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Development of Models, New Approach Methodologies, and Biological Materials for Studying Human Health and Diseases (R21 Clinical Trial Not Allowed)

National Institutes of Health

Forecast — not yet open
Estimated deadline 2028-02-16Last verified: 2026-09-17

About This Grant

This notice of funding opportunity (NOFO) encourages innovative research to develop, characterize, improve or preserve research models and model related biological materials, and to develop or improve technologies, including new approach methodologies (NAMs), for studies relevant to human health and diseases. This NOFO also seeks projects aimed at improving the identification and control of factors that could confound or interfere with the use of research models in biomedical research. The proposed project must have broad applicability to multiple NIH Institutes or Centers (ICs) to align with the NIH-wide mission of the Office of Research Infrastructure Programs (ORIP). The proposed studies must include research model(s) or NAM(s) and must explore multiple body systems or multiple categories of diseases affecting multiple body systems. Applications that develop models focused on a specific disease, a narrow area of research, or a single body system, or propose studies primarily relevant to a single NIH IC will be considered not acceptable to this NOFO.

Grant Summary

Development of Models, New Approach Methodologies, and Biological Materials for Studying Human Health and Diseases (R21 Clinical Trial Not Allowed) is a National Institutes of Health grant providing $190K to $500K for municipality, tribal government, small business. This is a forecast: it is not yet open for applications, and the estimated deadline is 2028-02-16. Check eligibility and apply with FindGrants.

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Focus Areas

health

Eligibility

  • Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions).
municipalitytribal governmentsmall businessuniversityschool districtnonprofit

How to Apply

Funding Range

$190K–$500K

Estimated Deadline

Estimated 2028-02-16

Complexity
Medium
  1. 1Confirm your organization is eligible for Development of Models, New Approach Methodologies, and Biological Materials for Studying Human Health and Diseases (R21 Clinical Trial Not Allowed) from National Institutes of Health, checking organization type, location, and any population or project requirements.
  2. 2Gather the required documents and information, including your organization details, project plan, and budget figures.
  3. 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
  4. 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to National Institutes of Health before the deadline.
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Development of Models, New Approach Methodologies, and Biological Materials for Studying Human Health and Diseases (R21 Clinical Trial Not Allowed): Frequently Asked Questions

Who is eligible for the Development of Models, New Approach Methodologies, and Biological Materials for Studying Human Health and Diseases (R21 Clinical Trial Not Allowed)?

Development of Models, New Approach Methodologies, and Biological Materials for Studying Human Health and Diseases (R21 Clinical Trial Not Allowed) is offered by National Institutes of Health. The listing names these applicant types: municipality, tribal government, small business, university, school district, nonprofit. It is open to organizations nationwide unless the funder specifies otherwise. The funder's eligibility section is the authority, so confirm your organization type, location, and the population or project served against it before applying.

How much funding does the Development of Models, New Approach Methodologies, and Biological Materials for Studying Human Health and Diseases (R21 Clinical Trial Not Allowed) provide?

Development of Models, New Approach Methodologies, and Biological Materials for Studying Human Health and Diseases (R21 Clinical Trial Not Allowed) provides between $190K and $500K per award from National Institutes of Health. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.

When is the Development of Models, New Approach Methodologies, and Biological Materials for Studying Human Health and Diseases (R21 Clinical Trial Not Allowed) deadline?

Development of Models, New Approach Methodologies, and Biological Materials for Studying Human Health and Diseases (R21 Clinical Trial Not Allowed) is a forecast from National Institutes of Health: it is not yet open for applications. The funder's estimated deadline is 2028-02-16, and forecast dates often change. Confirm the official posting with the funder before you prepare an application.

How do you apply for the Development of Models, New Approach Methodologies, and Biological Materials for Studying Human Health and Diseases (R21 Clinical Trial Not Allowed)?

To apply for Development of Models, New Approach Methodologies, and Biological Materials for Studying Human Health and Diseases (R21 Clinical Trial Not Allowed), confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from National Institutes of Health.

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