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Permanent Local Housing Allocation/ 2022 PLHA NOFA

open

Department of Housing and Community Development

B. Eligible Activities 1. The predevelopment, development, acquisition, rehabilitation, and preservation of multifamily, residential live-work, rental housing that is affordable to extremely low-, very low-, low-, or moderate-income households, including necessary Operating subsidies.2. The predevelopment, development, acquisition, rehabilitation, and preservation of Affordable rental and ownership housing, including Accessory Dwelling Units (ADUs), that meets the needs of a growing workforce earning up to 120 percent of Area Median Income (AMI), or 150 percent of AMI in High-cost areas. ADUs shall be available for occupancy for a term of no less than 30 days. See Appendix B for a list of High-cost areas in California. 3. Matching portions of funds placed into Local or Regional Housing Trust Funds.4. Matching portions of funds available through the Low- and Moderate-Income Housing Asset Fund pursuant to subdivision (d) of HSC Section 34176.5. Capitalized Reserves for Services connected to the preservation and creation of new Permanent supportive housing.6. Assisting persons who are experiencing or At risk of homelessness, including, but not limited to, providing rapid rehousing, rental assistance, supportive/case management services that allow people to obtain and retain housing, operating and capital costs for navigation centers and emergency shelters, and the new construction, rehabilitation, and preservation of permanent and transitional housing.a. This Activity may include subawards to Administrative Entities as defined in HSC Section 50490(a)(1-3) that were awarded California Emergency Solutions and Housing (CESH) Program or Homeless Emergency Aid Program (HEAP) funds for rental assistance to continue assistance to these households.b. Applicants must provide rapid rehousing, rental assistance, navigation centers, emergency shelter, and transitional housing activities in a manner consistent with the Housing First practices described in 25 CCR, Section 8409, subdivision (b)(1)-(6) and in compliance with Welfare Institutions Code (WIC) Section 8255(b)(8). An Applicant allocated funds for the new construction, rehabilitation, and preservation of Permanent supportive housing shall incorporate the core components of Housing First, as provided in WIC Section 8255(b).7. Accessibility modifications in Lower-income Owner-occupied housing.8. Efforts to acquire and rehabilitate foreclosed or vacant homes and apartments.9. Homeownership opportunities, including, but not limited to, down payment assistance.10. Fiscal incentives made by a county to a city within the county to incentivize approval of one or more Affordable housing projects, or matching funds invested by a county in an Affordable housing development project in a city within the county, provided that the city has made an equal or greater investment in the project. The county fiscal incentives shall be in the form of a grant or low-interest loan to an Affordable housing project. Matching funds investments by both the county and the city also shall be a grant or low-interest deferred loan to the Affordable housing project.  

Up to $335M
2027-02-28
Housingcommunity and economic development

Free to search & build · $99 one-time to unlock the application pack · No subscription

Permanent Local Housing Allocation/ 2022 PLHA NOFA

open

Department of Housing and Community Development

B. Eligible Activities 1. The predevelopment, development, acquisition, rehabilitation, and preservation of multifamily, residential live-work, rental housing that is affordable to extremely low-, very low-, low-, or moderate-income households, including necessary Operating subsidies.2. The predevelopment, development, acquisition, rehabilitation, and preservation of Affordable rental and ownership housing, including Accessory Dwelling Units (ADUs), that meets the needs of a growing workforce earning up to 120 percent of Area Median Income (AMI), or 150 percent of AMI in High-cost areas. ADUs shall be available for occupancy for a term of no less than 30 days. See Appendix B for a list of High-cost areas in California. 3. Matching portions of funds placed into Local or Regional Housing Trust Funds.4. Matching portions of funds available through the Low- and Moderate-Income Housing Asset Fund pursuant to subdivision (d) of HSC Section 34176.5. Capitalized Reserves for Services connected to the preservation and creation of new Permanent supportive housing.6. Assisting persons who are experiencing or At risk of homelessness, including, but not limited to, providing rapid rehousing, rental assistance, supportive/case management services that allow people to obtain and retain housing, operating and capital costs for navigation centers and emergency shelters, and the new construction, rehabilitation, and preservation of permanent and transitional housing.a. This Activity may include subawards to Administrative Entities as defined in HSC Section 50490(a)(1-3) that were awarded California Emergency Solutions and Housing (CESH) Program or Homeless Emergency Aid Program (HEAP) funds for rental assistance to continue assistance to these households.b. Applicants must provide rapid rehousing, rental assistance, navigation centers, emergency shelter, and transitional housing activities in a manner consistent with the Housing First practices described in 25 CCR, Section 8409, subdivision (b)(1)-(6) and in compliance with Welfare Institutions Code (WIC) Section 8255(b)(8). An Applicant allocated funds for the new construction, rehabilitation, and preservation of Permanent supportive housing shall incorporate the core components of Housing First, as provided in WIC Section 8255(b).7. Accessibility modifications in Lower-income Owner-occupied housing.8. Efforts to acquire and rehabilitate foreclosed or vacant homes and apartments.9. Homeownership opportunities, including, but not limited to, down payment assistance.10. Fiscal incentives made by a county to a city within the county to incentivize approval of one or more Affordable housing projects, or matching funds invested by a county in an Affordable housing development project in a city within the county, provided that the city has made an equal or greater investment in the project. The county fiscal incentives shall be in the form of a grant or low-interest loan to an Affordable housing project. Matching funds investments by both the county and the city also shall be a grant or low-interest deferred loan to the Affordable housing project.  

Up to $335M
2027-02-28
Housingcommunity and economic development

Free to search & build · $99 one-time to unlock the application pack · No subscription

Permanent Local Housing Allocation/ 2023 PLHA NOFA

open

Department of Housing and Community Development

B. Eligible Activities 1. The predevelopment, development, acquisition, rehabilitation, and preservation of multifamily, residential live-work, rental housing that is affordable to extremely low-, very low-, low-, or moderate-income households, including necessary Operating subsidies.2. The predevelopment, development, acquisition, rehabilitation, and preservation of Affordable rental and ownership housing, including Accessory Dwelling Units (ADUs), that meets the needs of a growing workforce earning up to 120 percent of Area Median Income (AMI), or 150 percent of AMI in High-cost areas. ADUs shall be available for occupancy for a term of no less than 30 days. See Appendix B for a list of High-cost areas in California. 3. Matching portions of funds placed into Local or Regional Housing Trust Funds.4. Matching portions of funds available through the Low- and Moderate-Income Housing Asset Fund pursuant to subdivision (d) of HSC Section 34176.5. Capitalized Reserves for Services connected to the preservation and creation of new Permanent supportive housing.6. Assisting persons who are experiencing or At risk of homelessness, including, but not limited to, providing rapid rehousing, rental assistance, supportive/case management services that allow people to obtain and retain housing, operating and capital costs for navigation centers and emergency shelters, and the new construction, rehabilitation, and preservation of permanent and transitional housing.a. This Activity may include subawards to Administrative Entities as defined in HSC Section 50490(a)(1-3) that were awarded California Emergency Solutions and Housing (CESH) Program or Homeless Emergency Aid Program (HEAP) funds for rental assistance to continue assistance to these households.b. Applicants must provide rapid rehousing, rental assistance, navigation centers, emergency shelter, and transitional housing activities in a manner consistent with the Housing First practices described in 25 CCR, Section 8409, subdivision (b)(1)-(6) and in compliance with Welfare Institutions Code (WIC) Section 8255(b)(8). An Applicant allocated funds for the new construction, rehabilitation, and preservation of Permanent supportive housing shall incorporate the core components of Housing First, as provided in WIC Section 8255(b).7. Accessibility modifications in Lower-income Owner-occupied housing.8. Efforts to acquire and rehabilitate foreclosed or vacant homes and apartments.9. Homeownership opportunities, including, but not limited to, down payment assistance.10. Fiscal incentives made by a county to a city within the county to incentivize approval of one or more Affordable housing projects, or matching funds invested by a county in an Affordable housing development project in a city within the county, provided that the city has made an equal or greater investment in the project. The county fiscal incentives shall be in the form of a grant or low-interest loan to an Affordable housing project. Matching funds investments by both the county and the city also shall be a grant or low-interest deferred loan to the Affordable housing project.  

Up to $296M
2027-06-30
Housingcommunity and economic development

Free to search & build · $99 one-time to unlock the application pack · No subscription

Permanent Local Housing Allocation/ 2023 PLHA NOFA

open

Department of Housing and Community Development

B. Eligible Activities 1. The predevelopment, development, acquisition, rehabilitation, and preservation of multifamily, residential live-work, rental housing that is affordable to extremely low-, very low-, low-, or moderate-income households, including necessary Operating subsidies.2. The predevelopment, development, acquisition, rehabilitation, and preservation of Affordable rental and ownership housing, including Accessory Dwelling Units (ADUs), that meets the needs of a growing workforce earning up to 120 percent of Area Median Income (AMI), or 150 percent of AMI in High-cost areas. ADUs shall be available for occupancy for a term of no less than 30 days. See Appendix B for a list of High-cost areas in California. 3. Matching portions of funds placed into Local or Regional Housing Trust Funds.4. Matching portions of funds available through the Low- and Moderate-Income Housing Asset Fund pursuant to subdivision (d) of HSC Section 34176.5. Capitalized Reserves for Services connected to the preservation and creation of new Permanent supportive housing.6. Assisting persons who are experiencing or At risk of homelessness, including, but not limited to, providing rapid rehousing, rental assistance, supportive/case management services that allow people to obtain and retain housing, operating and capital costs for navigation centers and emergency shelters, and the new construction, rehabilitation, and preservation of permanent and transitional housing.a. This Activity may include subawards to Administrative Entities as defined in HSC Section 50490(a)(1-3) that were awarded California Emergency Solutions and Housing (CESH) Program or Homeless Emergency Aid Program (HEAP) funds for rental assistance to continue assistance to these households.b. Applicants must provide rapid rehousing, rental assistance, navigation centers, emergency shelter, and transitional housing activities in a manner consistent with the Housing First practices described in 25 CCR, Section 8409, subdivision (b)(1)-(6) and in compliance with Welfare Institutions Code (WIC) Section 8255(b)(8). An Applicant allocated funds for the new construction, rehabilitation, and preservation of Permanent supportive housing shall incorporate the core components of Housing First, as provided in WIC Section 8255(b).7. Accessibility modifications in Lower-income Owner-occupied housing.8. Efforts to acquire and rehabilitate foreclosed or vacant homes and apartments.9. Homeownership opportunities, including, but not limited to, down payment assistance.10. Fiscal incentives made by a county to a city within the county to incentivize approval of one or more Affordable housing projects, or matching funds invested by a county in an Affordable housing development project in a city within the county, provided that the city has made an equal or greater investment in the project. The county fiscal incentives shall be in the form of a grant or low-interest loan to an Affordable housing project. Matching funds investments by both the county and the city also shall be a grant or low-interest deferred loan to the Affordable housing project.  

Up to $296M
2027-06-30
Housingcommunity and economic development

Free to search & build · $99 one-time to unlock the application pack · No subscription

Permanent Local Housing Allocation/ 2024 PLHA NOFA

open

Department of Housing and Community Development

1. The predevelopment, development, acquisition, rehabilitation, and preservation of multifamily, residential live-work, rental housing that is affordable to extremely low-, very low-, low-, or moderate-income households, including necessary Operating subsidies.2. The predevelopment, development, acquisition, rehabilitation, and preservation of Affordable rental and ownership housing, including Accessory Dwelling Units (ADUs), that meets the needs of a growing workforce earning up to 120 percent of Area Median Income (AMI), or 150 percent of AMI in High-cost areas. ADUs shall be available for occupancy for a term of no less than 30 days. See Appendix B for a list of High-cost areas in California. 3. Matching portions of funds placed into Local or Regional Housing Trust Funds.4. Matching portions of funds available through the Low- and Moderate-Income Housing Asset Fund pursuant to subdivision (d) of HSC Section 34176.5. Capitalized Reserves for Services connected to the preservation and creation of new Permanent supportive housing.6. Assisting persons who are experiencing or At risk of homelessness, including, but not limited to, providing rapid rehousing, rental assistance, supportive/case management services that allow people to obtain and retain housing, operating and capital costs for navigation centers and emergency shelters, and the new construction, rehabilitation, and preservation of permanent and transitional housing.a. This Activity may include subawards to Administrative Entities as defined in HSC Section 50490(a)(1-3) that were awarded California Emergency Solutions and Housing (CESH) Program or Homeless Emergency Aid Program (HEAP) funds for rental assistance to continue assistance to these households.b. Applicants must provide rapid rehousing, rental assistance, navigation centers, emergency shelter, and transitional housing activities in a manner consistent with the Housing First practices described in 25 CCR, Section 8409, subdivision (b)(1)-(6) and in compliance with Welfare Institutions Code (WIC) Section 8255(b)(8). An Applicant allocated funds for the new construction, rehabilitation, and preservation of Permanent supportive housing shall incorporate the core components of Housing First, as provided in WIC Section 8255(b).7. Accessibility modifications in Lower-income Owner-occupied housing.8. Efforts to acquire and rehabilitate foreclosed or vacant homes and apartments.9. Homeownership opportunities, including, but not limited to, down payment assistance.10. Fiscal incentives made by a county to a city within the county to incentivize approval of one or more Affordable housing projects, or matching funds invested by a county in an Affordable housing development project in a city within the county, provided that the city has made an equal or greater investment in the project. The county fiscal incentives shall be in the form of a grant or low-interest loan to an Affordable housing project. Matching funds investments by both the county and the city also shall be a grant or low-interest deferred loan to the Affordable housing project.

2027-02-28
Housingcommunity and economic development

Free to search & build · $99 one-time to unlock the application pack · No subscription

Permanent Local Housing Allocation/ 2024 PLHA NOFA

open

Department of Housing and Community Development

1. The predevelopment, development, acquisition, rehabilitation, and preservation of multifamily, residential live-work, rental housing that is affordable to extremely low-, very low-, low-, or moderate-income households, including necessary Operating subsidies.2. The predevelopment, development, acquisition, rehabilitation, and preservation of Affordable rental and ownership housing, including Accessory Dwelling Units (ADUs), that meets the needs of a growing workforce earning up to 120 percent of Area Median Income (AMI), or 150 percent of AMI in High-cost areas. ADUs shall be available for occupancy for a term of no less than 30 days. See Appendix B for a list of High-cost areas in California. 3. Matching portions of funds placed into Local or Regional Housing Trust Funds.4. Matching portions of funds available through the Low- and Moderate-Income Housing Asset Fund pursuant to subdivision (d) of HSC Section 34176.5. Capitalized Reserves for Services connected to the preservation and creation of new Permanent supportive housing.6. Assisting persons who are experiencing or At risk of homelessness, including, but not limited to, providing rapid rehousing, rental assistance, supportive/case management services that allow people to obtain and retain housing, operating and capital costs for navigation centers and emergency shelters, and the new construction, rehabilitation, and preservation of permanent and transitional housing.a. This Activity may include subawards to Administrative Entities as defined in HSC Section 50490(a)(1-3) that were awarded California Emergency Solutions and Housing (CESH) Program or Homeless Emergency Aid Program (HEAP) funds for rental assistance to continue assistance to these households.b. Applicants must provide rapid rehousing, rental assistance, navigation centers, emergency shelter, and transitional housing activities in a manner consistent with the Housing First practices described in 25 CCR, Section 8409, subdivision (b)(1)-(6) and in compliance with Welfare Institutions Code (WIC) Section 8255(b)(8). An Applicant allocated funds for the new construction, rehabilitation, and preservation of Permanent supportive housing shall incorporate the core components of Housing First, as provided in WIC Section 8255(b).7. Accessibility modifications in Lower-income Owner-occupied housing.8. Efforts to acquire and rehabilitate foreclosed or vacant homes and apartments.9. Homeownership opportunities, including, but not limited to, down payment assistance.10. Fiscal incentives made by a county to a city within the county to incentivize approval of one or more Affordable housing projects, or matching funds invested by a county in an Affordable housing development project in a city within the county, provided that the city has made an equal or greater investment in the project. The county fiscal incentives shall be in the form of a grant or low-interest loan to an Affordable housing project. Matching funds investments by both the county and the city also shall be a grant or low-interest deferred loan to the Affordable housing project.

2027-02-28
Housingcommunity and economic development

Free to search & build · $99 one-time to unlock the application pack · No subscription

Section 4 Capacity Building for Community Development and Affordable Housing

open

Department of Housing and Urban Development

Purpose. The program enhances the capacity and ability of Community Development Corporations (CDCs) and Community Housing Development Organizations (CHDOs) to carry out community development and affordable housing activities that benefit low-income persons, homeless, physically disabled persons, first responders and veterans. Additionally, this program provides a set-aside for rural capacity building activities and a set aside to benefit Native Hawaiian, American Indian, and Alaska Native communities and populations in areas including, but not limited to, rural areas. Eligible Activities and Priorities. Funds may only be used to conduct the following activities:* Eligible Activities and Priorities. Funds may only be used to conduct the following activities: 1. Training, education, support, and advice to enhance the technical and administrative capabilities of CDCs and CHDOs. This may include building the capacity of CDCs and CHDOs to:• Navigate the housing and community development resources provided by the Federal Government and assist in directing Federal investments to areas with high needs specific to low income persons, homeless, physically disabled persons, first responders and veterans;• Provide training best practices for utilizing Opportunity Zones as incentives for community investment;• Cooperatively plan for the use of available resources in a comprehensive and holistic manner; more specifically in accordance with EO 14296, providing direct technical assistance to beneficiaries that can provide services to the National Center for Warrior Independence to help veterans earn back their self-sufficiency. and• Assist in evaluating performance under these community planning and coordination efforts and in linking plans with neighboring communities to foster regional planning.2. Pass-through grants, housing financing, loans, predevelopment assistance, or other financial assistance to CDCs and CHDOs to increase their capacity to carry out community development and affordable housing activities that benefit low-income persons, including low-income families that include homeless persons, physically disabled persons, first responders and veterans.3. Such other activities as may be determined by the grantees in consultation with the Secretary or his or her designee.At this time, eligible program activities allowed under the third listed eligible activity only include HUD reviewed and approved reasonable administrative activities directly related to the grantee's management of its Section 4 program. Some examples of reasonable administrative activities specific to the management of the Section 4 program include the preparation of Section 4 action plans and activities, preparation of Section 4 program reports, and management of the implementation of the first and second eligible activities.Any Section 4 funded activity that results in the creation of intangible property, including but not limited to the creation of curriculum, trainings, data or research findings is subject to the rules at 2 CFR 200.315. In accordance with 2 CFR 200.315, the Federal awarding agency reserves a royalty-free, nonexclusive and irrevocable right to reproduce, publish, or otherwise use the work for Federal purposes, and to authorize others to do so.Program Priorities. Activities undertaken as part of, or as a result of, capacity building efforts described in this section should build pipelines and support the implementation of other HUD housing and community development programs such as Opportunity Zones, Promise Zones, the National Center for Warrior Independence facilities, voucher programs to support homeless veterans specifically in Los Angeles Metropolitan and around the Nation, in addition to issues related to comprehensive neighborhood revitalization activities.Through these activities, grantees are encouraged to align with and support projects that create opportunities for investments focused on job growth, economic recovery, and neighborhood revitalization. Additionally, grantees are encouraged to consider how CDCs and CHDOs may align investments with regional planning for sustainable economic development if such efforts are underway in the jurisdiction.

$1M – $42M
2026-07-06
Community DevelopmentHousing

Free to search & build · $99 one-time to unlock the application pack · No subscription

Section 4 Capacity Building for Community Development and Affordable Housing

open

Department of Housing and Urban Development

Purpose. The program enhances the capacity and ability of Community Development Corporations (CDCs) and Community Housing Development Organizations (CHDOs) to carry out community development and affordable housing activities that benefit low-income persons, homeless, physically disabled persons, first responders and veterans. Additionally, this program provides a set-aside for rural capacity building activities and a set aside to benefit Native Hawaiian, American Indian, and Alaska Native communities and populations in areas including, but not limited to, rural areas. Eligible Activities and Priorities. Funds may only be used to conduct the following activities:* Eligible Activities and Priorities. Funds may only be used to conduct the following activities: 1. Training, education, support, and advice to enhance the technical and administrative capabilities of CDCs and CHDOs. This may include building the capacity of CDCs and CHDOs to: Navigate the housing and community development resources provided by the Federal Government and assist in directing Federal investments to areas with high needs specific to low income persons, homeless, physically disabled persons, first responders and veterans; Provide training best practices for utilizing Opportunity Zones as incentives for community investment; Cooperatively plan for the use of available resources in a comprehensive and holistic manner; more specifically in accordance with EO 14296, providing direct technical assistance to beneficiaries that can provide services to the National Center for Warrior Independence to help veterans earn back their self-sufficiency. and Assist in evaluating performance under these community planning and coordination efforts and in linking plans with neighboring communities to foster regional planning.2. Pass-through grants, housing financing, loans, predevelopment assistance, or other financial assistance to CDCs and CHDOs to increase their capacity to carry out community development and affordable housing activities that benefit low-income persons, including low-income families that include homeless persons, physically disabled persons, first responders and veterans.3. Such other activities as may be determined by the grantees in consultation with the Secretary or his or her designee.At this time, eligible program activities allowed under the third listed eligible activity only include HUD reviewed and approved reasonable administrative activities directly related to the grantee's management of its Section 4 program. Some examples of reasonable administrative activities specific to the management of the Section 4 program include the preparation of Section 4 action plans and activities, preparation of Section 4 program reports, and management of the implementation of the first and second eligible activities.Any Section 4 funded activity that results in the creation of intangible property, including but not limited to the creation of curriculum, trainings, data or research findings is subject to the rules at 2 CFR 200.315. In accordance with 2 CFR 200.315, the Federal awarding agency reserves a royalty-free, nonexclusive and irrevocable right to reproduce, publish, or otherwise use the work for Federal purposes, and to authorize others to do so.Program Priorities. Activities undertaken as part of, or as a result of, capacity building efforts described in this section should build pipelines and support the implementation of other HUD housing and community development programs such as Opportunity Zones, Promise Zones, the National Center for Warrior Independence facilities, voucher programs to support homeless veterans specifically in Los Angeles Metropolitan and around the Nation, in addition to issues related to comprehensive neighborhood revitalization activities.Through these activities, grantees are encouraged to align with and support projects that create opportunities for investments focused on job growth, economic recovery, and neighborhood revitalization. Additionally, grantees are encouraged to consider how CDCs and CHDOs may align investments with regional planning for sustainable economic development if such efforts are underway in the jurisdiction.

$1M – $42M
2026-07-06
community development

Free to search & build · $99 one-time to unlock the application pack · No subscription

Self-Help Homeownership Opportunity Program (SHOP)

open

Department of Housing and Urban Development

This NOFO solicits applications for the Self-Help Homeownership Opportunity Program (SHOP). This grant awards funds to eligible national and regional nonprofit organizations and consortia to purchase home sites and develop or improve the infrastructure needed to set the stage for sweat equity and volunteer-based homeownership programs. The SHOP program is a tool to promote the production of affordable housing for low-income persons and families, including first-responders, veterans, and persons with disabilities, while fostering safe, stable neighborhoods in communities nationwide.The SHOP grant program provides competitive awards to national and regional nonprofit organizations and consortia to purchase home sites and develop or improve the infrastructure needed to set the stage for sweat equity and volunteer-based homeownership programs and to promote the production of affordable housing for low-income persons and families, including veterans, homeless persons , first responders, and persons with disabilities . The SHOP units must:Be sold to homebuyers at below market prices;Homebuyers must be low-income and contribute a significant amount of sweat equity towards the development of their SHOP home; andSHOP homes must be non-luxury units that comply with state and local codes, ordinances, and zoning requirements, and with all other SHOP requirements.Applicants must also:Propose to use a significant amount of SHOP grant funds in at least two states.Use the SHOP grant funds for only land acquisition, infrastructure improvements, and reasonable and necessary planning and administration costs (not to exceed 10 percent).The average SHOP expense for the combined cost of land acquisition and infrastructure improvements cannot exceed $25,000 per SHOP unit.Applicants must leverage other public and private funds to pay for the construction or rehabilitation costs of every SHOP unit.Leveraged funds may also be used for other program costs not covered by SHOP grant funds.All communications between HUD, SHOP applicants, SHOP awardees, and SHOP beneficiaries must be in English. The application must be received through Grants.gov in English.This NOFO makes available $24,000,000 ($12,000,000 in FY2025 and $12,000,000 in FY2024) to carry out eligible activities of the SHOP program.

$1.1M – $12M
2026-07-15
Community DevelopmentHousingopportunity_zone_benefits

Free to search & build · $99 one-time to unlock the application pack · No subscription

Self-Help Homeownership Opportunity Program (SHOP)

open

Department of Housing and Urban Development

This NOFO solicits applications for the Self-Help Homeownership Opportunity Program (SHOP). This grant awards funds to eligible national and regional nonprofit organizations and consortia to purchase home sites and develop or improve the infrastructure needed to set the stage for sweat equity and volunteer-based homeownership programs. The SHOP program is a tool to promote the production of affordable housing for low-income persons and families, including first-responders, veterans, and persons with disabilities, while fostering safe, stable neighborhoods in communities nationwide.The SHOP grant program provides competitive awards to national and regional nonprofit organizations and consortia to purchase home sites and develop or improve the infrastructure needed to set the stage for sweat equity and volunteer-based homeownership programs and to promote the production of affordable housing for low-income persons and families, including veterans, homeless persons , first responders, and persons with disabilities . The SHOP units must:Be sold to homebuyers at below market prices;Homebuyers must be low-income and contribute a significant amount of sweat equity towards the development of their SHOP home; andSHOP homes must be non-luxury units that comply with state and local codes, ordinances, and zoning requirements, and with all other SHOP requirements.Applicants must also:Propose to use a significant amount of SHOP grant funds in at least two states.Use the SHOP grant funds for only land acquisition, infrastructure improvements, and reasonable and necessary planning and administration costs (not to exceed 10 percent).The average SHOP expense for the combined cost of land acquisition and infrastructure improvements cannot exceed $25,000 per SHOP unit.Applicants must leverage other public and private funds to pay for the construction or rehabilitation costs of every SHOP unit.Leveraged funds may also be used for other program costs not covered by SHOP grant funds.All communications between HUD, SHOP applicants, SHOP awardees, and SHOP beneficiaries must be in English. The application must be received through Grants.gov in English.This NOFO makes available $24,000,000 ($12,000,000 in FY2025 and $12,000,000 in FY2024) to carry out eligible activities of the SHOP program.

$1.1M – $12M
2026-07-15
community development

Free to search & build · $99 one-time to unlock the application pack · No subscription

Solid Phase Peptide Synthesizer

open

OD - NIH Office of the Director

ABSTRACT/SUMMARY This proposal requests funds to purchase a Liberty Blue 2.0 solid-phase peptide synthesizer. At present, Vanderbilt lacks a comparable capacity for customized peptide synthesis, compelling researchers to rely on commercial vendors. While standard peptides can often be sourced at reasonable cost, the synthesis of peptides incorporating non-proteinogenic amino acids, macrocyclizations, or site-specific chemical modifications incurs prohibitive costs and prolonged lead times. These limitations negatively affect numerous NIH-funded research programs and severely lowers the chemical novelty accessible to investigators who make use of peptides in their research. Acquisition of an institutional instrument will directly address this gap, enabling timely and affordable access to high-quality, customized peptides that are increasingly central to modern biomedical research. This instrument will serve a large and scientifically expansive group of investigators across 15 departments in the College of Arts and Science, the School of Medicine Basic Sciences, and the Vanderbilt Institute of Chemical Biology. Investigators from the Vanderbilt University Medical Center will also have access. The user base spans a wide array of NIH-funded projects that rely on synthetic peptides. For example, one group synthesizes fluorophore-labeled peptides to monitor receptor trafficking. Another develops cleavable linkers that release antibiotics from antibody-drug conjugates designed to target methicillin-resistant Staphylococcus aureus. A third focuses on macrocyclic peptides that modulate the activity of CFTR and thus show promise as future therapeutics for cystic fibrosis. Several other groups engage heavily in structure- and AI-guided design and require rapid synthesis of candidate molecules to support downstream biochemical and cellular validation. The Liberty Blue 2.0, manufactured by CEM Corporation, uses microwave-assisted chemistry to accelerate synthesis cycles, improve coupling efficiency, and enhance overall yield and purity. The instrument accommodates a wide range of chemistries and scales, offering flexibility to support exploratory screening, structure-activity relationship campaigns, and early-stage preclinical development. Importantly, it also provides significant cost and time savings compared to commercial synthesis, especially for chemically complex sequences. The instrument will be housed within the Molecular Design and Synthesis Core, which has provided synthetic chemistry expertise and training to the Vanderbilt community since 2006. This core will oversee daily operation and user access, supported by administrative and financial contributions from the School of Medicine Basic Sciences and the College of Arts and Science. Acquisition of the Liberty Blue 2.0 will significantly enhance Vanderbilt’s infrastructure for chemical biology, lower the barrier to peptide-based experimentation, and accelerate discovery across multiple scientific disciplines and therapeutic categories.

Up to $129K
2027-05-14
health research

Free to search & build · $99 one-time to unlock the application pack · No subscription

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