Molecular and Cellular Determinants of Tolerance to Second Generation Antipsychotics
About This Grant
Contact PD/PI: lewis, elinor PROJECT SUMMARY Second generation antipsychotics (SGAs) are widely used clinical tools for the treatment of severe mental illness. However, their utility is highly variable, and they take weeks to become effective. The mechanisms behind this time course are not understood. SGAs are thought of as antagonists at the D2 dopamine receptor. Yet our recent work suggests that some SGAs function as arrestin-biased agonists at the less-characterized D3 dopamine receptor (D3R). Activation of the arrestin-3 pathway leads to degradation of D3R, potentially altering response to these drugs over time. I have generated preliminary data that shows mice grow tolerant to preclinical measures of SGA activity after chronic treatment of an arrestin-biased SGA. I hypothesize that D3R neurons are the locus of tolerance to select SGAs, and this tolerance is driven by decreased D3R membrane expression caused by arrestin-3 recruitment to D3R. I will use in vivo optical methods to assess changes in D3-neuron activity after chronic SGA treatment. I will also measure behavioral tolerance to SGA treatment in transgenic mice with altered abilities to degrade D3Rs and compare D3R levels using saturation binding and PET scans. This project will reveal mechanisms of tolerance to select SGAs at gross anatomy, cell- type, and protein levels. Project Summary/Abstract Page 6
Grant Summary
Molecular and Cellular Determinants of Tolerance to Second Generation Antipsychotics is a NIMH - National Institute of Mental Health grant providing up to $34K for university, nonprofit, healthcare org. Applications are due 2027-10-31 (open). Check eligibility and apply with FindGrants.
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Up to $34K
2027-10-31
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Molecular and Cellular Determinants of Tolerance to Second Generation Antipsychotics: Frequently Asked Questions
Who is eligible for the Molecular and Cellular Determinants of Tolerance to Second Generation Antipsychotics?
Molecular and Cellular Determinants of Tolerance to Second Generation Antipsychotics is offered by NIMH - National Institute of Mental Health and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the Molecular and Cellular Determinants of Tolerance to Second Generation Antipsychotics provide?
Molecular and Cellular Determinants of Tolerance to Second Generation Antipsychotics provides up to $34K per award from NIMH - National Institute of Mental Health. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the Molecular and Cellular Determinants of Tolerance to Second Generation Antipsychotics deadline?
Applications for Molecular and Cellular Determinants of Tolerance to Second Generation Antipsychotics are due 2027-10-31 (open). Because deadlines can change, verify the date with the funder, NIMH - National Institute of Mental Health, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the Molecular and Cellular Determinants of Tolerance to Second Generation Antipsychotics?
To apply for Molecular and Cellular Determinants of Tolerance to Second Generation Antipsychotics, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NIMH - National Institute of Mental Health.