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NIMH - National Institute of Mental Health

Project Summary/Abstract Interval timing, the ability to estimate event durations on the scale of seconds to minutes, is crucial for adaptive behaviors. Prior work investigating the neural basis of interval timing has focused on brain circuits in the basal ganglia and frontal and parietal cortices. However, recent research, including our own, indicates that the entorhinal cortex (EC) also plays a key role in the learning of timing behavior. In our recent work, we have discovered "time cells" in the medial entorhinal cortex (MEC) that fire at fixed intervals, forming sequences crucial for timing behavior. In contrast, lateral entorhinal cortex (LEC) neurons exhibit ramping activity over seconds to minutes as animals forage and/or perform spatial navigation tasks. This suggests distinct neural dynamics in the LEC and MEC for encoding elapsed time, hinting at different roles in timing behavior. A major limitation of this interpretation is that all LEC recordings to date have been from animals not engaged in active timing tasks, making it impossible to determine whether these neural correlates of ramping activity are actually involved in timing behavior or are simply a result of other task demands. To determine the functional roles of LEC and MEC in timing behavior, it is necessary to use tasks with explicit timing demands. Using a novel behavioral paradigm in which mice are trained to report non-matching stimuli durations, combined with neural recording and manipulation techniques, this proposal tests a model in which LEC and MEC function together to encode elapsed time and drive interval timing behavior. Specifically, we hypothesize that LEC encodes event boundaries through brief phasic activity, which then helps align sequential dynamics in MEC to these salient moments. In Aim 1, we will determine if LEC activity is necessary to align MEC time cell sequences and whether LEC activity is essential for learning timing behavior. In Aim 2, we will examine neural dynamics simultaneously in LEC and MEC during timing behavior to see if they function independently or in an integrated manner. Since interval timing is a fundamental component of nearly all major brain functions, understanding the cellular and circuit mechanisms of interval timing will provide a basis for understanding how the brain performs complex functions that depend on encoding time on the scale of seconds to minutes. This work also has the potential to guide the development of therapies targeting specific neural mechanisms in a wide range of diseases and psychiatric disorders that display altered temporal processing, including Alzheimer’s Disease, Parkinson’s Disease, and Schizophrenia.

National Institutes of Health

-Purpose. This Funding Opportunity Announcement (FOA) is a program announcement (PA) issued by the National Institute of Neurological Disorders and Stroke (NINDS), the National Eye Institute (NEI), the National Institute on Aging (NIA), the National Cancer Institute (NCI), and the National Institute of Mental Health (NIMH), National Institutes of Health (NIH). The aim of this FOA is to invite applications to study angiogenesis in the nervous system. Specific areas of research this FOA seeks to encourage include study of the mechanisms controlling angiogenic responses to physiological and pathological stimuli, the development and patterning of nervous system vasculature, and the etiology of disorders affecting development and/or ongoing angiogenesis in nervous system vasculature. -Mechanism of Support. This FOA will use the NIH Exploratory/Developmental (R21) grant mechanism and runs in parallel with a FOA of identical scientific scope, PA-08-015, that encourages applications under the NIH Research Project Grant (R01) award mechanism. Please note that NIMH is not participating in the companion R01 FOA. -Funds Available and Anticipated Number of Awards. Awards issued under this FOA are contingent upon the availability of funds and the submission of a sufficient number of meritorious applications.

Education Department

The Department of Education (Department) is issuing a notice inviting applications for new awards for fiscal year (FY) 2025 funds for the Mental Health Service Professional Demonstration Grant program (MHSP).

Education Department

The Department of Education (Department) is issuing a notice inviting applications for new awards for fiscal year (FY) 2025 funds for the School-Based Mental Health Services Grant program (SBMH).

NIMH - National Institute of Mental Health

Project Summary/Abstract It is well established that inflammatory markers are increased in individuals with stress-related psychiatric disorders and can contribute to their pathology. However, we lack a thorough understanding of the circuits, receptors, and transcriptional mechanisms driving these inflammatory processes in the brain and how they might differ in males and females. Stress activates the canonical “fight or flight” sympathetic nervous system, which uses noradrenaline as a neurotransmitter. Noradrenaline activates nuclear factor kappa B (NFkB), a master transcriptional regulator of inflammatory genes, to increase inflammation in peripheral immune cells. Stress also activates the locus coeruleus (LC), the primary source of noradrenaline in the brain. However, it is unknown whether the LC increases pro-inflammatory NFkB-mediated transcription in the hippocampus, a brain region that controls stress-related behaviors and is prone to stress-induced inflammatory processes. We found 1) 10 days of chronic social defeat stress (CSDS) increases nuclear NFkB in the hippocampus of males and females, 2) overall levels of NFkB are higher in females compared to males, suggesting it might be primed to transcribe inflammatory transcripts more readily, 3) compared to female in metestrus, females in proestrus transcribe more genes known to regulated by NFkB, which might be because the female LC is particularly sensitive to the neuroendocrine stress response, which is active during proestrus, and 4) daily administration of the α1 adrenergic receptor (α1-AR) antagonist prazosin prior to daily CSDS prevents reductions in sociability normally caused by CSDS, a stress paradigm that increases pro-inflammatory effects in the hippocampus. We hypothesize that inhibiting α1-ARs promotes sociability by mitigating inflammatory processes normally caused by CSDS. Our central hypothesis is that stress-induced noradrenergic neurotransmission increases NFkB- mediated inflammatory transcription in the hippocampus to reduce sociability. In Aim 1, we will determine whether chemogenetically inhibiting the LC throughout stress mitigates NFkB-mediated transcription in the hippocampus of males and females. We predict that the inhibitory Designer Receptor Exclusively Activated by Designer Drug (DREADD), hM4D, in noradrenergic LC neurons will increase subsequent sociability in a social interaction paradigm and reduce the transcription of a pre-defined set of transcripts regulated by NFkB, which we will identify using RNA-sequencing in hippocampal tissue. In Aim 2, we will determine whether five days of systemic administration of the α1 adrenergic receptor agonist, cirazoline, is sufficient to drive NFkB-mediated transcription in hippocampal microglia in males and estrus cycle-tracked females in metestrus or proestrus. We predict that cirazoline will increase nuclear NFKB in hippocampal microglia and neurons and increase NFkB- mediated transcripts in hippocampal microglia, with the strongest effects in females in proestrus. This project is highly conducive to undergraduates, who have already demonstrated they can successfully complete most assays described in this proposal.

Arizona Veterans Commission

State grants for veteran service programs in Arizona including housing, employment, education, and mental health support.

Substance Abuse and Mental Health Services Adminis

Assertive Community Treatment

NIMH - National Institute of Mental Health

PROJECT SUMMARY Human subjects research with novel neural devices raises unique ethical issues, such as post-trial responsibilities, privacy of brain data, and atypical risks such as changes to personality. To manage the discrepancy between research practices and ethics oversight, in 2018 the NIH added a mandatory neuroethics section to a subset of neuroscience grants in addition to the standard protection of human subjects component. However, despite the unique nature of this requirement, to date there have been no systematic efforts to assess stakeholders’ experiences with and attitudes toward these mandates. This represents both a critical gap and opportunity. Without empirical research evaluating the impact of neuroethics mandates, we risk implementing ineffective requirements, lack the information needed to make useful modifications, and remain unaware of their strengths and weaknesses. Furthermore, given that there is no established pathway nor guidance for investigators to address neuroethics requirements, examining researchers’ experiences offers a valuable opportunity to understand how they devise neuroethics plans as well as barriers they might encounter when implementing them. The overall objective of this short-term R21 exploratory proposal is to assess the impact of mandatory NIH neuroethics guidelines on the ethical design and conduct of brain-related research and to identify effective strategies that investigators have utilized to address neuroethics in their research. This will be achieved through two complementary aims that involve interviewing researchers who have been funded through NIH grants requiring neuroethics sections (Aim 1) and surveying those who review neuroethics components of grant applications (Aim 2). This project directly addresses the broad area of RFA-MH-25-171 (“enhance integration of neuroethics and neuroscience”). The expected outcomes of this two-year exploratory R21 project are a set of multistakeholder perspectives on the impact of neuroethics mandates and recommendations for improving them, an identification of strategies that researchers have utilized to address neuroethics mandates, and a determination of areas of unmet needs regarding resources for addressing neuroethics requirements. Our findings will benefit funders, by providing insights into the impact of neuroethics requirements and recommendations for improving them; researchers, by providing a set of effective strategies that have been used to address neuroethics sections; neuroethicists, by determining areas of unmet need regarding neuroethics resources; and the public, by identifying pathways for enhancing the ethical conduct of neurotechnology research. This project is significant because it has the potential to impact the way that the ethics is integrated and assessed across BRAIN Initiative research and in other scientific endeavors.

NIH

Attention deficits (AD) frequently co-occur with posttraumatic stress disorder (PTSD). The presence of AD is associated with greater PTSD clinical severity and poorer clinical outcomes. Knowledge regarding the mechanism underlying this association is limited, though the emerging evidence has indicated that executive function deficit (EFD) is strongly correlated with AD and PTSD symptoms. While treatments developed for PTSD have existed for years, a substantial portion of individuals do not fully respond to conventional treatment. Accumulating evidence suggest that attention deficit (AD) and EFD may be a driving force for PTSD treatment resistance. However, treatment of executive impairment in PTSD is very limited. As a result, untreated co- occurring AD and EFD in PTSD poses severe negative impacts on patients’ functional recovery, treatment outcomes, and quality of life (QoL). Given that up to 50% of patients do not respond well to the first-line pharmacological PTSD treatments, it is imperative to seek novel treatment strategies to improve EF that may improve both standard treatment response and QoL, social function. The proposed study directly addresses this knowledge gap by testing the efficacy of atomoxetine (ATX) in improving EF and attention among Veterans with PTSD, which will further improve Veterans’ QoL and social function. ATX represents a promising novel candidate pharmacotherapy for individuals with PTSD. ATX is a non-stimulant selective norepinephrine reuptake inhibitor (SNRI), approved by the FDA for the treatment of ADHD. Studies suggest that ATX, unlike stimulants, lacks addictive properties and shows efficacy in the treatment of comorbid depression and anxiety, which is ideal in the treatment of PTSD. Data from our preliminary study provides encouraging support for the therapeutic potential of ATX in improving EF in Veterans with comorbid PTSD/ADHD. Our recent research uncovered a higher rate of ADHD among veterans with PTSD, and the comorbid AD symptoms were correlated with PTSD severity and poorer treatment outcomes. Treatment with ATX showed significant symptoms reduction in ADHD and improvement in inhibitory function in Veterans with ADHD/PTSD. In the proposed study, we will focus on ATX in improvement of EF and attention, and further psycho-social life function and QoL. We will (1) employ a randomized, double-blind design that will consist of 12 weeks of treatment with ATX or placebo medication; (2) use standardized, repeated dependent measures to rigorously assess AD and EFD symptomatology; (3) measure impairment in associated mental and behavioral health problems (e.g., attention deficit, depression, anxiety, suicidality, QoL, family/social functioning); and (4) use response inhibition task GoNogo, working memory and attention tests Digit Span and Trail Making to investigate the underlying pathophysiology of PTSD and prognostic indicators of treatment outcome. To achieve these goals, we have assembled a multidisciplinary team of investigators with expertise in PTSD, ADHD clinical trials, and human laboratory paradigms who have successfully collaborated in the past and are uniquely qualified to implement this type of investigation. The proposed project is directly responsive to the mission of the VA-RRD “to maximize Veterans’ functional independence, quality of life and participation in their lives and community.” Successful completion of this study will provide a platform for a large multi-center trial to further confirm the important role of EF in PTSD treatment outcomes. The findings from this study will provide critically needed evidence to help inform clinical practice guidelines on the treatment of PTSD. The outcome of the proposed research will be significant, because it provides a knowledge base to allow for development of new PTSD intervention strategies. More importantly, this clinical trial may immediately benefit Veterans by enhancing their cognitive function, reducing AD related disability, and further improving quality of life for veterans who suffer from PTSD.

NIMH - National Institute of Mental Health

Project Summary/Abstract Decision making is a core cognitive process underlying myriad behaviors in day-to-day life. While great strides have been made in uncovering elements of the neural processes underlying decision making, key questions remain, especially related to the type of complex multi-attribute decisions that are common in the real world. Our novel task isolates each piece of information related to the value of options and requires subjects to view these attributes of options one at a time. Because of this design, we can monitor attention throughout and study the neural responses at each stage. This task also presents the distinct advantage of being viable for both human subjects and non-human primates. Already, we have gained key insights from recordings of neuronal activity in the pre-supplementary motor area (preSMA) of macaques performing the task. We found that preSMA neurons encode action value signals that accumulate information about the options. We also discovered that the focus of attention plays a key role in the value estimation process in these neurons. Attention both uniformly enhances the activity of neurons when the option in their preferred spatial position is attended and increases the gain of value representation in these neurons. With fundamentally the same task, we have collected data from patients undergoing intracranial recordings as part of their treatment for medically intractable focal epilepsy. With broad coverage of the brain across the population of patients, we have been able to identify a number of brain regions involved in different aspects of the task. Now, we can combine the advantages of both data sets to make additional progress. First, in Aim 1, I will implement a computational model for Attention Modulated Multi- Attribute Decisions (AM-MAD) consistent with the observed activity patterns in the preSMA data. This model will allow us to test the hypothesis that the observed forms of attentional modulation of value representation serve to prevent premature choices by allowing attended options to overcome inhibition. In Aim 2, broader networks for value estimation and option selection will be identified from the human sEEG data using a set of dimensionality reduction tools. This approach should reveal whether similar attentional modulation of value representation is present in corresponding areas in humans, as well as how these factors influence activity in other areas. Finally, in Aim 3, I will use new tools that have been developed for causal inference and are ideally suited to multi- channel intracranial recordings. This will allow us to study the flow of information through large-scale networks in the brain and test whether regions that show activity changes related to specific aspects of the task are directly interacting, e.g. whether activity in premotor areas is driven by both attention- and value-encoding frontal areas. With this additional information, the AM-MAD model will be refined with more detail about value and attention- related inputs. Together, this will serve to both advance our understanding of the neural mechanisms of attention in multi-attribute decision making and establish a set of tools that will be broadly applicable for studying cognitive processes across species and recording modalities.

National Institutes of Health

<p>The <i>Eunice Kennedy Shriver </i>National Institute for Child Health and Human Development (NICHD), with the National Institute on Deafness and Other Communication Disorders (<a href="https://www.nidcd.nih.gov/">NIDCD</a>), National Institute of Environmental Health Sciences (<a href="https://www.niehs.nih.gov/">NIEHS</a>), National Institute of Mental Health (<a href="https://www.nimh.nih.gov/index.shtml">NIMH</a>), and National Institute of Neurological Disorders and Stroke (<a href="https://www.ninds.nih.gov/">NINDS</a>), intends to publish a Notice of Funding Opportunity (NOFO) for the Autism Centers of Excellence (ACE) to solicit applications for research that will build on the progress and momentum of the past 23 years of ACE research and that takes advantage of cutting-edge technologies and methods.</p><p>Applications are not being solicited at this time. This Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects.&nbsp; This NOFO will utilize the <a href="https://grants.nih.gov/grants/funding/ac_search_results.htm?text_curr=p50&amp;Search_Type=Activity">P50</a> - Research Program Projects and Centers&nbsp;activity code. Investigators with expertise and insights into this area of research are encouraged to begin to consider applying for this new NOFO. In addition, collaborative investigations combining expertise in scientific disciplines will be encouraged, and these investigators should also begin considering applying for this opportunity. Grant authorities that allow the <i>Eunice Kennedy Shriver </i>National Institute of Child Health and Human Development&nbsp;to forecast this opportunity are as follows: Public Health Service Act, Section 301, 448 and 487, as amended, Public Laws 78-410 and 99-158, as amended, 42 U.S.C. 241; 42 U.S.C. 285g; 42 U.S.C. 288; Small Business Research and Development Enhancement Act of 1992, Public Law 102-564, Public Law 118-47.</p>

National Institutes of Health

The Eunice Kennedy Shriver National Institute for Child Health and Human Development (NICHD), with the National Institute on Deafness and Other Communication Disorders (NIDCD), National Institute of Environmental Health Sciences (NIEHS), National Institute of Mental Health (NIMH), and National Institute of Neurological Disorders and Stroke (NINDS), intends to publish a Notice of Funding Opportunity (NOFO) for the Autism Centers of Excellence (ACE) to solicit applications for research that will build on the progress and momentum of the past 23 years of ACE research and that takes advantage of cutting-edge technologies and methods.Applications are not being solicited at this time. This Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the P50 - Research Program Projects and Centers activity code. Investigators with expertise and insights into this area of research are encouraged to begin to consider applying for this new NOFO. In addition, collaborative investigations combining expertise in scientific disciplines will be encouraged, and these investigators should also begin considering applying for this opportunity. Grant authorities that allow the Eunice Kennedy Shriver National Institute of Child Health and Human Development to forecast this opportunity are as follows: Public Health Service Act, Section 301, 448 and 487, as amended, Public Laws 78-410 and 99-158, as amended, 42 U.S.C. 241; 42 U.S.C. 285g; 42 U.S.C. 288; Small Business Research and Development Enhancement Act of 1992, Public Law 102-564, Public Law 118-47.

National Institutes of Health

The Eunice Kennedy Shriver National Institute for Child Health and Human Development (NICHD), with the National Institute on Deafness and Other Communication Disorders (NIDCD), National Institute of Environmental Health Sciences (NIEHS), National Institute of Mental Health (NIMH), and National Institute of Neurological Disorders and Stroke (NINDS), intends to publish a Notice of Funding Opportunity (NOFO) for the Autism Centers of Excellence (ACE) Network to solicit applications for research that will build on the progress and momentum of the past 23 years of ACE research and that takes advantage of cutting-edge technologies and methods. The ACE network has used R01 funding mechanism to allow multisite collaborations since the beginning of the ACE program in 2007. Each ACE Network will consist of a multi-site project focusing on a specific topic of research for R01 support through this FOA. Each ACE Network will submit one R01 application that includes sub-awards to the collaborating sites.Applications are not being solicited at this time. This Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the R01 Research Project Grant activity code. Investigators with expertise and insights into this area of science are encouraged to begin to consider applying for this new NOFO. In addition, collaborative investigations combining expertise in scientific disciplines will be encouraged, and these investigators should also begin considering applying for this application. Grant authorities that allow the Eunice Kennedy Shriver National Institute of Child Health and Human Development to forecast this opportunity are as follows: Public Health Service Act, Section 301, 448 and 487, as amended, Public Laws 78-410 and 99-158, as amended, 42 U.S.C. 241; 42 U.S.C. 285g; 42 U.S.C. 288; Small Business Research and Development Enhancement Act of 1992, Public Law 102-564, Public Law 118-47.

National Institutes of Health

<p>The<i> Eunice Kennedy Shriver</i> National Institute for Child Health and Human Development (NICHD), with the National Institute on Deafness and Other Communication Disorders (<a href="https://www.nidcd.nih.gov/">NIDCD</a>), National Institute of Environmental Health Sciences (<a href="https://www.niehs.nih.gov/">NIEHS</a>), National Institute of Mental Health (<a href="https://www.nimh.nih.gov/index.shtml">NIMH</a>), and National Institute of Neurological Disorders and Stroke (<a href="https://www.ninds.nih.gov/">NINDS</a>), intends to publish a Notice of Funding Opportunity (NOFO) for the Autism Centers of Excellence (ACE) Network to solicit applications for research&nbsp;that will build on the progress and momentum of the past 23 years of ACE research and that takes advantage of cutting-edge technologies and methods. &nbsp;The ACE network has used R01 funding mechanism to allow multisite collaborations since the beginning of the ACE program in 2007. &nbsp;Each ACE Network will consist of a multi-site project focusing on a specific topic of research for R01 support through this FOA. Each ACE Network will submit one R01 application that includes sub-awards to the collaborating sites.</p><p>Applications are not being solicited at this time. This Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects.&nbsp;This NOFO will utilize the&nbsp;R01 Research Project Grant&nbsp;activity code. Investigators with expertise and insights into this area of science are encouraged to begin to consider applying for this new NOFO. In addition, collaborative investigations combining expertise in scientific disciplines will be encouraged, and these investigators should also begin considering applying for this application. Grant authorities that allow the <i>Eunice Kennedy Shriver </i>National Institute of Child Health and Human Development&nbsp;to forecast this opportunity are as follows: Public Health Service Act, Section 301, 448 and 487, as amended, Public Laws 78-410 and 99-158, as amended, 42 U.S.C. 241; 42 U.S.C. 285g; 42 U.S.C. 288; Small Business Research and Development Enhancement Act of 1992, Public Law 102-564, Public Law 118-47.</p>

NIMH - National Institute of Mental Health

Project Summary Schizophrenia (SZ) involves distinct changes in brain network organization, in which disrupted oscillatory communication between brain regions is thought to contribute to a breakdown in cognitive and perceptual processes. In addition to widespread changes in central nervous system (CNS) activity, SZ involves distinct alterations in the rhythmic activity of the autonomic nervous system (ANS). A growing body of evidence suggests that physiological cycles such as heart rate, respiration, and heart rate variability (HRV) interact with the rhythms of the brain and may help coordinate oscillatory communication within brain networks. Whether and how ANS dysfunction in SZ mechanistically contributes to disorganized brain activity and cognition remain to be explored. SZ is characterized by prominent changes in the parasympathetic branch of the ANS, which can be indexed by the cyclical fluctuations in heart rate associated with respiration, known as high-frequency (HF) HRV. HF-HRV is robustly associated with psychological health and cognitive functioning and is consistently found to be lower in SZ. Our group recently showed that, rather than simply reflecting shared neural systems supporting physiological and psychological regulation, the associations between HF-HRV and psychological functioning may be due in part to a causal influence of cardiac autonomic rhythms on brain activity. We observed that HF-HRV oscillations modulate EEG oscillations through phase-amplitude coupling (PAC), a well-established mechanism of oscillatory organization in the brain that appears to extend to brain- body interactions. Crucially, directions of effects were stronger from heart-to-brain than brain-to-heart. We also found that HRV-EEG coupling is lower in individuals with SZ and that this deficit is associated with impaired sustained attention. Our findings suggest that dysregulated neural activity and cognitive dysfunction are due in part to disrupted body-to-brain communication in SZ. To further probe the causal mechanisms through which autonomic rhythms influence brain activity, the proposed study will examine whether increasing HF-HRV can lead to changes in oscillatory activity and cognitive functioning in patients with first-episode SZ and healthy comparison (HC) participants. Prior research shows that simply reducing respiratory rate results in immediate and sizeable increases in HF-HRV. In the proposed study, SZ and HC participants will complete a series of tasks measuring cognitive functioning before and after completing a slow-paced breathing exercise, with EEG, EKG, and respiration measured throughout. We hypothesize that increasing HF-HRV through slow-paced breathing will lead to increased HRV-EEG coupling, increased oscillatory connectivity within relevant brain networks, and cognitive improvements. We aim to clarify how autonomic rhythms influence brain activity and cognition and to bridge largely separate literatures on ANS and CNS dysfunction in SZ. Ultimately, understanding how psychological health depends on the integrated functioning of the brain and body may introduce new treatment avenues for SZ and other mental illnesses.

Department of Labor

AWARD PURPOSE THE PURPOSE OF BOOST GO IS TO PREPARE YOUNG ADULTS FOR EMPLOYMENT THROUGH EDUCATION AND TRAINING, PAID WORK EXPERIENCES, MENTORSHIP, AND LEADERSHIP DEVELOPMENT WITH DELIVERY OF EVIDENCE-BASED PRACTICES INTERVENTIONS. ACTIVITIES PERFORMED BOOST GO WILL SUPPORT JUSTICE INVOLVED YOUNG ADULTS FOR EMPLOYMENT AND VIOLENCE PREVENTION BY 1. HELPING YOUNG ADULTS TO INCREASE THEIR CONFLICT RESOLUTION SKILLS AND DEVELOP STRATEGIES TO PREVENT AND AVOID VIOLENCE. THIS WILL BE ACHIEVED IN PARTNERSHIP WITH SKY RANCH BEHAVIORAL SERVICES TO PROVIDE VIOLENCE PREVENTION, MENTORING, AND LEADERSHIP DEVELOPMENT THROUGH DELIVERY OF EVIDENCE-BASED INTERVENTIONS OF AGGRESSION REPLACEMENT TRAINING® ART) AND MENTORS IN VIOLENCE PREVENTION (MVP) CURRICULUM DESIGNED BY UNIVERSITY OF NORTHERN IOWA CENTER FOR VIOLENCE PREVENTION (CVP). PARTNERS WILL COLLABORATE TO RECRUIT AND TRAIN MULTICULTURAL MENTORS WITH LIVED EXPERIENCE. 2. PREPARING YOUNG ADULTS FOR THE WORLD OF WORK BY HELPING YOUNG ADULTS IDENTIFY CAREER INTERESTS, ATTAIN RELEVANT SKILLS, AND GAIN WORK EXPERIENCE. BOOST GO WILL ENSURE PARTICIPANTS RECEIVE COMPREHENSIVE EMPLOYMENT AND CAREER SERVICES UTILIZING STEP ON UP® CAREER READINESS AND GROWTH FOCUSED CASE MANAGEMENT (GFCM), RESULTING IN A CUSTOMIZED INDIVIDUAL DEVELOPMENT PLAN (IDP). PARTICIPANTS WILL GAIN WORK EXPERIENCE IN EMPLOYMENT, APPRENTICESHIP, INTERNSHIP; AND/OR ON-THE-JOB TRAINING WITH HIGH PRIORITY EMPLOYER PARTNERS HIGH DEMAND CAREERS, BASED ON CURRENT LABOR MARKET INFORMATION (LMI) AND IOWA WORKFORCE DEVELOPMENT TO INCLUDE CHILDCARE, CONSTRUCTION, FOOD/MEAT PROCESSING, HEALTH CARE, MAINTENANCE/ SAFETY, COMMERCIAL TRUCKING, WAREHOUSE LOGISTICS/OPERATIONS, AND WELDING. WRAPAROUND SERVICES TO ADDRESS HOUSING, MENTAL HEALTH, ADDICTION, CHILDCARE, LEGAL SERVICES, WILL BE CUSTOMIZED TO EACH INDIVIDUAL. DELIVERABLES OUTCOMES WILL EXCEED ALL REQUIRED PERFORMANCE OUTCOMES TO INCLUDE A 73% EMPLOYMENT RATE- SECOND QUARTER AFTER EXIT, 65% EMPLOYMENT RATE- FOURTH QUARTER AFTER EXIT, 6,000 MEDIAN EARNINGS, 60% CREDENTIAL ATTAINMENT, 73% MEASURABLE SKILL GAIN, LESS THAN 3% ARRESTS FOR VIOLENT CRIMES, AND LESS THAN AN 8% RECIDIVISM RATE. INTENDED BENEFICIARY BOOST GO WILL REACH AND SERVE 180 YOUNG ADULTS 18-24 YEARS OLD MOST IMPACTED BY POVERTY AND CRIME, WITH PRIORITY ON REACHING MINORITY COMMUNITIES IN THE CENSUS TRACTS. SUBRECIPIENT ACTIVITIES N/A

Department of Labor

AWARD PURPOSE THE PURPOSE OF THE PROGRAM IS TO INTRODUCE AND PREPARE JUSTICE-INVOLVED YOUNG ADULTS FOR THE WORLD OF WORK THROUGH PLACEMENT INTO PAID WORK EXPERIENCES, AND ON A PATH TO MORE EQUITABLE CAREER OPPORTUNITIES WITH THEIR PEERS. ACTIVITIES PERFORMED SERJOBS WILL PROVIDE AN INNOVATIVE, INTEGRATED PROGRAM THAT INCLUDES PREVENTATIVE MEASURES PROVEN TO REDUCE VIOLENT CRIME AND SUPPORT PUBLIC SAFETY AND COMMUNITY WELL-BEING FOR 200 JUSTICE-INVOLVED INDIVIDUALS, DESIGNED BY EVIDENCE-BASED RESEARCH, INFORMED INTERVENTIONS, AND PROMISING PRACTICES THAT INVOLVE COMPREHENSIVE WORKFORCE DEVELOPMENT SERVICES INCLUDING CASE MANAGEMENT, EDUCATION, CAREER EXPLORATION/ PLANNING, MENTORSHIP, OCCUPATIONAL TRAINING LEADING TO INDUSTRY-RECOGNIZED CREDENTIALS, PAID-WORK EXPERIENCE, JOB PLACEMENT, FOLLOW-UP SERVICES, AND TRAUMA-INFORMED CARE THROUGH WARM REFERRALS. SER'S COMPREHENSIVE APPROACH UTILIZES A DIVERSE SUPPORT NETWORK AND MULTIPLE ACCOUNTABILITY LEVELS, ENSURING THAT PARTICIPANTS BECOME PRODUCTIVE, LAW-ABIDING MEMBERS OF SOCIETY; ARE PROVIDED WITH POSITIVE OPPORTUNITIES TO ENGAGE IN PRO-SOCIAL ACTIVITIES, MAINTAIN LONG-TERM EMPLOYMENT; SUSTAIN A STABLE RESIDENCE, AND; SUCCESSFULLY ADDRESS ID ATTAINMENT, LEGAL AND SUBSTANCE ABUSE ISSUES, AND PHYSICAL AND MENTAL HEALTH NEEDS. THROUGH ITS EXPERIENCE, RENOWNED TRAINING AND PRE-APPRENTICESHIP PROGRAMMING, PARTNERSHIPS, AND UNIQUE BLEND OF SERVICES, THE PROGRAM WILL ENSURE THAT PARTICIPANTS ARE PREPARED TO MEET THE NEEDS OF THE LOCAL LABOR MARKETS WITH THE SKILLS VALUED BY EMPLOYERS, RESULTING IN THE ATTAINMENT OF HIGH-GROWTH, HIGH-DEMAND JOBS, SO THEY CAN STABILIZE THEIR LIVES AND BREAK THE CYCLE OF POVERTY AND VIOLENT VICTIMIZATION. DELIVERABLES ENROLLED 200; COMPLETE SOFT SKILLS TRAINING 150; START OCCUPATIONAL TRAINING 150; COMPLETE OCCUPATIONAL TRAINING 140; PARTICIPATING IN PAID WORK EXPERIENCE/OJT 150; EMPLOYMENT ATTAINMENT 135; EMPLOYMENT RATE SECOND QUARTER AFTER EXIT 70%; EMPLOYMENT RATE FOURTH QUARTER AFTER EXIT 60%; MEDIAN EARNINGS SECOND QUARTER AFTER EXIT $5,750; MEASURABLE SKILLS GAIN 70; ARRESTED FOR VIOLENT CRIMES <5%; RECIVIDISM <10% INTENDED BENEFICIARY MALES AND FEMALES IN THE TARGETED GEOGRAPHIC AREA, OR PLAN TO RETURN TO THE AREA UPON CUSTODY RELEASE OR UPON THE CONCLUSION OF OUT-OF-HOME PLACEMENT; AND HAVE BEEN EXPELLED FROM A SCHOOL OR HAD JUVENILE OR ADULT JUSTICE SYSTEM CONTACT, AND HAVE ONE OR MORE RISK-FACTORS ASSOCIATED WITH DELINQUENT OR CRIMINAL ACTIVITY. SUBRECIPIENT ACTIVITIES N/A

Department of Labor

AWARD PURPOSE TO HELP FORMERLY INCARCERATED YOUNG ADULTS GAIN WORK EXPERIENCE TO BECOME PERMANENTLY EMPLOYED IN ORDER TO REDUCE COMMUNITY VIOLENCE AND PREVENT RECIDIVISM. ACTIVITIES PERFORMED OUR PROGRAM IS AN 18-MONTH MODEL WHERE FORMERLY INCARCERATED PARTICIPANTS BEGIN TO HEAL AND WORK ON THEMSELVES. EVERY PROGRAM PARTICIPANT IS ASSIGNED A CASE MANAGER AND A NAVIGATOR TO CREATE A CUSTOMIZED SERVICE PLAN THAT INCLUDES ALL THE WRAPAROUND SERVICES INCLUDING EDUCATION, WORKFORCE DEVELOPMENT, MENTAL HEALTH, TATTOO REMOVAL, LEGAL SERVICES, AND SUBSTANCE ABUSE. ONCE THE TRAINEES/PARTICIPANTS HAVE ACHIEVED SOME OF THE MARKERS ASSOCIATED WITH HEALING IN PHASE 1, THE TRAINEE RECEIVES WORK READINESS TRAINING AND ARE PLACED IN OUR OWN SOCIAL ENTERPRISES TO CONTINUE TO HEAL WITH WRAP AROUND SERVICES AND LEARN THROUGH ON-THE-JOB TRAINING. ONCE THE TRAINEE HAS MET MARKERS IN OUR PHASE 2 WORK-AND-LEARN MODEL, THE TRAINEE WOULD MOVE ON TO ADVANCED TRAINING AND PLACEMENT IN OUR SOCIAL ENTERPRISES FOR FURTHER TRAINING IN OUR PAID WORK EXPERIENCE PROGRAM UNDER OUR CAREER PATHWAYS. IN PHASE 3, THE PARTICIPANTS BECOME A FULL-TIME EMPLOYEE AT HBI OR ARE PLACED WITH OUR EMPLOYER PARTNERS. ALL PARTICIPANTS OF OUR PROGRAM RECEIVE: • MENTORSHIP THROUGH OUR LIVED EXPERIENCED NAVIGATORS ASSIGNED TO EACH PARTICIPANT • INDIVIDUAL DEVELOPMENT PLANS (IDPS) (SERVICE PLAN) • EMPLOYMENT AND CAREER SERVICES; EDUCATION AND OCCUPATIONAL TRAINING; AND TRAUMA-INFORMED, GROWTH FOCUSED CASE MANAGEMENT • WORK READINESS TRAINING • PAID WORK EXPERIENCE IN PHASE 2 OF THE PROGRAM AT MINIMUM WAGE • SUPPORTIVE SERVICES • FOLLOW-UP FOR 12-MONTHS AFTER PROGRAM EXIT DELIVERABLES WIOA PERFORMANCE GOALS: I. EDUCATION AND EMPLOYMENT RATE-SECOND QUARTER AFTER EXIT 70% II. EDUCATION AND EMPLOYMENT RATE- FOURTH QUARTER AFTER EXIT 60% III. MEDIAN EARNINGS-SECOND QUARTER AFTER EXIT $5,750 IV. CREDENTIAL ATTAINMENT 50% V. MEASURABLE SKILL GAINS 70% REO-SPECIFIC INDICATORS OF PERFORMANCE: I. ARRESTS FOR VIOLENT CRIMES THAT ARE COMMITTED AFTER PROGRAM ENTRY. THE GOAL IS LESS THAN 5% II. RECIDIVISM—AS DEFINED AS THE PERCENTAGE OF PARTICIPANTS CONVICTED OF NEW CRIME COMMITTED WITHIN 12 MONTHS OF RELEASE FROM FACILITY, PLACEMENT ON PROBATION, OR DIVERSION WITH A GOAL OF LESS THAN 10% III. ARRESTS, RECIDIVISM, AND RETURNS-TO-INCARCERATION WILL BE BASED ON FOA PARAMETERS INTENDED BENEFICIARY COMMUNITY; FORMERLY INCARCERATED AGES 18-24; EMPLOYERS SUBRECIPIENT ACTIVITIES PEACE OVER VIOLENCE: CONDUCT GROUPS AND ASSIST WITH LEADERSHIP TRAINING SUCCESS STORIES: OFFER CLASSES FOR VICTIMS OF DOMESTIC VIOLENCE PUBLIC WORKS: DEVELOP INSTRUMENTS, REPORTING PROCESS AND EVALUATION CARE4: DEVELOPMENT OF TRACKING SYSTEM

Substance Abuse and Mental Health Services Admin

The purpose of Behavioral Health and Community Safety Partnerships is to support communities in reducing the behavioral health impacts of crime, violence, and disorder; strengthening community safety; and improving outcomes for youth, families, and other individuals affected by crime, violence, and disorder.

Substance Abuse and Mental Health Services Admin

Behavioral Health and Community Safety Partnerships

Substance Abuse and Mental Health Services Adminis

Behavioral Health Mobile Crisis Team Partnerships

Substance Abuse and Mental Health Services Adminis

The purpose of this program is to establish new, or enhance existing, mobile crisis teams that serve children, youth, and adults experiencing mental health or substance use crises. Its focus is the expansion of behavioral health crisis response capacity and the development of structured partnerships that reduce reliance on law enforcement and emergency departments for behavioral health crises.

Substance Abuse and Mental Health Services Adminis

The purpose of this program is to develop and implement a program to divert youth and/or adults with mental health or co-occurring disorders who are at risk of criminal and/or juvenile justice involvement to community-based services before arrest or booking.

Substance Abuse and Mental Health Services Adminis

Behavioral Health Partnerships for Early Diversion of Adults and Youth