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Oregon Community Foundation

Oregon Community Foundation ($2.7B in assets) supports nonprofits in OR through grants focused on education, environment, arts, community development. Awards range from $2,500 to $200,000.

NIAMS - National Institute of Arthritis and Musculoskeletal and Skin Diseases

PROJECT SUMMARY The 2026 biennial meeting of the Orthopaedic Research Society-International Section for Fracture Repair is entitled: ORS-ISFR 19th Biennial Meeting: Advancing Bone Repair – From Basic Science to Clinical Solutions. The overall objective of this two-day meeting is to promote state-of-the-art research and scientific discourse on topics related to bone repair, with an emphasis on the ongoing need for collaboration between basic scientists, engineers and clinicians. We are committed to an interactive conference that is welcoming for trainees and early-stage investigators, with opportunities to present research, moderate sessions and network. The meeting program has been designed based on the success of past meetings, but with changes based on attendee feedback from the prior meeting. The meeting will address the most challenging problems in bone repair, with a focus on recent advances. Each session will address topics of relevance to the research priorities of the NIH. Three sessions on Day 1 will focus on basic and translational science: a) Advanced model systems and -omics in bone healing; b) Microenvironmental cues and cell metabolism in bone regeneration; and c) Innervation and angiogenesis in bone repair. Day 2 will have three clinically relevant sessions: a) Early detection of failed healing; b) Immune system and fracture – from infection to healing; c) The immune-bone axis in polytrauma and healing. There is often an information gap between what front-line clinicians treating fractures recognize as important problems, and problems that basic scientists perceive as most important. This ISFR conference aims to bridge this gap and accomplish three objectives: 1) provide a forum for clinicians to learn about the latest in basic and translational research, 2) expose basic scientists to the clinical issues that are most pressing in orthopaedic trauma, and 3) foster collaborations between researchers and clinician-scientists. Multidisciplinary approaches are essential to address challenging clinical problems. The ORS-ISFR 19th Biennial Meeting will advance understanding of fracture healing across basic, translational, and clinical perspectives.

Fugro USA Land, Inc.

Editorial and Design and Graphic and Fine Art Services

NEI - National Eye Institute

Project Summary Vision is our primary sense. We rely on vision for everything from building our sense of reality, to navigating obstacles, identifying threats, and reading text and emotions. Untreatable vision loss beginning in childhood is often emotionally devastating and incurs a lifetime of healthcare expenses. This is the situation for people with Cone Dystrophy with Supernormal Rod Response (CDSRR), alternatively referred to as KCNV2 Retinopathy. In CDSRR there is a decline of vision in early childhood, followed by progressive macular degeneration by early adulthood. The hindrance to developing sight preserving treatments for CDSRR is that the etiology of macular degeneration is unknown. CDSRR is caused by mutations in a photoreceptor-specific potassium channel, Kv2.1/Kv8.2. As such CDSRR can be considered a disease of disrupted potassium homeostasis in the outer retina. Regulated potassium flux is essential for the electrical response of photoreceptors to light and can create osmotic gradients that drive water transport. Since photoreceptors have a high rate of mitochondrial respiration, generating excess metabolic wastewater that must be exported, we propose that loss of Kv2.1/Kv8.2 potassium channels in CDSRR reduces clearance of wastewater from photoreceptors, activating chronic osmotic stress signaling. In this project, we will use state-of- the-art imaging biomarkers and transcriptomics to evaluate osmotic regulation in mouse models of CDSRR.

NIMHD - National Institute on Minority Health and Health Disparities

Originating within urban Black and Latinx communities, the House Ball Community (HBC) is a gender- and sexuality expansive population facing overlapping hardships such as stigma and family rejection that contribute to their overrepresentation in the HIV epidemic. The HBC population, estimated at 8,000 nationwide, is concentrated in New York City (NYC) with growth in the US South and includes a large proportion of Black Gender and Sexual Minority (BGSM) individuals, primarily Black and Latinx gay men who have sex with men (MSM) and transwomen and men. BGSM remain deeply impacted by the US HIV epidemic, with low uptake of pre-exposure prophylaxis (PrEP) and limited HIV care engagement due to stigma and systemic barriers, particularly in the US South. Despite the HBC’s longstanding role as a site for advocacy and normative change within the broader BGSM community, the HBC has received minimal targeted HIV treatment/prevention efforts and remains severely understudied. Our Family, Our Voices (OFOV) addresses these gaps through a community-driven, HIV status-neutral, gender-expansive, group-level intervention developed in collaboration with the HBC. Leveraging the HBC’s hierarchical family structure (e.g., house mother, house father), OFOV’s intervention format includes a family-based retreat for HBC members to empower them to advocate for their own health, cultivate leadership skills, and improve clinical outcomes. OFOV builds on core elements of Many Men, Many Voices (3MV), the only CDC “best evidence” intervention for Black gay MSM that has demonstrated increased HIV testing rates. Previously adapted in NYC (R34 MH124082), OFOV has shown feasibility, but further research in a powered study is needed to evaluate efficacy and scalability across 3 areas, including NYC: Aim 1 (pre-intervention phase): Tailor OFOV materials to local contexts through collaborations with indigenous Black gay CBOs in Atlanta and Dallas. Aim 1 (intervention phase): Conduct a cluster-randomized stepped wedge trial with 27 HBC houses (≥ 20 members each) to evaluate OFOV’s efficacy. Primary outcomes include engagement and retention in HIV prevention (testing, PrEP) and care (antiretroviral therapy (ART), viral suppression) at baseline, 3, 6, and 12-months post-intervention, with 24- and 36- month maintenance periods. Hypotheses include increased leadership skills and HIV-related self-efficacy. Aim 2 (post-intervention phase): Use a mixed-methods approach to identify contextual factors influencing OFOV adoption and implementation. Aim 2 (post-intervention phase): Explore how leadership training impacts community norms and behaviors, hypothesizing high acceptability and adaptability across geographic and cultural settings. The NIMHD framework will guide qualitative work (in Aims 1 and 2) with HBC members and house leaders (directly exposed and unexposed to OFOV) to assess individual, interpersonal, and community-level barriers and facilitators to sustainability. Collaborations with HBC leaders, CBOs, and a multidisciplinary team will ensure cultural relevance, sustainability, and implementation feasibility across jurisdictions.

NIGMS - National Institute of General Medical Sciences

PROJECT SUMMARY – Overall It is predicted that virtually every type of clinician will use data science, such as artificial intelligence (AI) and machine learning (ML), in the future. Further, AI/ML is expected to play a dominant role across medical disciplines throughout the human lifespan. The utilization and ultimate training of deep learning models require specialized education and skills. The curation and processing of large datasets from locally sourced patient populations requires a curation and analysis team with specialized knowledge of transferring medical data between sites and potentially federated learning. Adding to this complexity is the potential for bias when diagnostic models are trained on datasets that don’t contain the characteristics of the population utilizing the model. There is a need to develop a talented AI and data science biomedical workforce that is trained in innovative approaches to working with large research datasets. In response to the Notice of Special Interest (NOSI): Supporting Data Sciences Research in IDeA States through the Centers of Biomedical Research Excellence (COBRE) Phase 1 Program (NOT-GM- 23-011), we propose to create the Pacific Center for Artificial Intelligence and Data Science in Medicine (PAC-AID). The long-term goal of the PAC-AID is to form self-sustaining core facilities and an AI and biomedical data science program that continually trains investigators to utilize advanced data science to utilize all available biomedical data sources to improve health outcomes in Hawaii and the Pacific region. The objective is to create a nucleating site for the use of AI/ML data science technologies to further our understanding of human health in communities in Hawaii. Specifically, we will 1) foster a next-generation workforce to conduct biomedical research using Artificial Intelligence and advanced machine learning; 2) develop interactive state-of-the-art research cores and projects that support training opportunities for local investigators and foster collaboration across the national IDeA network; 3) establish a supportive Advisory Committee and Mentoring Team of academic leaders and content experts to provide the investigators and RPLs guidance on the successful completion of the Center’s and RPLs’ goals. The expected outcome of the PAC-AID is to form a synergistic environment for investigators to integrate AI and advanced machine learning into problems that were not solvable before. The positive impact on the state and large US community will be experienced investigators in various fields who can take full advantage of complex clinical, translational, and basic research data using AI and advanced data science methods.

National Endowment for the Humanities

PAINTING THE NATURE OF AMERICA [THE THOMAS COLE NATIONAL HISTORIC SITE IS REQUESTING A CELEBRATE AMERICA! GRANT OF $25,000 TO SUPPORT THE SEMIQUINCENTENNIAL INITIATIVE, ?PAINTING THE NATURE OF AMERICA,? IN HONOR OF THE FOUNDING OF THE COUNTY. THIS AMERICAN HISTORY AND ART HUMANITIES PUBLIC PROJECT WILL BE PRESENTED THROUGHOUT 2026 AT THE TCNHS, THE HOME OF AMERICAN LANDSCAPE PAINTING, WHERE THE ARTIST THOMAS COLE LIVED AND WORKED IN CATSKILL, NEW YORK. "PAINTING THE NATURE OF AMERICA? WILL INCLUDE THREE TEMPORARY EXHIBITS WITH COMMUNITY PROGRAMS PRESENTING HISTORIC AND CONTEMPORARY AMERICAN ART AND RELATED PROGRAMMING THAT CELEBRATES THE STUNNING NATURAL LANDSCAPE OF THE UNITED STATES. THE PROJECT WILL EXPLORE THE ENDURING INFLUENCE OF THOMAS COLE?S AMERICAN LANDSCAPE PAINTINGS, WHICH GAVE RISE TO THE NEWLY INDEPENDENT COUNTRY'S IDENTITY OF AMERICA THE BEAUTIFUL. AS WE MARK THE NATION?S 250TH ANNIVERSARY, COLE?S VISION OF THIS PLACE IN ALL ITS NATURAL BEAUTY CONTINUES TO INSPIRE AND ENGAGE GENERATIONS TODAY.]

Palm Beach Cultural Council

Project and operating grants for arts organizations and individual artists from Palm Beach Cultural Council. Supports visual, performing, literary, and media arts.

Center for Linguistic and Cultural Democracy

The center for Linguistic and Cultural Democracy will have an event a pan-Caribbean, family oriented, arts and cultural event on the message of restoring and strengthening the ocean. The project would like to engage our local Caribbean communities and all who are interested -- in storytelling in our culturally responsive, art-based ways.

NHLBI - National Heart Lung and Blood Institute

PROJECT SUMMARY Heart valve replacement in children is marred with problems because state-of-the art heart valve implants do not grow. This commits affected children to serial re-operations to replace outgrown valve implants. Partial heart transplantation (PHT) is a new approach to deliver growing heart valve implants that is based on transplantation. PHT differs from heart transplantation (HT) because only the part of the heart containing the necessary heart valve is transplanted, while the native ventricles are spared. Sparing the native ventricles eliminates ventricular dysfunction from chronic rejection or ischemic injury and increases the donor pool. Importantly, PHTs grow adap- tively with recipient children. This avoids morbid re-operations to replace outgrown valve implants. However, PHT transplant biology remains unexplored. This is a critical barrier to progress of the field. Without knowledge of PHT transplant biology, clinical protocols cannot be tailored to children with PHTs. Instead, children with PHTs are empirically treated according to HT clinical protocols because the valves contained in HTs are known to grow. The proposed project seeks to advance the field by exploring clinically relevant aspects of PHT transplant biology. This will contribute the evidence-base for clinical protocols tailored to children with PHTs. The central hypothesis is that the transplant biology of PHT differs from HT, which allows for longer donor ischemia times (Aim 1), less stringent recipient immunosuppression (Aim 2) and ABO incompatible transplantation (Aim 3). This hypothesis is based on preliminary data. The approach for the proposed project leverages a unique piglet model and innovative outcome measures for valve growth including leaflet length echocardiography. The central hy- pothesis will be tested by completing the following specific aims: (1) model the effect of ischemia time on PHT growth potential and function; (2) determine the optimal immunosuppression strategy for PHT; (3) determine the effect of donor antigen variability on PHT growth potential and function. Achieving these aims will contribute evidence-based protocols specifically tailored to PHT. Protocols tailored to PHT will improve clinical practice by decreasing the morbidity and mortality of PHT. This is significant because PHT is a game-changer for children with unrepairable heart valve defects. It is also innovative because it is non-derivative, and a radical departure from the status quo for growing heart valve implants. The proposed project shifts research and clinical paradigms for growing heart valve implants using this new theoretical concept based on transplantation. This new clinical intervention opens new horizons for children who need heart valve replacements because it eliminates the mor- bidity and mortality of serial implant exchanges as the children grow.

National Endowment for the Arts

The National Endowment for the Arts’ State & Regional Partnership Agreement grants are awarded to the nation’s 56 state and jurisdictional arts agencies (SAAs), and the six regional arts organizations (RAOs) whose members comprise SAAs.

National Endowment for the Arts

The National Endowment for the Arts State & Regional Partnership Agreement grants are awarded to the nation s 56 state and jurisdictional arts agencies (SAAs), and the six regional arts organizations (RAOs) whose members comprise SAAs.

Pasadena Community Foundation

Pasadena Community Foundation ($200M in assets) supports nonprofits in CA through grants focused on education, health, arts, community development. Awards range from $2,500 to $100,000.

National Park Service

Artrain will carry out an international youth art hisotry and education project from 2011-2015 as part of the commenorative activities for the Bicentennial of the War of 1812 and the Battle of Lake Erie. Paths to Peace: War of 1812 Arts Legacy Project will interpret the War of 1812 and the long lasting peace between nations that were once at war.

NIAID - National Institute of Allergy and Infectious Diseases

PROJECTSUMMARY/ABSTRACT There are ~40 million people worldwide living with the Human Immunodeficiency Virus Type 1 (PLWH), commonly referred to as HIV. In the absence of a functional cure, antiretroviral therapy (ART) represents the primary treatment option. However, ART fails over time due to the development of drug resistance, even against latest generation drugs. Thus, there is an urgent need to understand the pathways and mechanisms through which resistance emerges, which can then be harnessed for developing next-gen therapeutics to specifically target drug-resistant variants. The proposed research seeks to elucidate the mutational pathways and molecular mechanisms through which resistance evolves against the latest ART drugs. Firstly, a Potts sequence- covariation fitness landscape model built on HIV sequences from the Stanford HIV database will be used to determine the epistatic interactions modulating drug resistance and to identify the specific sequential order in which mutations arise forming pathways to complex resistant variants. This aim builds directly from the candidate’s doctoral research developing the Potts fitness landscape models for HIV. Secondly, a combination of structural biology using cryogenic electron microscopy (cryo-EM) and multiscale molecular simulations will be employed to determine the atomistic mechanisms of resistance against latest generation ART drugs. This aim builds on the candidate’s ongoing training in cryo-EM and will serve as a vehicle to obtain complementary research skills in protein biochemistry, and hybrid quantum mechanics molecular mechanics simulations. Finally, in the independent phase, the project aims to combine the Potts fitness landscape models, structural biology and molecular simulations within a Reinforcement Learning (RL) framework, a state-of-the art artificial intelligence (AI) method, to forecast the evolution of drug resistance in HIV. The aim will prognostically predict the dominant emerging pathway trajectories and mechanisms in the PLWH population to prospectively inform the design of optimum therapeutic strategies. The principles learned (by the RL model) and the methodology developed can be applied to forecast emerging resistance in other RNA viruses including those with scarce data. This aim builds on the candidate’s ongoing training in AI methods through the Eric & Wendy Schmidt AI-in- Science Fellowship and combines the multidisciplinary research methods and training obtained through his doctoral and postdoctoral tenure. Overall, the project seeks to produce critical insights into the mechanisms of HIV evolution under drug selection pressure that can help design next generation therapeutic strategies targeting resistant strains and lead to the development of surveillance tools to monitor and forecast emerging drug resistance. The career development plan will take place at The Salk Institute and provide an important opportunity for training and development that will prepare the candidate to start his independent research career.

NIDA - National Institute on Drug Abuse

Project Summary/Abstract People with HIV (PWH) remain at an elevated risk of developing cognitive impairments. Such impairments are the most common neurological complication of HIV disease, and research targeting these comorbidities is one of four overarching priorities identified by the Office of AIDS Research (NOT-OD-20-018). Over the past decade, our work has focused on identifying the neurological origins of these impairments and determining the impact of substance use, which has led to the exciting discovery of neurophysiological markers that distinguish cognitively impaired PWH from unimpaired PWH, patients with Alzheimer’s disease or mild cognitive impairment, and healthy aging controls. We now propose to embark on the next stage of this research program through a transformational team science project, which will leverage these markers as primary outcomes in high-dimensional models that include key molecular pathways thought to be aberrant in PWH and methamphetamine use disorder (METH). The molecular precursors and pathways that lead to dysfunction in neural circuits serving cognitive processing in PWH remain poorly understood, and this is a critical barrier to the development of new pharmacotherapeutics. Given the scale and complexity of this barrier, we contend that a team science approach is required to deliver the transformational discoveries that are ultimately needed to significantly advance the field. Thus, we have assembled a multidisciplinary team with expertise in neuroHIV, addiction science, clinical psychology, systems biology, cognitive and computational neuroscience, signal processing, neurophysiology, and machine learning. Our overarching hypotheses are that HIV and chronic methamphetamine use imbalances mitochondrial redox environments, triggering increases in inflammation and elevated subcortical iron levels in key brain structures, which then leads to altered neurotransmitter levels, aberrant oscillations and neurophysiological dynamics, and ultimately, cognitive decline in PWH. To address this, our team science approach will enable the latest tools of systems biology to be integrated with state-of-the-art multimodal neuroimaging using both high-dimensional structural equation modeling and advanced variants of machine learning. We will maximize rigor by using a large, deeply-phenotyped sample of PWH and METH who are demographically matched to three other groups who vary based on HIV and METH status in the context of a longitudinal study. Importantly, if confirmed, treatments aimed at this molecular pathway could have a major impact, as we have repeatedly shown that the end point (i.e., altered brain dynamics) distinguishes cognitively impaired PWH from unimpaired PWH and those with other forms of cognitive dysfunction. In sum, while past studies have provided critical advances on the neural circuitry and dynamics underlying cognitive impairments in PWH who do and do not use illicit substances, the primary mechanisms and pathways leading to such dysfunction have remained beyond reach. Herein, we will use a high- dimensional computational approach to identify the modulatory role of mitochondrial redox environments and inflammation on subcortical brain iron, neurotransmitter levels, neuronal dynamics, and cognitive dysfunction.

Paul Hamlyn Foundation

Funds arts access, education & learning, migration & integration. Focuses on social justice and opening up opportunities.

Government of PEI

Provides grants for artists and cultural organizations on Prince Edward Island for creation, exhibition, and community arts programming.

Pennsylvania Council on the Arts

General operating support grants for arts organizations in Pennsylvania. Funded by the National Endowment for the Arts and state appropriations.

Pennsylvania Council on the Arts

Project-based grants for arts programming, performances, exhibitions, and community engagement in Pennsylvania.

Pennsylvania Council on the Arts

Pennsylvania Council on the Arts provides grants to support arts and cultural programming, artist fellowships, arts education, and community-based arts projects across PA.

Pennsylvania Council on the Arts

The Cultural Organizations Program supports Pennsylvania nonprofit arts organizations through general operating support grants, helping them maintain quality programming and build organizational capacity.

NICHD - Eunice Kennedy Shriver National Institute of Child Health and Human Development

ABSTRACT Sub-Saharan Africa's (SSA) 400 million adolescent girls and young women (AGYW, age 15-24) face disproportionate rates of HIV acquisition and suboptimal HIV care engagement. Despite the widespread availability of oral PrEP at public health facilities, uptake is impeded by low awareness, socio-cultural and access barriers, provider bias, and user dissatisfaction. Moreover, among PrEP-aware AGYW, uptake and continuation of PrEP is low due to side effects, fear of being seen with medicines, and low adherence support, undermining PrEP's preventative effects and leaving AGYW in need of critical HIV prevention. Our team and others have demonstrated that AGYW are interested in PrEP, especially newer modalities such as injectables, and that they prefer to seek HIV care at locations that foster privacy, are convenient, and are girl-friendly. Given the growing recognition that pharmacies, staffed by health workers who can be trained to provide expanded services, outnumber health facilities, can promote beneficial health behaviors, bridge gaps in health services, and mitigate health workforce shortages, we aim to expand this body of research to conduct an implementation science study on potential implementation models of pharmacy-based PrEP provision and adherence support for AGYW. In Uganda, the Community Retail Private Pharmacy Drug Distribution Point (CRPDDP) already provides pharmacy-based anti-retroviral therapy (ART) to over 48,000 clients across 160+ pharmacies (and increasing). Given the Uganda Ministry of Health's interest to expand this pharmacy-based differentiated service delivery model for increased reach and extended prevention offerings, we propose a mixed-methods study to garner foundational evidence to evaluate how this cadre of pharmacies already providing ART refills to PLHIV can include PrEP services generally and specifically tailored to AGYW. We hypothesize that these pharmacies can be well-equipped to reach AGYW with PrEP, given the critical role they already play in the community providing expanded care. As such, we propose to conduct formative research among CRPDDP pharmacies and their AGYW clients to advance implementation of pharmacy-based PrEP and adherence support. Guided by participatory processes of human-centered design, including in-depth interviews with AGYW who are potential PrEP users, pharmacists, and focus groups with pharmacy and youth advisory boards and MOH stakeholders, we will conduct formative research to understand barriers, facilitators, and desires for pharmacy-based PrEP to inform a discrete choice experiment (DCE) (Aim 1). We will then evaluate a series of implementation science outcomes—willingness, acceptability, feasibility, and readiness—among CRPDDP pharmacists (n=~160) (Aim 2), and conduct parallel DCE surveys among CRPDDP pharmacists and their AGYW clients (n=300) to evaluate preferences for pharmacy-based PrEP implementation models (Aim 3). By the end of the study, we will understand how a potentially ready platform of pharmacies can be expanded to provide PrEP care to a key population, and will have identified potential implementation gaps from user, provider, and policy perspectives .

Philadelphia Cultural Fund

The Philadelphia Cultural Fund provides general operating support to Philadelphia-based nonprofit arts and cultural organizations, with a focus on organizations that enrich the cultural life of Philadelphia's communities.