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NIGMS - National Institute of General Medical Sciences

PROJECT SUMMARY/ABSTRACT The University of Puerto Rico at Aguadilla (UPR-Aguadilla) requests funding to acquire a Nikon AX Galvo Confocal Laser Scanning Microscope (LSCM) with a TI2-E inverted platform and a four- laser configuration (405/488/561/640 nm) to establish transformative imaging capabilities at our resource-limited institution serving 96% Pell Grant recipients. This state-of-the-art instrument addresses a critical infrastructure gap, enabling high-resolution fluorescence imaging, live-cell microscopy, and quantitative analysis essential for competitive biomedical research and undergraduate education. The LSCM will directly support four active research projects spanning parasitology (monogenean host-specificity studies), plant pathology (coffee biocontrol development), environmental chemistry (metalloprotein biomarkers), and neuroscience (astrocyte dysfunction in diabetic epilepsy) while integrating into core laboratory courses including Immunology (BIOL 4009) and Undergraduate research courses (BIOL 3108 and QUIM 4999). Our multidisciplinary faculty, in partnership with the Neuroimaging and Electrophysiology Facility (NIEF) Excellence Imaging Center, offers expertise in confocal microscopy, encompassing advanced imaging and specialized sample preparation techniques. This collaboration ensures effective implementation of the technology, sustained technical support, and high-quality training programs that will enhance research productivity and broaden educational impact. The broad, long-term objective is to transform UPR-Aguadilla from a primarily teaching institution into a research-active campus capable of producing graduate-school-ready students equipped with cutting-edge technical skills. Access to advanced confocal microscopy will stimulate new research collaborations, enhance faculty productivity, and provide 30-40 students annually with hands-on experience in modern imaging technologies currently absent from our curriculum. The instrument will strengthen our partnership with the emerging Natural History Museum of Puerto Rico for specimen digitization and support comprehensive outreach programs targeting 25-50 high school students annually through "Seeing Science Up Close" workshops. Expected outcomes include 1- 2 peer-reviewed publications within three years, establishment of 1-2 new institutional collaborations, and measurable enhancement of biomedical research capacity. This investment will significantly advance STEM education and research opportunities at UPR-Aguadilla while expanding access to cutting-edge scientific instrumentation for students pursuing biomedical careers and contributing to the development of skilled researchers in the biomedical sciences.

U.S. National Science Foundation

To facilitate fundamental research in the atmospheric sciences, the Division of Atmospheric and Geospace Sciences (AGS) supports state-of-the-art instruments and facilities through the Facilities for Atmospheric Research and Education (FARE) Program. The FARE Program includes the Lower Atmosphere Observing Facilities (LAOF) and the Community Instruments and Facilities (CIF). Lower Atmospheric Observing Facilities The National Science Foundation (NSF) Division of Atmospheric and Geospace Sciences (AGS)Lower Atmospheric Observing Facilities (LAOF) Program oversees a portfolio of multi-user national facilities that are sponsored by NSF for use by the geosciences research community. Program management resides within AGS in the NCAR and Facilities Section (NFS) which provides a single point for coordination of planning and resources.The LAOF program enables geoscience research through the provision of specialized facilities, instrumentation, and field support services necessary to carry out the scientific field work associated with investigations of a wide range of geophysical phenomena. The program is actively involved in oversight of LAOF facilities and decisions about the acquisition, operation, maintenance, upgrading and replacement of these facilities based on input from the scientific community. LAOF funding supports both the planning for scientific field programs (e.g., experimental design, operational plans, logistical support) and the deployment of NSF-sponsored facilities. Proposals to the LAOF program are acceptedby invitation only. Please contact the FARE program director if you intend to submit a proposal to this program. Community Instrumentation and Facilities (CIF) The CIF program provides the NSF-sponsored atmospheric sciences research community with access to specialized instrumentation for field and laboratory-based studies.The program requests proposals from instrument and facility providers who will make their equipment available for community use through an NSF-defined request process.Support will be provided for limited technician time, minor upgrades, and travel for outreach.

U.S. National Science Foundation

To facilitate fundamental research in the atmospheric sciences, the Division of Atmospheric and Geospace Sciences (AGS) supports state-of-the-art instruments and facilities through the Facilities for Atmospheric Research and Education (FARE) Program. The FARE Program includes the Lower Atmosphere Observing Facilities (LAOF) and the Community Instruments and Facilities (CIF). Lower Atmospheric Observing Facilities The National Science Foundation (NSF) Division of Atmospheric and Geospace Sciences (AGS)Lower Atmospheric Observing Facilities (LAOF) Program oversees a portfolio of multi-user national facilities that are sponsored by NSF for use by the geosciences research community. Program management resides within AGS in the NCAR and Facilities Section (NFS) which provides a single point for coordination of planning and resources.<br /><br />The LAOF program enables geoscience research through the provision of specialized facilities, instrumentation, and field support services necessary to carry out the scientific field work associated with investigations of a wide range of geophysical phenomena. The program is actively involved in oversight of LAOF facilities and decisions about the acquisition, operation, maintenance, upgrading and replacement of these facilities based on input from the scientific community. LAOF funding supports both the planning for scientific field programs (e.g., experimental design, operational plans, logistical support) and the deployment of NSF-sponsored facilities. Proposals to the LAOF program are acceptedby invitation only. Please contact the FARE program director if you intend to submit a proposal to this program. Community Instrumentation and Facilities (CIF) The CIF program provides the NSF-sponsored atmospheric sciences research community with access to specialized instrumentation for field and laboratory-based studies.The program requests proposals from instrument and facility providers who will make their equipment available for community use through an NSF-defined request process.Support will be provided for limited technician time, minor upgrades, and travel for outreach.

NIAMS - National Institute of Arthritis and Musculoskeletal and Skin Diseases

Polyethylene (PE) wear and implant-related failure remain leading causes of revision in total shoulder arthroplasty (TSA), a procedure which now surpasses the growth rate of hip and knee arthroplasty. Both anatomic (aTSA) and reverse (rTSA) TSA outcomes are heavily influenced by complex interactions between rotator cuff function, scapular motion, implant design, and patient-specific loading—factors not adequately captured in current preclinical implant testing standards. Emerging evidence suggests that PE wear progression in TSA is highly dependent on shoulder kinematics, joint loading, implant positioning, and individual patient factors. Nonetheless, data on in vivo motion and load profiles remain sparse, and few tools exist to link these profiles to clinically relevant wear patterns or associated periprosthetic inflammatory tissue responses. Accordingly, the primary objective of this project is to develop validated, patient-specific models that predict PE wear in TSA and identify modifiable surgical, design, and rehabilitation targets to improve implant longevity and restore patient mobility. Additionally, we will establish histopathological hallmarks that indicate TSA failure caused by PE wear debris. Our central hypothesis is that specific shoulder kinematics and joint loading drive distinct PE wear patterns in TSA associated with mechanical failure or inflammatory-mediated osteolysis, depending on implant design and positioning. To achieve the overall objective of this work, shoulder motions and muscle excitations across 25 activities of daily living will be collected at pre-op and post-op (>6 months) in both aTSA and rTSA patients, with long-term follow-up of patient-reported outcomes via validated surveys (5 years). Unsupervised machine learning will categorize patients into movement-based phenotypes, which will then inform a multi-scale modeling framework to estimate in vivo shoulder joint loads and implant wear across the varying movement strategies. Predicted wear patterns will be validated using state-of-the-art preclinical wear simulators. Simultaneously, we will quantify how patient, surgical, and implant factors contribute to wear in retrieved TSA components (>400 samples), correlating imaging-based wear patterns with clinical outcomes, patient-reported function, inflammatory tissue responses, and radiographic indications of loosening. For that purpose, we will establish benchmarks of TSA wear rates and introduce a new histopathological approach augmented by infrared spectroscopic imaging. This work is innovative because we are linking patient-specific movement patterns following TSA with multi-scale computational models to predict PE wear, breaking the current approaches of using generic motions and loads in existing testing standards. This work will produce the first integrated, publicly available database of TSA kinematics, joint loading, and PE wear patterns and rates, along with validated computational tools to inform implant design, surgical planning, rehabilitation strategies, and personalized risk assessment. Ultimately, these advances will improve functional outcomes and long-term success for TSA patients and enable better preclinical testing methods and standards.

Fairfield County's Community Foundation

Fairfield County's Community Foundation ($400M in assets) supports nonprofits in CT through grants focused on education, economic opportunity, health, arts. Awards range from $2,500 to $100,000.

Freeway Park Association

The Freeway Park Association will organize a community lantern installation and Fall Festival event on Friday, October 26, 4-7pm, at Freeway Park, 700 Seneca St. Communities neighboring the park will be invited to help make lanterns and participate in the festival. The lanterns will hang throughout the fall and winter as a way to bring light, movement, color and community art into the park, making people feel safe and invested in Freeway Park.

Arts Corps

Arts Corps will organize a series of arts-based family workshops to strengthen intergenerational and community connections. Three workshops will be held between January and May 2019. They will take place at Martin Luther King Jr Elementary School located at 6725 45th Ave S. All workshops will be held during non-school hours to ensure public accessibility.

Group for Promotion of Family Entertainment in Seattle

To improve the accessibility of the arts to everyone, regardless of age or income, we propose producing twelve monthly family friendly variety shows to take place over a year. We will focus on including the many different kinds and nationalities of performing arts, circus arts, and musical styles in Seattle.

Fargo-Moorhead Area Foundation

Fargo-Moorhead Area Foundation ($200M in assets) supports nonprofits in ND through grants focused on education, community development, health, arts. Awards range from $1,000 to $50,000.

NIGMS - National Institute of General Medical Sciences

PROJECT SUMMARY/ABSTRACT This proposal requests funds for acquisition of an AKTA pure 25 fast protein liquid chromatography (FPLC) system for biomolecule purification at Eastern Washington University (EWU), a primarily undergraduate institute. This instrument will greatly enhance our research and education capacities. At EWU we strive to provide students with hands-on biomedical research experiences through our classes and research labs. The AKTA pure will provide a much needed high quality protein purification system for our biomedical research community. Currently our protein purification projects mainly use gravity flow purification methods with poor yield, and purification quality. With the AKTA pure, we will be able to make use of advanced purification methods, and perform chromatography based biochemical assays, considerably expanding our experimentation capabilities. The instrument will enable us to offer a new class focused on protein purification using the FPLC. We will also incorporate FPLC skills into several current upper-level classes. It will support a diverse range of ongoing research projects, including two NIH funded projects, and allow researchers to gather data for new grant applications. Furthermore, it will enable users to explore new avenues of research, such as small RNA purification and analytical chromatography techniques for protein characterization that we are currently not able to perform. The classes and research projects supported by the AKTA pure will provide a large number of EWU students the opportunity to gain training in a state of the art instrument widely used in biomedical research. Students will gain valuable research experience, and proficiency in using the FPLC will give them a career-ready skill for the biomedical field. The AKTA pure FPLC system will be an invaluable tool for advancing research and education at EWU.

NHLBI - National Heart Lung and Blood Institute

PROJECT SUMMARY The production of red blood cells (RBC), known as ‘erythropoiesis’, serves as a paradigm for understanding cellular differentiation and terminal maturation. Defects in erythropoiesis or RBC function cause various forms of anemia, a health burden affecting nearly one-third of the global population. Each step of erythropoiesis, including lineage specification, proliferation, differentiation, and terminal maturation into RBCs filled with hemoglobin for oxygen transport, has unique metabolic requirements with potential opportunities for therapeutic intervention. For instance, recent evidence indicates that hemoglobinopathies can be treated by stimulating glycolysis with pyruvate kinase agonists. We demonstrated previously that glutamine synthesis is uniquely upregulated during erythropoiesis to detoxify ammonium generated by heme synthesis and that enhanced glutamine synthetase activity alleviates -thalassemia. However, the comprehensive metabolic regulation of erythropoiesis remains poorly understood, which limits therapeutic opportunities. To address this knowledge gap, we performed global metabolomic profiling, isotope tracing and transcriptome analysis of staged erythroid precursors from mouse fetal liver and bone marrow. We discovered that distinct, ontogeny-specific metabolic processes govern erythropoiesis. While glucose is the primary nutrient for bioenergetics and biosynthesis in fetal liver erythroid precursors, mitochondrial fatty acid β-oxidation (FAO) becomes more active during postnatal bone marrow erythropoiesis. Surprisingly, isotope tracing showed that long chain fatty acids are essential metabolic precursors for TCA cycle intermediates and heme during adult-type erythropoiesis. Moreover, genetic disruption of FAO enzymes caused impaired erythropoiesis and anemia in adult mice, whereas erythroid FAO was profoundly dysregulated in sickle cell disease (SCD). These findings support our central hypotheses that FAO provides essential nutrients to support erythropoietic energy demands and biosynthetic needs, including heme biosynthesis, and that dysfunctional FAO contributes to the pathophysiology of SCD. Thus, the objective of this project is to elucidate the functional and mechanistic roles of fatty acid metabolism as a new regulatory pathway in erythropoiesis and RBC disorders according to three specific aims: 1) Define the functional roles of FAO in erythropoiesis; 2) Elucidate the mechanistic roles of fatty acid metabolism in erythrocyte development and function; and 3) Determine the role of fatty acid metabolism in the pathophysiology of sickle cell disease. Our hypotheses and the feasibility of proposed studies are supported by extensive preliminary data combining orthogonal, state-of-the-art metabolic and transcriptomic approaches with orthogonal mouse and human models to analyze erythropoiesis in vivo. Now we will elucidate fatty acid metabolism as a critical metabolic regulator of normal postnatal erythropoiesis and a potential therapeutic target for SCD.

National Endowment for the Humanities

FESTIVAL AND SYMPOSIUM FOR AMERICA'S 250TH [THE PROJECT BEGINS WITH A FESTIVAL OF WEEKLY SPEAKER EVENTS FOR STUDENTS, FACULTY, AND THE GENERAL PUBLIC TO CELEBRATE THE NATION?S FOUNDING, DEEPENING THEIR UNDERSTANDING OF THE REVOLUTION, FOCUS ON ITS VALUES, MEANINGS, AND LEGACIES, AND REFLECT ON ITS CALL TO CIVIC ENGAGEMENT. THE SPEAKERS ARE SERIOUS SCHOLARS WHO WILL ATTRACT AUDIENCES BY FRAMING THEIR PRESENTATIONS AROUND "HOOKS" SUCH AS ESPIONAGE, SATURDAY NIGHT LIVE, ART, AND THE MODERN RELEVANCE OF THE FOUNDERS. SEVERAL HUMANITIES DEPARTMENTS ARE INVOLVED. THE EVENTS OCCUR NEAR AN EXHIBITION OF ORIGINAL AMERICAN REVOLUTION DOCUMENTS FROM THE UNIVERSITY?S WEINER COLLECTION WITH COMPLEMENTS FROM THE AMERICAN BATTLEFIELD TRUST. AFTER THIS PERIOD OF INTENSE REFLECTION, OUR FACULTY AND STUDENT RESEARCHERS WILL PRODUCE ORIGINAL SCHOLARSHIP AND CREATIVE WORKS ON THE REVOLUTION?S THEMES. THEY WILL RECONVENE FOR A TWO-DAY PUBLIC SYMPOSIUM UNDER THE LEADERSHIP OF A KEYNOTE SPEAKER, WITH THE WEINER COLLECTION AGAIN AT THE CENTER.]

Sundiata African American Cultural Association

Festival Sundiata is the largest African American festival in the Northwest celebrating the culture and people of African decent, through music, food, dance and artistic expression. The 2017 Festival will be held Saturday June 10th from 11:00am - 8:00pm and June 11th from noon - 6:00pm at the Seattle Center 305 Harrison Street.

Sundiata African American Cultural Association

Festival Sundiata Black Arts Fest, an annual celebration of people of African descent is scheduled for Friday June 14 through Sunday, June 16, 2019 at Seattle Center, 305 Harrison Street. The event includes, music, dance, historical exhibits and arts and crafts.

festival:festival

The festival:festival organization will host a free two day arts festival to support artists and cultural workers. It will take place on August 2, 2019 from 5 pm - 10 pm at Northwest Film Forum located at 1515 12th Ave, on August 3, 2019 from 11 am - 4 pm at Amplifier located at 901 Hiawatha Pl S, and on E Denny Wy between 10th Ave and Broadway Ave from 5 pm - 10 pm on August 2 and 3, 2019.

Fidelity Foundation

Supports education, arts, health, and community development with emphasis on the Greater Boston area.

Sea-Mar Community Health Center

Fiestas Patrias is a free two-day cultural festival where the community to comes together to celebrate Latin American arts, culture and heritage through music, dance, food and more. Fiestas Patrias begins with a community parade and festival in the predominately Latino South Park neighborhood on Saturday September 16th from 11am-6pm at 1040 S. Henderson St. followed by a community fiesta with concerts, folk dancers, children's arts and crafts, and a health fair at the Seattle Center 305 Harrison St. from noon- 9pm on Saturday September 16th and noon-6pm on Sunday September 17th.

Sea-Mar Community Health Center

Fiestas Patrias is a two-day, free admission cultural festival which provides opportunities for the Puget Sound community to come together to celebrate Latin American arts, culture, and heritage through music, dance, food and more. Fiestas Patrias will take place in South Park located at 8319 8th Avenue South on September 14th and 15th from 11:00 a.m. - 6:00 p.m. beginning with a parade. There will also be a community fiesta and health fair located at the Seattle Center at 305 Harrison Street on September 14th and 15th from noon - 9:00 p.m. This project will be completed by November 29, 2019.

THE FIREHOUSE COMMUNITY ARTS CENTER OF CHICAGO

Politics and Civic Affairs Services-Community and social services

Florida Division of Arts & Culture

Florida Division of Arts & Culture provides grants to support arts and cultural programming, artist fellowships, arts education, and community-based arts projects across FL.

Florida Division of Arts and Culture

Supports Florida arts and cultural organizations through general program support, specific project grants, and cultural facility improvement funding.

NIGMS - National Institute of General Medical Sciences

This proposal outlines a request to acquire a BD Biosciences FACSMelody Cell Sorter at Florida A&M University (FAMU), a state-controlled public institution. The BD FACSMelody has standard forward scatter (FSC) and side scatter (SSC) detection with nine fluorescence channels and the ability to sort 34,000 drops per second with up to 4-way sorting, enabling analysis and sorting of cell populations based on fluorescently labeled phenotypic markers and reporter gene expressions. The state-of-the-art equipment will greatly enhance research capability and capacity at FAMU, aiding several on-going NIH projects including: 1) engineering liver organoids for in vivo tissue restoration and ex-vivo drug screening, 2) enhancing efficacy of nanoparticles in pancreatic patient-derived xenografts (PDX) models, and 3) development of organoid systems tailored to probe lung cancer. The shared use equipment will improve research and biomedical activities at FAMU and promote collaborations with other biomedical researchers in Tallahassee. Aims of this project are to: (1) Acquire the BD Biosciences FACSMelody System at FAMU, (2) combine the instrument into research programs to promote and expand collaborations across disciplines between FAMU and other research-intensive institutions in Tallahassee and north Florida. This equipment item has been highly requested by the faculty, students, and staff members engaged in the areas of biomedical engineering, biology, pharmaceutical sciences, and food systems. The advanced functions of the FACSMelody are currently unavailable to FAMU researchers. Acquisition of the state-of-the-art system will foster long-term shared instrumentation use and promote collaboration between research groups across campus. As FAMU's west campus in Tallahassee's Innovation Park is currently without fluorescence-activated cell sorting (FACS) capabilities, the requested system would fill a major need to advance biomedical activities at the institution. To facilitate usage, the instrument will be housed in a newly constructed research building at the college of engineering that has a collaborative concept design. Graduate and undergraduate students in biomedical engineering, biological systems engineering, and pharmaceutics will incorporate use of equipment in their undergraduate research theses and Ph.D. dissertations. The requested system will improve workforce development, while also increasing success of external research funding, further improving the research ability of the FAMU faculty.

National Institutes of Health

This Notice of Funding Opportunity (NOFO) supports projects relevant to the NIGMS mission that focus solely on the development of technologies with potential to enable acquisition of biomedical knowledge. Projects should be justified in terms of technical innovation and utility of such technical innovation for impacting future biomedical research. Outcomes or products of the proposed project should significantly advance the current state of the art and be sufficiently characterized for application in addressing a broad range of biomedical research questions.

National Institutes of Health

This Notice of Funding Opportunity (NOFO) supports projects relevant to the NIGMS mission that focus solely on the development of technologies with potential to enable acquisition of biomedical knowledge. Projects should be justified in terms of technical innovation and utility of such technical innovation for impacting future biomedical research. Outcomes or products of the proposed project should significantly advance the current state of the art and be sufficiently characterized for application in addressing a broad range of biomedical research questions.