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Collaborative Research: Wireless Implantable NanoEAB Sensors for Opioid Monitoring in the Brain
NSF
About This Grant
Opioid use disorder (OUD) and addiction affects approximately 3.7% of U.S. adults (9.37 million) and caused more than 70,000 deaths from fentanyl overdoses in 2023. However, we have a limited understanding of where, when, and how opioids modulate the diverse behavioral outputs of the brain. This is partly due to the limited technology available for in vivo opioid monitoring in the brain. This project aims to develop new technology to monitor fentanyl in the brain. The developed technology has a significant impact in several settings. It offers urgently needed technologies to understand with high spatiotemporal resolution how opioids modulate diverse behavioral outputs of the brain. Moreover, the underlying bioelectronic design principles and knowledge generated will be applicable to other fields, including biosensors for therapeutic drug monitoring, immune response tracking, and chronic disease management. The project will involve high school and undergraduate students. Students will receive training in experimental techniques, data analysis, and scientific writing. New course modules leveraging the results of the work will be incorporated into existing undergraduate and graduate courses at North Carolina State University and the University of Connecticut. The goal of the project is to develop and characterize a wireless bioelectronic system for high-performance fentanyl monitoring in the brain of freely moving small animal models. To achieve this goal, we will: 1) isolate, characterize, and engineer aptamers targeting fentanyl, a primary opioid associated with OUD, 2) develop an implantable nanoporous electrochemical aptamer-based (nanoEAB) fentanyl sensor, and study the structure–property relationship of a new surface coating to improve its in vivo longevity, and 3) establish and validate a wireless bioelectronic system for fentanyl monitoring in the brain of freely moving animals. The project will significantly advance the design and development of wireless bioelectronic systems for high-performance fentanyl monitoring in the brain. Additionally, the developed fentanyl sensors could serve as a technology platform for developing wearable emergency response systems for real-time opioid monitoring and closed-loop delivery of therapeutic drugs such as naloxone. Finally, due to the generalizability of the aptamer selection and nanoEAB platform, this technology will serve as a template for designing sensors for monitoring other molecules of biomedical interest by simply replacing the aptamers functionalized on the sensor surface. This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
Grant Summary
Collaborative Research: Wireless Implantable NanoEAB Sensors for Opioid Monitoring in the Brain is a NSF grant providing up to $200K for university, nonprofit, small business. Applications are due 2028-09-30 (open). Check eligibility and apply with FindGrants.
Focus Areas
Eligibility
How to Apply
Up to $200K
2028-09-30
- 1Confirm your organization is eligible for Collaborative Research: Wireless Implantable NanoEAB Sensors for Opioid Monitoring in the Brain from NSF, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NSF before the deadline.
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Collaborative Research: Wireless Implantable NanoEAB Sensors for Opioid Monitoring in the Brain: Frequently Asked Questions
Who is eligible for the Collaborative Research: Wireless Implantable NanoEAB Sensors for Opioid Monitoring in the Brain?
Collaborative Research: Wireless Implantable NanoEAB Sensors for Opioid Monitoring in the Brain is offered by NSF and is generally open to university, nonprofit, small business. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the Collaborative Research: Wireless Implantable NanoEAB Sensors for Opioid Monitoring in the Brain provide?
Collaborative Research: Wireless Implantable NanoEAB Sensors for Opioid Monitoring in the Brain provides up to $200K per award from NSF. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the Collaborative Research: Wireless Implantable NanoEAB Sensors for Opioid Monitoring in the Brain deadline?
Applications for Collaborative Research: Wireless Implantable NanoEAB Sensors for Opioid Monitoring in the Brain are due 2028-09-30 (open). Because deadlines can change, verify the date with the funder, NSF, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the Collaborative Research: Wireless Implantable NanoEAB Sensors for Opioid Monitoring in the Brain?
To apply for Collaborative Research: Wireless Implantable NanoEAB Sensors for Opioid Monitoring in the Brain, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NSF.