NAD-dependent Signaling and Pulmonary Vascular Remodeling in PAH
About This Grant
ABSTRACT Pulmonary arterial hypertension (PAH), a rare, debilitating and fatal disease for which there is currently no available cure. There is compelling evidence that NAD-dependent signaling via NAMPT is a novel and therapeutic target for PAH. To facilitate the translation of current in vivo and in vitro observations on the role of NAMPT dependent signaling in PAH pathobiology, this proposal will explore the hypothesis that the NAMPT/NAD signaling axis regulates physiologic, cellular and molecular pathways in PAH that result in pulmonary vascular remodeling. SA1 seeks to define the role of pulmonary artery endothelial cell NAMPT in the regulation on metabolic reprograming associated with the PH response. SA2 define the role of NAMPT in regulating mitochondrial dynamics in pulmonary artery endothelial cells. SA3 will seek discover and validate biochemical and genetic NAMPT-centric biomarkers of PAH susceptibility and prognosis.
Grant Summary
NAD-dependent Signaling and Pulmonary Vascular Remodeling in PAH is a NHLBI - National Heart Lung and Blood Institute grant providing up to $189K for university, nonprofit, healthcare org. Applications are due 2027-02-28 (open). Check eligibility and apply with FindGrants.
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Focus Areas
Eligibility
How to Apply
Up to $189K
2027-02-28
- 1Confirm your organization is eligible for NAD-dependent Signaling and Pulmonary Vascular Remodeling in PAH from NHLBI - National Heart Lung and Blood Institute, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NHLBI - National Heart Lung and Blood Institute before the deadline.
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NAD-dependent Signaling and Pulmonary Vascular Remodeling in PAH: Frequently Asked Questions
Who is eligible for the NAD-dependent Signaling and Pulmonary Vascular Remodeling in PAH?
NAD-dependent Signaling and Pulmonary Vascular Remodeling in PAH is offered by NHLBI - National Heart Lung and Blood Institute and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the NAD-dependent Signaling and Pulmonary Vascular Remodeling in PAH provide?
NAD-dependent Signaling and Pulmonary Vascular Remodeling in PAH provides up to $189K per award from NHLBI - National Heart Lung and Blood Institute. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the NAD-dependent Signaling and Pulmonary Vascular Remodeling in PAH deadline?
Applications for NAD-dependent Signaling and Pulmonary Vascular Remodeling in PAH are due 2027-02-28 (open). Because deadlines can change, verify the date with the funder, NHLBI - National Heart Lung and Blood Institute, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the NAD-dependent Signaling and Pulmonary Vascular Remodeling in PAH?
To apply for NAD-dependent Signaling and Pulmonary Vascular Remodeling in PAH, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NHLBI - National Heart Lung and Blood Institute.