR using the NSF merit reviewprocess.Actual funding format and agency split for an award(depending on availabilityof funds) will be determined after the proposal selection process. The AFOSR program that participates in this initiative is the program on Energy, Combustion, and Nonequilibrium Thermodynamics.</li> </ul> Innovative proposals outside of these specific interest areas may be considered.However, prior to submission, it is recommended that the Principal Investigator contact the program director to avoid the possibility of the proposal being returned without review. <div> <div id="_com_1"> INFORMATION COMMON TO MOST CBET PROGRAMS </div> </div> Proposals should address the novelty and/or<a href="http://www.nsf.gov/about/transformative_research/faq.jsp">potentially transformative nature</a>of the proposed work compared to previous work in the field.Also, it is important to address why the proposed work is important in terms of engineering science, as well as to also project the potential impact on society and/or industry of success in the research.The novelty or potentially transformative nature of the research should be included, as a minimum, in the Project Summary of each proposal. The duration of unsolicited proposal awards in CBET is generally up to three years. Single-investigator award budgets typically include support for one graduate student (or equivalent) and up to one month of PI time per year(awards for multiple investigator projects are typically larger). Proposal budgets that are much larger than typical should be discussed with the program director prior to submission. Proposers can view budget amounts and other information from recent awards made by this program via the &ldquo;What Has Been Funded (Recent Awards Made Through This Program, with Abstracts)&rdquo; link towards the bottom of this page. Faculty Early Career Development(CAREER)program proposals are strongly encouraged.Award duration is five years.The submission deadline for Engineering CAREER proposals is in July every year. Learn more in the<a href="https://www.nsf.gov/funding/pgm_summ.jsp?pims_id=503214">CAREER program description</a>. Proposals for Conferences, Workshops, and Supplements: PIs are strongly encouraged to discuss their requests with the program director before submission of the proposal. Grants forRapid Response Research(RAPID)andEArly-concept Grants for Exploratory Research(EAGER)are also considered when appropriate.Please note that proposals of these types must be discussed with the program director before submission.Grant Opportunities for Academic Liaison with Industry (GOALI)proposals that integrate fundamental research with translational results and are consistent with the application areas of interest to each program are also encouraged. Please note that RAPID, EAGER, and GOALI proposals can be submitted anytime during the year. Details about RAPID, EAGER, and GOALI are available in the Proposal &amp; Award Policies &amp; Procedures Guide (PAPPG), Part 1, Chapter II, Section E: Types of Proposals. Compliance: Proposals that are not compliant with the<a href="https://www.nsf.gov/publications/pub_summ.jsp?ods_key=pappg">Proposal &amp; Award Policies &amp; Procedures Guide (PAPPG)</a>will be returned without review.

National Endowment for the Humanities

COMMEMORATING AMERICA?S 250 [CIVIC SPIRIT?S COMMEMORATING AMERICA?S 250 PROGRAM WILL HONOR THE NATION?S SEMIQUINCENTENNIAL BY ENGAGING EDUCATORS AND THE PUBLIC IN CIVIC REFLECTION AND HISTORICAL LEARNING. THROUGH A YEAR-LONG WE THE EDUCATORS SERIES, MIDDLE AND HIGH SCHOOL TEACHERS IN FAITH-BASED SCHOOLS WILL EXPLORE FOUNDING TEXTS, PIVOTAL MOMENTS, AND CIVIC VIRTUES WHILE GAINING TOOLS TO FOSTER THOUGHTFUL CLASSROOM DIALOGUE. COMPLEMENTING THIS, THE WE THE PEOPLE SERIES WILL BRING SCHOLARS AND CITIZENS TOGETHER FOR LECTURES, TEXT-BASED DISCUSSIONS, AND CIVIL DISCOURSE ON AMERICAN PRINCIPLES AND DEMOCRATIC DEBATES. TOPICS WILL INCLUDE THE DECLARATION OF INDEPENDENCE, THE CONSTITUTION, CIVIC IDENTITY, FAITH AND DEMOCRACY, AND THE ROLE OF THE ARTS IN CIVIC CULTURE. THESE PROGRAMS WILL CREATE LASTING RESOURCES, STRENGTHEN CIVIC EDUCATION, AND MODEL PLURALISTIC DIALOGUE, ENSURING THE 250TH ANNIVERSARY SERVES AS A CATALYST FOR ENDURING CIVIC ENGAGEMENT.]

Communities Foundation of Texas

Communities Foundation of Texas ($2.2B in assets) supports nonprofits in TX through grants focused on education, community development, arts, health. Awards range from $5,000 to $250,000.

International Capoeira Angola Foundation - Seattle

Over the next 12 months the International Capoeira Angola Foundation will host a series of monthly events to showcase cultural arts from the African Diaspora. The location is the Union Cultural Center, 803 S. King St. The community will be brought together to share, learn, and participate in the vibrant cultures found in the region. The program will begin in January of 2020 and will conclude in December.

Community Foundation for a Greater Richmond

Community Foundation for a Greater Richmond ($1.0B in assets) supports nonprofits in VA through grants focused on education, community development, health, arts. Awards range from $5,000 to $200,000.

Community Foundation for Greater Atlanta

Community Foundation for Greater Atlanta ($1.4B in assets) supports nonprofits in GA through grants focused on education, community development, health, arts. Awards range from $2,500 to $200,000.

Community Foundation for Muskegon County

Community Foundation for Muskegon County ($200M in assets) supports nonprofits in MI through grants focused on education, community development, health, arts. Awards range from $1,000 to $50,000.

Community Foundation for Southeast Michigan

Community Foundation for Southeast Michigan ($1.0B in assets) supports nonprofits in MI through grants focused on education, arts, environment, health, community development. Awards range from $5,000 to $250,000.

Community Foundation for Southeast Michigan

The Community Foundation for Southeast Michigan funds nonprofits serving the seven-county region for arts and culture, education, environment, health, human services, and civic affairs, with emphasis on equity and opportunity.

Community Foundation of Acadiana

Community Foundation of Acadiana ($200M in assets) supports nonprofits in LA through grants focused on education, community development, health, arts. Awards range from $1,000 to $50,000.

Community Foundation of Broward

Community Foundation of Broward ($300M in assets) supports nonprofits in FL through grants focused on education, community development, health, arts. Awards range from $2,000 to $100,000.

Community Foundation of Broward

Community Foundation of Broward ($300M in assets) supports nonprofits in FL through grants focused on education, health, arts, community development. Awards range from $2,000 to $100,000.

Community Foundation of Central Illinois

Community Foundation of Central Illinois ($100M in assets) supports nonprofits in IL through grants focused on education, community development, health, arts. Awards range from $1,000 to $50,000.

Community Foundation of Collier County

Community Foundation of Collier County ($200M in assets) supports nonprofits in FL through grants focused on education, health, community development, arts. Awards range from $1,000 to $75,000.

Community Foundation of Frederick County

Community Foundation of Frederick County ($100M in assets) supports nonprofits in MD through grants focused on education, community development, health, arts. Awards range from $1,000 to $50,000.

Community Foundation of Greater Birmingham

Community Foundation of Greater Birmingham ($400M in assets) supports nonprofits in AL through grants focused on education, community development, arts, health. Awards range from $2,000 to $100,000.

Community Foundation of Greater Chattanooga

Community Foundation of Greater Chattanooga ($400M in assets) supports nonprofits in TN through grants focused on education, community development, health, arts. Awards range from $2,500 to $100,000.

Community Foundation of Greater Des Moines

Community Foundation of Greater Des Moines ($500M in assets) supports nonprofits in IA through grants focused on education, community development, arts, health. Awards range from $2,500 to $100,000.

Community Foundation of Greater Des Moines

Community Foundation of Greater Des Moines ($700M in assets) supports nonprofits in IA through grants focused on education, community development, arts, economic opportunity. Awards range from $2,000 to $150,000.

Community Foundation of Greater Dubuque

Community Foundation of Greater Dubuque ($200M in assets) supports nonprofits in IA through grants focused on education, community development, health, arts. Awards range from $1,000 to $50,000.

Community Foundation of Greater Dubuque

Community Foundation of Greater Dubuque ($150M in assets) supports nonprofits in IA through grants focused on education, community development, arts, health. Awards range from $1,000 to $50,000.

Community Foundation of Greater Greenville

Community Foundation of Greater Greenville ($200M in assets) supports nonprofits in SC through grants focused on education, community development, health, arts. Awards range from $2,000 to $75,000.