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Bridging the gap between basic and clinical research to prevent cardiovascular disease in diabetes

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NHLBI - National Heart Lung and Blood Institute

Abstract Currently, over 11% of the US population (nearly 40 million people) are affected by type 1 or type 2 diabetes (T1D or T2D), with T2D representing >90% of diabetes cases. In addition, 97.6 million youth and adults have pre-diabetes and are therefore at high risk of developing T2D and associated vascular complications. Alarmingly, T2D is rapidly increasing in youth, with incidence projected by some models to rise by 700% between 2017 and 2060. Youth-onset T2D is characterized by more severe insulin resistance than adult-onset T2D, and a substantial incidence of arterial stiffening—an early marker of atherosclerotic cardiovascular disease (CVD). Since both T1D and T2D markedly increase the risk of CVD, and because CVD events occur at younger ages in people with diabetes, it is critical to understand how diabetes increases CVD risk and how CVD can be prevented. Preventive strategies likely need to start early in youth. Although LDL-cholesterol lowering for CVD risk reduction is recommended for children >10 years of age as in adults with high CVD risk, a substantial residual CVD risk remains. This residual CVD risk in individuals with diabetes is linked to abnormal metabolism of triglyceride-rich lipoproteins (TRLs). Size-distributions and concentrations of TRL particle subpopulations and their partly-lipolyzed remnant lipoprotein particles (RLPs) are governed in part by apolipoprotein C3 (APOC3) and may predict CVD risk in adults and youth with diabetes. We hypothesize that increased hepatic APOC3 production resulting from adipose tissue insulin resistance in both T2D and T1D causes accumulation of a mid-sized atherogenic TRL particle subpopulation. These particles promote CVD by increasing vascular inflammation, with changes occurring early in youth at risk for CVD. This research program will ask three overarching questions to address this hypothesis: i) Does increased plasma APOC3 associate with accumulation of a mid-sized TRL particle population and worsened trajectories of insulin resistance and arterial stiffness in youth with T1D or T2D?; ii) How do TRL/RLP subpopulations differ structurally and functionally?; and iii) Does dysfunction in the hepatic sortilin 1-APOB100 secretion pathway explain the increased APOC3 secretion and atherosclerosis in diabetes? By combining longitudinal and mechanistic studies in youth with diabetes with investigation of mouse models of diabetes-accelerated atherosclerosis and cell systems, we believe we are in an excellent position to fill an important and clinically significant gap in our understanding of how diabetes promotes CVD risk and to identify new treatment and prevention strategies.

Up to $1.2M
2033-02-28
health research

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Buddy Bison Fishing Clinic School Program

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National Park Service

A. Project Goals 1. The goal of this Agreement is to enhance recreational fishing and other public uses of aquatic resources on public lands by hosting fishing clinics through the NPT Buddy Bison Program. 2. Increase access to fishing locations on public lands thereby reducing barriers to participation especially among low-income and disadvantaged youth. 3. Increase public awareness and understanding of sound fishing and conservation practices. 4. Facilitate the learning of fundamental fishing skills and outdoor ethics by hosting Fishing Clinics. 5. Connecting youth to the nature and the outdoors. 6. Introduce a new generation of youth and their families to the NPS Junior Ranger Program through the Junior Ranger: Let s Go Fishing Program. B. Project Objectives 1. To engage approximately 480 young anglers by hosting 4 clinics in/near national parks or other public lands before August 30, 2020. The events will be designed to create a ladder of engagement by providing pathways for deepening park community relationships (i.e., service learning experiences, increased recreational opportunities beyond fishing, and potential work opportunities for young adults). 2. 4 possible locations under consideration: a. Channel Island National Park (Ventura, CA) b. Juan Bautista de Anza National Historic Trail (Oakland, CA) c. Washington D.C. area national parks sites d. Mississippi National River and Recreation Area (St. Paul, MN) e. NPT may also involve Big Thicket National Park, Indiana Dunes National Lakeshore or St. Croix National Scenic Riverway as backup sites. 3. Increase understanding, appreciation, and awareness of NPS aquatic resources. 4. Facilitate the learning of angling skills, outdoor ethics, and angling opportunities on public lands. 5. Ensure 100% of kids have fun fishing.

$1 – $36K
rolling
Education

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Building Skills, Strengthening Communities, and Advancing Innovation in Northwest Mexico

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U.S. Mission to Mexico

The Public Diplomacy Sections of the U.S. Consulates General Tijuana, Nogales, and Hermosillo announce an open competition for programs that strengthen workforce readiness, promote safe border communities, and support a transparent and innovative information ecosystem in northwest Mexico. This Notice of Funding Opportunity (NOFO) seeks merit-based proposals that equip Mexican educators, youth, and media professionals with practical skills needed to succeed in a dynamic, binational environment. Through U.S. Federal assistance for programs and projects that support economic development and internal and external security, this NOFO promotes the foreign policy, better understanding, and general welfare of the United States. Implementers are required to inform, emphasize, and be sure participants are aware of the funding source and these purposes during implementation. Competitive proposals must address one of four objectives: (1) improve English language teaching capacity to better prepare students for participation in the binational economy; (2) advance STEM education through innovative, hands-on training that leverages U.S. technology, expertise, and institutional partnerships; (3) promote youth development and safer communities through sports diplomacy programs that build leadership, teamwork, and drug-free lifestyles; or (4) strengthen journalists' capacity to responsibly use artificial intelligence and digital tools to enhance reporting, promote accountability, and counter false narratives.Successful proposals will demonstrate practical skills-building, strong partnerships with U.S. institutions, measurable outputs and outcomes, and sustainability plans. Programs should reach participants based on merit and reinforce U.S. interests in security, prosperity, and accurate information flow.

$10K – $20K
2026-08-27
community development

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Building Skills, Strengthening Communities, and Advancing Innovation in Northwest Mexico

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U.S. Mission to Mexico

<p>The Public Diplomacy Sections of the U.S. Consulates General Tijuana, Nogales, and Hermosillo announce an open competition for programs that strengthen workforce readiness, promote safe border communities, and support a transparent and innovative information ecosystem in northwest Mexico. This Notice of Funding Opportunity (NOFO) seeks merit-based proposals that equip Mexican educators, youth, and media professionals with practical skills needed to succeed in a dynamic, binational environment.</p><p>&nbsp;</p><p>Through U.S. Federal assistance for programs and projects that support economic development and internal and external security, this NOFO promotes the foreign policy, better understanding, and general welfare of the United States. Implementers are required to inform, emphasize, and be sure participants are aware of the funding source and these purposes during implementation.&nbsp;</p><p>Competitive proposals must address one of four objectives: (1) improve English language teaching capacity to better prepare students for participation in the binational economy; (2) advance STEM education through innovative, hands-on training that leverages U.S. technology, expertise, and institutional partnerships; (3) promote youth development and safer communities through sports diplomacy programs that build leadership, teamwork, and drug-free lifestyles; or (4) strengthen journalists' capacity to responsibly use artificial intelligence and digital tools to enhance reporting, promote accountability, and counter false narratives.</p><p>Successful proposals will demonstrate practical skills-building, strong partnerships with U.S. institutions, measurable outputs and outcomes, and sustainability plans. Programs should reach participants based on merit and reinforce U.S. interests in security, prosperity, and accurate information flow.</p>

$10K – $20K
2026-08-27
Community DevelopmentEducationinformation_and_statistics+1

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CE25-021 - Disrupting the Cycle: Expansion of a Novel Hospital-Based Violence Intervention in New Orleans.

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NCIPC - National Center for Injury Prevention and Control

Abstract The proposed project aims to test the short- and long-term effects of a hospital-initiated, community-integrated intervention and examine how social contexts influence its adoption and sustained effects. This study will be conducted in collaboration with the Spirit of Charity Trauma Center to implement a hospital-initiated motivational interviewing (MI) approach augmented by firearm safety training (FST) and monthly case management. We will employ a randomized control trial, to test the efficacy of the prevention approach (MI/FST) compared to treatment as usual (TAU) control condition. The scientific premise is that the intervention will be more effective in changing firearm-related behaviors and beliefs than the control at 6-months while meeting the needs of victims of violent injury. Firearm violence disproportionately occurs in black communities and hospitalized victims of firearm injury are at increased risk for violent injury reoccurrence. This calls for community-integrated, evidence-based approaches that identify critical barriers to prevention, including the need to test the effectiveness of hospital- initiated violent injury prevent program (HVIP) and examine how social contexts influence HVIP adoption and sustained effects. This proposal is quite feasible to complete because it leverages our ongoing community- integrated youth HVIP through our Violence Prevention Institute, including a CDC-supported Youth Violence Prevention Research Center (U01CE003384), currently being conducted in youth aged 18-24 in New Orleans. Our aims are to 1) establish the effects (at 6 months) of an expanded hospital-initiated, community-integrated intervention on firearm related behaviors and beliefs amongst adults ages 16-34, 2) to establish the effects (at 6-months) of the MI/FST intervention on meeting the needs of traumatically injured victims of violence that allow them to avoid violent injury recurrence, and 3) to understand and analyze stakeholders’ perspectives and experiences with the MI/FST intervention components and its implementation. Results will continue and expand a novel HVIP aimed at mitigating recurrent firearm injuries in New Orleans—particularly in largely black communities—and inform future studies on the root issues underlying firearm violence recurrence nationwide. This research is significant because it will expand our understanding of the efficacy of community-based HVIPs in New Orleans that decrease the risk of recurrent violent injury in a growing and underappreciated, high-risk population that has already been hospitalized with a firearm injury. This proposal addresses the RFA’s first primary objective by testing the effectiveness of an innovative approach with the potential for immediate and near immediate benefits to reduce community violence and racial/ethnic inequities in risk for community violence.

Up to $400K
2028-09-29
health research

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CE25-021 - Rise Up! A Youth-Informed Video Program To Prevent Community Violence Before The First Shot

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NCIPC - National Center for Injury Prevention and Control

ABSTRACT Community gun violence (assault or homicide) is the leading cause of firearm injury and death in urban youth in the United States, yet upstream primary prevention efforts are lacking.1-3 Risk factors for community gun violence include aggression and violent conflict resolution, gun carrying, and living in socially and economically disadvantaged neighborhoods with high prevalence of violence.27-30 Youth are not always equipped to make smart or safe decisions regarding fighting, retaliation, and gun use. Additionally, they are easily influenced by social perceptions regarding gun carrying, especially vulnerable in communities where they could easily be victims of violence.20 Mentorship and conflict resolution skills for high-risk youth provided by school-based or community violence interruption programs are effective at reducing community gun violence; however, these services are limited resource-intensive.9-11,36,37 We propose development of a video-based program (“Rise Up Against Gun Violence”) that is informed by youth ambassadors with lived experience and leverages the expertise of violence interrupters to influence adolescents to avoid risky behaviors that lead to community gun violence. The video topics and messaging will be developed by the youth ambassadors and a multidisciplinary team of content experts, and refined through community feedback. The series will focus on risk-reduction topics such as non-violent conflict resolution, avoiding retaliation, and posting safely on social media, and will deliver hard facts about the dangers of firearm injuries and other salient topics that youth identify. Our study design includes youth ambassadors and violence interrupters from two cities with high levels of community gun violence (Houston and Memphis) to work with experts to develop a series of videos. The video program intervention will be tested with youth cohorts (community testers) in diverse settings in high-risk communities in both cities, and a mixed-methods approach will assess attitude change about the consequences of gun carrying and use (primary outcome), behavior change in gun carrying and fighting, increased awareness regarding risks of gun use, and establishment of adult support (secondary outcomes). Our proposal is a novel and innovative, multi-faceted approach, a “plug- and-play” program that could be disseminated to diverse community youth programs to utilize as part of their programming to tackle primary prevention of the leading public health problem for American youth.

Up to $399K
2028-09-29
health research

Free to search & build · $99 one-time to unlock the application pack · No subscription

CE25-026 - An Impact Evaluation of the Monique Burr Foundation Teen Safety Matters Prevention Education Program

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NCIPC - National Center for Injury Prevention and Control

Project Summary Abstract Child sexual abuse (CSA) and problematic sexual behavior (PSB) among youth are pervasive public health issues with significant physical, emotional, and societal impacts requiring community-level interventions. This evaluation is a field experiment designed to test the effectiveness of Teen Safety Matters (TSM), a school- based prevention program developed and implemented in multicultural school settings to equip both middle school adults and students with the knowledge and skills to identify and prevent CSA and PSB. This researcher-practitioner partnership will be conducted in a community population (New York City Public Schools) that is not only racially and ethnically diverse, but also serves learners who are predominantly economically disadvantaged (four out of five) among other vulnerabilities that confer disproportionate risk of CSA and PSB. The program evaluation has three specific aims: (1) Conduct a randomized controlled trial to assess the effectiveness of the TSM program on middle school students’ CSA and PSB outcomes; (2) Investigate the durability of TSM effects throughout middle school and into the first year of high school; and (3) Assess the differential impact of TSM on student outcomes by demographic subgroups. The study will engage 40 middle schools which will be randomized into one of two experimental conditions—TSM for students and school adults (Condition A), TSM for school adults only (Condition B)—or to the control condition (business as usual) in which school are eligible for delayed rollout. Data will be collected from adults and students at baseline, after one year, after two years, and (for the two older student cohorts) during high school. The primary adult outcomes are their preparation and actions for the prevention of CSA and PSB. The primary student outcomes include program effects on their knowledge, social-emotional competencies, skillsets and safety outcomes relevant to the prevention of PSB. Analyses of the outcomes for participants in Condition B will yield insights about the value of extra training for school adults to shift the middle school environment towards prevention; compared to the Control condition, we will learn if TSM for School Adults is by itself an effective intervention. Similarly, analysis of the outcomes for participants in Condition A will provide information on the efficacy of the combination of TSM for School Adults and classroom instructional time. Finally, because educating youth to prevent PSB will always remain an important learning goal for this age group, direct comparison of Condition A to Condition B will yield information about the relative value of added classroom instructional time compared to TSM for adults only. Key innovations include TSM’s adult-focused training component, a rules-based approach, a flexible delivery model requiring less instructional time, and a dual focus on preventing negative outcomes while promoting positive developmental competencies. Methodological innovations include examining cumulative and cross-sectional effects across three student cohorts and evaluating practices for Safe Adult and Safe Peer-to-Peer Communications to prevent CSA and PSB.

Up to $399K
2029-09-29
health research

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Changing Developmental Trajectories through Early Executive Function Intervention in Early Childhood Education

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NIMH - National Institute of Mental Health

PROJECT ABSTRACT There is a paucity of interventions targeted to changing developmental trajectories for young children with disabilities. As we face a continuing youth mental health crisis (currently estimated to affect 13% of youth, with a 35% increase between 2016-2023), there is an urgent need for evidence-based, early intervention that can address skill deficits and improve outcomes. Executive function has been identified as a transdiagnostic, underlying driver of mental health outcomes, and deficits are present across childhood disabilities. Executive function deficits in early childhood predict later aggression, anxiety, and mood challenges, as well as emotional, academic, and adaptive functioning in neurodevelopmental conditions such as autism and ADHD. Children with disabilities and associated early executive function challenges are at elevated risk for preschool expulsion and a subsequent cascade of poor mental health and academic outcomes. Universal (Tier 1) programs for early childhood executive functioning have mixed outcomes and do not adequately meet the needs of children with disabilities and identified challenges with executive function. This project proposes to test a novel executive function intervention, Unstuck and On Target for Early Childhood (Unstuck-EC), compared to a services-as-usual control, implemented by preschool classroom teachers of children with disabilities, as the first Tier 2 (selective) executive function intervention for young children. Unstuck-EC is adapted from the evidence-based Unstuck and On Target: 8-11, which is designed to be implemented in schools as a Tier 2 intervention for executive function challenges in neurodivergent youth. Unstuck-EC has been developed with input from early childhood providers and shown promise of efficacy in a preliminary development trial, when implemented by behavioral and development specialists. Grounded in the PRISM framework, we will collaborate with an advisory board to adapt Unstuck-EC for implementation by preschool teachers. We will partner with local public preschools to conduct a hybrid (Type 1) effectiveness-implementation trial (N=100 Unstuck-EC, N=60 Services as Usual Control), over the course of two school years. We predict that children in Unstuck-EC will show gains in executive function, and teachers will show improved knowledge and use of executive-function supporting strategies. We will also explore potential improvements in child mental health and expulsion risk, as well as in teacher strain and self-efficacy. Finally, we will assess factors related to reach, adoption, and implementation of Unstuck-EC, preparing for a future, larger randomized comparative effectiveness trial.

Up to $479K
2029-04-30
health research

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Characterization of Infant Energy Balance to Optimize Early Life Growth

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NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases

PROJECT SUMMARY One in four U.S. children enter kindergarten with overweight or obesity, yet the fundamental determinants of infant energy balance (i.e., the interplay of intake and expenditure) are poorly defined. Current reference standards for infant energy intake rely on decades-old and limited data. Our preliminary data demonstrates large errors (mean 16%, up to 71%) in predicted energy needs among 1–3-month-old infants, showing that such standards promote unintentional overfeeding during a critical window of metabolic programming. This highlights the lack of longitudinal energy balance phenotyping studies to understand the drivers of a more positive energy balance, thus, accelerated growth. Here we propose, Characterization of Infant Energy Balance to Optimize Early Life Growth, a first-of-its-kind prospective observational study healthy infants (N=100) longitudinally assessed from one to 12 months of age; at one, three, six, nine, and 12 months. Using gold-standard, rigorously adapted methods for infants, we will objectively assess energy intake (intake-balance method) and quantify free-living total daily energy expenditure (TDEE), sedentary energy expenditure, and physical activity energy expenditure. We will combine these with other physiological measures including biomarkers T3, leptin, and epinephrine, behavioral factors (feeding patterns, milk type, timing of complementary foods, accelerometry) and developmental progression (gross motor milestones) to precisely phenotype infants and identify drivers of growth. The principal aims are to objectively assess components of energy balance throughout the first year of life and compare between those with accelerated and appropriate growth. This is novel because while we propose a prospective study design, we have opportunities to perform retrospective analyses at each three-month assessment to utilize point estimates along each of the three months to predict growth using newly identified drivers. This allows for identification of vulnerable periods for excess growth, such as specific ages or developmental milestones such as the introduction to complementary foods or periods of delayed gross motor achievements. This study will generate the first robust dataset on infant energy balance and its mechanistic underpinnings. By revealing physiological and behavioral drivers of early growth and updating imprecise energy standards, findings will directly inform strategies to prevent youth- onset obesity.

Up to $732K
2031-04-30
health research

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Circadian epigenetic regulation of aging skeletal muscle & the impact of exercise

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NIA - National Institute on Aging

Skeletal muscle mass, quality and function decline with age, leading to a reduction in quality of life, an increased risk of falls, and higher mortality rates. By 2030, 1 in 6 people worldwide are predicted to be over 60 years of age. Recent estimates suggest that extending health span and increasing life expectancy by just 1 year is worth $38 trillion per year to the global economy, around 6 times the federal budget. Developing a comprehensive understanding of the molecular underpinnings of biological aging to enhance and maintain health span into old age is an imminent global challenge and is therefore the focus of this proposal. Age related loss of homeostatic control is well characterized. However, little is known about the potential role of the age-related decline in the circadian clock mechanism as a driving force of reduced homeostatic control, leading to dysfunction and disease. Preliminary data suggest that there is a progressive loss in the number of genes that present circadian oscillations in skeletal muscle, leading to a progressive decline between 6 and 27 months of age (~50% ). This proposal puts forward the concept that circadian oscillations within the skeletal muscle epigenome and transcriptome are an essential homeostatic feature that is lost with aging but is modifiable by exercise training. Male and female mice from the NIA colony will be assessed at 6, 18 and 28 months of age. Gastrocnemius muscle tissue from these mice will be collected every 4-hours for 24-hours. Muscle will be used in different molecular assays including RNA-sequencing, assays for transposase accessible chromatin, and chromatin immunoprecipitation with sequencing targeting RNA Polymerase II. Integrative bioinformatic analyses will provide the first genome-wide, circadian epigenetic/ transcriptomic map of skeletal muscle and how it is altered with age, in addition to identifying sexually dimorphisms. To test the plasticity of these declining CCG programs, we will employ an 8-week exercise intervention to identify responsive/nonresponsive elements, identifying relationships with physiological outcomes. We will also elucidate the role of the pioneer circadian transcription factor BMAL 1 in the age-related decline and exercise induced remodeling of the circadian epigenome/ transcriptome. We will compare 6- and 28-month-old muscle-specific BMAL 1 KO mice to naturally aged mice, with and without an exercise intervention. My global hypotheses are that aging will dysregulate chromatin accessibility at promoters which converge, leading to more aberrant transcriptional profiles and a reduction in the number of genes that show circadian oscillations. I hypothesize that many features will be restored to more 'youthful' levels by exercise training. I also hypothesize that loss of muscle BMAL 1 will recapitulate many features of natural aging and that its loss will suppress exercise related remodeling of the epigenome and thus, circadian transcriptome. The experiments and training opportunities afforded by this proposal will facilitate my transition into independent research, focused on interventions and therapeutics that improve muscle molecular clock function and health span in humans

Up to $104K
2028-06-30
health research

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Coastal Landform Change in the NPS Arctic Inventory and Monitoring Network

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National Park Service

This announcement is to provide public notice of the National Park Service (NPS), intention to fund the following project with University of Alaska Fairbanks under a Cooperative Ecosystem Studies Unit (CESU) program. CESUs are partnerships that provide research, technical assistance, and education. The project intended award is $60,216. STATUTORY AUTHORITY: Agreements Concerning Cooperative Research and Training on NPS Resources (16 U.S.C. 1a-2(j)): The Secretary may enter into agreements with public or private educational institutions, States and their political subdivisions, for the purpose of developing adequate, coordinated, cooperative research and training programs concerning the resources of the National Park System, and pursuant to such agreements, to accept from and make available to the cooperator such technical and support staff, financial assistance for mutually agreed upon research projects, supplies and equipment, facilities, and administrative services relating to cooperative research units as the Secretary deems appropriate. STATEMENT OF JOINT OBJECTIVES/PROJECT MANAGEMENT PLAN: The public purposes served by this agreement include: increasing our understanding and ability to predict coastal changes that will affect subsistence resource use and private infrastructure in and near the NPS units; educating University of Alaska students through research opportunities, advising, and financial support; and education and outreach to the public through interpretive products. In addition, this project coordinates and supports work currently being supported by the George Melendez Wright Climate Change Youth Initiative (CCYI), which manages paid internships in which undergraduate or beginning graduate students work for approximately 12 weeks on projects in research, interpretation, park operations, policy development, or other fields. The CCYI in cooperation with UAF is currently funding initial work on this project. Work has been done by the student starting in September 2013 will be continued by this project. The partner, in cooperation with the National Park Service will: 1) complete digitizing of the water and erosions lines on 2003 and 2013 imagery for the CAKR coast, and where possible the erosion line of both BELA and CAKR on earlier imagery (c. 1950 and c. 1980). 2) Complete geomorphic analysis of the processes responsible for coastal change, based both on image analysis and fieldwork in the summer of 2015. 3) Produce a set of GIS layers and one or more chapters of a graduate dissertation that will be devoted to a discussion of the process that control coastal geomorphic change in ARCN. NATIONAL PARK SERVICE INVOLVEMENT -Substantial Involvement :1. Provide a scientist (D. K. Swanson) to work with and give technical guidance to the student who working on this project. Dr. Swanson will serve as a member of the student s graduate committee and provide local knowledge and advice regarding the natural environment of the study area. 2. Provide access to NPS bunkhouses and expediting support in Kotzebue for summer fieldwork. 3. Collaborate as co-authors in written reports 4. Provide the imagery required for the remote sensing portion of this project, including orthorectified aerial photographs from c. 1950, c 1980, and 2003, new high-resolution satellite imagery from 2013, and USGS DSAS data from the 2003 and earlier images. 5. Provide a high-resolution (5 m) digital elevation model of the study area. 6. Provide funding sufficient for a graduate student to complete the work outlined above SINGLE-SOURCE JUSTIFICATION: Department of the Interior Policy (505 DM 2) requires a written justification which explains why competition is not practicable for each single-source award . The National Park Service did not solicit full and open competition for this award based the following criteria: Unique Qualifications: The UAF graduate student was the successful recipient of an NPS George M. Wright Climate Change Youth Initiative Fellowship, with which she is completing roughly half of the work planned for ARCN Coastal Erosion vital sign monitoring. This planed project continues that effort. Technical contact information: Dr. Jim Lawler, Jim_Lawler@nps.gov National Park Service, Alaska Region, End of FOA

$60K
rolling
natural resources

Free to search & build · $99 one-time to unlock the application pack · No subscription

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