NIH AI Restriction
NIH policy NOT-OD-25-132 prohibits the use of AI-generated text in grant applications that is not substantially modified by the applicant. All AI-drafted sections must be thoroughly rewritten in your own words before submission.
View full policyNIH Director’s Transformative Research Awards (R01 Clinical Trial Optional)
National Institutes of Health
About This Grant
<p style="margin-left:0in;"><span style="background-color:white;">The </span><a href="https://commonfund.nih.gov/TRA"><span style="background-color:white;">NIH Director’s Transformative Research Award</span></a><span style="background-color:white;"> supports individual scientists or groups of scientists proposing bold, groundbreaking, exceptionally innovative, original, and/or unconventional research with the potential to create new scientific paradigms, establish entirely new and improved clinical approaches, or develop transformative technologies. Applications in any area within the biomedical sciences are welcome. No preliminary data are required. Projects must clearly demonstrate, based on the strength of the logic, a compelling potential to produce a major impact in a broad area of relevance to the NIH. The NIH Director’s Transformative Research Award is a component of the </span><a href="http://commonfund.nih.gov/highrisk/"><span style="background-color:white;">High-Risk, High-Reward Research (HRHR) Program</span></a><span style="background-color:white;"> of the </span><a href="http://commonfund.nih.gov/"><span style="background-color:white;">NIH Common Fund</span></a><span style="background-color:white;"><strong>.</strong></span></p>
Grant Summary
NIH Director’s Transformative Research Awards (R01 Clinical Trial Optional) is a National Institutes of Health grant providing funding that varies by award for municipality, small business, tribal government. Applications are due 2026-09-03 (open). Check eligibility and apply with FindGrants.
Focus Areas
Eligibility
- Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government, excluding the NIH Intramural Research Program (NIH IRP);U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions).
How to Apply
Up to $0K
2026-09-03
- 1Confirm your organization is eligible for NIH Director’s Transformative Research Awards (R01 Clinical Trial Optional) from National Institutes of Health, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to National Institutes of Health before the deadline.
Don't want to draft it yourself?
We'll draft the complete application against National Institutes of Health's requirements, run a quality review, and email you a submission-ready PDF plus an editable Word doc within 5 business days. Most orders deliver in 24-48 hours. Flat $399, any grant size.
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NIH Director’s Transformative Research Awards (R01 Clinical Trial Optional): Frequently Asked Questions
Who is eligible for the NIH Director’s Transformative Research Awards (R01 Clinical Trial Optional)?
NIH Director’s Transformative Research Awards (R01 Clinical Trial Optional) is offered by National Institutes of Health and is generally open to municipality, small business, tribal government, university, nonprofit, school district. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the NIH Director’s Transformative Research Awards (R01 Clinical Trial Optional) provide?
NIH Director’s Transformative Research Awards (R01 Clinical Trial Optional) provides an amount that varies by award per award from National Institutes of Health. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the NIH Director’s Transformative Research Awards (R01 Clinical Trial Optional) deadline?
Applications for NIH Director’s Transformative Research Awards (R01 Clinical Trial Optional) are due 2026-09-03 (open). Because deadlines can change, verify the date with the funder, National Institutes of Health, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the NIH Director’s Transformative Research Awards (R01 Clinical Trial Optional)?
To apply for NIH Director’s Transformative Research Awards (R01 Clinical Trial Optional), confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from National Institutes of Health.