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24 grants worth up to $5.3M match your search

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Temperature-Related Mortality in U.S. State Prisons

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NIA - National Institute on Aging

Extreme weather events pose major risks for population health and mortality, particularly for incarcerated people who have limited control over their thermal environments. Several aspects of the prison built environment (such as overcrowding, insufficient heating or air-conditioning, and heat-retaining building materials) likely worsen extreme temperature exposure, yet there has been no comprehensive investigation of the health consequences of extreme temperature exposure inside US prisons. Research on non-institutionalized populations has established extreme heat and cold temperature exposures as acute contributors to cardiovascular and respiratory disease mortality, which are leading causes of death among the 1.2 million people imprisoned in the U.S. (and among the leading causes of death in incarcerated people over the age of 55, the fastest growing cohort in U.S. prisons today). This project’s overall objective is to assess extreme indoor prison temperatures in relation to mortality among incarcerated adults in the U.S. and identify prison conditions and policies that prevent these harms. Aim 1 will use state-of-the-art building science methods and leverage a unique database of prison conditions to develop the first estimates of daily indoor temperatures for facilities in the 20 largest state prison systems, including over 600 prisons and 800,000 imprisoned adults, representing over three quarters of the imprisoned adult population. Indoor temperature and humidity estimates and prison policy and conditions data will be linked with the latest data from Mortality in Correctional Institutions to examine associations with excess all-cause cardiovascular and respiratory disease mortality in prisons. Aim 2 will evaluate prison overcrowding and lack of air-conditioning as factors that may elevate risk for temperature-related mortality. Aim 3 will apply legal epidemiologic methods to develop a comprehensive database of temperature safety strategies and examine relationships with temperature-related mortality in prisons.

Up to $560K
2031-01-31
health research

Free to search & build · $99 one-time to unlock the application pack · No subscription

Texas Center for AIDS Research

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NIA - National Institute on Aging

PROJECT SUMMARY – TEXAS CENTER FOR AIDS RESEARCH In 2019, the US announced a plan to End the HIV Epidemic by 2030. To be successful, strategies that improve HIV prevention and HIV treatment outcomes are needed. Only 58% of people with HIV (PWH) were virally suppressed in 2023, a critical determinant of health outcomes and transmission risk, and 52% of HIV diagnoses in 2023 were in the US South, despite constituting only 38% of the population in the US. More people were diagnosed with HIV in Texas than in any other state in 2022. Unfortunately, this large Texas population lags in critical HIV-related health outcomes. There is an urgent need for more research and research infrastructure to combat the HIV epidemic in the US South and specifically in Texas to both contribute to ending the US HIV epidemic and to learn how to best do that in resource constrained areas of the US. In 2021, Baylor College of Medicine, The University of Texas Health Science Center at Houston, and the Texas Biomedical Research Institute were collectively funded as the Texas Developmental Center for AIDS Research (D-CFAR). The Texas D-CFAR made a substantial impact in HIV research in Texas, having increased the funded research base of the D-CFAR partner institutions from $12.2M in 2021 to $22.2M in 2024. Its members have published 388 HIV-related papers since 2021. Its pilot grant program has a return on investment of $13 in subsequent grant funding for every $1 invested in the pilot program to date. Based on these results, the partner institutions will form the Texas CFAR, and will continue its research theme, “Ending HIV and Optimizing HIV Health in Texas and Beyond.” To accomplish its goals, the Texas CFAR will: 1) Provide organizational and financial management and facilitate activities and programs that strengthen and enrich the CFAR research and intellectual environment; 2) Support targeted high-priority interdisciplinary pilot research projects, assist in responding to new HIV-related research initiatives, and facilitate research on ending HIV and improving health of PWH in Texas and beyond; and 3) Provide state-of-the-art expertise, advice, and services to facilitate the range of HIV-related research for CFAR investigators. The Texas CFAR will support an Administrative Core, a Developmental Core, an Advanced Technology Core, a Clinical and Biostatistics Core, and a Community Engagement Research Core to meet investigator needs and catalyze innovative research. The scientific Cores will build on outstanding strengths in virology, non-human primate resources, clinical trials research and biostatistics. The Texas CFAR has the consistent support of a Community Engagement Board and Internal and External Advisory Boards for guidance. The CFAR will continue to energize new research and collaborations among basic, translational, clinical, health services, implementation science, public health, and community researchers. The Texas CFAR will continue to transform research in HIV in Texas, train the next generation of HIV scientists, and gain knowledge needed to improve the health of people with or at high risk for HIV in Texas and similar areas, contributing to ending the HIV epidemic in Texas, the U.S. South, and beyond.

Up to $1.8M
2031-06-30
health research

Free to search & build · $99 one-time to unlock the application pack · No subscription

Thailand HIV/AIDS and Infectious Disease Clinical Trials Unit (THAI CTU)

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NIAID - National Institute of Allergy and Infectious Diseases

Thailand HIV/AIDS and Infectious Disease Clinical Trials Unit (THAI CTU) SF 424 (R&R) Other Project Information – Project Summary The Thailand HIV/AIDS and Infectious Disease Clinical Trials Unit (THAI CTU), current NIAID CRMS site 60338, is a collaboration between the Chiang Mai University-Research Institute for Health Sciences (CMU- RIHES) in Chiang Mai, Thailand, and the Thai Red Cross AIDS Research Centre (TRC-ARC) in Bangkok, Thailand. The specific aims of this application are 1) to renew the THAI CTU as a Clinical Trials Unit to provide scientific, administrative expertise, and infrastructure to conduct clinical studies developed by the four NIH HIV/AIDS Clinical Trials Networks: HIV/AIDS Adult Therapeutics, HIV/AIDS Maternal, Adolescent and Pediatric Therapeutics, HIV Prevention, and HIV Vaccines; and 2) to participate in the development of clinical trials and provide four Clinical Research Sites (CRS) to conduct clinical trials proposed by the four Networks. This CTU renewal involves a change of THAI CTU Principal Investigators from "Suwat Chariyalertsak and Kiat Ruxrungtham" to “Khuanchai Supparatpinyo and Kiat Ruxrungtham". The THAI CTU and its four CRSs will contribute scientifically to the Networks and recruit HIV+ and HIV- participants to clinical studies according to HIV/AIDS research priorities: 1) HIV/AIDS adult therapeutics: 1) interventions to reduce HIV reservoirs; 2) novel and durable interventions targeting HIV treatment; 3) treatment and prevention of drug-sensitive and drug-resistant tuberculosis; 4) treatment and prevention of HIV-related, non-infectious co-morbidities; and 5) studied strategies to cure hepatitis B virus infection in people with and without HIV. High national incidence of viral hepatitis and endemicity of carriage facilitates research on HBV and HCV infections, particularly for cure of hepatitis B. 2) HIV/AIDS maternal, adolescent and pediatric therapeutics: 1) optimization of antiretroviral treatment for these populations; 2) interventions for ART-free remission; 3) treatment and prevention of tuberculosis; 4) treatment and prevention of HIV-related co-morbidities; and 5) treatment and prevention of co-infections. 3) HIV prevention: 1) evaluation of long-acting antiretroviral agents and delivery systems for pre- exposure prophylaxis; 2) evaluation of multipurpose prevention technologies for HIV, pregnancy, sexually transmitted infections, and opioid dependence; 3) evaluation of broadly neutralizing antibodies for pre-exposure prophylaxis; and 4) integrated strategies for HIV prevention. 4) HIV vaccines: 1) evaluation of passive immunization to reduce HIV acquisition in adults; 2) investigation of vaccination of infants; 3) evaluation of immunological, microbiological, and diagnostic technologies for TB vaccination; and 4) research on epidemiological, behavioral, and social sciences for optimization of outcomes of HIV vaccination.

Up to $468K
2027-11-30
health research

Free to search & build · $99 one-time to unlock the application pack · No subscription

The Art's Room

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Anne Plaisance

The Art's Room

Up to $4K
Rolling
arts

Free to search & build · $99 one-time to unlock the application pack · No subscription

The Art's Room

open

Anne Plaisance

The Art's Room

Up to $4K
Rolling
arts

Free to search & build · $99 one-time to unlock the application pack · No subscription

The Child Health Research Career Development Program at UCSF

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NICHD - Eunice Kennedy Shriver National Institute of Child Health and Human Development

Project Summary/Abstract This application is submitted in response to RFA-HD-18-011, Child Health Research Career Development Award (CHRCDA) Program to provide K12 awards through the CHRCDA mechanism to young pediatric investigators. This new application requests resources to support three pediatricians each year who hold MD or MD/PhD degrees and have completed scholarship training in a clinical subspecialty. The rationale for the program is based on the well-documented and urgent need to support mentored career development for pediatricians to enable them to become fully independent and productive basic science researchers, and the fact that the department of Pediatrics at UCSF has the vision, experience and infrastructure to train the next generation of leaders in pediatric science. Our aims are to (1) offer a structured program for training academic pediatricians, (2) foster career development and promote retention of junior faculty, (3) expose promising early career pediatricians to the intellectual richness of UCSF research and (4) promote diversity in academic pediatrics. The scholars trained by this program will bring state-of-the-art approaches to bear on diagnosis, treatment and prevention of health problems in children as well as childhood onset of adult illness. The design of this program involves harnessing the expertise of world- class basic laboratory scientists who will serve as mentors for interdisciplinary training. The basic science training program is focused around eight scientific cores: cancer, cardiopulmonary medicine, developmental biology, genetics, immunology, neurobiology, stem cell biology, and our new computational sciences core. Each core has a Director, designated faculty, and a specific didactic curriculum. The scholars, in conjunction with their mentor and Core Director, will also participate in a program of additional discipline-specific course work dependent on both the prior experience and training of the applicant and the scientific theme of the trainee’s research, which may often overlap amongst different cores. In this application, we provide evidence that the Department of Pediatrics together with the broader UCSF research community comprise an exceptional environment for preparing young pediatricians who will receive support through the CHRCDA mechanism for successful careers as basic science researchers. There are > 1,200 research laboratories and > 2,200 active research projects at UCSF, and the faculty includes 5 Nobel laureates, 64 members of the American Academy of Arts and Sciences, 76 members of the Institute of Medicine, and 18 Howard Hughes Medical Institute investigators. This program is an investment in the future of children's health, as the diverse group of researchers we will train will harness advanced research strategies to address urgent problems that will result in new treatments to improve child health.

Up to $445K
2027-03-31
health research

Free to search & build · $99 one-time to unlock the application pack · No subscription

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