Integrating Genomic Risk Assessment for Chronic Disease Management in a Clinical Population
About This Grant
Abstract In the United States, 60% of adults have a chronic disease, and 42% have two or more, accounting for over 90% of the nation’s $4.5 trillion in annual healthcare expenditures. Incorporating genomic risk (polygenic risk scores (PRS) and monogenic risk), and clinical and family health history (FHHx) data into a genome-informed risk assessment (GIRA) can support proactive healthcare by identifying those at elevated risk who may benefit from earlier screening, preventive strategies, or timely initiation or intensification of treatment to delay, reduce, or prevent disease onset. The electronic MEdical Records and GEnomics (eMERGE) network brought together expertise and experience of investigators at 10 sites to develop and validate PRS for 10 chronic conditions. GIRA reports, communicating PRS, monogenic, clinical, and FHHx-based risk for 11 conditions (Asthma, Atrial fibrillation, Breast Cancer, Chronic Kidney Disease, Colorectal Cancer, Coronary Heart Disease, Hypercholesterolemia, Obesity, Prostate Cancer, Type 1 and Type 2 Diabetes) were returned to 23,840 participants (19,535 adults and 4305 children), including risk-reduction recommendations for high-risk individuals. The University of Alabama at Birmingham (UAB) has led network-wide outcomes assessment, data extraction and harmonization, and statistical analyses and actively collaborated with the eMERGE network developing PRS for Chronic Kidney Disease and Type 2 Diabetes, enrolled and completed GIRA returns to 2927 participants (2871 adults, 56 children). All GIRAs were returned to the provider, and participants and uploaded to the EHR. We have completed provider and participant surveys and extracted 6-month EHR outcomes. Participants have completed 12-month follow-up. Data extraction, quality control and harmonization of 12- month outcomes is underway with expected completion by April 2026. This one-year extension (Year 7) request will allow UAB eMERGE IV site to QC and harmonize 12-month outcome data, analyze whether returning high risk GIRA leads to new preventive and screening healthcare actions, and disseminate results through manuscripts. UAB will lead the outcomes assessment and assess provider and participant adoption of recommendations using 12-month data. We will collaborate with the emerge investigative team and NHGRI leadership to continue to discover and publish the findings from the eMERGE IV study.
Grant Summary
Integrating Genomic Risk Assessment for Chronic Disease Management in a Clinical Population is a NHGRI - National Human Genome Research Institute grant providing up to $856K for university, nonprofit, healthcare org. Applications are due 2027-04-30 (open). Check eligibility and apply with FindGrants.
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Eligibility
How to Apply
Up to $856K
2027-04-30
- 1Confirm your organization is eligible for Integrating Genomic Risk Assessment for Chronic Disease Management in a Clinical Population from NHGRI - National Human Genome Research Institute, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NHGRI - National Human Genome Research Institute before the deadline.
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Integrating Genomic Risk Assessment for Chronic Disease Management in a Clinical Population: Frequently Asked Questions
Who is eligible for the Integrating Genomic Risk Assessment for Chronic Disease Management in a Clinical Population?
Integrating Genomic Risk Assessment for Chronic Disease Management in a Clinical Population is offered by NHGRI - National Human Genome Research Institute and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the Integrating Genomic Risk Assessment for Chronic Disease Management in a Clinical Population provide?
Integrating Genomic Risk Assessment for Chronic Disease Management in a Clinical Population provides up to $856K per award from NHGRI - National Human Genome Research Institute. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the Integrating Genomic Risk Assessment for Chronic Disease Management in a Clinical Population deadline?
Applications for Integrating Genomic Risk Assessment for Chronic Disease Management in a Clinical Population are due 2027-04-30 (open). Because deadlines can change, verify the date with the funder, NHGRI - National Human Genome Research Institute, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the Integrating Genomic Risk Assessment for Chronic Disease Management in a Clinical Population?
To apply for Integrating Genomic Risk Assessment for Chronic Disease Management in a Clinical Population, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NHGRI - National Human Genome Research Institute.