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Oklahoma Center for Biomedical Research Excellence in Sensory Biology

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NIGMS - National Institute of General Medical Sciences

The COBRE program in this application is designed to develop the field of sensory biology on the OUHSC campus by supporting innovative research focusing on the processes used by cells to sense their environment. The COBRE will support a wide spectrum of projects using a variety of model organisms, from worms and green algae to mice and human tissue. It will support studies on cell signaling across the plasma membrane mediated by sensory organelles such as cilia and flagella; specialized signaling domains on the cell surface such as dendrites and immunological synapses; and cell surface molecules such as receptors and ion channels. It will also support research projects investigating disease and syndromes associated with sensory defects. Initially, the Oklahoma Center for Biomedical Research Excellence in Sensory Biology (OCBRESB) will take advantage of the rapidly expanding talent and expertise in cilia biology and diseases associated with defects in primary cilia on campus and then will expand to all sensory modalities. The essential biological and biomedical importance of cilia biology and the growing nexus of cilia biology researchers at OUHSC makes us uniquely positioned to develop a multidisciplinary biomedical Center of Excellence. OCBRESB will consist of an Administrative Core led by Dr. Leonidas Tsiokas, Professor and Chair of the Department of Cell Biology with research expertise on cilia biology and ion channel signaling, four Research Projects exploring mechanisms of sensory signaling in diseases affecting vision (Bennett), neurodevelopment (Craft Van de Weghe), neuronal function (Zhang), and neuropsychiatric disorders (Paterno), and two Research Cores, which will provide state-of the art support in super-resolution imaging and cell and genetic engineering. Strategically, the OCBRESB integrates perfectly well with OUHSC’s ongoing research on obesity/diabetes, vision, cancer biology; builds on the strength of Geroscience/Healthy Brain Aging; and functions as the springboard for new research activities in Neuroscience. Critically, it supports cutting-edge infrastructure needed for basic science research, traditionally the engine for discovery at OUHSC, to excel and achieve our short- and long- term strategic goals. Finally, it is essential for the development of the next generation of independent, NIH-funded talented investigators who will become leaders in an emerging area of highly relevant biomedical research. Completion of the OCBRESB will have a significant impact in enhancing biomedical research in the state of Oklahoma.

Up to $2.1M
2031-01-31
health research

Free to search & build · $99 one-time to unlock the application pack · No subscription

Optimizing Use of Clinical Decision Support Tools to Enhance and Scale Delivery of Long-Acting Injectables for HIV Prevention and Treatment

open

NIMH - National Institute of Mental Health

PROJECT ABSTRACT Long-acting injectable (LAI) pre-exposure prophylaxis (PrEP) and antiretroviral therapy (ART) represent a promising but underutilized class of HIV medications that can significantly benefit patients who struggle with oral medication adherence. Despite their potential, LAIs face substantial implementation barriers due to their logistical complexity compared to traditional oral medications. While high-volume LAI delivery is currently rare across U.S. HIV clinics, clinical decision support (CDS) systems offer a potential solution for efficiently scaling LAI programs. This project addresses the critical need for infrastructural support in LAI delivery by developing and evaluating a comprehensive Resource Package to accelerate the adoption of LAI-specific CDS in HIV clinics nationwide. We hypothesize that providing clinics with a standardized Resource Package will lead to more efficient workflows, improved care coordination, enhanced patient outcomes, and sustainable LAI program growth. The Resource Package will include: (1) a compendium of LAI-specific CDS tool options with implementation guidance, (2) decision-making worksheets for CDS design, (3) low-fidelity prototypes with adaptable wireframes, (4) build checklists for tool development, and (5) evaluation metrics for assessing CDS tools. Our project has three specific aims. First, we will identify promising CDS tools and processes through synthesis of practices at 10 Clinical Partner Sites currently delivering LAIs at high volume. Second, we will co-create the Resource Package through five multi-disciplinary working groups, each including clinicians, CDS end-users, builders, and implementation scientists. Third, we will assess the Resource Package's impact on clinics' readiness to build LAI CDS tools and their progress in the build process through pre-post surveys and in-depth qualitative analysis. The project will be carried out by an interdisciplinary team including implementation scientists, clinicians, and CDS specialists, working collaboratively with 10 Clinical Partner Sites, two national dissemination partners, and a Community Advisory Board. This research directly responds to NIMH priorities (PAR-22-060 and NOT-MH-23-275) by developing a systematic intervention to promote organizational readiness and capacity for implementing LAIs with fidelity and effectiveness. By establishing a standardized approach to CDS development for LAIs, this project aims to overcome a significant barrier to widespread LAI implementation, ultimately expanding access to these valuable HIV prevention and treatment options for vulnerable populations currently underserved by conventional oral medication approaches.

Up to $751K
2029-03-31
health research

Free to search & build · $99 one-time to unlock the application pack · No subscription

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