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View full policyRestoring Joint Health and Function to Reduce Pain (RE-JOIN) 2.0
About This Grant
The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), in conjunction with other NIH Institutes and Centers (ICs) as a part of the congressionally mandated NIH Helping to End Addiction Long Term (HEAL) initiative intends to publish a Notice of Funding Opportunity (NOFO) to leverage and accelerate the progress achieved in the Restoring Joint Health and Function to Reduce Pain (RE-JOIN) Consortium.
The NOFO aims to more fully refine and map the innervation of the different articular and peri-articular tissues that collectively form the joint (including bone, cartilage, synovium, joint capsule, ligament, tendon, fascia and muscle), by sensory neurons that mediate the sensation of pain.
The NOFO seeks to expand initial and ongoing efforts by:
• Enhancing clinical pain phenotyping with multimodal profiling of new and expanded patient samples across life span and disease conditions (i.e., other musculoskeletal and/or rheumatic conditions associated with joint pain beyond knee and temporomandibular joint (TMJ)). • Expanding to new preclinical and New Approach Methodologies (NAMs) in modeling joint disease. • Preclinical testing of novel joint-targeted candidates identified in RE-JOIN 1.0. • Focusing on peri-articular tissues in joint pain, such as vasculature, synovium, adipose, myofascial tissue, etc. • Prioritizing secondary analysis of datasets and/or validation of methods and approaches in human samples. • Improve data integration by developing/enhancing joint atlases that will enable integration of imaging and molecular datasets.
Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful multidisciplinary collaborations and responsive projects. Investigators with expertise and insights in neurobiology, pain science, data science, orthopedics, rheumatic disease, etc. are encouraged to consider applying for this NOFO.
Grant Summary
Restoring Joint Health and Function to Reduce Pain (RE-JOIN) 2.0 is a National Institutes of Health grant providing funding that varies by award for university, nonprofit, municipality. This is a forecast: it is not yet open for applications, and the estimated deadline is 2026-12-01. Check eligibility and apply with FindGrants.
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Focus Areas
Eligibility
- Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions).
How to Apply
Not stated by funder
Estimated 2026-12-01
- 1Confirm your organization is eligible for Restoring Joint Health and Function to Reduce Pain (RE-JOIN) 2.0 from National Institutes of Health, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to National Institutes of Health before the deadline.
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Restoring Joint Health and Function to Reduce Pain (RE-JOIN) 2.0: Frequently Asked Questions
Who is eligible for the Restoring Joint Health and Function to Reduce Pain (RE-JOIN) 2.0?
Restoring Joint Health and Function to Reduce Pain (RE-JOIN) 2.0 is offered by National Institutes of Health. The listing names these applicant types: university, nonprofit, municipality, tribal government, small business, school district. It is open to organizations nationwide unless the funder specifies otherwise. The funder's eligibility section is the authority, so confirm your organization type, location, and the population or project served against it before applying.
How much funding does the Restoring Joint Health and Function to Reduce Pain (RE-JOIN) 2.0 provide?
National Institutes of Health does not publish a set award amount for Restoring Joint Health and Function to Reduce Pain (RE-JOIN) 2.0, so award sizes vary. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs, and confirm the expected range with the funder.
When is the Restoring Joint Health and Function to Reduce Pain (RE-JOIN) 2.0 deadline?
Restoring Joint Health and Function to Reduce Pain (RE-JOIN) 2.0 is a forecast from National Institutes of Health: it is not yet open for applications. The funder's estimated deadline is 2026-12-01, and forecast dates often change. Confirm the official posting with the funder before you prepare an application.
How do you apply for the Restoring Joint Health and Function to Reduce Pain (RE-JOIN) 2.0?
To apply for Restoring Joint Health and Function to Reduce Pain (RE-JOIN) 2.0, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from National Institutes of Health.
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