Skip to main content
9,000+ open opportunities indexed

Search Grants — Free, No Account Required

Search federal, state, and foundation grants by keyword, state, or focus area. When you find a match, apply with our AI-assisted application builder.

67 grants foundClear search

24 grants worth up to $13.6M match your search

Enter your email to see grant names, funders, and application links

Hierarchical Control in an Endocrine-mediated Gene Regulatory Network Supporting Innate Immunity

open

NIAID - National Institute of Allergy and Infectious Diseases

PROJECT SUMMARY Hormones pleiotropically regulate diverse physiological processes, often through tiered gene regulatory networks (GRNs) which consist of primary response genes that are directly regulated by the hormone and secondary response genes that are regulated by transcription factors in the primary response set. A central hypothesis in this proposal is that pleiotropic hormones can enact distinct gene regulatory programs via hierarchically tiered gene regulation. It is further hypothesized that modest differences in the primary level of regulation can result in larger differences at the secondary level, leading to functionally specialized GRNs over development and in response to environmental stimulus. However, distinguishing primary from secondary regulation is difficult or impossible from transcriptomic data alone, presenting a major hindrance to deciphering how hormones regulate pleiotropic balances. This project will overcome that challenge by combining transcriptomic profiling with computational analysis and direct assays of DNA-binding to decipher primary and secondary levels of gene regulation. The project will focus on the hormone 20- hydroxyecdysone (or ecdysone, 20E) in the Drosophila melanogaster model system. 20E has well-defined roles in development and a documented but undefined role in regulating the immune system. In Aim 1, an ex vivo tissue assay will be used to build the 20E gene-regulatory network. Transcriptomic analysis, measurement of direct DNA binding by the nuclear hormone receptor, and characterization of the chromatin landscape will be combined to identify primary targets of 20E signaling. Transcription factors in the primary-regulated gene set will then be computationally and experimentally evaluated for regulation of genes in the secondary level of control. In Aim 2, experimental infections with pathogenic bacteria will be used to define the 20E modulation of the immune system in vivo. Both 20E and innate immune signaling are highly conserved across insects, including in agricultural pests and human disease vectors, and the endocrine-mediated development-immunity pleiotropy can be exploited for insect control mechanisms to promote food security and improve public health. More broadly, the principles hormonal regulation of immune function are likely to be conserved across all animals, including humans, and pleiotropic endocrine GRNs allow evolutionary adaptation in life history balances. The methodology and workflow developed in this proposal can be applied broadly to hierarchical gene regulatory networks in any system.

Up to $196K
2028-04-30
health research

Free to search & build · $99 one-time to unlock the application pack · No subscription

Improving Food Assistance to Women and Children

open

NICHD - Eunice Kennedy Shriver National Institute of Child Health and Human Development

PROJECT SUMMARY Food insecurity has detrimental effects on individual and community health. Individuals who are food insecure have worse diet quality, and in turn, greater risk for developing diet-related diseases (e.g., type 2 diabetes). This is especially concerning for children, as proper nutrition is essential for their growth and development. Louisiana has the fourth highest prevalence rate of food insecurity in the U.S, and low-income individuals and households with children carry a disproportionate burden of food insecurity and related health outcomes. The Special Supplemental Nutrition Program for Women, Infants, and Children (WIC) is one of the U.S.’s largest federal interventions aimed at reducing food insecurity risk. WIC is a means-tested program that provides eligible individuals (pregnant, postpartum, and children up to age 5) with a food package to support their nutritional needs. Research has shown that WIC participation is associated with improved food security and related health outcomes. Despite national, state, and local efforts to improve program retention, many WIC participants leave the program prematurely. In Louisiana, a southern U.S. state with high prevalence rates for food insecurity, only 21.6% of eligible children participate in WIC. Satisfaction with WIC services has been identified as a primary driver of program retention, yet few studies have examined correlates of satisfaction. The 2024 revisions to the WIC food package provide a novel opportunity to conduct research aimed at characterizing factors related to WIC satisfaction. Set to be implemented in April 2027, these revisions aim to align the WIC food package with the 2025 Dietary Guidelines for Americans and accommodate cultural and dietary needs. Informed by the Practical, Robust Implementation and Scalability Model (PRISM) framework, the proposed F31 will conduct a pre-implementation evaluation of the 2024 WIC food package revisions in Louisiana. This mixed-methods study will be accomplished by completing three aims. Semi-structured in-depth interviews with WIC participants (n = 20) and administrative/clinical staff (n = 20) in New Orleans will be thematically analyzed using PRISM constructs to identify factors related to the food package’s impact on program satisfaction and household food security (Aim 1). Multivariable regression analyses will be used to test associations between participants’ satisfaction (n = 500) with each change to the WIC food package and select individual (e.g., dietary needs), and household (e.g., food insecurity) factors (Aim 2). Finally, spatial data will be used to assess the relationship between select neighborhood factors (e.g., distance to a WIC- authorized retailer) and satisfaction with the changes to the WIC food package (Aim 3). Completion of these aims will provide insight into factors related to implementation outcomes as outlined by PRISM. Assessing the 2024 WIC food package revisions prior to their implementation in Louisiana will yield important insights useful for guiding implementation and can inform future legislation aimed at improving WIC satisfaction and retention.

Up to $37K
2028-06-30
health research

Free to search & build · $99 one-time to unlock the application pack · No subscription

Improving Health Outcomes and Advancing Health Equity in Imperial County Rural Communities through Increasing Healthy Food Access

open

NIMHD - National Institute on Minority Health and Health Disparities

Rural communities experience higher food insecurity prevalence and residents face challenges in obtaining food due to a number of barriers, including economic and financial instability, transportation limitations, and lack of or limited access to stores that offer varied, healthy, and affordable food options. Supermarkets are not readily accessible and independently- owned small markets, corner, liquor, and convenience stores are more prevalent. While these small stores generally offer limited healthy food options, they are existing assets in the community that are already serving community residents and can become an important source of healthy food access that increases the visibility and variety of nutritious foods within rural communities. The long-term goal of this project is to test the effectiveness of the introduction of a produce distribution service into small stores on increasing healthy food access, reducing health disparities, and improving psychosocial health outcomes among low-income, primarily Hispanic rural community residents in Imperial County, CA. This project will accomplish three specific aims: Specific Aim 1: Assess and characterize the food environment in Imperial County, CA. The food environment will be evaluated by creating a Geographic Information System that captures existing food retailers, conducting in-store observational audits of all food retailers to assess current healthy food accessibility and availability, and analyzing the data to identify healthy food access gaps and potential small store partners for produce distribution services. Specific Aim 2: Adapt and implement the produce distribution service. The produce distribution service will be adapted based on input from a community advisory board and small store owners. Quantitative and qualitative data will assess the feasibility and acceptability of the service and indicate if its elements met the needs of small store owners and community residents, and were acceptable, feasible, cost-effective, and contextually-relevant. Specific Aim 3: Evaluate the preliminary multi-level effectiveness of produce distribution services to partner stores. Multi-method, longitudinal data will be analyzed to evaluate the effectiveness of the produce distribution service in improving produce accessibility and availability and food security, and changing food acquisition and dietary intake behaviors. By adapting and implementing a produce distribution service for rural communities that has been successful in urban communities, this project has the potential to inform approaches for leveraging existing assets in the community to increase healthy food access within rural communities that face considerable barriers in improving the food environment.

Up to $900K
2030-11-30
health research

Free to search & build · $99 one-time to unlock the application pack · No subscription

Interdisciplinary Neurotrauma Research, Innovation, and Scientific Excellence (NEURO-RISE)

open

NICHD - Eunice Kennedy Shriver National Institute of Child Health and Human Development

PROJECT ABSTRACT The overarching goal of the Neuro-RISE (Training in Interdisciplinary Neurotrauma Research, Innovation, and Scientific Excellence) program is to train the next generation of neurotrauma scientists to become leaders in advancing research that improves the lives of people with spinal cord injury (SCI) and traumatic brain injury (TBI). Trainees will be equipped to develop and translate novel therapeutic, rehabilitative, behavioral, and technological strategies that reduce disability and promote health, independence, and quality of life across the lifespan. This goal will be met by taking advantage of an exceptionally rich institutional environment that offers myriad resources and a complementary and collaborative team of 17 primary and 16 secondary mentors committed to training and career development. The program is further enriched by the inclusion of 16 lived-experience mentors—eight individuals with SCI and eight with TBI—with varied backgrounds and injury experiences. Predoctoral trainees will benefit from 2 years of interdisciplinary training that carefully melds four core levels of scientific inquiry: (i) adaptation and plasticity, (ii) rehabilitation diagnostics and interventions, (iii) novel devices and technologies, and (iv) chronic symptom management. Training will occur in one of two areas of concentrated expertise: (i) SCI or (ii) TBI. Predoctoral trainees will be selected from a highly competitive national pool admitted to the Neuroscience, Psychology, or Health and Rehabilitation Science Graduate programs. The training team is truly interdisciplinary. Each trainee’s primary mentor and Translational Mentoring Team will be drawn from expert faculty spanning the Colleges of Medicine (COM), Education and Human Ecology (CEHE), Food, Agricultural and Environmental Sciences (CFAES), and Engineering (COE). Neuro-RISE also offers a distinctly immersive and human-centered training experience that integrates people with lived experience of SCI or TBI into each trainee’s research project—bringing real-world insights directly into scientific inquiry. The program promotes bench-to-bedside and bedside-to-bench translation by preparing trainees to apply mechanistic discoveries to clinical care and interpret clinical phenomena through rigorous scientific inquiry. Trainees will participate in a curated curriculum that includes commercialization and team science training, advanced methods seminars tailored to neurotrauma research, and a community-engaged research workshop co-led by individuals with SCI and TBI. With intentional focus on research ethics, scientific rigor, and impact-driven scholarship, Neuro-RISE prepares emerging scientists not only to publish, but to lead multidisciplinary teams, secure competitive funding, and transform care for people with neurotrauma across the lifespan. Neuro-RISE will recruit two predoctoral trainees in year one, then grow to admit four annually thereafter. As a top-tier NIH-funded academic medical center, The Ohio State University is uniquely positioned to train translational neurotrauma researchers poised to lead future innovations.

Up to $101K
2031-04-30
health research

Free to search & build · $99 one-time to unlock the application pack · No subscription

Leveraging Agriculture and Uniting Communities to Improve HIV Outcomes in Senegal: A cluster randomized controlled trial

open

NIMH - National Institute of Mental Health

PROJECT SUMMARY Innovative strategies are needed to address the unique challenges faced by women living with HIV (WLHIV) in West Africa. Among the 5.1 million people living with HIV (PLHIV) in West and Central Africa in 2023, 65% were adolescent girls and women. Among PLHIV in the region, 81% knew their HIV status, 76% were receiving antiretroviral therapy (ART), and 70% had suppressed viral loads. Addressing the social and structural barriers that disproportionally impact women is critical to achieving the 95-95-95 targets and ending the HIV epidemic. Our previous work in Senegal, West Africa has shown that the majority of WLHIV are food insecure and that food insecurity is associated with poor HIV outcomes, including loss to follow-up, poor adherence to ART, and virologic failure. The high prevalence of food insecurity among WLHIV in Senegal and its role as a driver of poor outcomes across the HIV care cascade, suggest that strategies to address food insecurity are essential to interrupting transmission, improving quality of life, and preventing mortality. The Casamance region, located in the south of Senegal, has been the most severely affected by the HIV epidemic and has the highest prevalence of food insecurity in the country. In collaboration with our longstanding partners at the NGO DIG (“Development in Gardening”), the Service des Maladies Infectieuses et Tropical-CHNU de Fann, and the Région Médicale de Ziguinchor, we recently conducted an NIH funded pilot study to evaluate the experience and impact of a multisectoral nutrition-sensitive agricultural intervention among WLHIV in the Casamance. The findings from our pilot study suggest that participation in the intervention is associated with improvements in food security, virologic suppression, and mental health. In the proposed study, we will leverage our longstanding partnerships in Senegal and build upon our findings to conduct a cluster randomized trial to evaluate the impact of a multisectoral nutrition-sensitive agricultural (MNSA) intervention on HIV outcomes among women in the Casamance region. The AIMS of this study are, AIM 1. Determine the impact of a MNSA intervention on HIV outcomes among WLHIV in Senegal, AIM 2. Determine the mechanisms by which the MNSA intervention improves HIV outcomes among WLHIV in Senegal, Aim 2a. Determine the impact of the MNSA intervention on food security, dietary diversity, and nutritional status, Aim 2b. Determine the impact of the MNSA intervention on mental health outcomes and empowerment, and AIM 3. Determine the costs, cost-effectiveness, scalability, and sustainability of the MNSA intervention.

Up to $613K
2031-05-31
health research

Free to search & build · $99 one-time to unlock the application pack · No subscription

Mapping Stakeholder Networks for Comprehensive Food and Nutrition Security Interventions: A Multilevel Network Analysis Approach

open

NIMHD - National Institute on Minority Health and Health Disparities

Food and nutrition insecurity (FNI) is a complex public health challenge shaped by the food environment, community factors, economic conditions, and individual behavior. In Los Angeles County, 30% of households report experiencing FNI. FNI is associated with increased risk of obesity, hypertension, type 2 diabetes, and other cardiometabolic conditions. Despite its multifactorial nature, interventions often focus on individual-level factors while overlooking interactions across the broader food system network. To address FNI effectively, a multilevel, system-level approach is needed that supports coordinated stakeholder action. This study aims to address key gaps in understanding stakeholder networks and their role in addressing FNI. Using a systems modeling framework grounded in The Community Coalition Action Theory and The Health Disparities Framework, the study will examine the multilevel networks of stakeholders working on FNI in Los Angeles County, focusing on collaborative activities. By employing multilevel social network analysis, this research will address two specific aims: i) identify characteristics of stakeholder collaboration networks within the Los Angeles County food system, examining organizational roles, coordination patterns, and network relationships to better understand the context of FNI interventions; and ii) determine whether network structures predict stakeholder actions during initiative implementation, exploring how collaboration patterns and organizational structure influence implementation efforts intended to reduce FNI, a key contributor to cardiometabolic diseases. The study will engage 50 stakeholders from the L.A. CFER stakeholder coalition addressing FNI to participate in multilevel network surveys and qualitative interviews (n=30). It will also refine an existing systems map developed through the NSF-funded Smart and Connected Community Food System Project, incorporating information on current and planned interventions. This approach will examine how stakeholders work collectively within the network (level one) to address FNI-related factors (level two). By identifying key stakeholders, collaboration patterns, and implementation facilitators, this study will generate practical tools and strategies for strengthening stakeholder coordination and supporting coordinated interventions. These findings will contribute to more effective efforts to reduce diet-related disease burden. The award of this fellowship will allow Ms. Wasim to pursue advanced training in multilevel network analysis and systems modeling, preparing her to lead innovative network-informed approaches to address FNI. This work supports NIMHD priorities related to improving public health through evidence-based and actionable research solutions.

Up to $50K
Rolling
health research

Free to search & build · $99 one-time to unlock the application pack · No subscription

NIOSH Centers for Agriculture, Forestry, and Fishing Safety and Health (U54)

upcoming

Centers for Disease Control and Prevention - ERA

<p>The Agriculture, Forestry, and Fishing (AgFF) sector is essential to the safety, security, and economic stability of the U.S. because it produces the nation's food, fuel, and fiber.&nbsp;&nbsp;At the same time, AgFF workers experience some of the highest occupational fatality and non-fatal injury rates of any sector. AgFF workers also face increased risk of poor mental health, death by suicide, and substance use disorder.&nbsp;</p><p>The National Institute for Occupational Safety and Health (NIOSH) is committed to addressing a wide range of occupational health and safety hazards affecting people who work in the production, processing, and transportation of AgFF products.</p><p>This notice of funding opportunity (NOFO) will support up to twelve regional NIOSH Centers for Agriculture, Forestry, and Fishing Safety and Health (AgFF Centers). Each AgFF Center will advance the NIOSH mission and priorities through high-quality research, education, training, and outreach. Key Center activities include:</p><ul style="list-style-type:disc;"><li data-list-item-id="ecbc15055073bfd4ee1bee7fafd580922">Conducting high-quality, multidisciplinary science, with an emphasis on intervention and implementation research;&nbsp;</li><li data-list-item-id="ea8c3dd54dc1292a89bb61a1cdf2eb69a">Advancing AgFF research-to-practice (r2p) by translating scientific discoveries into practical, real-world solutions;</li><li data-list-item-id="e560e02d11c0e68e6bd98948fa1c0f846">Developing and evaluating technology, including AI and automation, to reduce workplace hazards and improve health outcomes for AgFF workers;</li><li data-list-item-id="ef6f1fb998df5b92ffd4d4c31230ac51a">Engaging with a variety of regional and national partners to effectively communicate new knowledge and best practices;</li><li data-list-item-id="ed88da01ebac507ea824283572a8d57fd">Integrating food systems and One Health approaches into occupational safety, health, and well-being; and</li><li data-list-item-id="e7a784ea833b49df8fac02fa4b226b921">Improving the coordination and collection of data on injury, illness, disability, and death for AgFF workers.</li></ul><p style="margin-left:.25in;">AgFF Centers work closely with NIOSH AgFF program leadership and collaborate with other AgFF Centers, NIOSH scientists (when applicable), academic and research partners, industry and community groups, and other organizations. Funded Centers are expected to have significant, widespread, and sustained local and regional impact. Together, these efforts should collectively contribute to the national advancement of AgFF workers' safety, health, and well-being.&nbsp;</p>

Up to $2.2M
2027-03-03
Health

Free to search & build · $99 one-time to unlock the application pack · No subscription

NIOSH Centers for Agriculture, Forestry, and Fishing Safety and Health (U54)

upcoming

Centers for Disease Control and Prevention - ERA

The Agriculture, Forestry, and Fishing (AgFF) sector is essential to the safety, security, and economic stability of the U.S. because it produces the nation's food, fuel, and fiber. At the same time, AgFF workers experience some of the highest occupational fatality and non-fatal injury rates of any sector. AgFF workers also face increased risk of poor mental health, death by suicide, and substance use disorder. The National Institute for Occupational Safety and Health (NIOSH) is committed to addressing a wide range of occupational health and safety hazards affecting people who work in the production, processing, and transportation of AgFF products.This notice of funding opportunity (NOFO) will support up to twelve regional NIOSH Centers for Agriculture, Forestry, and Fishing Safety and Health (AgFF Centers). Each AgFF Center will advance the NIOSH mission and priorities through high-quality research, education, training, and outreach. Key Center activities include:Conducting high-quality, multidisciplinary science, with an emphasis on intervention and implementation research; Advancing AgFF research-to-practice (r2p) by translating scientific discoveries into practical, real-world solutions;Developing and evaluating technology, including AI and automation, to reduce workplace hazards and improve health outcomes for AgFF workers;Engaging with a variety of regional and national partners to effectively communicate new knowledge and best practices;Integrating food systems and One Health approaches into occupational safety, health, and well-being; andImproving the coordination and collection of data on injury, illness, disability, and death for AgFF workers.AgFF Centers work closely with NIOSH AgFF program leadership and collaborate with other AgFF Centers, NIOSH scientists (when applicable), academic and research partners, industry and community groups, and other organizations. Funded Centers are expected to have significant, widespread, and sustained local and regional impact. Together, these efforts should collectively contribute to the national advancement of AgFF workers' safety, health, and well-being.

Up to $2.2M
2027-03-03
Healthhealthcare

Free to search & build · $99 one-time to unlock the application pack · No subscription

Notice of Intent to Issue Fiscal Year 15 Biomass Research and Development Initiative

open

Golden Field Office

The U.S. Department of Agriculture (USDA), in conjunction with the U.S. Department of Energy (DOE) Office of Energy Efficiency and Renewable Energy (EERE), intends to issue, on behalf of USDA?s National Institute of Food and Agriculture (NIFA) and DOE?s Bioenergy Technologies Office (BETO), a Request for Applications (RFA) entitled ?Fiscal Year 15 Biomass Research and Development Initiative (?BRDI?).? The RFA will address USDA and DOE programmatic objectives, administrative roles, and areas of interest in implementing Biomass Research and Development Initiative (BRDI) grants. Section 9001(a) of the Food, Conservation, and Energy Act of 2008 (FCEA) (Pub. L. 110-246) re-authorized the BRDI competitive grants program by amending section 9008 of the Farm Security and Rural Investment Act of 2002 (FSRIA), as amended, (Pub. L. 107-171) (7 U.S.C. 8108). For fiscal year (FY) 2015, BRDI will require that funded projects address only one (1) of the following three (3) legislatively mandated technical areas: 1. Feedstocks development ? The intent of this Topic Area is to address research, development, and demonstration (RD&amp;D) activities regarding feedstocks and feedstock logistics (including harvest, handling, transport, preprocessing, and storage) relevant to production of raw materials for conversion to biofuels and biobased products. The BRDI program is designed to support near-term commercial systems. Projects should emphasize development and optimization of existing feedstocks that will be available for testing and demonstration during the life of the project. Proposals that include breeding or genetic improvement of feedstocks should reconcile this work with the Program?s emphasis on near-term impacts. 2. Biofuels and biobased products development ? The intent of this Topic Area is to address RD&amp;D activities to support (i) development of diverse cost-effective technologies for the use of cellulosic biomass in the production of biofuels, bioenergy, and biobased products; and, (ii) product diversification through technologies relevant to the production of a range of biobased products (including chemicals, animal feeds, and cogeneration power) that potentially can increase the feasibility of fuel production in a biorefinery. 3. Biofuels development analysis ? The intent of this Topic Area is to apply systems evaluation methods that can be used to optimize system performance and market potential and to quantify the project?s impact on sustainability; therefore, successful applications will consider the lifecycle (cradle-to-grave) impacts including environmental, social, and economic implications that are attributable to the project. Successful projects should include these sustainability data in engineering process models and be used over the life of the project to improve the system and quantify sustainability impacts. This Notice is issued so that interested parties are aware of NIFA's and EERE's intention to issue a RFA in the near term. NO APPLICATIONS WILL BE ACCEPTED THROUGH THIS NOTICE. Please do not submit questions or respond to this Notice of Intent. Prospective applicants to the RFA should begin developing partnerships, formulating ideas, and gathering data in anticipation of the issuance of this RFA. It is anticipated that the RFA will be posted to Grants.gov in November 2014.

rolling
energyclean energy

Free to search & build · $99 one-time to unlock the application pack · No subscription

FindGrants Pro

Save unlimited matches with FindGrants Pro — $19/mo

Includes 1 application credit per month, weekly emailed grant alerts matching your org, and deadline reminders. Cancel anytime.

See Pro details

Found a grant that fits? Get matched to even more.

Answer a 2-minute questionnaire and our engine scores every grant in the database against your organization — surfacing opportunities you might miss browsing manually.

Get Personalized Matches — Free