Search Grants — Free, No Account Required

FIC - John E. Fogarty International Center for Advanced Study in the Health Sciences

In Vietnam, adolescent and young men vulnerable to HIV through sexual behaviors are among those most affected by the infection, with an HIV prevalence that quadrupled from 3% in 2011 to 13% in 2020. More than 20% of Vietnamese young men living with HIV had moderate-to-severe depression and anxiety symptoms. These youths experienced extensive stigma related to their HIV status and sexual behaviors. There is a dearth of youth-friendly mental health services in Vietnam where there is less than one psychiatrist per 100,000 people. Project YES+ is an intervention integrating two evidence-based interventions, Project YES! and Self-Help+ to improve mental health, stigma, and HIV outcomes among youth living with HIV in Zambia (5R01TW012411). Youth Engaging for Success (Project YES!) is an HIV clinic-based peer mentoring CDC-designated intervention that successfully decreased HIV self-stigma and increased viral suppression. Self-Help+ is a group-based lay-delivered program endorsed by WHO that effectively prevents the onset of mental disorders and reduces mental health symptoms in different cultures. We propose to adapt Project YES+ for adolescent and young men living with HIV in Vietnam to create To Hieu (I Understand) and to pilot test the adapted intervention. The specific aims are to (1) Adapt Project YES+ to create To Hieu to improve mental health and reduce internalized HIV stigma for adolescent and young men living with HIV in Vietnam and (2) Examine acceptability and feasibility of To Hieu among adolescent and young men living with HIV through a pilot randomized controlled trial. In Aim 1, the adaption will follow the 8-step ADAPT-ITT framework.38 We will conduct in-depth interviews with adolescent and young men living with HIV (N=20) to explore preferences for the core components and formats of To Hieu. We will hold a human-centered design workshop to engage adolescent and young men living with HIV in co-design activities to refine To Hieu. In Aim 2, we will recruit 80 adolescent and young men living with HIV with depression or anxiety symptoms at two HIV clinics in Hanoi, Vietnam and randomize them 1:1 into two arms. The intervention arm will receive To Hieu in 4 months, while the control arm will receive standard of care at the clinics. The RE-AIM (Reach, Effectiveness, Adoption, Implementation, Maintenance) framework will guide the measurement of the outcomes. We will calculate participation rates of participants (Reach) at baseline. We will assess acceptability through the Client Satisfaction Questionnaire and feasibility through intervention attendance (Adoption) at 4 months. Depression, anxiety symptoms, internalized HIV and sexual stigma, ART adherence and viral suppression of participants will be evaluated at baseline, 4 months and compared between groups (preliminary Effectiveness). We will conduct exit interviews with participants, youth peer mentors and HIV providers (N=30) to explore acceptability, feasibility (Implementation) and sustainability (Maintenance) of To Hieu. This research will build local capacity and develop networks for collaborative research on mental health and stigma among adolescent and young men living with HIV between Vietnam and the US.

NIMH - National Institute of Mental Health

ABSTRACT Despite advancements in antiretroviral therapy (ART), only 65% of people with HIV (PWH) in the United States (US) achieve viral suppression, with significant differences observed across sociodemographic groups. Long- acting injectable ART (LA ART) has the potential to address challenges associated with daily oral ART, but its adoption has been slow, with only 1.44% of PWH—approximately 15,000 individuals—on LA ART after two years of availability. This low uptake highlights persistent barriers and mirrors challenges seen with pre-exposure prophylaxis (PrEP), including slow adoption and differences in awareness, interest, and use. Further research is needed to understand factors shaping PWH decisions regarding innovative ART therapies. PWH face complex considerations when selecting treatment regimens, including regimen characteristics, psychosocial factors, and logistical barriers. While these factors are well-studied for oral ART, less is known about how PWH weigh these considerations for LA ART. This study will use advanced quantitative methods, including latent class analysis (LCA) and structural equation modeling (SEM), to identify treatment preference typologies and examine how individual, provider, and clinic-level factors shape ART preferences, addressing critical gaps in knowledge. Guided by the Consolidated Framework for Implementation Science 2.0, this project has two aims: 1) Identify HIV treatment regimen consideration patterns (classes) and assess the association between class membership and sociodemographic characteristics among PWH; and 2) Examine how patient (treatment regimen preference patterns), provider (trust, shared decision-making) and clinic-level factors (quality of clinical care) influence ART preferences among PWH. Findings will inform multilevel interventions to improve outcomes. Moreover, the identification of patient treatment typologies will enable providers to align discussions and interventions with the unique preferences of PWH. To achieve these aims, the proposed training plan focuses on developing advanced skills in LCA and SEM, deepening expertise in implementation science frameworks, and applying these findings to design multilevel interventions. Through mentorship, coursework, workshops, and applied research, the applicant will gain the knowledge and experience necessary to become an independent behavioral and implementation scientist, equipped to address access challenges in the evolving landscape of HIV treatment. This NRSA award will provide the necessary mentorship and resources to achieve these goals.

NIAID - National Institute of Allergy and Infectious Diseases

7. PROJECT SUMMARY/ABSTRACT Globally, approximately 300 million live with chronic HBV (CHB) and 40 million people live with HIV. Due to shared transmission routes, approximately 10% of people with HIV (PWH) also live with HBV (PHBV). Importantly, HIV/HBV coinfection is associated with increased mortality. Like HIV, while effective HBV treatments are available, there is no cure for HBV. Hepatitis B surface antigen (HBsAg) loss, the definition of HBV functional cure, decreases incidence of hepatocellular carcinoma (HCC) and end-stage liver disease (ESLD), yet is not easily attained with current therapy. As such, the development of novel HBV therapies, aiming for HBV functional cure, is rapidly advancing. HBV functional cure research has become a scientific priority of the NIH, industry, academia, and the community with over 50 clinical trials and compounds in development. Interestingly, HBV functional cure occurs more often in PWH/PHBV, making this an ideal cohort in which to study HBV curative therapies. Despite the pace and volume of HBV cure research, there is little knowledge about patient and provider perspectives on key HBV clinical trial approaches – unlike in HIV cure research, where over a decade of experience has informed priorities. One of the key clinical trial–related questions is whether and how to implement HBV treatment discontinuations, which will be necessary to study the efficacy of curative and finite HBV novel therapies. This will pose specific challenges in PWH/PHBV, such as the heightened likelihood of rebound hepatitis and the ongoing need for HIV antiretroviral treatment (ART). There is a notable lack of data regarding both patient and provider knowledge and priorities concerning this pivotal research phase, including questions of whether HBV treatment discontinuations are desired, the duration of discontinuation, or how to manage it. Similarly, there are limited data on trial design elements such as type of novel therapies, timing of therapy initiation, and willingness to participate in HBV cure trials. These knowledge gaps remain key hurdles to advancing effective, safe, and acceptable HBV cure strategies. Data from this application will be crucial for the development of HBV clinical trials attractive to PWH/PHBV and PHBV. Our proposed work will inform outreach, recruitment, consent, and retention of participants in future HBV clinical trials. To this end, our Specific Aims are as follows: Aim 1 will explore priorities of PWH/PHBV, PHBV and providers around key aspects of HBV clinical trials including HBV treatment discontinuations, choice of novel HBV agents, and trial participation using in-depth interviews. Aim 2 will quantify priorities of PWH/PHBV and PHBV around these same trial elements through a national U.S. survey. Aim 3 will develop ethical considerations and obtain feedback on provider- and patient- facing materials in collaboration with key stakeholders. Together, our three aims will clarify therapeutic advancement priorities and guide the ethical design of future innovative HBV clinical research with significant implications for population health. This work is directly relevant to the health of all Americans, as it addresses chronic disease management, co-morbidities, and the reduction of long-term burdens on the healthcare system.

NIDA - National Institute on Drug Abuse

Project Summary Multimodal data have been generated and collected as part of HIV care delivery and research including, but not limited to, structured data and unstructured data in electronic health records (EHRs), claims data, pharmacy records data, imaging data, omics data and other molecular biomarker data. Such rich data offer great opportunities for harnessing the transformative power of artificial intelligence (AI) and machine learning (ML) to enhance personalized clinical decision support and address unmet needs in HIV prevention and care. Multimodal AI that can integrate multiple modalities of data encountered in clinical practice has been shown to yield superior performance over simpler, unimodal models in various disease areas outside of HIV. However, multimodal biomedical data are typically complex and heterogeneous, and are fraught with missing data and other sources of biases. For example, patients with less access to healthcare or lower socio-economic status tend to have more incomplete data in their EHRs. Thus, advancing multimodal AI for HIV applications faces significant technical challenges in the training, validation, and implementation, including, but not limited to, quantifying the dimension of heterogeneity, identifying interconnections, and addressing missing data. Another major barrier in advancing multimodal AI in HIV applications is that multimodal data in HIV are typically not publicly available. Our project seeks to address these and other challenges through three specific aims. In Aim 1, we will develop novel accurate, efficient and unbiased multimodal AI models for HIV care and prevention. In Aim 2, we will adapt and create causal knowledge graphs to enhance interpretability for applications in HIV care and prevention. In Aim 3, we will develop synergistic integration of knowledge graphs and multimodal AI models for more precise model and increased usability in HIV care and prevention. We will train and test the proposed multimodal AI models and knowledge graphs using multimodal data from the Veteran Health Administration, the largest integrated health system in the US, and the Veteran Aging Cohort Study for three important use cases in HIV prevention and care, namely, 1) identification of HIV patients at risk of medication non-adherence and/or loss to care; 2) prediction of complications of HIV patients; and 3) identification of patients at high risk of HIV infection. Our model development will be guided by ethical principles to ensure data privacy, security, and transparency. We will adopt a human-centered approach that seeks valuable inputs from and meaningful engagements with key stakeholders informed by the theory of Participatory Action Research. Once successfully completed, our project is expected to advance the state-of- the-art multimodal AI and knowledge graphs that can be applied/adapted to other use cases in HIV and transform HIV care and prevention.

NICHD - Eunice Kennedy Shriver National Institute of Child Health and Human Development

PROJECT SUMMARY More than one million children who are HIV-exposed but uninfected (CHEU) are born to pregnant people with HIV (PPHIV) every year. CHEU have a higher risk of adverse early-life outcomes than HIV-unexposed peers, including neurodevelopmental deficits and a >2-fold risk of growth stunting. The pathophysiology of adverse CHEU outcomes is incompletely understood, but mounting evidence suggests that placental abnormalities play a key role. A better understanding of the causes and mechanisms of poor developmental outcomes in CHEU is essential to improve the care of PPHIV and their offspring. Our overarching goal is to determine which 1) clinical, 2) placental histological, and 3) placental stereologic features predict adverse CHEU neurodevelopmental and growth outcomes. Leveraging our ongoing multi-country (Uganda, South Africa) birth cohort (n=1,200) and linked placental biobank, we will perform state-of-the-art 3D placental stereology and build artificial intelligence (AI) classifier models to predict CHEU child health outcomes, employing causal inference and instrumental variable analysis to account for confounding. We will also perform mediation analysis to determine whether placental features mediate the relationship between clinical and laboratory features and child outcomes. Innovation: Distinct advantages of our proposed research include 1) simultaneous collection and comparison of CHEU and HIV/antiretroviral-unexposed placentas and children, 2) use of rich clinical data and complementary methods [3D stereologic imaging and histopathology] to evaluate associations between placental abnormalities and adverse CHEU neurodevelopmental and growth outcomes, and 3) use of causal inference and mediation analysis methods to identify key and modifiable features. Investigators: Our interdisciplinary team with expertise in placental collection and birth cohorts (Bebell, Gray), placental pathology and AI (Goldstein), bioinformatics, AI, and mediation analysis (Dreyfuss, Kawuma), placental ARV effects (Serghides), developmental psychology (Malcolm-Smith), and pediatric neurodevelopment (Donald) is well-poised to complete this work. Approach: We will leverage biobanked placental samples and extend follow-up of enrolled mother-child dyads in Dr. Bebell’s (R01HD11232) and Dr. Gray’s (R01HD102050) birth cohorts; Dr. Serghides’ laboratory infrastructure, Dr. Goldstein’s AI algorithms, and Dr. Dreyfuss’ mediation analysis and causal inference methods to elucidate the effects of HIV and specific ARV exposure on the placenta and child neurodevelopment and growth through age 5 years via these Specific Aims: 1a) Identify clinical and laboratory features that predict neurodevelopmental and growth outcomes in CHEU, 1b) Determine whether placental histologic diagnoses advance neurodevelopmental and growth outcome prediction, and 2) Incorporate placental stereology features into prediction models for neurodevelopmental and growth outcomes. Identifying HIV- and specific ARV-related placental abnormalities and associations with adverse CHEU outcomes has great potential to improve child health by informing ARV selection in pregnancy and early identification and intervention for at-risk children.

NIGMS - National Institute of General Medical Sciences

Project Summary Advancing Probe Technology for Ultrasensitive RNA Imaging via Hybridization Chain Reaction Encoded in the genome of each organism, biological circuits direct development, maintain integrity in the face of attacks, control responses to environmental stimuli, and sometimes malfunction to cause disease. RNA in situ hybridization (RNA-ISH) methods provide drug developers, pathologists, and biologists with a critical window into the spatial organization of this circuitry, enabling imaging of RNA expression in an anatomical context. While it is desirable to perform multiplex experiments in which multiple targets are imaged quantitatively at high resolution in a single specimen, using traditional RNA-ISH methods in whole-mount vertebrate embryos and thick tissue sections, multiplexing is cumbersome, staining is non-quantitative, and spatial resolution is routinely compromised by diffusion of reporter molecules. These multi-decade technological shortcomings have significantly impeded the study of gene regulatory networks in systems most relevant to human development and disease. To overcome these challenges, in situ amplification based on the mechanism of hybridization chain reaction (HCR) draws on concepts from the new field of dynamic nucleic acid nanotechnology to redefine the state-of-the- art for RNA fluorescence in situ hybridization (RNA-FISH), achieving four breakthroughs in highly autofluorescent samples including whole-mount vertebrate embryos, thick brain slices, and FFPE tissue sections: 1) straight- forward multiplexing with 1-step quantitative signal amplification for up to 10 target mRNAs simultaneously; 2) analog mRNA relative quantitation with subcellular resolution in an anatomical context; 3) digital mRNA abso- lute quantitation with single-molecule resolution in an anatomical context; 4) automatic background suppression throughout the protocol, dramatically enhancing performance and ease-of-use. However, automatic background suppression is achieved using a dual-probe technology that does not apply to short RNA targets (e.g., miRNAs) that are only long enough to stably bind a single probe. Moreover, for single- molecule imaging of low-abundance mRNA targets, where each target molecule is resolved as a distinct dot, variable probe hybridization yield due to competing secondary structure within the target leads to a distribution of dot intensities that can overlap with autofluorescence, leading to false-negatives or false-positives. The proposed R&D will address these two critical technology gaps. To suppress background for imaging short RNA targets, we will develop a new probe architecture that minimizes non-specific binding while preserving robust HCR am- plification. To achieve high-fidelity single-molecule imaging across all classes of RNA targets, we will develop an automated probe design pipeline that combines physics-based simulations with bioinformatics to generate probe sequences with minimal off-target binding and high-yield hybridization to cognate RNA targets. These advances will enable biologists, drug developers, and pathologists to perform ultrasensitive imaging of all classes of target RNAs with anatomical context in the samples most relevant to human development and disease.

National Park Service

The National Park Service (NPS), through its National Center for Preservation Technology and Training (NCPTT), supports basic and applied research and develops and disseminates technologies for the preservation of cultural resources. NCPTT trains practitioners in new technologies and promotes technical preservation education for student and career professionals. The Recipient and NPS have identified mutual interests and goals for this agreement including: A. Research: develop and implement new technologies for the preservation and conservation of cultural heritage. B. Training: adapt new and existing technologies to the field of art conservation. Offer training courses for students and convene experts on technical and scientific aspects of hands-on conservation. C. Information Management: serve as knowledge centers and clearinghouses for conservation and preservation information. D. Financial Assistance: serve the preservation and conservation community by offering professional development opportunities through internships and training. E. Conference participation: to include holding sessions, participation in exhibits, and sharing meeting facilities.

Africa Regional Services

Priority Region: Sub-Saharan Africa Africa Regional Services (ARS) Paris, part of the U.S. Department of State s Bureau of African Affairs, invites U.S. citizen speakers, artists, and athletes/coaches to submit Statements of Interest (SOIs) for inclusion on the ARS U.S. Speaker Program roster. Roster members may be selected for small program specific grants to conduct in-person and virtual outreach across sub-Saharan Africa. The ARS Speaker Program supports U.S. foreign policy goals in Africa by strengthening security, supporting shared prosperity, and promoting American excellence. In line with the Department s Freedom 250 initiative marking the 250th anniversary of the United States and the Decade of Sport in America programs are encouraged to: Share the American story and 250 years of American excellence in innovation, technology, and culture; and celebrate American achievement in sports. Lead the next era of results driven U.S. Africa partnership. This Annual Program Statement seeks U.S. citizen individuals with demonstrated expertise who can deliver programs in English and either French or Portuguese. Priority Program Areas include security; economic prosperity, innovation, technology, and entrepreneurship; energy security, and critical minerals; and American arts, sports, and creative industries as engines of economic opportunity. Selected individuals will be added to the ARS roster following review and interview. Being on the roster does not guarantee funding; individual grants will be made only when a specific U.S. embassy or consulate request matches a roster member s expertise and availability. SOIs must be submitted using the dedicated form available at https://forms.office.com/g/NyK95VxSH9. All supporting documents (credentials/testimonials/endorsements, U.S. passport and a CV or r sum ) must be emailed to arsspeaker@state.gov. Make sure the email subject line says SOI with your full name. Incomplete Statements of Interest will be rejected.

NIA - National Institute on Aging

PROJECT SUMMARY/ABSTRACT Difficulties finding one’s way in novel environments may lead to anxiety and restrictions in daily activities for older adults. There is a substantial literature documenting age-related deficits in spatial navigation, with particular deficits observed in the acquisition, retrieval and use of a cognitive map of the environment relative to route learning. This is particularly problematic as cognitive mapping permits more flexible navigation, such as taking shortcuts. However, the most common design involves learning and retrieval in a single session. However, the typical study design used in this literature involves learning and retrieving a novel virtual environment in a single session, which could lead to an under-estimation of the full navigation capacities of older adults. Thus, we have gained knowledge of the nature of age deficits in cognitive mapping in the early phases of acquisition and retrieval, but we now need an enhanced understanding of the evolution of older adults’ environmental knowledge and flexible navigation behaviors over more extended time frames, which is more similar to our everyday navigation. Our underlying model is that age-related limitations in processing speed as well as in attentional control and associative processes slow acquisition of relevant associative details of an environment thereby limiting flexible navigation; as well as contribute to greater forgetting and impaired retrieval of this knowledge and thus a reduction in flexible navigation after an extended delay. We will test this model in a paradigm that entails study-test trials across 3 days and a 2-week retention interval. During study, participants will take a “tour” of our city art museum. During test, measures of environmental knowledge and flexible navigation will be obtained. Our experiment will be conducted in a real-world environment as this provides a strong foundation for acquisition, flexible navigation and retention for older adults. Furthermore, it is estimated that around 20-30% of healthy older adults have elevated Alzheimer disease (AD) pathology (i.e., preclinical AD). Enhanced understanding of whether there are specific patterns of acquisition or enhanced forgetting over time in preclinical AD would be useful in developing more sensitive cognitive indicators of the earliest disease stages. In addition, the presence of AD pathology is generally not taken into account in much of the healthy aging literature on spatial navigation. Thus, what is considered an “aging” deficit may to some degree reflect the preclinical AD stage. Thus, the proposed research will determine (1) the pattern of age differences in acquisition and use of a cognitive map over multiple learning episodes; (2) the pattern of age differences in long-term retention and use of a cognitive map; and (3) the role of AD pathology in acquisition and retention of a cognitive map. We will secondarily consider the roles of basic cognitive abilities (i.e., processing speed, attentional control and associative learning), visual attention, and sleep quality as potential contributing factors to spatial navigation deficits. Collectively, these aims will provide a strong basis for programmatic research investigating an array of encoding and retention manipulations to enhance cognitive mapping in older adults. Examining the role of AD pathology provides a foundation for additional cognitive tools for distinguishing healthy aging from the very earliest stages of AD.

European Commission - HORIZON

AI integration in CCSI work practice: catalysing innovation and competitiveness. Call: Culture, Creativity and Inclusive Society 2026. Programme: HORIZON. Keywords: Artificial intelligence, intelligent systems, multi agent systems, Business models, Capacity building, Creativity management, Cultural heritage, cultural memory, Data and image processing, Digitalisation/ICT and cultural heritage, Entrepreneurship, Experimentally-driven research and innovation, High performance computing, Intangible cultural heritage, Knowledge transfer, Machine learning, statistical data processing and applications using signal processing (e.g. speech, image, video), Open innovation, Public administration, Social innovation, Tangible cultural heritage, Trustworthy ICT, Visual arts, performing arts, design. Open call from the EU Funding & Tenders Portal.

NIGMS - National Institute of General Medical Sciences

PROJECT SUMMARY Macrocyclic peptides offer unique therapeutic potential, particularly for targeting intracellular protein-protein interactions considered ‘undruggable’ with traditional therapeutic modalities. Additionally, peptides can combine the benefits and bridge the gap between conventional small molecule therapeutics and large biologics. However, developing new peptide-based therapeutics using traditional approaches, such as natural product discovery or high-throughput library screening, has remained slow and challenging. Moreover, these conventional approaches cover a small fraction of the chemical and structural space, are restricted to a few starting peptide scaffolds, and typically fail to optimize for multiple therapeutic properties simultaneously. Our central hypothesis is that structure-guided deep learning methods can rapidly explore the chemical and structural space beyond natural products and enable precise, rapid, and custom design of functional peptides simultaneously optimized for target binding, selectivity, and membrane permeability. In our recent work, we developed physics-based methods for designing constrained peptides and macrocycles and, more recently, introduced deep learning methods for structure prediction, sequence redesign, and de novo design of peptide monomers and targeted binders. Here, we propose to develop a new generation of structure-guided deep learning (DL) tools to address the current limitations of computational and experimental methods and enable accurate, accessible, and broadly applicable design of macrocycles. Specifically, we will pursue the projects focused on: (i) leveraging DL methods to systematically enumerate the chemical and structural space of constrained peptides and membrane-traversing peptides to develop scaffolds and core design principles for functional peptide design; (ii) high-throughput design and data collection to improve design selection, filtering metrics, and sequence design algorithms; (iii) developing generative DL methods that expand beyond current capabilities and allow sequence and structure design with vast chemical space of non-canonical amino acids; and (iv) use those new generative methods to design macrocyclic binders against different therapeutically-relevant targets, including the critical fusion and attachment proteins from viruses of pandemic concern. Our preliminary work in these proposed areas demonstrates the feasibility of this approach. The proposed computational tools, scaffold sets, and designed peptides will significantly advance therapeutic design beyond the state-of-the-art and enable rapid and custom design of drug- like peptides tailored for addressing complex therapeutic, diagnostic and research challenges.

AK Arts Council

General operating and project support for arts organizations and individual artists in AK. Funds visual arts, performing arts, literary arts, and arts education.

NIH

Background and Innovation: Infection is a leading cause of death after acute kidney injury (AK). Poor innate immune function, dysregulated cytokine production and clearance, and other comorbid conditions are often implicated as reasons for the high rates of infections in individuals with AKI. However, there is little consensus or progress in understanding the unique immunodeficiency AKI creates in a host, and if acute kidney disease (AKD), defined as a more subacute decline in kidney function that encompasses many individuals with and without AKI predisposes to similar risk. We propose a series of highly innovative studies to study and intervene on this apparent immunodeficiency: 1) we have developed novel animal models of AKI and AKD, which are sequentially paired with peritoneal infection to recreate a complex but common human disease with high fidelity, 2) we test both immune blocking, and immune stimulating therapies in our model, establishing a translational rationale for treating individuals with AKI and AKD, 3) we propose using state of the art approaches: non-invasive kidney function monitoring, spectral flow cytometry, and transfer of donor inflammatory cells into our AKI and AKD rodents with immunodeficiency to test our hypotheses. Significance and Impact to Veterans Healthcare: AKI and AKD are extraordinarily common in the Veteran population, both in and out of the intensive care unit (ICU). Very few therapeutic approaches have demonstrated benefit to improve the outcomes of veterans with AKI or AKD. As mentioned, infection is a leading cause of death after AKI, and even without AKI, infection rates are higher in veterans than the general population. Our studies will effectively “reverse model” a common clinical scenario appreciated all to common in veterans, then screen therapeutics which can be rapidly translated to clinical trials. Path to translation/implementation: Data from our studies will inform the approach to treat patients with AKI and AKD with subsequent infection. Given that trials of these therapies in individuals with sepsis are already ongoing, our approaches may rapidly expand the indications for this therapy, but in a different population who has a unique predisposition to sepsis. Notably, we are designing our animal studies to mirror many of the approaches used in these ongoing human clinical trials. This will add heightened translational impact to our results. Outside the immediate clinical translational potential, the novel animal model system we have built can effectively screen many other therapeutics and provide a more rapid bench to bedside pipeline.

Akron Community Foundation

Akron Community Foundation ($300M in assets) supports nonprofits in OH through grants focused on education, community development, health, arts. Awards range from $1,000 to $75,000.

AL Arts Council

General operating and project support for arts organizations and individual artists in AL. Funds visual arts, performing arts, literary arts, and arts education.

Alabama State Council on the Arts

Alabama State Council on the Arts provides grants to support arts and cultural programming, artist fellowships, arts education, and community-based arts projects across AL.

Alabama State Council on the Arts

Supports partnerships between arts organizations and schools to integrate arts into K-12 education, funding artist residencies, professional development for teachers, and arts programming for students across Alabama.

Alabama State Council on the Arts

The Alabama State Council on the Arts provides general operating support grants to established arts organizations across Alabama, funding programming, staff, and operations that deliver arts and cultural experiences to communities.

Alaska State Council on the Arts

ASCA provides grants to arts organizations and community groups for arts programming, arts education, and cultural activities that enrich the lives of Alaskans and support the state's creative economy.

Alberta Foundation for the Arts

AFA provides grants to support the development of arts and culture in Alberta through project grants, operating grants, and individual artist grants.

Albuquerque Community Foundation

Albuquerque Community Foundation ($150M in assets) supports nonprofits in NM through grants focused on education, community development, health, arts. Awards range from $1,000 to $50,000.

U.S. Mission to Indonesia

C. PROGRAM DESCRIPTION1. Project Background, Goals, and ObjectivesThe Alumni United Conference is a day-long professional conference program featuring notable alumni as speakers, facilitators, and moderators; the conference that is preceded by a kick-off gala dinner with keynote addresses from high-level Indonesian alumni and a cultural component (such as a musical, dance, or other performance by Indonesians with U.S. connections, an art exhibit, etc.).The conference must incorporate a theme that aligns with U.S. government priorities to make the United States safer, stronger, and more prosperous, and/or demonstrates American excellence. Priority will be given to organizations that submit projects and themes that highlight U.S. interests, elevate U.S. leadership, and reinforce the United States as Indonesia's partner of choice.Project Audience(s): The primary beneficiaries of the Alumni United Conference are the diverse and influential network of Indonesian alumni with direct ties to the United States, including: Alumni of U.S. government funded exchange programs Alumni of U.S. military education and training programs Graduates of U.S. universities who studied on Indonesian-government grants or private fundingThe audience profile includes mid- to senior-level professionals and emerging leaders from a wide range of sectors, including government, academia, business, creative industries, civil society, and media. Many attendees hold positions of influence and are actively shaping public discourse, policy, and innovation within Indonesia.In addition to alumni, the conference also attracts key stakeholders and partners, such as Indonesian government institutions, private sector leaders, and community organizations with U.S. connections.Project Goal: The goal is to strengthen U.S. Indonesia bilateral relations, particularly through alumni networks, showcase the impact and achievements of Indonesian alumni connected to the United States, and to enhance public diplomacy and outreach efforts of the U.S. Mission in Indonesia.Project Objectives: The specific objectives of the project are to: Hold a high-visibility event that engages key stakeholders and promotes alumni networking; the event will generate coverage in traditional media and online. Expand outreach nationwide fostering alumni engagement and connections with the United State, U.S. officials, and the U.S. government. Deliver a large-scale conference combining a gala and professional program featuring prominent alumni and cultural elements. Ensure all events are executed effectively, on schedule, and within budget, delivering a high-quality participant experience while advancing U.S. strategic communication goals.2. Substantial InvolvementThe recipient organization will be responsible for the day-to-day management and execution of the Alumni United Conference and all related activities, ensuring high-quality delivery in accordance with the approved proposal and cooperative agreement terms.The recipient will: Lead overall project management and implementation, including detailed planning, coordination, and execution of the conference and any related events. Develop and manage the event agenda and logistics, in close coordination with the U.S. Embassy, including venue, production, participant management, and on-site operations. Identify, recruit, and coordinate speakers, moderators, and participants, incorporating Embassy recommendations and securing final approvals as required. Design and implement communications and outreach strategies to ensure strong participation and visibility, consistent with approved messaging and branding guidelines. Manage all financial aspects of the project, including budgeting, procurement, and financial reporting, in compliance with U.S. government regulations. Establish and implement a monitoring and evaluation plan, collect data on outputs and outcomes, and submit required programmatic reports. Ensure compliance with all applicable U.S. government grant regulations, branding requirements, and reporting deadlines. Coordinate closely with the U.S. Embassy through regular updates, meetings, and consultations to ensure alignment and address any implementation challenges.

Amarillo Area Foundation

Amarillo Area Foundation ($800M in assets) supports nonprofits in TX through grants focused on education, health, community development, arts. Awards range from $2,500 to $200,000.

National Endowment for the Humanities

AMERICA250 COMMISSIONS CELEBRATING AMERICA PROJECT [THE AMERICA250 COMMISSION TRAVELING MUSEUM PROJECT WILL BE THE FIRST OF ITS KIND FOR THE ARIZONA SECRETARY OF STATE?S (AZ SOS) OFFICE. IT WILL ENTAIL MULTIPLE ACTIVITIES HONORING THE FOUNDING OF THE UNITED STATES OF AMERICA AND THE PRINCIPLES OF THE DECLARATION OF INDEPENDENCE. PROPOSED ACTIVITIES INCLUDE TOURING ARIZONA?S REPLICA LIBERTY BELL, HISTORICAL DOCUMENTS, ART PIECES, AND INTERACTIVE EXHIBITS IN ALL 15 COUNTIES THROUGHOUT ARIZONA.]