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Biomarker Development and Applications to Inform Cancer Prevention

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NCI - National Cancer Institute

ABSTRACT Biomarkers of exposure and biological effects are invaluable tools for studying the etiology of environmentally- induced cancers, identifying individuals and populations at risk, and developing and evaluating preventive interventions. This proposal will leverage the expertise and the teaching and capacity building experience of the Masonic Cancer Center (MCC), University of Minnesota faculty to provide an innovative, hands-on course to develop skills necessary for employing biomarkers of carcinogen exposure and biological effects in studies of cancer etiology and prevention. The course is targeted towards researchers-in-training (RITs) such as predoctoral and medical students and postdoctoral trainees from the US and from countries that represent high burden of exposure to environmental and lifestyle cancer risk factors. We will recruit 10 RITs each year, with each cohort consisting of four US-based participants and – leveraging our existing partnerships – six participants from India, Thailand, and African countries (two participants from each site). Specific Aims are (1) Provide a course that offers structured didactic content and hands-on experiences for developing skills in biomarker measurement and data analysis and interpretation. The course will include virtual modules focused on the fundamentals of chemical carcinogenesis and examples of biomarker development and applications, and a 5- week in-person laboratory training in state-of-the art biomarker measurement techniques. (2) Provide course participants with an understanding of clinical and translational biomarker applications to inform cancer prevention and control. Participants will learn and practice methodologies for designing, planning, and implementing human cross-sectional and intervention studies employing biomarkers. This will include modules on the ethics of human subject research as well as the logistics of project management, such as participant recruitment, retention, compliance with study procedures, and biological sample collection, processing, and shipment. (3) Provide course participants with skills and opportunities to establish global collaborative partnerships for conducting biomarker-based research in the area of cancer prevention and control. Each participant will partner with a participant from a different country to develop a joint research proposal employing biomarker assessments. The proposal will address a cancer risk factor relevant to both countries (e.g., air pollution, tobacco, diet) and will be designed to ensure that its findings will serve to inform each country’s cancer prevention and control efforts. Our long-term goal is to establish a community of highly skilled researchers who can engage in collaborative, translational biomarker research aimed to inform policies and practices to reduce the global burden of cancer.

Up to $310K
2031-04-30
health research

Free to search & build · $99 one-time to unlock the application pack · No subscription

Brain-Focused Research on Antiretrovirals and Methamphetamine (Brain-FRAMe)

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NIDA - National Institute on Drug Abuse

Methamphetamine (METH) remains a major public health challenge for the clinical management of people with HIV (PWH) and for controlling HIV transmission. METH can increase HIV transcription, alter immune responses, and disrupt immunometabolism and the blood-brain barrier (BBB). These and other processes combine to worsen brain health, including cognition, mood, and impulsivity. Because PWH with active METH use disorder (aMUD) often struggle with medical adherence, some do not achieve durable viral suppression with oral antiretroviral therapy (ART). Advances in long-acting injectable (LAI)-ART and medication-assisted treatment (MAT) for addiction could change this. The combination of LAI-ART and MAT that includes LAI naltrexone could improve the durability of viral suppression and reduce METH use in PWH with aMUD, which creates an opportunity to investigate the brain health effects of these changes. Addressing this requires a multidisciplinary framework. We propose to leverage these advances and integrate methods from implementation science, pharmacology, virology, immunology, and clinical and basic neuroscience to understand how LAI-ART and MAT for aMUD interact to alter brain health and its biological underpinnings. The Brain-Focused Research on Antiretrovirals and Methamphetamine (Brain-FRAMe) program will pursue a single, transformative goal: to improve the clinical care and brain health of PWH with aMUD. The proposed research will be organized into three subgoals: Clinical Implementation, Brain Health Phenotyping, and Biological Mechanisms. Investigators will form four teams that will study the same participants over 52 weeks from different perspectives. The Clinical Implementation Team will deploy and evaluate the implementation of LAI-ART and MAT in PWH with aMUD in a primary care HIV clinic. The Neurobehavioral Phenotyping Team will characterize the neuromedical, neurocognitive, and psychiatric changes that result from LAI-ART and MAT. The Biophenotyping and Pharmacology Team will assess effects of METH and MAT on ART pharmacokinetics as well as changes in the HIV reservoir and proteomic and transcriptomic profiles in blood and CSF. Using biospecimens from the same participants over time, the Basic Science Mechanisms Team will interrogate targeted biological mechanisms that underlie the effects of aMUD, LAI-ART, and MAT, such as BBB integrity, immunometabolism, and immune competence. The robust and reproducible methods used by all teams will generate data that will be analyzed individually and in aggregate by the Data Integration and Analysis Group. The Scientific Program Coordinator and Contact PI will work with the MPIs and program staff to coordinate all aspects of the program, monitor progress, foster communication, curate data and biospecimens, convene advisory boards, and assure synergy and integration. Using these and other innovative methods, Brain-FRAMe will achieve within five years its goal of transforming the clinical care and brain health of this highly vulnerable group of people, which should also reduce new HIV infections in our community.

Up to $2.5M
2031-03-31
health research

Free to search & build · $99 one-time to unlock the application pack · No subscription

BRE-SPAD at Western Washington University

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NIGMS - National Institute of General Medical Sciences

Abstract Western Washington University (WWU) seeks BRE-SPAD funding to strengthen its research infrastructure and expand faculty and student engagement in biomedical research. As a Predominantly Undergraduate Institution (PUI) with a strong commitment to liberal arts education, WWU has seen steady growth in research activities in the past several years. Research expenditures have almost doubled in less than a decade from $8.5 million in 2014 to $15.9 million in 2023. Yet, WWU’s biological, biomedical, and health sciences R&D expenditures were only $864,000, representing just 5% of total institutional R&D expenditures. WWU will use BRE-SPAD funding to address several institutional challenges, including high teaching loads, lack of key research equipment, limited pre- and post-award administrative support, no central system for recruiting students into undergraduate research opportunities, and a lack of dedicated research development programming. The proposed SPAD initiative at WWU will enhance research capacity through the following specific aims: 1) Improve sponsored programs administration capacity by hiring a new research administrator, training all pre- and post-award staff on NIH proposal submission and award management best practices, and learning from an external evaluation process to improve overall research administration and research development services. 2) Enhance WWU’s research environment by establishing the Viking Biomedical Research Institute (VBR), hiring a program manager, purchasing key biomedical research equipment and supplies, training biomedical faculty in effective NIH research design and proposal writing, incentivizing faculty to develop new course- based undergraduate research experiences (CURES), and creating a centralized mentoring hub for students interested in pursuing biomedical research. and 3) Launch a pilot research project funding program by offering pilot awards, providing faculty release time to focus on research activities, providing resources for undergraduate student participation in the research projects, and enabling faculty to collect data and conduct preliminary analyses that will make subsequent NIH proposals more competitive. By achieving these aims, WWU expects to catalyze a significant increase in the number of faculty – and faculty from a wider range of disciplines – who submit NIH proposals, growth in biomedical research expenditures, increased student participation in biomedical research, an increase in the number of students who graduate with biomedical and health-related degrees and qualifications to enter the regional biomedical workforce, and the establishment of a sustainable and robust biomedical research enterprise.

Up to $599K
2031-01-31
health research

Free to search & build · $99 one-time to unlock the application pack · No subscription

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