NCI - National Cancer Institute
Metaclipse is developing a personalized immunotherapy priming stage followed by boosting with a neoantigen-based mRNA vaccine approach to treat nasopharyngeal carcinoma (NPC), a rare and aggressive form of head and neck cancer. NPC is often diagnosed in the later stages of progression with a 10–15% recurrence rate and only a 5-year survival rate of 49%. New targeted therapies are urgently needed. Toripalimab, an anti-PD-1 antibody, was recently approved for NPC, but many patients respond poorly. This suggests a lack of sufficient tumor-specific T cells for Toripalimab to act on. Since the majority of NPC tumors are Epstein-Barr virus (EBV) positive, we will transfect murine squamous cell carcinoma cell line SCCVII with EBV antigens to develop an NPC model system.
Up to $355K
2026-09-04
We'll draft the complete application against NCI - National Cancer Institute's requirements, run a quality review, and email you a submission-ready PDF plus an editable Word doc within 5 business days. Most orders deliver in 24-48 hours. Flat $399, any grant size.
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