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Functional Genetics And Genomics Of Drug Addiction (R01)

open

National Institutes of Health

Purpose. Genetic and genomic studies have identified genes and gene variants that potentially modulate the fundamental biological mechanisms underpinning addictive processes. Discovery of these genes/variants, while extremely valuable, is only a first step in understanding molecular mechanisms of addiction. This Funding Opportunity Announcement encourages basic functional genomic research in two areas: 1. functional validation to determine which candidate genes/variants have an authentic role in addictive processes, and 2. detailed elucidation of the molecular pathways and processes modulated by candidate genes/variants, particularly for those genes with an unanticipated role in addiction. Mechanism of Support. This FOA will utilize the R01 grant mechanism and runs in parallel with an FOA of identical scientific scope, PA-07-167 that solicits applications under the R21 and an FOA of identical scientific scope, PA-07-168 that solicits applications under R03 mechanisms. Funds Available and Anticipated Number of Awards. Awards issued under this FOA are contingent upon the availability of funds and the submission of a sufficient number of meritorious applications. Eligible Institutions/Organizations. Public/State Controlled Institution of Higher Education; Private Institution of Higher Education; Nonprofit with 501(c)(3) IRS Status (Other than Institution of Higher Education); Nonprofit without 501(c)(3) IRS Status (Other than Institution of Higher Education); Small Business; For-Profit Organization (Other than Small Business); State Government; U.S. Territory or Possession; Indian/Native American Tribal Government (Federally Recognized); Indian/Native American Tribal Government (Other than Federally Recognized); Indian/Native American Tribally Designated Organization; Non-domestic (non-U.S.) Entity (Foreign Organization); Hispanic-serving Institution; Historically Black Colleges and Universities (HBCUs); Tribally Controlled Colleges and Universities (TCCUs); Alaska Native and Native Hawaiian Serving Institutions; Regional Organization, and Eligible agencies of the Federal government; Faith-based or community based organizations.

rolling
Education

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Functional Genetics and Genomics of Drug Addiction (R21)

open

National Institutes of Health

Purpose. Genetic and genomic studies have identified genes and gene variants that potentially modulate the fundamental biological mechanisms underpinning addictive processes. Discovery of these genes/variants, while extremely valuable, is only a first step in understanding molecular mechanisms of addiction. This Funding Opportunity Announcement encourages basic functional genomic research in two areas: 1. functional validation to determine which candidate genes/variants have an authentic role in addictive processes, and 2. detailed elucidation of the molecular pathways and processes modulated by candidate genes/variants, particularly for those genes with an unanticipated role in addiction. Mechanism of Support. This FOA will use the NIH Exploratory/Developmental (R21) grant mechanism and runs in parallel with a FOA of identical scientific scope, PA-07-166 that solicits applications under the RO1 and PA-07-168 that solicits applications under the R03 mechanisms. Funds Available and Anticipated Number of Awards. Awards issued under this FOA are contingent upon the availability of funds and the submission of a sufficient number of meritorious applications Budget and Project Period: The total project period for an application submitted in response to this funding opportunity may not exceed two years. Direct costs are limited to $275,000 over an R21 two-year period, with no more than $200,000 in direct costs allowed in any single year. The R21 is not renewable. Eligible Organizations: Public/State Controlled Institution of Higher Education; Private Institution of Higher Education; Hispanic-serving Institution; Historically Black Colleges and Universities (HBCUs); Tribally Controlled Colleges and Universities (TCCUs); Alaska Native and Native Hawaiian Serving Institutions; Nonprofit with 501(c)(3) IRS Status (Other than Institution of Higher Education); Nonprofit without 501(c)(3) IRS Status (Other than Institution of Higher Education); Non-domestic (non-U.S.) Entity; Small Business; For-Profit Organization (Other than Small Business); State Government; Regional Organization; U.S. Territory or Possession; Indian/Native American Tribal Government (Federally Recognized); Indian/Native American Tribal Government (Other than Federally Recognized); Indian/Native American Tribally Designated Organization; Other(s): Eligible agencies of the Federal government; Faith-based or community based organizations.

Up to $200K
rolling
Education

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Grants for Basic Research in Glomerular Diseases (R01)

open

National Institutes of Health

Purpose. The Division of Kidney, Urologic and Hematologic Diseases (DKUHD) of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) invites applications from new or established investigators to pursue basic exploratory investigations of glomerular disease, which would foster development of new ideas enhancing the understanding of disease detection, pathogenesis, pre-emption and / or treatment. Mechanism of Support. This FOA will utilize the NIH Research Project Grant (R01) award mechanism Funds Available and Anticipated Number of Awards. Because the nature and scope of the proposed research will vary from application to application, it is anticipated that the size and duration of each award will also vary. The total amount awarded and the number of awards will depend upon the mechanism numbers, quality, duration, and costs of the applications received. Eligible Institutions/Organizations: Public/State Controlled Institution of Higher Education; Private Institution of Higher Education; Nonprofit with 501(c)(3) IRS Status (Other than Institution of Higher Education); Nonprofit without 501(c)(3) IRS Status (Other than Institution of Higher Education); Small Business; For-Profit Organization (Other than Small Business); State Government; U.S. Territory or Possession; Indian/Native American Tribal Government (Federally Recognized); Indian/Native American Tribal Government (Other than Federally Recognized); Indian/Native American Tribally Designated Organization; Non-domestic (non-U.S.) Entity (Foreign Organization); Hispanic-serving Institution; Historically Black Colleges and Universities (HBCUs); Tribally Controlled Colleges and Universities (TCCUs); Alaska Native and Native Hawaiian Serving Institutions; Regional Organization; Other(s): Eligible agencies of the Federal government; Faith-based or community based organizations Eligible Project Directors/Principal Investigators (PDs/PIs). Individuals with the skills, knowledge, and resources necessary to carry out the proposed research are invited to work with their institution/organization to develop an application for support. Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply for NIH support. Number of Applications. Applicants may submit more than one application, provided each application is scientifically distinct. Renewals and Resubmissions. Applications can be renewed by competing for additional project periods. Applicants may submit a resubmission application, but such application must include an Introduction addressing the previous peer review critique (Summary Statement).

rolling
Healthhealthcare

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Growing Great Ideas: Research Education Course in Product Development and Entrepreneurship for Life Science Researchers

upcoming

National Institutes of Health

<p>The National Institute on Drug Abuse (NIDA) seeks to advance its mission by establishing a well-recognized entrepreneurship teaching program with the demonstrated ability and passion to adapt, develop, and deliver a customized, substance use disorder (SUD)-centric curriculum in entrepreneurship and biomedical product development, targeting domestic innovators in the field of SUD research. With the appropriate training and guidance for the drug addiction science workforce, academic researchers will be better equipped with the skills to translate their discoveries into products, thus facilitating groundbreaking solutions generated in academic research to reach the populations they intend to help. The course will focus on early-stage innovation endeavors in preparing drug addiction researchers to recognize the potential of their research ideas and critically assess them for viable product development opportunities; utilize business ideation tools to evaluate the market and understand paths to commercialization; perform customer discovery; establish intellectual property protections; develop approaches to regulatory considerations; understand the reimbursement landscape; source capital, such as Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) funding; and generate revenue.</p><p>Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop a grant application to include both a proposed curriculum to be delivered in a hybrid format, in which a portion of the course must be offered for in-person attendance, and outreach strategy outlining the plans to recruit US-based SUD researchers and innovators to take part in the course. Grant authorities that allow NIDA to forecast this opportunity are as follows: Section 301 (42 U.S.C. § 241) and Section 405 (42 U.S.C. § 284).</p>

2026-10-01
Health

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Growing Great Ideas: Research Education Course in Product Development and Entrepreneurship for Life Science Researchers

upcoming

National Institutes of Health

The National Institute on Drug Abuse (NIDA) seeks to advance its mission by establishing a well-recognized entrepreneurship teaching program with the demonstrated ability and passion to adapt, develop, and deliver a customized, substance use disorder (SUD)-centric curriculum in entrepreneurship and biomedical product development, targeting domestic innovators in the field of SUD research. With the appropriate training and guidance for the drug addiction science workforce, academic researchers will be better equipped with the skills to translate their discoveries into products, thus facilitating groundbreaking solutions generated in academic research to reach the populations they intend to help. The course will focus on early-stage innovation endeavors in preparing drug addiction researchers to recognize the potential of their research ideas and critically assess them for viable product development opportunities; utilize business ideation tools to evaluate the market and understand paths to commercialization; perform customer discovery; establish intellectual property protections; develop approaches to regulatory considerations; understand the reimbursement landscape; source capital, such as Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) funding; and generate revenue.Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop a grant application to include both a proposed curriculum to be delivered in a hybrid format, in which a portion of the course must be offered for in-person attendance, and outreach strategy outlining the plans to recruit US-based SUD researchers and innovators to take part in the course. Grant authorities that allow NIDA to forecast this opportunity are as follows: Section 301 (42 U.S.C. 241) and Section 405 (42 U.S.C. 284).

2026-10-01
Healthhealthcare

Free to search & build · $99 one-time to unlock the application pack · No subscription

Healthcare Expansion Loan Program II (HELP II)

open

State Treasurer's Office

Eligibility -Must be a health facility as defined in the Authority's Act (Section 15432(d) of the California Government Code) -Must be a non-profit 501(c)(3) corporation and qualify as a small or rural health facility or public health facility (e.g., district hospital) as defined in the Authority's Act (Section 15432(e) of the California Government Code)  -Small facilities must have annual gross revenues of $30 million or less (no revenue limit for rural facilities or district hospitals) -Must be licensed by the State of California, typically through the Department of Health Care Services, Public Health, or Social Services -Must have been in existence for at least three years, providing the same types of services -Must demonstrate evidence of discal soundness and the ability to meet the terms of the proposed loan -Facility must be certified, organized, maintained and operated for the diagnosis, care, prevention, and treatment of human illness, or physical, mental, or developmental disability, including convalescence and rehabilitation and including during care during and after pregnancy Use of Funds Funds may be used for: -Purchase, construction, renovation, or remodeling of real property -Purchase equipment and furnishings -Perform feasibility studies, site tests, and surveys associated with real property -Pay permit fees, architectural fees, and pre-construction costs -Refinancing existing debt Loan Terms -Minimum loan amount of $25,000 -Maximum loan amount of $1.5 million ($1 million for refinancing existing debt) -Interest rate of 3% (4% for refinancing existing debt) -Maximum loan maturity depends on use of funds.  Between 5 years for equipment and furnishings and 20 years for the purchase, construction and renovation of real property (15 years for refinancing existing debt) -Gross revenue pledge, as well as a lien on the equipment or property, is required -Maximum loan-to-value ratio of 95% -Borrowers must contribute a minimum of 5% (in the form of cash or documented project expenditures) toward project costs -Proforma debt service coverage of at least 1.0x Fees -$50 non-refundable application fee -Initial fee of 1.25% of the loan amount payable at closing -No ongoing program fees Required Documentation -Three most recent fiscal years of audited financial statements -Proof of adequate property and business insurance  

Rolling
health & human services

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