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24 grants worth up to $3.3M match your search

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Next Generation Visualization and Analysis Software for Multiscale Modeling

open

NIGMS - National Institute of General Medical Sciences

ABSTRACT The goal of this project is to enable scientific discovery and advances in biomedical research through the development of cutting-edge software tools that provide integrated visualizations and analyses of molecular structures and related biological information. Our tools can be applied to diverse types of biomolecular data, including atomic-resolution coordinates, 3D cryo-EM and cryo-ET density maps, and protein and nucleic acid sequences, annotations, and networks. During the next five years we will continue our emphasis on the unmet software needs for basic and applied biomedical research using highly trained and talented staff, with excellent interdisciplinary knowledge and specialized, state-of-the-art expertise in software engineering, computer graphics, and data analysis. Our primary focus will be on the interactive visualization and analysis of structures of molecules, molecular assemblies, and sequence-structure relationships. These areas are critical for addressing important and highly relevant biomedical problems such as identifying the molecular bases of disease, identifying targets for drug development, designing drugs, and engineering proteins with new functions. The tools we develop and disseminate will enable scientists to understand, analyze, and illustrate to others the important principles of molecular structure, function, and interactions. Our tools such as ChimeraX are widely recognized as works of the highest quality, and are available for free on our website as executable applications and in source-code form through our GitHub repository. We fully support and maintain these tools, and provide detailed documentation and tutorials. Our technological developments are disseminated widely via scientific publications, lectures, software distribution, and web-accessible videos.

Up to $562K
2031-04-30
health research

Free to search & build · $99 one-time to unlock the application pack · No subscription

Nfe2l3-regulated mechanisms of retinal ganglion cell neuroprotection and optic nerve axon regeneration

open

NEI - National Eye Institute

Project Summary The molecular mechanisms controlling the growth of axonal projections in the central nervous system (CNS) are still poorly understood. Similarly, the molecular basis of the failure of axon regeneration in the CNS are still elusive, and no regenerative therapies exist to date that could help patients with axonal injuries. Retinal ganglion cells (RGCs) are prototypical CNS projection neurons that do not spontaneously regenerate axons disrupted in optic neuropathies caused by trauma, ischemia, or glaucoma, resulting in irreversible loss of vision. Our goal is to investigate the molecular mechanisms through which the Nfe2l3 protein, whose neuroprotective functions we recently identified, regulates the regeneration process of the damaged optic nerve axons, and to test their potential for restoring simple visual functions after optic nerve injury. We will utilize established animal models and state-of-the-art technologies for investigating through which molecular mechanism the Nfe2l3 protein activates the retinal ganglion cells’ intrinsic capacity for regenerating long-distance axons through the optic nerve. We will also determine which retinal ganglion cells respond to the Nfe2l3 protein by regenerating injured axons. We expect that these studies will lead to the development of a novel approach for restoring simple visual functions after optic nerve injury, with the potential to treat different types of optic neuropathies.

Up to $416K
2030-03-31
health research

Free to search & build · $99 one-time to unlock the application pack · No subscription

NIAMS P30 Centers Program (P30 - Clinical Trial Not Allowed)

upcoming

National Institutes of Health

The overall goal of this program is to accelerate scientific discovery, improve research efficiency, and enhance the translation of research findings into improved health outcomes. Centers funded under this program will also foster multidisciplinary collaboration, support workforce development across career stages, and promote training in emerging areas such as data science, artificial intelligence, and implementation research. The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) requests applications for the NIAMS P30 Centers Program to support integrated research Centers within its mission areas of skin biology and diseases; bone, muscle, and orthopaedic research; and rheumatic diseases. The NIAMS P30 Centers Program supports Centers that provide coordinated research infrastructure, shared resources, and methodological expertise to advance basic, translational, and clinical research. These Centers are expected to integrate state-of-the-art research resources with capabilities that support clinical and translational research, including the development, testing, and dissemination of novel analytical methods, study designs, outcome measures, and data-driven approaches. The overall goal of this program is to accelerate scientific discovery, improve research efficiency, and enhance the translation of research findings into improved health outcomes. Centers funded under this program will also foster multidisciplinary collaboration, support workforce development across career stages, and promote training in emerging areas such as data science, artificial intelligence, and implementation research.

2026-10-01
Healthhealthcare

Free to search & build · $99 one-time to unlock the application pack · No subscription

Nigeria HIV Research Training Program

open

NICHD - Eunice Kennedy Shriver National Institute of Child Health and Human Development

Women comprise about 50% of the 36.7 million people living with HIV worldwide and in many sub-Saharan African countries including Nigeria, ~2 out of 3 HIV infected adults are women. Even more worrisome is the observation that overwhelming number of new infections in Nigeria occur among young women of childbearing age, and as such, one-third of all global cases of mother-to-child transmission of HIV occurs in the country. Not only is the burden of HIV higher in women, the impact of its scourge is far more reaching. HIV is the leading cause of morbidity and mortality among women of reproductive age in Nigeria. HIV complicates every aspect of health across a woman’s lifespan, including reproductive health where it impacts partner sero-sorting and sexual habits, fertility desires and contraceptive choices, pregnancy and delivery, menopause and aging. Tackling the myriads of health challenges confronting women living with HIV is a necessary step to achieving the WHO global strategy for women’s, children’s and adolescent health. It will require nurturing a critical mass of local health scientists and equipping them with the skills to conduct valid research that addresses the local health needs of women living with HIV. To address these needs, we established the Emory-Nigeria HIV Research Training Program (EN-RTP). The EN-RTP leverages the research education infrastructure at Emory University and the partnering Nigerian institutions (Nigerian Institute of Medical Research (NIMR); University of Lagos (UNILAG); and AIDS Prevention Initiative Nigeria (APIN)) to provide state-of-the-art in-country research training with focus on methodologies, rigorous mentorship, and grant management capacity building. The EN-RTP training is focused on three main domains of HIV/women’s health research: a) HIV prevention and reproductive health; b) Challenges in HIV therapeutics unique to women living with HIV (WLWH); and c) Complications of chronic HIV infection relevant to WLWH. Preceptors are selected based on their expertise in these areas and their international research education and mentoring experience. We can report that the EN- RTP is now an established program with a cohesive administrative structure and program plan that includes both didactic and mentored research components implemented by a multidisciplinary team of in-country faculty and US-based investigators who have a wide range of mentoring experiences. The short- and medium-term accomplishments include high scholar productivity (over $3M in grant funding, including 3 NIH K 43 awards and more than 150 peer-reviewed publications by trainees), fostering robust scientific networking opportunities, developing emerging in-country scientific leaders, and nurturing the next generation of HIV research mentors. The EN-RTP has demonstrated a potential to be truly transformative in promoting mentored research training and the growth of the HIV biomedical research workforce. Committed to the primary goal of capacity building in HIV research, we look forward with enthusiasm the next cycle – particularly the opportunity to pilot new initiatives and best practices arising from our evaluation processes to enhance program outcomes.

Up to $270K
2028-12-31
health research

Free to search & build · $99 one-time to unlock the application pack · No subscription

Nigeria HIV Research Training Program

open

FIC - John E. Fogarty International Center for Advanced Study in the Health Sciences

Women comprise about 50% of the 36.7 million people living with HIV worldwide and in many sub-Saharan African countries including Nigeria, ~2 out of 3 HIV infected adults are women. Even more worrisome is the observation that overwhelming number of new infections in Nigeria occur among young women of childbearing age, and as such, one-third of all global cases of mother-to-child transmission of HIV occurs in the country. Not only is the burden of HIV higher in women, the impact of its scourge is far more reaching. HIV is the leading cause of morbidity and mortality among women of reproductive age in Nigeria. HIV complicates every aspect of health across a woman’s lifespan, including reproductive health where it impacts partner sero-sorting and sexual habits, fertility desires and contraceptive choices, pregnancy and delivery, menopause and aging. Tackling the myriads of health challenges confronting women living with HIV is a necessary step to achieving the WHO global strategy for women’s, children’s and adolescent health. It will require nurturing a critical mass of local health scientists and equipping them with the skills to conduct valid research that addresses the local health needs of women living with HIV. To address these needs, we established the Emory-Nigeria HIV Research Training Program (EN-RTP). The EN-RTP leverages the research education infrastructure at Emory University and the partnering Nigerian institutions (Nigerian Institute of Medical Research (NIMR); University of Lagos (UNILAG); and AIDS Prevention Initiative Nigeria (APIN)) to provide state-of-the-art in-country research training with focus on methodologies, rigorous mentorship, and grant management capacity building. The EN-RTP training is focused on three main domains of HIV/women’s health research: a) HIV prevention and reproductive health; b) Challenges in HIV therapeutics unique to women living with HIV (WLWH); and c) Complications of chronic HIV infection relevant to WLWH. Preceptors are selected based on their expertise in these areas and their international research education and mentoring experience. We can report that the EN- RTP is now an established program with a cohesive administrative structure and program plan that includes both didactic and mentored research components implemented by a multidisciplinary team of in-country faculty and US-based investigators who have a wide range of mentoring experiences. The short- and medium-term accomplishments include high scholar productivity (over $3M in grant funding, including 3 NIH K 43 awards and more than 150 peer-reviewed publications by trainees), fostering robust scientific networking opportunities, developing emerging in-country scientific leaders, and nurturing the next generation of HIV research mentors. The EN-RTP has demonstrated a potential to be truly transformative in promoting mentored research training and the growth of the HIV biomedical research workforce. Committed to the primary goal of capacity building in HIV research, we look forward with enthusiasm the next cycle – particularly the opportunity to pilot new initiatives and best practices arising from our evaluation processes to enhance program outcomes.

Up to $30K
2028-12-31
health research

Free to search & build · $99 one-time to unlock the application pack · No subscription

Normal and Pathological Musculoskeletal Loss and Repair

open

NIAMS - National Institute of Arthritis and Musculoskeletal and Skin Diseases

Project Summary The purpose of this ‘A1 Single-Year NIAMS/NCI R13 Research Conference Grant’ is to host the highest impact scientific and mentoring conference on “Bone: Musculoskeletal Tumor Perspectives’ that will bring together translational and clinical investigators from diverse specialties. Musculoskeletal Tumor Society (MSTS) is the primary host organization that will partner with OREF, ORS, AAOS, and JOR. Musculoskeletal Oncology is a distinct hybrid clinical and research field that requires the solution to 3 distinct problems: ‘Diagnosing’ and ‘Treating’ molecular oncogenesis of MSK tissues and ‘Reconstructing’ afflicted tissue structures to restore limb function. Due to underlying oncological pathophysiology and massive skeletal defects, traditional orthopaedic treatments using trauma or arthroplasty disciplines were associated with high rate of complications. Furthermore, no cross-disciplinary research and mentoring endeavors on bone tumors have not been offered. Many bone and osteoclast-associated molecules were discovered from bone diseases and tumors such as the giant cell tumor of bone. The last AAOS-initiated R13 Conference was in 2017. There is a serious issue of discontinuation of clinician scientists and basic scientists who conduct cross-disciplinary research on bone and reconstruction science from a perspective of musculoskeletal tumors. There is an urgent need to host a R13 conference to offer mentorship for emerging investigators and to develop new collaborations. Our innovative meeting format features sessions addressing challenging clinical problems with plenary overview talks by experts on state-of the art techniques (spatial biology, artificial intelligence, novel signaling & targeted therapies, novel skeletal stem cells, RNA/DNA therapeutics, 3D printed custom device, and mixed reality). We will invite junior surgeon-scientists to present their innovative solutions in mentoring sessions where a panel of established investigators will critique proposed strategies and Specific Aims in a live multi-disciplinary “study section”. ESI selection criteria are based on one-page Specific Aims that summarizes clinical barriers, hypothesis-/technology-driven scientific and clinical investigation plans, and specific needs for mentorship. A meet-the-mentors session will be set up to foster multi-disciplinary collaboration among mentors and emerging surgeon-scientists, engineers, and basic scientists. In order to facilitate networking and matching mentors- mentees, the meeting phone Apps and website will list mentors and participants with well-prepared research ideas (Specific Aims) and other scientific abstracts. Two Specific Aims are Aim 1. Innovative Mentorship for Emerging Clinicians and Scientists; and Aim 2. Dissemination of Cross-Disciplinary New Knowledge and Techniques for New Collaborations and Enhanced Patient Care. A stand-alone R13 conference could be ideal but too costly for meeting space rent, audio/visual services, and support for young investigators. The R13 Conference will be strategically held immediately prior to the 50th MSTS Annual Meeting for cost reduction and improved participation from clinicians, scientists, allied health care workers, and industry R&D staffs.

Up to $20K
2027-05-31
health research

Free to search & build · $99 one-time to unlock the application pack · No subscription

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