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Montana Arts Council

The Montana Arts Council provides operating support grants to established arts organizations that demonstrate excellence in programming, community engagement, and organizational management, strengthening Montana's cultural infrastructure.

MS Arts Council

General operating and project support for arts organizations and individual artists in MS. Funds visual arts, performing arts, literary arts, and arts education.

MT Arts Council

General operating and project support for arts organizations and individual artists in MT. Funds visual arts, performing arts, literary arts, and arts education.

Muddy Lotus Festival

The Muddy Lotus Art planning committee will organize a free community art celebration featuring performances, demonstrations, and instruction in various artistic genres including painting, clay arts, and creative movement. It will be held on July 7, 2018 from 1 pm - 6 pm at Pritchard Island Beach located at 8400 55th Ave S.

NCI - National Cancer Institute

Project Abstract Glioblastoma outcomes have not improved substantially over the past decades, with median survival remaining at 12-15 months despite aggressive therapy. A major limitation in the current radiotherapy (RT) planning is it defines clinical target volumes (CTVs) using uniform geometric expansions around MRI-visible tumor boundaries. This conventional approach fails to capture GBM’s diffuse infiltrative spread and ignores patient-specific tumor biology. As a result, microscopic disease often extends beyond the treated field while normal brain is unnecessarily irradiated, leading to universal recurrences and treatment-induced toxicity. Although diffusion tensor imaging (DTI) can visualize white matter tracts, current tractography does not distinguish between tract pathways that facilitate tumor cell migration and those that are anatomically present but rarely involved in tumor spread. Additionally, molecular biomarkers such as MGMT methylation and TERT promoter mutations reflect distinct tumor progression patterns, yet these factors are not incorporated into RT target delineation. This project investigates DTI-based infiltrative risk mapping integrated with molecular biomarkers to improve glioblastoma progression prediction and RT CTV definition using a dataset of over 500 patients with pre-operative DTI, anatomical MRI, and molecular biomarker data. We will develop White Matter Infiltrative Risk maps by identifying population-level infiltration patterns across major white matter tracts and combining these with patient-specific fiber density maps. The infiltrative risk maps will be integrated with anatomical MRI, MGMT methylation and TERT promoter mutation status through a transformer-based deep learning framework with cross-attention mechanisms. Validation will be conducted via spatial accuracy assessment against ground truth progression, comparison with standard RT targets, and histopathological correlation using tissue samples with matched imaging coordinates from 298 patients. This fusion of advanced DTI mapping and genomics with state-of-the-art Artificial Intelligence modeling will produce voxel-level risk maps that reveal otherwise occult tumor infiltration pathways and can be directly incorporated into RT planning. This work will provide proof-of-concept for integrating infiltration pathways and biological factors into RT target definition and establish the foundation for future clinical trials testing personalized radiation therapy strategies. The goal is to transition from geometric margins to biology-guided targeting that improves GBM control while preserving healthy brain tissue.

NIEHS - National Institute of Environmental Health Sciences

Summary Objective: This study aims to determine whether micro- and nanoplastics (MNPs) accumulate in the human brain, evaluate their relationship with Alzheimer’s disease (AD) pathology, and explore whether environmental disadvantage, measured by the Area Deprivation Index (ADI), is related to variation in cerebral MNP burden. Rationale: MNPs are widespread environmental pollutants with emerging evidence of human tissue accumulation and potential neurotoxicity. Preliminary data show detectable MNPs in the brains of individuals with AD and progressive supranuclear palsy. Social disadvantage may increase exposure to environmental risks, potentially elevating MNP burden and susceptibility to neurodegeneration. Aims: 1. Quantify MNPs in the olfactory bulb (OB) and middle temporal gyrus (MTG) of 140 postmortem human brains (70 with AD pathology, 70 without AD pathology) using five complementary detection methods. 2. Assess associations between cerebral MNP burden and AD pathology, adjusting for age, sex, APOE genotype, postmortem interval (PMI), and other covariates. 3. (Exploratory) Examine the relationship between ADI and cerebral MNP burden, investigating whether MNP burden varies by level of socioeconomic disadvantage. Innovation: This study employs state-of-the-art environmental toxicology methods rarely applied to human brain tissue, integrated with high-resolution neuropathology and life-course social determinants data. It represents the largest and most methodologically rigorous study of cerebral MNPs to date, and the first to directly examine their links to AD and environmental disadvantage. Significance: Findings could identify a novel, modifiable environmental contributor to AD, inform targeted public health interventions, and advance our understanding of how plastic pollution and social disadvantage may shape brain disease. Impact: By bridging environmental science, neuropathology, and social epidemiology, this study could redefine how we think about environmental risks in neurodegeneration. Demonstrating a link between MNP accumulation, AD pathology, and social disadvantage would establish a new line of inquiry with major implications for public health, regulation, and disease prevention.

OD - NIH Office of the Director

Project Summary/Abstract The Center for Chemical Genomics (CCG) at the Life Sciences Institute (LSI) serves as the high throughput screening core facility, available to all faculty at the University of Michigan (U-M) and seeks funding to support the purchase of a new microplate reader, the PHERAstar FSX. The current instruments, a 17-year- old Perkin Elmer EnVision 2104 and a 21-year-old PHERAstar, have each reached the end of their operational lifespan and manufacturer support is being terminated. Given that these microplate readers are used to support approximately 90% of the screening experiments that the CCG performs, they are critical to the continuation of CCG services, and failure to obtain a replacement option for these aging machines will dramatically impact the early phase drug discovery program at U-M. The PHERAstar FSX is the ideal replacement due to its state-of-the-art capabilities, enabling the CCG to conduct a comprehensive array of experiments as requested by U-M faculty, as well as researchers external to U-M. The CCG is a critical component of both basic research and the early-phase drug discovery pipeline at U-M. It conducts approximately 20 high-throughput screening (HTS) campaigns, as well as supporting ~3-5 Structural-Activity Relationship (SAR) campaigns, annually. Despite advances in computational approaches, HTS of large chemical libraries, consisting of over 100,000 samples, remains the most commonly employed method for identifying novel compounds that modulate the activity of a target protein. This “unbiased” screening approach is used to identify active molecules that can be optimized for use as in vitro or in vivo research tools, and/or as potential drug leads. The vast majority of HTS assays are designed to utilize some form of fluorescence or luminescence as the final readout, as this approach can yield HTS assays that are both robust and cost-effective. The CCG’s microplate readers are essential for conducting these HTS assays. The CCG supports NIH projects for U-M researchers and external collaborators across an incredible breadth of research fields, including research on cancer, cardiomyopathy, nicotine and opioid addiction, and drug metabolism. The university is a national leader in academic drug discovery, demonstrated by its 15 drugs in current clinical development. The initial identification of candidate drugs is a vital part of this pipeline and aligns with the mission of the NIH and U-M’s overarching goal of improving public health. Replacing the dated microplate readers in the CCG with the PHERAstar FSX will ensure the continuation of CCG support for groundbreaking drug discovery research at the University of Michigan.

NIDA - National Institute on Drug Abuse

Despite the success of antiretroviral therapy (ART), HIV remains incurable due to the persistence of viral reservoirs, particularly in the central nervous system (CNS). Myeloid cells—macrophages and microglia— serve as long-lived HIV reservoirs in the CNS and are implicated in neuroinflammation and HIV-associated neurocognitive disorders (HAND). Unlike CD4+ T cells, infected myeloid cells exhibit a state we define as semi‗quiescence, in which transcription from the HIV-1 promoter persists, but viral protein production is minimal. This persistent yet attenuated activity complicates efforts to eradicate the virus from the CNS. Our preliminary data show that ART-treated human monocyte-derived macrophages (hMDMs) maintain stable proviral levels over time, with reduced p24 Gag protein expression but active transcription. Chromatin immunoprecipitation (ChIP-qPCR) analysis of these cells revealed euchromatin markers at the viral LTR, consistent with transcriptionally active but translationally restricted infection. Strikingly, treatment with benzodiazepines (BDZs)—commonly prescribed to people living with HIV—reactivates viral protein production in these cells, suggesting they may act as latency reversal agents (LRAs) in the CNS. BDZs appear to target RUNX1, a transcription factor that interacts with the HIV-1 LTR, and may disrupt epigenetic control of viral persistence. We hypothesize that HIV-infected myeloid cells adopt a unique global epigenetic signature early in infection, orchestrated in part by RUNX1 and HIV Tat, which modulates effector function and maintains semi-quiescence. BDZs may override this regulation, reactivating latent virus and worsening neuroinflammatory outcomes. We aim to: 1) define the global epigenetic landscape of HIV-infected hMDMs under ART and characterize how RUNX1 and Tat occupancy correlates with gene expression and viral activity and 2) determine how BDZ exposure alters the global epigenetic state of infected and uninfected hMDMs, testing the hypothesis that BDZs promote viral reactivation via a euchromatic shift. This research will uncover new mechanisms of HIV persistence in myeloid reservoirs and inform safer therapeutic strategies for PLWH, especially those at risk for HAND.

NIGMS - National Institute of General Medical Sciences

ABSTRACT / SUMMARY Reactive oxygen species (ROS) and regulation of redox pathways are critical to human health and disease, as they influence cellular metabolism, signaling, and stress responses. Disruptions in redox homeostasis contribute to the pathophysiology of numerous disorders, including neurodegenerative diseases, muscular degeneration, and drug-induced cardiotoxicity. However, the tools for monitoring redox dynamics in living human cells remain limited in dimensionality, sensitivity, and applicability to disease-relevant models. To overcome these challenges, my research program aims to develop a next-generation, multiplexed optical platform for quantitative redox phenotyping and apply it to disease modeling and drug screening in human induced pluripotent stem cell (iPSC)- derived systems. Over the past five years, my lab has engineered two advanced genetically encoded hydrogen peroxide (H₂O₂) sensors, oROS-G and oROS-HT, exhibiting improved dynamic range, kinetics, and spectral flexibility. We established a high-throughput optical screening platform and integrated machine learning approaches to accelerate protein sensor engineering. These sensors have been applied in diverse host systems, including iPSC-derived neurons and cardiomyocytes, and have revealed new aspects of redox signaling in cell health. Building on this foundation, our future research will continue along three complementary directions. First, we will complete the development of a fully multiplexed, intensity-based TreDox sensor suite to simultaneously monitor oxidative pressure and antioxidant capacity with single-cell resolution in real time. Second, we will engineer lifetime-resolved redox biosensors and use fluorescence lifetime imaging microscopy (FLIM) to enable robust, expression-independent quantification of intracellular redox states. Third, using single-cell optical phenotyping, we will apply these tools to profile redox imbalances and early cytotoxicity signals in human iPSC- derived cardiomyocytes, neurons, and skeletal muscle cells. We aim to detect subtle cellular imbalances in redox pathways that precede cellular dysfunction and are often missed by traditional high throughput assays. This research program will fill critical gaps in our ability to study redox biology in human-derived host systems by integrating state-of-the-art protein engineering, advanced imaging, and human stem cell models. The tools and knowledge generated will improve our understanding of redox-linked disease mechanisms, enhance the predictive power of preclinical drug testing, and establish a flexible, generalizable platform for functional phenotyping at single-cell resolution.

NIA - National Institute on Aging

Cognition is intricately linked to the metabolic processes of the brain, yet existing computational models often overlook the metabolic costs associated with cognitive function. This oversight is critical, especially in neurodegenerative diseases like Alzheimer's, where metabolic dysfunctions play a significant role in cognitive decline. Despite advancements, research biases towards familial AD models have hindered a comprehensive understanding of metabolic changes in aging and late- onset AD, calling for focused investigations into sporadic late-life AD models. Our proposal aims to bridge this gap by comprehensively studying neuro-metabolic coupling using state-of-the-art imaging techniques and computational models. We propose a multifaceted approach involving in vivo microscopy, wide-field imaging, and MRI to elucidate the intricate relationship between neuronal activity and metabolic processes such as oxidative phosphorylation, glucose, lactate, and creatine dynamics. Our specific Aims include (1) Modeling SingleCell Neurometabolic Coupling: Utilizing in vivo two- photon microscopy, we will investigate the astrocyte-neuronal lactate shuttle and quantify the relationship between red blood cell velocity, lactate levels, and neural activity in late-onset AD mouse models. (2) Establishing Cortical Network Models of Neuro-Metabolic Coupling: We will employ multispectral wide-field imaging to examine the role of oxidative phosphorylation in neuronal connectivity, validate computational models with experimental capillary obstructions, and assess sex-specific differences in mitochondrial function. (3) Building a WholeBrain Theory of Neuro-Metabolic Coupling: Through non-invasive brain imaging techniques, we will explore the impact of glucose and creatine metabolism on whole-brain functional connectivity. We will integrate data from animal models and human cohorts to predict Excitation- Inhibition Balance patterns and identify metabolic biomarkers of cognitive decline. This project addresses critical gaps in our understanding of neuro-metabolic coupling in aging and late-onset AD, offering insights into metabolic vulnerabilities and potential targets for personalized therapeutic interventions. Our proposal combines modern neuroscience with multiscale imaging to construct comprehensive models of neuro-metabolic coupling, providing a novel framework for understanding brain function and dysfunction in aging and AD. By integrating data from animal models and human cohorts, we will uncover new insights into the metabolic underpinnings of cognitive decline, advance early diagnosis, and develop more accurate metabolic biomarkers for AD.

Friends of Music of the Americas

The project will offer a series of four free and inclusive arts and culture events in March, May, September, and December 2024 at accessible and welcoming Seattle venues, including Town Hall. The events will feature special guest artists and composers of South and Central America and will celebrate their diverse cultures with classical and traditional orchestra, voice/choral, and dance performances as well as poetry readings and original art.

U.S. National Science Foundation

The Nano-Biosensing program is part of the Engineering Biology and Health cluster, which includes also 1) Cellular and Biochemical Engineering; 2) Engineering of Biomedical Systems; 3) Biophotonics; and 4) Disability and Rehabilitation Engineering. The Nano-Biosensing program supports fundamental engineering research on devices and methods for measurement and quantification of biological analytes. Proposals that incorporate emerging nanotechnology methods are especially encouraged. Areas of interest include: Multi-purpose sensor platforms that exceed the performance of current state-of-the-art devices. Novel transduction principles, mechanisms and sensor designs suitable for measurement in practical matrix and sample-preparation-free approaches. These include error-free detection of pathogens and toxins in food matrices, waterborne pathogens, parasites, toxins, biomarkers in body fluids, and others that improve human condition. Nano-biosensors that enable measurement of biomolecular interactions in their native states, transmembrane transport, intracellular transport and reactions, and other biological phenomena. Studies that examine intracellular measurements must include discussion on the significance of the measurement. Proposals should clearly identify the proposed problem to be solved, describe why the proposed approach is superior to current available methods, and articulate the benefit of solving the identified problem for the society at large. Sensor designs that yield reliable measurements are encouraged. While sensitivity is important, it cannot be at the expense of reproducibility. Every application must include research strategies for addressing reproducibility of measurement and sensor response, as well as approaches that reduce errors. The program does not support applications with incremental improvements of existing approaches and technologies. Projects that do not include experimental characterization of sensor responses to biological analytes are discouraged, and may be returned without a review. Studies on surface functionalization and immobilization of bio-recognition molecules, and/or orientation of them are not encouraged. Research that is focused on new recognition chemistry is also discouraged. The novelty or potentially transformative nature of the research must be included in the Project Summary. The last line in Project Summary must include three key phrasesthat describe: (1) sensor transduction principles, (2) type of biological analytes, (3) potential application areas. Innovative ideas outside of the above specific interest areas may be considered. However, prior to submission, it is recommended that the PI contact the Program Director to avoid the proposal being returned without review. NOTE: Projects related to water quality may be jointly supported with the Environmental Engineering program (CBET 1440). Photonic nanosensors with medical applications and/or imaging should be submitted to Biophotonics (CBET 7236). The Nano-Biosensing program does not support imaging applications. The duration of unsolicited awards is generally one to three years. The typical award size for the program is approximately $100,000 per year. Proposals requesting a substantially higher amount than this, without prior consultation with the Program Director, may be returned without review. INFORMATION COMMON TO MOST CBET PROGRAMS Proposals should address the novelty and/orpotentially transformative natureof the proposed work compared to previous work in the field. Also, it is important to address why the proposed work is important in terms of engineering science, as well as to also project the potential impact on society and/or industry of success in the research. The novelty or potentially transformative nature of the research should be included, as a minimum, in the Project Summary of each proposal. Faculty Early Career Development(CAREER)program proposals are strongly encouraged. Award duration is five years. The submission deadline for Engineering CAREER proposals is in July every year. Please see the CAREER URLherefor more information. Proposals for Conferences, Workshops, and Supplements: PIs are strongly encouraged to discuss their requests with the Program Director before submission of the proposal. Grants forRapid Response Research(RAPID)andEArly-concept Grants for Exploratory Research(EAGER)are also considered when appropriate. Please note that proposals of these types must be discussed with the program director before submission. Further details are available in theProposal and Award Policies and Procedures Guide(PAPPG)download foundhere.Grant Opportunities for Academic Liaison with Industry (GOALI)proposals that integrate fundamental research with translational results and are consistent with the application areas of interest to each program are also encouraged. Please note that GOALI proposals must be submitted during the annual unsolicited proposal window for each program. More information on GOALI can be foundhere. COMPLIANCE: Proposals which are not compliant with theProposal and Award Policies and Procedures Guide (PAPPG)will be returned without review.

NASA Headquarters

Awards will be made as grants, cooperative agreements, and inter- or intra-agency transfers depending on the nature of the proposing organization and/or project requirements. The period of performance for an award may be one to five years. Note that it is NASA policy that all investigations involving non-U.S. organizations will be conducted on the basis of no exchange of funds. An optional pre-proposal teleconference will be held on Feb 20, 2013 from 1:00 p.m. Eastern Time to 3:00 p.m. Eastern Time. Prospective proposers are requested to submit any questions in writing to CP4SMP@jpl.nasa.gov no later than 4 business days before the teleconference so that NASA will be able to cover as much information as possible at the teleconference. NASA plans to post written questions and answers and teleconference charts to the NSPIRES website. An opportunity to ask questions and solicit clarification will be provided in the teleconference. To dial into the teleconference, call 1-888-469-1385. The participant passcode is CP4SMP. For relay services for the hearing impaired, call 711 at least 30 minutes before the call is to begin. Only non-profits that are legally recognized by a federal, state or local authority, including all types of NASA Visitor Centers (e.g., private, state or federal entities) located in the United States or its Territories that provide science, technology, engineering and mathematics (STEM) education programming (such as but not limited to exhibits) are eligible to apply for this NASA Research Announcement (NRA). An eligible institution does not need to have the words museum, visitor center, science, or planetarium in its legal name. No later than the due date for proposals, proposers to this NRA are required to have: 1) a Data Universal Numbering System (DUNS) number, 2) a valid registration with the System for Award Management (SAM) [formerly known as the Central Contractor Registry (CCR)], 3) a valid Commercial And Government Entity (CAGE) Code, 4) a valid registration with NASA Solicitation and Proposal Integrated Review and Evaluation System (NSPIRES) (this also applies to any entities proposed for subawards or subcontracts.) Consult Section VII. Eligibility Requirements of this NRA for the complete detailed explanations and caveats related to institutional and all other eligibility criteria. Principal Investigator Requirement: Principal Investigators (PIs) must be the President, Vice President, Chief Executive Officer, Chief Financial Officer, Chairman of the Board, or similarly ranked executive (e.g., Planetarium Director, Director of Sponsored Research) from an eligible institution. Limit on Number of Proposals per Organization: Eligible organizations shall submit only ONE (1) proposal per DUNS number. If an eligible organization submits more than one proposal using the same DUNS number, then none of the proposals will be evaluated. The NASA Office of Education, in cooperation with NASA Headquarters' Offices of Communications and Chief Technologist, Mission Directorates (i.e., Aeronautics Research, Human Exploration and Operations, and Science), and Mission Support Directorate solicits proposals to support NASA-inspired space, science, technology, engineering, or mathematics (S-STEM) informal education projects, including exhibits and partnerships with K-12 schools or districts, to support inquiry-based education. This NRA or solicitation seeks projects featuring NASA-themed content in space exploration, aeronautics, space science, Earth science, or microgravity, or a combination of these topics (See Section III of this document) to support NASA education outcomes. Leadership of the proposed projects must reside at informal education institutions (IEI); partnership relationships are highly encouraged (See Appendix C for partnership discussion). Proposed projects should address NASA's most current Strategic Plan and propose efforts that are well-aligned with NASA and do not duplicate other federal investments. Proposals also should address substantiated (e.g., through an existing needs assessment or other evidence) national, regional or local educational needs or challenges and offer solutions with potential for significant impact. Examples of eligible projects include but are not limited to: exhibits (permanent, traveling, or virtual); STEM programming serving educators, students, youth, parents, and the general public; STEM programming for informal education providers and staff professional development (e.g., youth groups, out-of-school-time programs, youth group leaders, workshop or activity leaders, curriculum developers, docent managers, exhibit designers, library professionals, community education leaders, education and public outreach (EPO) professionals); informal learning research in STEM, informal education programs, data usage and analysis; curriculum support for informal science education, technology development, performing arts, or activities that are culturally focused on targeted populations, such as women and minorities. Grantee institutions have the responsibility for budgeting and documenting compliance with Code of Federal Regulations, 14 CFR 1230, commonly referred to as "the Common Rule for the Protection of Human Subjects." Research to develop NASA-themed exhibits, programs, curriculum products, etc., may involve full human subjects review through an Institutional Review Board or IRB or it may be exempt. An IRB also certifies when research is exempt. Every institution that intends to submit a proposal to this NRA, including the proposed prime award or any partner whether an informal education institution, other non-profit institutions, state and local Government agencies, and other organizations that will serve as subawardees or contractors, must be registered in NSPIRES. Electronic submission of proposals is required by the due date and must be submitted by an authorized official of the proposing organization. Such registration must identify the authorized organizational representative(s) who will submit the electronic proposal. All principal investigators and other participants (e.g. co-investigators) must be registered in NSPIRES regardless of submission system. Potential proposers and proposing organizations are urged to access the system(s) well in advance of the proposal due date(s) of interest to familiarize themselves with its structure and enter the requested information. Electronic proposals may be submitted via the NASA proposal data system NSPIRES or via Grants.gov. Organizations that intend to submit proposals via Grants.gov must be registered 1-- with Grants.gov and 2--with NSPIRES. Additional programmatic information for this NRA may develop before the proposal due date. If so, such information will be added as a Frequently Asked Question or FAQ or formal amendment to this NRA and posted on http://nspires.nasaprs.com . It is the proposer's responsibility to regularly check NSPIRES for updates to this NRA. When the CP4SMP+ portal page on NSPIRES is updated a notice will be added to the NASA Education Express weekly news service. To subscribe to NASA Express, go to http://www.nasa.gov/education/express .

Nashville Arts Commission

Project and operating grants for arts organizations and individual artists from Nashville Arts Commission. Supports visual, performing, literary, and media arts.

National Council of Teachers of English

Supports English language arts education, literacy programs, and research advancing teaching of English and language arts.

NASA Headquarters

OPPORTUNITY FOR THE USE OF THE INTERNATIONAL SPACE STATION BY DOMESTIC ENTITIES OTHER THAN U.S. FEDERAL GOVERNMENT AGENCIES 1.0 INTRODUCTION AND BACKGROUND The National Aeronautics and Space Administration (NASA) is operating a share of the United States accommodations on the International Space Station (ISS) as a national laboratory in accordance with Section 507 of the NASA Authorization Act of 2005 (P.L. 109-155) and to seek to increase the utilization of the ISS by other federal entities and the private sector. To facilitate and increase such utilization of the ISS, NASA is providing access to the ISS for the conduct of basic and applied research, technology development and industrial processing (collectively, R&D) to U.S. federal, state and local government entities, and to U.S. private entities (including, but not limited to, commercial firms, non-profit entities, and academic institutions) as part of the national laboratory. In preparation for the ISS post-assembly phase and during the post-assembly complete phase, NASA is seeking proposals from domestic entities other than U.S. federal government agencies for the conduct of R&D activities on the ISS as a national laboratory. NASA anticipates using its authority to enter into Space Act Agreements to support national laboratory activities, including providing necessary access to NASA facilities, personnel and technical information, however, there will be no provision of funds in connection with this opportunity. Respondents will be responsible for financing their own activities. Participation in this National Lab Opportunity will be contingent upon selection by NASA and negotiation of an appropriate Agreement between NASA and the proposer. Proposed activities should involve R&D, including, but not limited to, life sciences, sensors, communication equipment, engineering testbeds, spacecraft design and testing, or education and should demonstrate potential benefit to the public, such as development of future products and services contributing to U.S. industrial capacity and economic growth or improving STEM education. This opportunity is not exclusive; NASA, at its discretion, may negotiate with other parties for access to ISS under this opportunity. Response Date: This announcement is open through December 31, 2014. NASA will engage in ongoing review of proposals as received prior to the Response Date of December 31, 2014. NASA reserves the right to amend or withdraw this Announcement at any time prior to the Response Date. NASA will not issue paper copies of this Announcement. NASA reserves the right to select for Space Act Agreement negotiations all, some, or none of the proposals submitted in response to this Announcement. NASA provides no funding for reimbursement of proposal development costs. Material submitted in response to this Announcement will not be returned. It is the policy of NASA to safeguard all proposals as confidential and privileged information, as provided by law. NASA will not, without permission of the proposers, use the proposal contents for other than evaluation purposes. It is not NASA's intent to publicly disclose proprietary information obtained during this solicitation. To the full extent that it is protected pursuant to the Freedom of Information Act and other laws and regulations, information identified by a respondent as "Proprietary or Confidential" will be kept confidential. NASA may use contractor support personnel to assist in providing expertise regarding proposals. Any support contractor involved in the evaluation process shall be free of conflicts of interest, will be bound by appropriate non-disclosure agreements to protect proprietary and competition sensitive information. By submitting a proposal under this Announcement, the proposer is deemed to have consented to release of data in its proposal to NASA contractors supporting evaluation of proposals. 2.0 GENERAL INFORMATION Agency Name: NASA (National Aeronautics and Space Administration) Opportunity Title: Opportunity for the use of the International Space Station by Domestic Entities Other than U.S. Federal Government Agencies Response Date: Electronic Proposals must be received by December 31, 2014 at 4:30 P.M. EST via email to jason.c.crusan@nasa.gov. Proposals may be submitted at any time before the response date. Points of Contact: If you have any questions concerning this opportunity please contact: Marybeth Edeen Manager, ISS National Lab Office Telephone: 281-483-9122 Fax: 281-244-8292 Email: marybeth.a.edeen@nasa.gov Jason Crusan SOMD Agreement Manager 202-358-0635 202-358-3530 jason.crusan@nasa.gov Instrument Type(s): It is anticipated that awards under this Opportunity will be in the form of Space Act Agreements, executed under the authority of 42 U.S.C. 2473(c)(5). Selection Recommendation Committee: Government personnel from NASA, other Federal agencies, and NASA contractors may participate in the evaluation of proposals. All contractor personnel participating in the evaluation will be bound by conflict of interest provisions and appropriate non-disclosure requirements to protect proprietary information. Selection Notification Date: Selection for negotiations is anticipated to be within 60 days of receiving a proposal. Submission Instructions: All Proposals under this Announcement must be emailed to jason.c.crusan@nasa.gov. Paper submissions will not be reviewed. Proposals may be submitted at any time before the Response Date. You are encouraged to submit as early as practicable prior to the Response Date. Proposals received by the Government after the Response Date will not be accepted. If a proposer is concerned about information security during transmission NASA has the ability to accept secure transmission. Contact the Point of Contact for secure transmission requirements. Files can be submitted in MS Word, PDF, or RTF. 3.0 ELIGIBILITY INFORMATION All categories of domestic entities other than U.S. federal government agencies are eligible to submit proposals in response to this Announcement. NASA will not consider proposals which do not include a domestic entity as the lead proposer. 4.0 PROPOSAL EVALUATION AND SELECTION 4.1 Evaluation and Selection Process All proposals will be initially screened to determine their compliance to the eligibility (section 3.0) and proposal instructions (section 5.0) of this Announcement. Proposals that do not comply may be declared noncompliant and rejected without further review. A submission compliance checklist is provided in section 5.0. This checklist provides proposers a list of the items that NASA will check for compliance before releasing a proposal for evaluation. Proposals deemed in compliance with this Announcement will be assessed against the evaluation criteria outlined in Section 4.2 by the Selection Recommendation Committee. Proposed collaborators should be aware that during the evaluation and selection process, NASA may request clarification of a specific point or points in a proposal. Such a request and the proposed collaborator's response shall be in writing. NASA reserves the right to suggest collaboration between proposers where it will enhance the effort, in which case proposers will be given the opportunity to accept or decline participation with other proposers prior to selection. The Selection Recommendation Committee members will conduct independent assessments of the proposals according to evaluation criteria outlined in Section 4.2. 4.2 Evaluation Criteria The evaluation factors below are of equal weighting during evaluation. Factor 1: Approach to Proposed Effort: The overall merit, rationale, feasibility, and suitability of the proposed effort or concept and its relevance to R&D that access to the ISS provides. Highest priority will be placed on an approach or concept that will create substantial increases in the current state-of-the-art. Describe how the proposer proposes to receive resulting data and/or samples from orbit. Factor 2: Level of Benefit to the Public: The proposed effort or concept's anticipated benefit to the public, in terms such as development of future products and services, and contribution to U.S. industrial capacity and/or economic growth. Factor 3: Level of Financial Commitment and Business Plan: The description of the level of financial commitments supporting the proposed efforts, including any third party financing required. Include a brief business plan for the proposed efforts or describe how the proposed efforts contribute to existing business plans. Identify the non-U.S. Government market potential for the R&D efforts. The proposed space activity is essential to product research, development, or processing, and is targeted to an addressable market. A roadmap exists; it includes the essential activities to bring the product to market beyond the development space activities. In addition, describe all cargo to be transported between Earth and the ISS that your proposed efforts require and how your business plan addresses meeting those requirements including any sample return and disposition of the on-orbit equipment/payloads. In addition, NASA reserves the right to assess information outside the proposal as it relates to the factors listed above. 4.3 Selection Factors As described in Section 4.1, the results of the proposal evaluations based on the criteria above and the subsequent Selection Recommendation Committee deliberations will be considered in the selection process. The Selection Recommendation Committee may take into account a variety of programmatic factors in deciding whether or not to select any proposals, including, but not limited to, available on-orbit resources, and compatibility to the ISS. The Selection Authority shall be the Associate Administrator for Space Operations. The Selection Authority will make the final selection of those approved for this opportunity after the completion of negotiations, depending on the outcome of the negotiations. 4.4 Selection Notification NASA will notify all proposed collaborators of the results of the evaluation and selection process. Selection does not guarantee a launch opportunity. Selection does guarantee NASA will provide the on orbit resources and trained crew to perform the experiment once it is on board. After the completion of the evaluation and selection process, NASA will begin negotiations with the selected proposer(s). The purpose of the negotiations is to define the terms and conditions of the Agreement supporting the participation of the proposers and to align the selected proposals with the anticipated on-orbit resource availability. All work will commence after the parties execute the Space Act Agreement. 5.0 PROPOSAL INSTRUCTIONS Proposals must comply with the following requirements. Page Limitations Proposal Section - Total Pages Proposal Cover Page - 1 Proposal Title Page - 1 Points of Contact - 1 Proposal Abstract - 750 words Proposal Detail - 10 Appendix Resumes - No Page Limit Additional Documentation - No Page Limit Pages in excess of the page limitations for each section will not be evaluated. A page is defined as one (1) sheet 8 x 11 inches using a minimum of 12-point font size for text and 8-point for graphs. There is no limit on appendix documentation. The intent is to allow proposals to include current documentation in its current format without having to alter any documents. The proposal must include the following sections, in this order: Proposal Cover Page: Solicited Proposal Application - Title of Announcement and Proposal Contact Information. An optional graphic image may be included. Proposal Title Page, with Notice of Restriction on Use and Disclosure of Proposal Information, if any. Points of Contact: List contact information for all Points of Contact including a Technical Point of Contact. Provide: a. Name b. Title c. Address d. Phone and Fax e. Email Proposal Abstract: Executive summary describing the prominent and distinguishing features of the proposal. Proposal Detail: The proposal shall contain sufficient information to enable reviewers to make informed judgments to assess the three criteria of the proposed effort. Proposal Appendix: * Resumes o Resumes may be included for key personnel. In general, resumes should be limited to no more than 1-2 pages each. * Additional documentation Include any documentation in the appendix that validates or supports the proposal Compliance checklist and required documents o The proposer is a domestic entity other than U.S. federal government agency o Proposal includes demonstration of the overall merit, rationale, feasibility, and suitability that access to the ISS provides o Proposal includes a description of the level of benefit to the public o Proposal includes a description of the level of financial commitment and business plan o Proposal includes a schedule for remaining development required before flight o Proposal includes a management/ project plan for remaining development o Proposal includes funding commitment letters demonstrating sufficient financial support for remaining development or financial milestones required to complete development

NC Arts Council

The NC Arts Council awards grants to arts organizations, artists, schools, and communities to promote excellence in the arts, expand access to arts experiences, and integrate arts into community and economic development across North Carolina.

ND Arts Council

General operating and project support for arts organizations and individual artists in ND. Funds visual arts, performing arts, literary arts, and arts education.

NE Arts Council

General operating and project support for arts organizations and individual artists in NE. Funds visual arts, performing arts, literary arts, and arts education.

National Endowment for the Arts

Project-based grants supporting public engagement with, and access to, the arts including visual arts, music, dance, theater, literature, design, and media arts.

National Endowment for the Arts

Grants for Arts Projects (GAP) provides project-based funding for organizations in the areas of Arts Education, Challenge America, Dance, Design & Our Town, Folk & Traditional Arts, Literary Arts, Local Arts Agencies, Museums, Music, Opera, Presenting & Multidisciplinary Works, Theater & Musical Theater, and Visual and Media Arts. Funded activities may include a wide range of arts projects described in the application guidelines. Awards require a 1:1 cost share. We welcome applications from first-time and returning applicants; from organizations serving rural, urban, suburban, and tribal communities of all sizes; and from organizations with a range of operating budgets. Eligible applicants include: nonprofit, tax-exempt 501(c)(3), U.S. organizations; units of state or local government; and federally recognized tribal communities or tribes. Funding in this category is not available for individuals, fiscally sponsored entities, commercial/for-profit enterprises, State Arts Agencies (SAA), or Regional Arts Organizations (RAO).

National Endowment for the Arts

The purpose of this Program Solicitation is to select an organization ( Cooperator ) to assist the NEA with the 2027 NEA National Heritage Fellowships Awards program. The agency anticipates that the Cooperator will coordinate a range of events, including an awards ceremony, showcase(s) featuring the 2027 fellows, video vignettes about each fellow, participant travel, and associated activities. This award will be made as a cooperative agreement. A cooperative agreement is a type of award in which the federal government will be substantially involved in the project undertaken by the award recipient (known as a Cooperator). Eligible applicants include nonprofit, tax-exempt 501(c)(3), U.S. organizations; units of state or local government; or federally recognized tribal communities or tribes.

National Endowment for the Arts

The purpose of this Program Solicitation is to select an organization (“Cooperator”) to assist the NEA with the 2027 NEA National Heritage Fellowships Awards program. The agency anticipates that the Cooperator will coordinate a range of events, including an awards ceremony, showcase(s) featuring the 2027 fellows, video vignettes about each fellow, participant travel, and associated activities. This award will be made as a cooperative agreement. A cooperative agreement is a type of award in which the federal government will be substantially involved in the project undertaken by the award recipient (known as a Cooperator). Eligible applicants include nonprofit, tax-exempt 501(c)(3), U.S. organizations; units of state or local government; or federally recognized tribal communities or tribes.

National Endowment for the Arts

Grants for creative placemaking projects that integrate arts and culture into community revitalization, improving livability, economic development, and social outcomes.